In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer (Q37855883)

24 August 2017

1 reference

title

In search of second-generation HIV integrase inhibitors: targeting integration beyond strand transfer (English)

1 reference

24 August 2017

3

Zeger Debyser

0 references

Marc De Maeyer

series ordinal

2

object named as

Marc De Maeyer

1 reference

24 August 2017

4

Frauke Christ

1 reference

24 August 2017

Arnout Rd Voet

1

1 reference

24 August 2017

publication date

1 October 2009

1 reference

Future Medicinal Chemistry

24 August 2017

published in

1 reference

24 August 2017

volume

1

1 reference

24 August 2017

issue

7

1 reference

24 August 2017

page(s)

1259-1274

1 reference

Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy

24 August 2017

cites work

1 reference

The ins and outs of HIV replication

21 January 2018

1 reference

Stages of HIV Replication and Targets for Therapeutic Intervention

21 January 2018

1 reference

Transportin-SR2 imports HIV into the nucleus

21 January 2018

1 reference

Cellular reservoirs of HIV-1 and their role in viral persistence

21 January 2018

1 reference

Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy

21 January 2018

1 reference

A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team

21 January 2018

1 reference

HIV/AIDS: the management of treatment-experienced HIV-infected patients: new drugs and drug combinations

21 January 2018

1 reference

Current use of antiretroviral treatment

21 January 2018

1 reference

HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy

21 January 2018

1 reference

Viral dynamics in human immunodeficiency virus type 1 infection

21 January 2018

1 reference

Molecular mechanism of retroviral DNA integration

21 January 2018

1 reference

Activities of human immunodeficiency virus (HIV) integration protein in vitro: specific cleavage and integration of HIV DNA

21 January 2018

1 reference

Stereospecificity of reactions catalyzed by HIV-1 integrase

21 January 2018

1 reference

HIV-1 pre-integration complexes selectively target decondensed chromatin in the nuclear periphery

21 January 2018

1 reference

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

21 January 2018

1 reference

Mechanisms governing lentivirus integration site selection

21 January 2018

1 reference

Dynamic modulation of HIV-1 integrase structure and function by cellular lens epithelium-derived growth factor (LEDGF) protein

21 January 2018

1 reference

Integrase, LEDGF/p75 and HIV replication

21 January 2018

1 reference

Chromatinized templates reveal the requirement for the LEDGF/p75 PWWP domain during HIV-1 integration in vitro

21 January 2018

1 reference

Identification and characterization of PWWP domain residues critical for LEDGF/p75 chromatin binding and human immunodeficiency virus type 1 infectivity.

21 January 2018

1 reference

Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.

21 January 2018

1 reference

Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration

21 January 2018

1 reference

Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting

21 January 2018

1 reference

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

21 January 2018

1 reference

Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication

21 January 2018

1 reference

Identification and characterization of the chromatin-binding domains of the HIV-1 integrase interactor LEDGF/p75.

21 January 2018

1 reference

An essential role for LEDGF/p75 in HIV integration

21 January 2018

1 reference

Repair of gaps in retroviral DNA integration intermediates

21 January 2018

1 reference

Domains of the integrase protein of human immunodeficiency virus type 1 responsible for polynucleotidyl transfer and zinc binding

21 January 2018

1 reference

Retroviral integrase, putting the pieces together

21 January 2018

1 reference

Identification of the catalytic and DNA-binding region of the human immunodeficiency virus type I integrase protein

21 January 2018

1 reference

Structural determinants of metal-induced conformational changes in HIV-1 integrase

21 January 2018

1 reference

X-ray structure of simian immunodeficiency virus integrase containing the core and C-terminal domain (residues 50-293)--an initial glance of the viral DNA binding platform

21 January 2018

1 reference

Crystal structure of an active two-domain derivative of Rous sarcoma virus integrase

21 January 2018

1 reference

Evidence for "unseen" transposase--DNA contacts

21 January 2018

1 reference

Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein

21 January 2018

1 reference

Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA binding

21 January 2018

1 reference

Structural basis for HIV-1 DNA integration in the human genome, role of the LEDGF/P75 cofactor

21 January 2018

1 reference

Single-particle image reconstruction of a tetramer of HIV integrase bound to DNA.

