Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer (Q37827165)

23 August 2017

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title

Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancer (English)

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23 August 2017

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Meng Wang

1

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23 August 2017

Bruno C Medeiros

2

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23 August 2017

Harry P Erba

3

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23 August 2017

Daniel J DeAngelo

4

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23 August 2017

Francis J Giles

5

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23 August 2017

Ronan T Swords

6

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23 August 2017

language of work or name

English

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publication date

10 January 2011

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Expert Opinion on Therapeutic Targets

23 August 2017

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23 August 2017

15

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23 August 2017

3

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23 August 2017

253-264

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New insights into the pathophysiology of chronic myeloid leukemia and imatinib resistance

23 August 2017

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https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Lessons learned from the development of imatinib

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Function and regulation of protein neddylation. 'Protein modifications: beyond the usual suspects' review series

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Novel substrates and functions for the ubiquitin-like molecule NEDD8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Ribosomal proteins are targets for the NEDD8 pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Identification of a set of genes with developmentally down-regulated expression in the mouse brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Identification of SCF ubiquitin ligase substrates by global protein stability profiling

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Velcade: U.S. FDA approval for the treatment of multiple myeloma progressing on prior therapy

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Bortezomib or high-dose dexamethasone for relapsed multiple myeloma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Identification of the activating and conjugating enzymes of the NEDD8 conjugation pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Covalent modifier NEDD8 is essential for SCF ubiquitin-ligase in fission yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Function and regulation of cullin-RING ubiquitin ligases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

NEDD8 acts as a 'molecular switch' defining the functional selectivity of VHL

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Regulation of nucleolar signalling to p53 through NEDDylation of L11

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

The RUB/Nedd8 conjugation pathway is required for early development in Arabidopsis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

The NED-8 conjugating system in Caenorhabditis elegans is required for embryogenesis and terminal differentiation of the hypodermis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

The NEDD8 system is essential for cell cycle progression and morphogenetic pathway in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Covalent modification of all members of human cullin family proteins by NEDD8

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Methionine residues may protect proteins from critical oxidative damage.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Regulation of the p53 tumor suppressor protein

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.550877

p53 mutations in human cancers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

NUB1 promotes cytoplasmic localization of p53 through cooperation of the NEDD8 and ubiquitin pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Chemotherapy induces NEDP1-mediated destabilization of MDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Control of cell proliferation via elevated NEDD8 conjugation in oral squamous cell carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Altered pattern of Cul-1 protein expression and neddylation in human lung tumours: relationships with CAND1 and cyclin E protein levels.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Modeling the therapeutic efficacy of p53 restoration in tumors

21 January 2018

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https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Restoration of p53 function leads to tumour regression in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Drug discovery: Fresh target for cancer therapy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

MDM2 is a central node in the p53 pathway: 12 years and counting

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Chemical genetics screen for enhancers of rapamycin identifies a specific inhibitor of an SCF family E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

An allosteric inhibitor of substrate recognition by the SCFCdc4 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

A functional link between Wnt signaling and SKP2-independent p27 turnover in mammary tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

The Wnt/beta-catenin pathway is required for the development of leukemia stem cells in AML.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

A targeted proteomic analysis of the ubiquitin-like modifier nedd8 and associated proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Nedd8 on cullin: building an expressway to protein destruction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Regulation of cullin-based ubiquitin ligases by the Nedd8/RUB ubiquitin-like proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

FBXO11 promotes the Neddylation of p53 and inhibits its transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Conjugation to Nedd8 instigates ubiquitylation and down-regulation of activated receptor tyrosine kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Inhibition of APP intracellular domain (AICD) transcriptional activity via covalent conjugation with Nedd8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

pVHL modification by NEDD8 is required for fibronectin matrix assembly and suppression of tumor development

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

Transcription factor Nrf1 mediates the proteasome recovery pathway after proteasome inhibition in mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F14728222.2011.550877

10.1517/14728222.2011.550877

21 January 2018

Identifiers

DOI

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23 August 2017

1 reference