Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease (Q37853789)

24 August 2017

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title

Molecular chaperones and associated cellular clearance mechanisms against toxic protein conformers in Parkinson's disease (English)

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24 August 2017

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Marie-Pierre Hinault

1

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PubMed ID

21411979

24 August 2017

America Farina-Henriquez-Cuendet

series ordinal

2

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PubMed ID

21411979

24 August 2017

Pierre Goloubinoff

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3

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24 August 2017

16 March 2011

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Neurodegenerative Diseases

24 August 2017

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24 August 2017

8

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24 August 2017

397-412

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Emerging pathways in genetic Parkinson's disease: autosomal-recessive genes in Parkinson's disease--a common pathway?

24 August 2017

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Molecular pathogenesis of Parkinson disease: insights from genetic studies

21 January 2018

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Ageing, neurodegeneration and Parkinson's disease

21 January 2018

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Elevated serum pesticide levels and risk of Parkinson disease

21 January 2018

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Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans

21 January 2018

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Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration

21 January 2018

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Mitochondrial biology and oxidative stress in Parkinson disease pathogenesis

21 January 2018

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Parkinson's disease: mechanisms and models

21 January 2018

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The biochemistry of Parkinson's disease

21 January 2018

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Physiological and pathological properties of alpha-synuclein

21 January 2018

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Alpha-synuclein cooperates with CSPalpha in preventing neurodegeneration

21 January 2018

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Vesicle permeabilization by protofibrillar alpha-synuclein is sensitive to Parkinson's disease-linked mutations and occurs by a pore-like mechanism.

21 January 2018

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Neurodegenerative disease: amyloid pores from pathogenic mutations.

21 January 2018

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Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils

21 January 2018

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Are amyloid diseases caused by protein aggregates that mimic bacterial pore-forming toxins?

21 January 2018

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Stable alpha-synuclein oligomers strongly inhibit chaperone activity of the Hsp70 system by weak interactions with J-domain co-chaperones

21 January 2018

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The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates alpha-synuclein degradation decisions between proteasomal and lysosomal pathways

21 January 2018

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Molecular chaperones in the cytosol: from nascent chain to folded protein

21 January 2018

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Chaperones and proteases: cellular fold-controlling factors of proteins in neurodegenerative diseases and aging.

21 January 2018

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Role of molecular chaperones in neurodegenerative disorders

21 January 2018

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Heat shock proteins and protection of the nervous system

21 January 2018

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Heat shock proteins in neurodegenerative diseases: pathogenic roles and therapeutic implications

21 January 2018

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Reconstitution of active dimeric ribulose bisphosphate carboxylase from an unfoleded state depends on two chaperonin proteins and Mg-ATP.

21 January 2018

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Structure and function of the small heat shock protein/alpha-crystallin family of molecular chaperones

21 January 2018

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Substrate specificity of the DnaK chaperone determined by screening cellulose-bound peptide libraries

21 January 2018

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Disaggregating chaperones: an unfolding story.

21 January 2018

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Meta-analysis of heat- and chemically upregulated chaperone genes in plant and human cells.

21 January 2018

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Interaction of the molecular chaperone alphaB-crystallin with alpha-synuclein: effects on amyloid fibril formation and chaperone activity

21 January 2018

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Does ORP150/HSP12A protect dopaminergic neurons against MPTP/MPP(+)-induced neurotoxicity?

21 January 2018

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Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

21 January 2018

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DJ-1 is a redox-dependent molecular chaperone that inhibits alpha-synuclein aggregate formation

21 January 2018

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PARK7 DJ-1 protects against degeneration of nigral dopaminergic neurons in Parkinson's disease rat model.

21 January 2018

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Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease

21 January 2018

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Aggresomes: a cellular response to misfolded proteins

21 January 2018

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Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera

21 January 2018

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Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease

21 January 2018

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Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease

21 January 2018

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Hsp70 Reduces alpha-Synuclein Aggregation and Toxicity

21 January 2018

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Heat shock protein 70 inhibits alpha-synuclein fibril formation via preferential binding to prefibrillar species

21 January 2018

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DnaJB6 is present in the core of Lewy bodies and is highly up-regulated in parkinsonian astrocytes.