21 January 2018

1 reference

HIV-1 integrase inhibitors: past, present, and future

21 January 2018

1 reference

Chicoric acid analogues as HIV-1 integrase inhibitors

21 January 2018

1 reference

Mode of interaction of G-quartets with the integrase of human immunodeficiency virus type 1.

21 January 2018

1 reference

Inhibition of the human immunodeficiency virus type 1 integrase by guanosine quartet structures

21 January 2018

1 reference

Structural determinants for HIV-1 integrase inhibition by beta-diketo acids

21 January 2018

1 reference

Tn5 transposase as a useful platform to simulate HIV-1 integrase inhibitor binding mode

21 January 2018

1 reference

Docking studies on a new human immunodeficiency virus integrase-Mg-DNA complex: phenyl ring exploration and synthesis of 1H-benzylindole derivatives through fluorine substitutions

21 January 2018

1 reference

Inhibitors of strand transfer that prevent integration and inhibit HIV-1 replication in cells

21 January 2018

1 reference

New developments in diketo-containing inhibitors of HIV-1 integrase

21 January 2018

1 reference

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase

21 January 2018

1 reference

4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors

21 January 2018

1 reference

Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors

21 January 2018

1 reference

Discovery of raltegravir, a potent, selective orally bioavailable HIV-integrase inhibitor for the treatment of HIV-AIDS infection

21 January 2018

1 reference

Raltegravir, elvitegravir, and metoogravir: the birth of "me-too" HIV-1 integrase inhibitors

21 January 2018

1 reference

Broad antiretroviral activity and resistance profile of the novel human immunodeficiency virus integrase inhibitor elvitegravir (JTK-303/GS-9137)

21 January 2018

1 reference

Selection of diverse and clinically relevant integrase inhibitor-resistant human immunodeficiency virus type 1 mutants

21 January 2018

1 reference

HIV-2 integrase gene polymorphism and phenotypic susceptibility of HIV-2 clinical isolates to the integrase inhibitors raltegravir and elvitegravir in vitro

21 January 2018

1 reference

Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors

21 January 2018

1 reference

New class of HIV integrase inhibitors that block viral replication in cell culture

21 January 2018

1 reference

Selection of human immunodeficiency virus type 1 resistance against the pyranodipyrimidine V-165 points to a multimodal mechanism of action.

21 January 2018

1 reference

Styrylquinoline derivatives: a new class of potent HIV-1 integrase inhibitors that block HIV-1 replication in CEM cells

21 January 2018

1 reference

Styrylquinolines, integrase inhibitors acting prior to integration: a new mechanism of action for anti-integrase agents

21 January 2018

1 reference

Mechanism of HIV-1 integrase inhibition by styrylquinoline derivatives in vitro

21 January 2018

1 reference

Nuclear import of HIV-1 integrase is inhibited in vitro by styrylquinoline derivatives

21 January 2018

1 reference

Investigations on the 4-quinolone-3-carboxylic acid motif. 1. Synthesis and structure-activity relationship of a class of human immunodeficiency virus type 1 integrase inhibitors

21 January 2018

1 reference

Branched oligonucleotide-intercalator conjugate forming a parallel stranded structure inhibits HIV-1 integrase

21 January 2018

1 reference

Inhibitors of human immunodeficiency virus integrase

21 January 2018

1 reference

Effect of topoisomerase inhibitors on the in vitro HIV DNA integration reaction

21 January 2018

1 reference

Specific interactions of distamycin A and its analogs with (A-T) rich and (G-C) rich duplex regions of DNA and deoxypolynucleotides

21 January 2018

1 reference

Binding of an antitumor drug to DNA, Netropsin and C-G-C-G-A-A-T-T-BrC-G-C-G

21 January 2018

1 reference

The molecular origin of DNA-drug specificity in netropsin and distamycin

21 January 2018

1 reference

Hydrogen-bonding patterns of minor groove-binder-DNA complexes reveal criteria for discovery of new scaffolds

21 January 2018

1 reference

The role of lysine 186 in HIV-1 integrase multimerization

21 January 2018

1 reference

Identification of a hexapeptide inhibitor of the human immunodeficiency virus integrase protein by using a combinatorial chemical library

