Transcriptional control of the proliferation cluster by the tumor suppressor p53. (Q37660051)

21 August 2017

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title

Transcriptional control of the proliferation cluster by the tumor suppressor p53. (English)

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21 August 2017

2

Varda Rotter

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21 August 2017

Ran Brosh

1

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21 August 2017

24 August 2009

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21 August 2017

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21 August 2017

6

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21 August 2017

1

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21 August 2017

17-29

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Gene-expression signatures in breast cancer

21 August 2017

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Utilization of genomic signatures to direct use of primary chemotherapy

21 January 2018

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Common markers of proliferation.

21 January 2018

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Distinctive gene expression patterns in human mammary epithelial cells and breast cancers

21 January 2018

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Systematic variation in gene expression patterns in human cancer cell lines

21 January 2018

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Molecular portraits of human breast tumours

21 January 2018

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A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers.

21 January 2018

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Expression profiling of serous low malignant potential, low-grade, and high-grade tumors of the ovary.

21 January 2018

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Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

21 January 2018

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A cell proliferation and chromosomal instability signature in anaplastic thyroid carcinoma.

21 January 2018

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Gene expression profiling identifies clinically relevant subtypes of prostate cancer

21 January 2018

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Identification of an integrated SV40 T/t-antigen cancer signature in aggressive human breast, prostate, and lung carcinomas with poor prognosis.

21 January 2018

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Gene expression patterns associated with p53 status in breast cancer.

21 January 2018

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TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

21 January 2018

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An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

21 January 2018

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A cell proliferation signature is a marker of extremely poor outcome in a subpopulation of breast cancer patients

21 January 2018

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A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer

21 January 2018

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Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

21 January 2018

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Identification of a proliferation gene cluster associated with HPV E6/E7 expression level and viral DNA load in invasive cervical carcinoma

21 January 2018

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Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen

21 January 2018

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Conditional expression of MCM7 increases tumor growth without altering DNA replication activity

21 January 2018

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Complete loss of the tumor suppressor MAD2 causes premature cyclin B degradation and mitotic failure in human somatic cells.

21 January 2018

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Activated p53 suppresses the histone methyltransferase EZH2 gene.

21 January 2018

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Deregulated minichromosomal maintenance protein MCM7 contributes to oncogene driven tumorigenesis

21 January 2018

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Increased levels of the FoxM1 transcription factor accelerate development and progression of prostate carcinomas in both TRAMP and LADY transgenic mice

21 January 2018

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Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line

21 January 2018

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Mad2 overexpression promotes aneuploidy and tumorigenesis in mice

21 January 2018

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Targeting cyclin B1 inhibits proliferation and sensitizes breast cancer cells to taxol

21 January 2018

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The spindle checkpoint, aneuploidy, and cancer

21 January 2018

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Overexpression of Cdc20 leads to impairment of the spindle assembly checkpoint and aneuploidization in oral cancer

21 January 2018

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Enhancement of radiation response in p53-deficient cancer cells by the Aurora-B kinase inhibitor AZD1152.

21 January 2018

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Topoisomerase levels determine chemotherapy responsein vitroandin vivo

21 January 2018

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Aurora kinase A inhibition leads to p73-dependent apoptosis in p53-deficient cancer cells

21 January 2018

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Autoregulatory control of E2F1 expression in response to positive and negative regulators of cell cycle progression.

21 January 2018

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The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.

21 January 2018

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E2F target genes: unraveling the biology

21 January 2018

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E2Fs link the control of G1/S and G2/M transcription

21 January 2018

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The Rb/E2F pathway and cancer

21 January 2018

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Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle

21 January 2018

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Posttranslational regulation of NF-YA modulates NF-Y transcriptional activity.

21 January 2018

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p53 mutations in human cancers

21 January 2018

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21 January 2018

Surfing the p53 network

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Decision making by p53: life, death and cancer

21 January 2018

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p53 must be competent for transcriptional regulation to suppress tumor formation

21 January 2018

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Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis

21 January 2018

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Transcriptional repression mediated by the p53 tumour suppressor

21 January 2018

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Ablation of key oncogenic pathways by RITA-reactivated p53 is required for efficient apoptosis

21 January 2018

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Cytoplasmic functions of the tumour suppressor p53.