21 January 2018

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A DNAJB chaperone subfamily with HDAC-dependent activities suppresses toxic protein aggregation

21 January 2018

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The molecular chaperone Hsp90 modulates intermediate steps of amyloid assembly of the Parkinson-related protein alpha-synuclein.

21 January 2018

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Degradation of wild-type alpha-synuclein by a molecular chaperone leads to reduced aggregate formation

21 January 2018

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Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

21 January 2018

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Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins

21 January 2018

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Sequential mechanism of solubilization and refolding of stable protein aggregates by a bichaperone network

21 January 2018

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Structure of the Hsp110:Hsc70 nucleotide exchange machine

21 January 2018

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Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities

21 January 2018

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Size-dependent disaggregation of stable protein aggregates by the DnaK chaperone machinery.

21 January 2018

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Active solubilization and refolding of stable protein aggregates by cooperative unfolding action of individual hsp70 chaperones

21 January 2018

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The mechanism of Hsp70 chaperones: (entropic) pulling the models together

21 January 2018

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Gene expression profiling of sporadic Parkinson's disease substantia nigra pars compacta reveals impairment of ubiquitin-proteasome subunits, SKP1A, aldehyde dehydrogenase, and chaperone HSC-70.

21 January 2018

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Alterations in lysosomal and proteasomal markers in Parkinson's disease: relationship to alpha-synuclein inclusions.

21 January 2018

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Proteomic identification of a stress protein, mortalin/mthsp70/GRP75: relevance to Parkinson disease.

21 January 2018

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Whole genome expression profiling of the medial and lateral substantia nigra in Parkinson's disease.

21 January 2018

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21 January 2018

The proteasomal system.

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Proteasomal dysfunction activates the transcription factor SKN-1 and produces a selective oxidative-stress response in Caenorhabditis elegans.

21 January 2018

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Diversity of proteasomal missions: fine tuning of the immune response

21 January 2018

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Proteasomal inhibition leads to formation of ubiquitin/alpha-synuclein-immunoreactive inclusions in PC12 cells

21 January 2018

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Dopaminergic neurons in rat ventral midbrain cultures undergo selective apoptosis and form inclusions, but do not up-regulate iHSP70, following proteasomal inhibition

21 January 2018

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α-Synuclein Is Degraded by Both Autophagy and the Proteasome

21 January 2018

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Alpha-synuclein and the Parkinson's disease-related mutant Ala53Thr-alpha-synuclein do not undergo proteasomal degradation in HEK293 and neuronal cells

21 January 2018

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Phosphorylated alpha-synuclein at Ser-129 is targeted to the proteasome pathway in a ubiquitin-independent manner

21 January 2018

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Aggregate formation inhibits proteasomal degradation of polyglutamine proteins.

21 January 2018

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The roles of intracellular protein-degradation pathways in neurodegeneration

21 January 2018

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Modeling proteasome dynamics in Parkinson's disease.

21 January 2018

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Altered proteasomal function in sporadic Parkinson's disease

21 January 2018

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Ubiquitination of alpha-synuclein in Lewy bodies is a pathological event not associated with impairment of proteasome function

21 January 2018

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Transcriptome analysis reveals link between proteasomal and mitochondrial pathways in Parkinson's disease.

21 January 2018

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A close association of torsinA and alpha-synuclein in Lewy bodies: a fluorescence resonance energy transfer study

21 January 2018

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TorsinA and heat shock proteins act as molecular chaperones: suppression of alpha-synuclein aggregation

21 January 2018

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Torsin-mediated protection from cellular stress in the dopaminergic neurons of Caenorhabditis elegans.

