Antisense drug discovery and development (Q37859009)

24 August 2017

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title

Antisense drug discovery and development (English)

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24 August 2017

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Tsuyoshi Yamamoto

1

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24 August 2017

Moeka Nakatani

series ordinal

2

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24 August 2017

Keisuke Narukawa

series ordinal

3

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24 August 2017

Satoshi Obika

series ordinal

4

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24 August 2017

1 March 2011

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Future Medicinal Chemistry

24 August 2017

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24 August 2017

3

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24 August 2017

339-365

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24 August 2017

3

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Oral delivery of antisense oligonucleotides in man.

24 August 2017

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Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible?

21 January 2018

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Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide

21 January 2018

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Inhibition of Rous sarcoma viral RNA translation by a specific oligodeoxyribonucleotide

21 January 2018

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Biochemical and biological effects of nonionic nucleic acid methylphosphonates

21 January 2018

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Phosphorothioate analogs of oligodeoxynucleotides: inhibitors of replication and cytopathic effects of human immunodeficiency virus

21 January 2018

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Binding affinity and specificity of Escherichia coli RNase H1: impact on the kinetics of catalysis of antisense oligonucleotide-RNA hybrids

21 January 2018

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Kinetic characteristics of Escherichia coli RNase H1: cleavage of various antisense oligonucleotide-RNA duplexes

21 January 2018

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Structural basis of cleavage by RNase H of hybrids of arabinonucleic acids and RNA

21 January 2018

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Chemically modified oligonucleotides with efficient RNase H response

21 January 2018

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Controlling morpholino experiments: don't stop making antisense.

21 January 2018

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Progress in muscular dystrophy research with special emphasis on gene therapy

21 January 2018

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Progress in antisense technology.

21 January 2018

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The ups and downs of nucleic acid duplex stability: structure-stability studies on chemically-modified DNA:RNA duplexes

21 January 2018

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Backbone modification of nucleic acids: synthesis, structure and therapeutic applications.

21 January 2018

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Building oligonucleotide therapeutics using non-natural chemistries

21 January 2018

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Antisense oligonucleotides containing conformationally constrained 2',4'-(N-methoxy)aminomethylene and 2',4'-aminooxymethylene and 2'-O,4'-C-aminomethylene bridged nucleoside analogues show improved potency in animal models

21 January 2018

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An Exocyclic Methylene Group Acts As a Bioisostere of the 2′-Oxygen Atom in LNA

21 January 2018

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Boranophosphates as mimics of natural phosphodiesters in DNA.

21 January 2018

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Stereo-enriched phosphorothioate oligodeoxynucleotides: synthesis, biophysical and biological properties

21 January 2018

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Diastereocontrolled synthesis of dinucleoside phosphorothioates using a novel class of activators, dialkyl(cyanomethyl)ammonium tetrafluoroborates

21 January 2018

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Solid-phase synthesis of stereoregular oligodeoxyribonucleoside phosphorothioates using bicyclic oxazaphospholidine derivatives as monomer units.

21 January 2018

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Nucleoside and oligonucleoside boranophosphates: chemistry and properties

21 January 2018

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Structural Studies of a Borane-Modified Phosphate Diester Linkage: Ab Initio Calculations on the Dimethylboranophosphate Anion and the Single-Crystal X-ray Structure of Its Diisopropylammonium Salt

21 January 2018

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A DNase from the trypanosomatid Crithidia fasciculata

21 January 2018

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A novel method for the synthesis of dinucleoside boranophosphates by a boranophosphotriester method.

21 January 2018

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Solid phase synthesis of oligodeoxyribonucleoside phosphorodithioates from thiophosphoramidites

21 January 2018

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Phosphorodithioate DNA as a potential therapeutic drug

21 January 2018

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Molecular interactions and hydrogen bond tunneling dynamics: some new perspectives

21 January 2018

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Oligonucleotide N3'-->P5' phosphoramidates

21 January 2018

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Oligonucleotide n3'-->p5' phosphoramidates and thio-phoshoramidates as potential therapeutic agents

21 January 2018

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N3'-->P5' Oligodeoxyribonucleotide Phosphoramidates: A New Method of Synthesis Based on a Phosphoramidite Amine-Exchange Reaction

21 January 2018

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An improved synthesis of oligodeoxynucleotide N3'-->P5' phosphoramidates and their chimera using hindered phosphoramidite monomers and a novel handle for reverse phase purification

21 January 2018

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Synthesis of oligodeoxyribonucleotide N3'-->P5' phosphoramidates

21 January 2018

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Antileukemia effect of c-myc N3'-->P5' phosphoramidate antisense oligonucleotides in vivo

21 January 2018

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Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Nonionic Modifications Better than DNA

21 January 2018

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Design and synthesis of deoxynucleic guanidine: a polycation analogue of DNA.

21 January 2018

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Design and synthesis of ribonucleic guanidine: a polycationic analog of RNA.

21 January 2018

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Binding studies of cationic uridyl ribonucleic guanidine (RNG) to DNA.

21 January 2018

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Ribonucleic guanidine demonstrates an unexpected marked preference for complementary DNA rather than RNA.