21 January 2018

1 reference

A synthetic peptide from the human immunodeficiency virus type-1 integrase exhibits coiled-coil properties and interferes with the in vitro integration activity of the enzyme. Correlated biochemical and spectroscopic results

21 January 2018

1 reference

Interfacial peptide inhibitors of HIV-1 integrase activity and dimerization

21 January 2018

1 reference

Synthesis and HIV-1 integrase inhibitory activity of dimeric and tetrameric analogs of indolicidin

21 January 2018

1 reference

Identification by phage display selection of a short peptide able to inhibit only the strand transfer reaction catalyzed by human immunodeficiency virus type 1 integrase

21 January 2018

1 reference

Design and synthesis of dimeric HIV-1 integrase inhibitory peptides

21 January 2018

1 reference

Self-association of an amphipathic helix peptide inhibitor of HIV-1 integrase assessed by electro spray ionization mass spectrometry in trifluoroethanol/water mixtures

21 January 2018

1 reference

Helical and coiled-coil-forming properties of peptides derived from and inhibiting human immunodeficiency virus type 1 integrase assessed by 1H-NMR--use of NH temperature coefficients to probe coiled-coil structures

21 January 2018

1 reference

Drug-like inhibitors of protein-protein interactions: a structural examination of effective protein mimicry

21 January 2018

1 reference

Targeting the dimerization interface for irreversible inhibition of HIV-1 protease

21 January 2018

1 reference

Small-molecule inhibition of TNF-alpha

21 January 2018

1 reference

Mechanism of suramin-induced deoligomerization of tumor necrosis factor alpha

21 January 2018

1 reference

Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry

21 January 2018

1 reference

Structure-function analysis of integrase interactor 1/hSNF5L1 reveals differential properties of two repeat motifs present in the highly conserved region

21 January 2018

1 reference

Retroviral cDNA integration: stimulation by HMG I family proteins

21 January 2018

1 reference

The barrier-to-autointegration factor is a component of functional human immunodeficiency virus type 1 preintegration complexes

21 January 2018

1 reference

Cellular co-factors of HIV-1 integration

21 January 2018

1 reference

Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication

21 January 2018

1 reference

Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication

21 January 2018

1 reference

LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration

21 January 2018

1 reference

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

21 January 2018

1 reference

Isolation of cDNAs encoding novel transcription coactivators p52 and p75 reveals an alternate regulatory mechanism of transcriptional activation

21 January 2018

1 reference

Lens epithelium-derived growth factor (LEDGF/p75) and p52 are derived from a single gene by alternative splicing

21 January 2018

1 reference

LEDGF activation of PKC gamma and gap junction disassembly in lens epithelial cells

21 January 2018

1 reference

Lens epithelium-derived growth factor (LEDGF/p75) expression in fetal and adult human brain

21 January 2018

1 reference

Disruption of Ledgf/Psip1 results in perinatal mortality and homeotic skeletal transformations

21 January 2018

1 reference

Antinuclear autoantibodies in prostate cancer: immunity to LEDGF/p75, a survival protein highly expressed in prostate tumors and cleaved during apoptosis

21 January 2018

1 reference

LEDGF/p75 has increased expression in blasts from chemotherapy-resistant human acute myelogenic leukemia patients and protects leukemia cells from apoptosis in vitro

21 January 2018

1 reference

Alternative splicing and caspase-mediated cleavage generate antagonistic variants of the stress oncoprotein LEDGF/p75.

21 January 2018

1 reference

The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding

21 January 2018

1 reference

Identification of the LEDGF/p75 binding site in HIV-1 integrase

21 January 2018

1 reference

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

21 January 2018

1 reference

Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75.

21 January 2018

1 reference

D77, one benzoic acid derivative, functions as a novel anti-HIV-1 inhibitor targeting the interaction between integrase and cellular LEDGF/p75.

21 January 2018

1 reference

Screening for antiviral inhibitors of the HIV integrase-LEDGF/p75 interaction using the AlphaScreen luminescent proximity assay

21 January 2018

1 reference

Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro

21 January 2018

1 reference

Binding Mode Prediction of Strand Transfer HIV-1 Integrase Inhibitors Using Tn5 Transposase as a Plausible Surrogate Model for HIV-1 Integrase

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.4155/FMC.09.86

1 reference

24 August 2017

1 reference