21 January 2018

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Aggresomes, inclusion bodies and protein aggregation

21 January 2018

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Accumulation and clearance of alpha-synuclein aggregates demonstrated by time-lapse imaging

21 January 2018

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Autophagy-mediated clearance of aggresomes is not a universal phenomenon

21 January 2018

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Parkin is recruited to the centrosome in response to inhibition of proteasomes

21 January 2018

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UCH-L1 aggresome formation in response to proteasome impairment indicates a role in inclusion formation in Parkinson's disease

21 January 2018

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Aggresomes formed by alpha-synuclein and synphilin-1 are cytoprotective

21 January 2018

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Triggering aggresome formation. Dissecting aggresome-targeting and aggregation signals in synphilin 1

21 January 2018

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Parkin is recruited into aggresomes in a stress-specific manner: over-expression of parkin reduces aggresome formation but can be dissociated from parkin's effect on neuronal survival

21 January 2018

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Rotenone induces aggregation of gamma-tubulin protein and subsequent disorganization of the centrosome: relevance to formation of inclusion bodies and neurodegeneration

21 January 2018

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Sorting, recognition and activation of the misfolded protein degradation pathways through macroautophagy and the proteasome

21 January 2018

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Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

21 January 2018

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HDAC6 and microtubules are required for autophagic degradation of aggregated huntingtin

21 January 2018

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HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

21 January 2018

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Involvement of macroautophagy in the dissolution of neuronal inclusions.

21 January 2018

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21 January 2018

Functions of lysosomes

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Autophagy: many paths to the same end.

21 January 2018

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Development by self-digestion: molecular mechanisms and biological functions of autophagy

21 January 2018

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The molecular machinery of autophagy: unanswered questions

21 January 2018

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Chaperone-mediated autophagy in aging and disease

21 January 2018

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Regulation of neuronal survival factor MEF2D by chaperone-mediated autophagy

21 January 2018

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Autophagy: principles and significance in health and disease

21 January 2018

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Impaired degradation of mutant alpha-synuclein by chaperone-mediated autophagy

21 January 2018

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Wild type alpha-synuclein is degraded by chaperone-mediated autophagy and macroautophagy in neuronal cells

21 January 2018

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Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein

21 January 2018

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Lysosomal degradation of alpha-synuclein in vivo.

21 January 2018

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Chaperone-mediated autophagy

21 January 2018

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Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy

21 January 2018

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Consequences of the selective blockage of chaperone-mediated autophagy

21 January 2018

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Aberrant interaction between Parkinson disease-associated mutant UCH-L1 and the lysosomal receptor for chaperone-mediated autophagy

21 January 2018

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Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species

21 January 2018

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Protein homeostasis and aging: taking care of proteins from the cradle to the grave

21 January 2018

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Mammalian stress proteins HSP70 and HSP28 coinduced by nicotine and either ethanol or heat

21 January 2018

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Bimoclomol: a nontoxic, hydroxylamine derivative with stress protein-inducing activity and cytoprotective effects

21 January 2018

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Stimulation of the stress-induced expression of stress proteins by curcumin in cultured cells and in rat tissues in vivo

21 January 2018

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Radicicol activates heat shock protein expression and cardioprotection in neonatal rat cardiomyocytes

21 January 2018

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Treatment with arimoclomol, a coinducer of heat shock proteins, delays disease progression in ALS mice

21 January 2018

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Celastrols as inducers of the heat shock response and cytoprotection.

21 January 2018

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Geldanamycin induces heat shock protein 70 and protects against MPTP-induced dopaminergic neurotoxicity in mice

21 January 2018

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Induction of HSP70 expression and recruitment of HSC70 and HSP70 in the nucleus reduce aggregation of a polyalanine expansion mutant of PABPN1 in HeLa cells

21 January 2018

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Heat shock response modulators as therapeutic tools for diseases of protein conformation

21 January 2018

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Modulation of Hsp90 function in neurodegenerative disorders: a molecular-targeted therapy against disease-causing protein

21 January 2018

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The thiol antioxidant 1,2-dithiole-3-thione stimulates the expression of heat shock protein 70 in dopaminergic PC12 cells

21 January 2018

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Acute effects of diclofenac and DMSO to Daphnia magna: immobilisation and hsp70-induction

21 January 2018

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Synthesis of reblastatin, autolytimycin, and non-benzoquinone analogues: potent inhibitors of heat shock protein 90.