21 January 2018

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p53-dependent cell cycle control: response to genotoxic stress

21 January 2018

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The p53 tumor suppressor participates in multiple cell cycle checkpoints

21 January 2018

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Regulation of the G2/M transition by p53.

21 January 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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14-3-3sigma is a p53-regulated inhibitor of G2/M progression

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Wild-type p53 can down-modulate the activity of various promoters

21 January 2018

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Effect of tumor suppressors on cell cycle-regulatory genes: RB suppresses p34cdc2 expression and normal p53 suppresses cyclin A expression.

21 January 2018

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p53-dependent G2 arrest associated with a decrease in cyclins A2 and B1 levels in a human carcinoma cell line

21 January 2018

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p53 negatively regulates cdc2 transcription via the CCAAT-binding NF-Y transcription factor

21 January 2018

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p130/E2F4 binds to and represses the cdc2 promoter in response to p53.

21 January 2018

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Identification of PRC1 as the p53 target gene uncovers a novel function of p53 in the regulation of cytokinesis

21 January 2018

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DNA damage-induced downregulation of Cdc25C is mediated by p53 via two independent mechanisms: one involves direct binding to the cdc25C promoter.

21 January 2018

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DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis

21 January 2018

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Transcriptional repression of the anti-apoptotic survivin gene by wild type p53.

21 January 2018

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Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression

21 January 2018

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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

21 January 2018

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Wild-type p53 and p73 negatively regulate expression of proliferation related genes

21 January 2018

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Gene expression profiling predicts clinical outcome of breast cancer

21 January 2018

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Requirement for p53 and p21 to sustain G2 arrest after DNA damage

21 January 2018

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DAVID: Database for Annotation, Visualization, and Integrated Discovery

21 January 2018

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

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Transcription regulation by mutant p53.

21 January 2018

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High topoisomerase IIalpha expression associates with high proliferation rate and and poor prognosis in oligodendrogliomas.

21 January 2018

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High cyclin B1 expression is associated with poor survival in breast cancer

21 January 2018

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High expression of EZH2 is associated with tumor proliferation and prognosis in human oral squamous cell carcinomas

21 January 2018

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Nuclear overexpression of mitotic regulatory proteins in biliary tract cancer: correlation with clinicopathologic features and patient survival

21 January 2018

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Overexpression and amplification of Aurora-A in hepatocellular carcinoma

21 January 2018

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DNA damage induced p53 downregulates Cdc20 by direct binding to its promoter causing chromatin remodeling

21 January 2018

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The tumour suppressor protein p53 can repress transcription of cyclin B.

21 January 2018

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E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest

21 January 2018

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p21/CDKN1A mediates negative regulation of transcription by p53.

21 January 2018

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21 January 2018

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Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway

21 January 2018

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Direct p53 transcriptional repression: in vivo analysis of CCAAT-containing G2/M promoters.

21 January 2018

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Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

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p53-dependent down-regulation of telomerase is mediated by p21waf1.

21 January 2018

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Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase

21 January 2018

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The molecular biology of the CCAAT-binding factor NF-Y

21 January 2018

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Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells

21 January 2018

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Role of the p16 tumor suppressor gene in cancer

21 January 2018

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The retinoblastoma tumor-suppressor gene, the exception that proves the rule

21 January 2018

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Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

21 January 2018

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Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

21 January 2018

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p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.

21 January 2018

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A microRNA expression signature of human solid tumors defines cancer gene targets

21 January 2018

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A microRNA polycistron as a potential human oncogene

21 January 2018

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E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer

21 January 2018

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MCM7 amplification and overexpression are associated with prostate cancer progression

21 January 2018

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c-Myc-regulated microRNAs modulate E2F1 expression

21 January 2018

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An E2F/miR-20a autoregulatory feedback loop.

21 January 2018

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Direct regulation of an oncogenic micro-RNA cluster by E2F transcription factors

21 January 2018

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MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression

21 January 2018

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miR-17-92 cluster accelerates adipocyte differentiation by negatively regulating tumor-suppressor Rb2/p130

21 January 2018

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The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma

21 January 2018

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21 January 2018

Identifiers

DOI

10.1039/B911416E

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21 August 2017

1 reference

PubMed ID

20024063