Serine/threonine phosphatases in the DNA damage response and cancer (Q37788536)

23 August 2017

title

Serine/threonine phosphatases in the DNA damage response and cancer (English)

1 reference

23 August 2017

0 references

A. Peng

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20838380

12 July 2024

J. L. Maller

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20838380

12 July 2024

language of work or name

English

0 references

publication date

13 September 2010

1 reference

full work available at URL

23 August 2017

https://www.nature.com/articles/onc2010371.pdf

file format

Portable Document Format

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.371

https://www.nature.com/articles/onc2010371

12 July 2024

1 reference

https://api.crossref.org/works/10.1038/ONC.2010.371

12 July 2024

1 reference

23 August 2017

volume

29

1 reference

23 August 2017

issue

45

1 reference

23 August 2017

page(s)

5977-5988

1 reference

23 August 2017

cites work

The Chk2 protein kinase

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Mutation status of the residual ATM allele is an important determinant of the cellular response to chemotherapy and survival in patients with chronic lymphocytic leukemia containing an 11q deletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Dephosphorylation of gamma H2A by Glc7/protein phosphatase 1 promotes recovery from inhibition of DNA replication.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Chemical inhibition of Wip1 phosphatase contributes to suppression of tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA damage-induced cell cycle regulation and function of novel Chk2 phosphoresidues.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

A protein phosphatase feedback mechanism regulates the basal phosphorylation of Chk2 kinase in the absence of DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Genomic instability in mice lacking histone H2AX

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Wip1 directly dephosphorylates gamma-H2AX and attenuates the DNA damage response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Identification of specific PP2A complexes involved in human cell transformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

A PP4-phosphatase complex dephosphorylates gamma-H2AX generated during DNA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Recovery from DNA damage checkpoint arrest by PP1-mediated inhibition of Chk1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Phosphorylation of p53 at serine 37 is important for transcriptional activity and regulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatases regulate DNA-dependent protein kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 6 interacts with the DNA-dependent protein kinase catalytic subunit and dephosphorylates gamma-H2AX.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Regulation of Chk2 phosphorylation by interaction with protein phosphatase 2A via its B' regulatory subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

p53: guardian of the genome and policeman of the oncogenes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 2A-dependent dephosphorylation of replication protein A is required for the repair of DNA breaks induced by replication stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Negative regulation of CHK2 activity by protein phosphatase 2A is modulated by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Mechanisms of checkpoint kinase Rad53 inactivation after a double-strand break in Saccharomyces cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

ATM gene and lymphoid malignancies

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Ionizing radiation activates nuclear protein phosphatase-1 by ATM-dependent dephosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

An oncogene-induced DNA damage model for cancer development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Phosphatase inhibition and cell survival after DNA damage induced by radiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Phosphatases, DNA damage checkpoints and checkpoint deactivation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

The combined status of ATM and p53 link tumor development with therapeutic response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA double-strand breaks: signaling, repair and the cancer connection

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Involvement of novel autophosphorylation sites in ATM activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 1 nuclear targeting subunit is a hypoxia inducible gene: its role in post-translational modification of p53 and MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Phosphorylation of Chk1 by ATR is antagonized by a Chk1-regulated protein phosphatase 2A circuit

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Oncogenic properties of PPM1D located within a breast cancer amplification epicenter at 17q23

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Wip1 phosphatase is associated with chromatin and dephosphorylates gammaH2AX to promote checkpoint inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Activation of DNA-PK by ionizing radiation is mediated by protein phosphatase 6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

PP2A regulates ionizing radiation-induced apoptosis through Ser46 phosphorylation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Emerging roles of nuclear protein phosphatases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA damage tumor suppressor genes and genomic instability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Rapid activation of ATR by ionizing radiation requires ATM and Mre11

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

PP4 is a gamma H2AX phosphatase required for recovery from the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Pph3-Psy2 is a phosphatase complex required for Rad53 dephosphorylation and replication fork restart during recovery from DNA damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Repo-man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Regulation of ATM/p53-dependent suppression of myc-induced lymphomas by Wip1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Activation of the cellular DNA damage response in the absence of DNA lesions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

gammaH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Distinct phosphatases mediate the deactivation of the DNA damage checkpoint kinase Rad53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

From promiscuity to precision: protein phosphatases get a makeover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA-PKcs function regulated specifically by protein phosphatase 5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

DNA-damage checkpoints: location, location, location.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Loss of Wip1 sensitizes cells to stress- and DNA damage-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

The Wip1 phosphatase PPM1D dephosphorylates SQ/TQ motifs in checkpoint substrates phosphorylated by PI3K-like kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 2A has an essential role in the activation of gamma-irradiation-induced G2/M checkpoint response

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Intrinsic kinase activity and SQ/TQ domain of Chk2 kinase as well as N-terminal domain of Wip1 phosphatase are required for regulation of Chk2 by Wip1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Protein phosphatase 5 is required for ATR-mediated checkpoint activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

The DNA damage response: putting checkpoints in perspective

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Erratum: Corrigendum: A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

ATM gene deletion in patients with adult acute lymphoblastic leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

The Wip1 phosphatase (PPM1D) antagonizes activation of the Chk2 tumour suppressor kinase

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

Wip1 Phosphatase Modulates ATM-Dependent Signaling Pathways

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FONC.2010.371

31 March 2020

Identifiers

DOI

10.1038/ONC.2010.371

1 reference

23 August 2017

1 reference