Mechanisms of resistance to HER family targeting antibodies (Q37671920)

21 August 2017

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title

Mechanisms of resistance to HER family targeting antibodies (English)

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21 August 2017

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Tim J Kruser

1

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ORCID Public Data File 2021

author name string

Deric L Wheeler

series ordinal

2

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PubMed ID

20064507

21 August 2017

language of work or name

English

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publication date

11 January 2010

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Experimental Cell Research

21 August 2017

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21 August 2017

316

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21 August 2017

7

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21 August 2017

1083-1100

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Loss of expression of the PTEN gene protein product is associated with poor outcome in breast cancer

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TGFalpha expression impairs Trastuzumab-induced HER2 downregulation

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Relationship of epidermal growth factor receptor expression to ErbB-2 signaling activity and prognosis in breast cancer patients

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Transforming growth factor beta engages TACE and ErbB3 to activate phosphatidylinositol-3 kinase/Akt in ErbB2-overexpressing breast cancer and desensitizes cells to trastuzumab

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Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation.

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Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin

7 January 2021

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https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Human breast cancer cells selected for resistance to trastuzumab in vivo overexpress epidermal growth factor receptor and ErbB ligands and remain dependent on the ErbB receptor network

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Molecular mechanisms underlying IGF-I-induced attenuation of the growth-inhibitory activity of trastuzumab (Herceptin) on SKBR3 breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Met receptor contributes to trastuzumab resistance of Her2-overexpressing breast cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Strategies for delaying or treating in vivo acquired resistance to trastuzumab in human breast cancer xenografts

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Cooperative inhibitory effect of ZD1839 (Iressa) in combination with trastuzumab (Herceptin) on human breast cancer cell growth.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Combined epidermal growth factor receptor targeting with the tyrosine kinase inhibitor gefitinib (ZD1839) and the monoclonal antibody cetuximab (IMC-C225): superiority over single-agent receptor targeting.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Signaling via ErbB2 and ErbB3 associates with resistance and epidermal growth factor receptor (EGFR) amplification with sensitivity to EGFR inhibitor gefitinib in head and neck squamous cell carcinoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Lapatinib plus capecitabine for HER2-positive advanced breast cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Combined lapatinib and cetuximab enhance cytotoxicity against gefitinib-resistant lung cancer cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Anti-tumor activity of the combination of cetuximab, an anti-EGFR blocking monoclonal antibody and ZD6474, an inhibitor of VEGFR and EGFR tyrosine kinases

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

An oncogenic isoform of HER2 associated with locally disseminated breast cancer and trastuzumab resistance

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Establishment and characterization of a model of acquired resistance to epidermal growth factor receptor targeting agents in human cancer cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

PIK3CA mutations are not a major determinant of resistance to the epidermal growth factor receptor inhibitor cetuximab in metastatic colorectal cancer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

Synergy between cetuximab and chemotherapy in tumors of the gastrointestinal tract

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

A novel mechanism of resistance to epidermal growth factor receptor antagonism in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.YEXCR.2010.01.009

10.1016/J.YEXCR.2010.01.009

7 January 2021

Identifiers

DOI

1 reference

21 August 2017

1 reference

PubMed ID

20064507