21 January 2018

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Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

21 January 2018

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17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy

21 January 2018

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Chemical chaperones regulate molecular chaperones in vitro and in cells under combined salt and heat stresses

21 January 2018

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Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.

21 January 2018

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Beclin 1 gene transfer activates autophagy and ameliorates the neurodegenerative pathology in alpha-synuclein models of Parkinson's and Lewy body diseases

21 January 2018

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Thioredoxin suppresses Parkin-associated endothelin receptor-like receptor-induced neurotoxicity and extends longevity in Drosophila

21 January 2018

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The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration

21 January 2018

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Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

21 January 2018

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Alpha-synuclein is part of a diverse and highly conserved interaction network that includes PARK9 and manganese toxicity

21 January 2018

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Methionine sulfoxide reductase A protects dopaminergic cells from Parkinson's disease-related insults

21 January 2018

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Synphilin-1 attenuates neuronal degeneration in the A53T alpha-synuclein transgenic mouse model

21 January 2018

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Characterization of alpha-synuclein interactions with selected aggregation-inhibiting small molecules

21 January 2018

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On the mechanism of nonspecific inhibitors of protein aggregation: dissecting the interactions of alpha-synuclein with Congo red and lacmoid

21 January 2018

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Inhibitors of alpha-synuclein oligomerization and toxicity: a future therapeutic strategy for Parkinson's disease and related disorders

21 January 2018

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Peptide ligand screening of alpha-synuclein aggregation modulators by in silico panning

21 January 2018

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Interactive sequences in the molecular chaperone, human alphaB crystallin modulate the fibrillation of amyloidogenic proteins

21 January 2018

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The flavonoid baicalein inhibits fibrillation of alpha-synuclein and disaggregates existing fibrils

21 January 2018

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Baicalein reduces E46K alpha-synuclein aggregation in vitro and protects cells against E46K alpha-synuclein toxicity in cell models of familiar Parkinsonism.

21 January 2018

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The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein

21 January 2018

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Pyrroloquinoline quinone (PQQ) prevents fibril formation of alpha-synuclein.

21 January 2018

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Gene expression profiling related to anti-inflammatory properties of curcumin in K562 leukemia cells

21 January 2018

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Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease

21 January 2018

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NSAID and antioxidant prevention of Alzheimer's disease: lessons from in vitro and animal models.

21 January 2018

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Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathology

21 January 2018

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Curcumin reduces alpha-synuclein induced cytotoxicity in Parkinson's disease cell model

21 January 2018

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Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for alpha-synuclein fibrils in vitro

21 January 2018

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Curcumin inhibits aggregation of alpha-synuclein

21 January 2018

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Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity

21 January 2018

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Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models.

21 January 2018

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Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

21 January 2018

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Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

21 January 2018

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Membrane-associated farnesylated UCH-L1 promotes alpha-synuclein neurotoxicity and is a therapeutic target for Parkinson's disease

21 January 2018

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Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone.

21 January 2018

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A chemical chaperone, sodium 4-phenylbutyric acid, attenuates the pathogenic potency in human alpha-synuclein A30P + A53T transgenic mice.

21 January 2018

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Can the stress protein response be controlled by 'membrane-lipid therapy'?

21 January 2018

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The heat shock response in moss plants is regulated by specific calcium-permeable channels in the plasma membrane

21 January 2018

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HSP72 protects against obesity-induced insulin resistance

21 January 2018

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Late stage treatment with arimoclomol delays disease progression and prevents protein aggregation in the SOD1 mouse model of ALS

21 January 2018

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Enhanced heat shock protein 70 expression alters proteasomal degradation of IkappaB kinase in experimental acute respiratory distress syndrome

21 January 2018

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The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase

21 January 2018

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Adapting proteostasis for disease intervention

21 January 2018

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Heat Shock Protein 70 Inhibits α-Synuclein Fibril Formation via Interactions with Diverse Intermediates

21 January 2018

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Autophagy: links with the proteasome

21 January 2018

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21 January 2018

Identifiers

DOI

10.1159/000324514

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24 August 2017

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PubMed ID

21411979