21 January 2018

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Complexation of single strand telomere and telomerase RNA template polyanions by deoxyribonucleic guanidine (DNG) polycations: plausible anticancer agents.

21 January 2018

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Development of potential anticancer agents that target the telomere sequence

21 January 2018

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Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents

21 January 2018

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Binding studies of cationic thymidyl deoxyribonucleic guanidine to RNA homopolynucleotides

21 January 2018

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Synthesis of a thymidyl pentamer of deoxyribonucleic guanidine and binding studies with DNA homopolynucleotides

21 January 2018

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Solid-phase synthesis of oligopurine deoxynucleic guanidine (DNG) and analysis of binding with DNA oligomers

21 January 2018

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Uniformly modified 2'-deoxy-2'-fluoro phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

21 January 2018

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Synthesis and biophysical properties of arabinonucleic acids (ANA): circular dichroic spectra, melting temperatures, and ribonuclease H susceptibility of ANA.RNA hybrid duplexes.

21 January 2018

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Crystal structures of B-DNA with incorporated 2'-deoxy-2'-fluoro-arabino-furanosyl thymines: implications of conformational preorganization for duplex stability

21 January 2018

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2'-Deoxy-2'-fluoro-beta-D-arabinonucleosides and oligonucleotides (2'F-ANA): synthesis and physicochemical studies

21 January 2018

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Oligodeoxynucleotides containing 2'-O-modified adenosine: synthesis and effects on stability of DNA:RNA duplexes

21 January 2018

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Crystal structure and improved antisense properties of 2'-O-(2-methoxyethyl)-RNA

21 January 2018

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2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides

21 January 2018

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Synthesis of 2'-O-[2-[(N,N-dimethylamino)oxy]ethyl] modified nucleosides and oligonucleotides

21 January 2018

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2'-O-[2-[(N,N-dimethylamino)oxy]ethyl]-modified oligonucleotides inhibit expression of mRNA in vitro and in vivo

21 January 2018

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2'-O-[2-(amino)-2-oxoethyl] oligonucleotides

21 January 2018

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Structural rationalization of a large difference in RNA affinity despite a small difference in chemistry between two 2'-O-modified nucleic acid analogues.

21 January 2018

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Comparing in vitro and in vivo activity of 2'-O-[2-(methylamino)-2-oxoethyl]- and 2'-O-methoxyethyl-modified antisense oligonucleotides

21 January 2018

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BNAs: novel nucleic acid analogs with a bridged sugar moiety

21 January 2018

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Synthesis of 2′-O,4′-C-methyleneuridine and -cytidine. Novel bicyclic nucleosides having a fixed C3, -endo sugar puckering

21 January 2018

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X-ray crystal structure of a locked nucleic acid (LNA) duplex composed of a palindromic 10-mer DNA strand containing one LNA thymine monomer

21 January 2018

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Perspectives on chemistry and therapeutic applications of Locked Nucleic Acid (LNA).

21 January 2018

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Stable oligonucleotide-directed triplex formation at target sites with CG interruptions: strong sequence-specific recognition by 2',4'-bridged nucleic-acid-containing 2-pyridones under physiological conditions.

21 January 2018

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Selective recognition of CG interruption by 2′,4′-BNA having 1-isoquinolone as a nucleobase in a pyrimidine motif triplex formation

21 January 2018

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Synthesis and properties of 3'-amino-2',4'-BNA, a bridged nucleic acid with a N3'-->P5' phosphoramidate linkage

21 January 2018

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3'-amino-2',4'-BNA: novel bridged nucleic acids having an N3'-->P5' phosphoramidate linkage

21 January 2018

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Highly stable pyrimidine-motif triplex formation at physiological pH values by a bridged nucleic acid analogue

21 January 2018

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Design, synthesis, and properties of 2',4'-BNA(NC): a bridged nucleic acid analogue

21 January 2018

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Synthesis and properties of 2'-O,4'-C-methyleneoxymethylene bridged nucleic acid

21 January 2018

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Synthesis of bicyclonucleosides having a C-C bridge.

21 January 2018

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2'-O,4'-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug

21 January 2018

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Synthesis and properties of 2′-O,4′-C-Ethylene-Bridged nucleic acids (ENA) as effective antisense oligonucleotides

21 January 2018

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Conformationally constrained 2'-N,4'-C-ethylene-bridged thymidine (aza-ENA-T): synthesis, structure, physical, and biochemical studies of aza-ENA-T-modified oligonucleotides.

21 January 2018

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Synthesis of functionalized carbocyclic locked nucleic acid analogues by ring-closing diene and enyne metathesis and their influence on nucleic acid stability and structure.

21 January 2018

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Synthesis and biophysical evaluation of 2',4'-constrained 2'O-methoxyethyl and 2',4'-constrained 2'O-ethyl nucleic acid analogues.

21 January 2018

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Short antisense oligonucleotides with novel 2'-4' conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals

21 January 2018

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Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity

21 January 2018

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Synthesis and properties of 4'-ThioDNA: unexpected RNA-like behavior of 4'-ThioDNA.

21 January 2018

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Unexpected A-form formation of 4'-thioDNA in solution, revealed by NMR, and the implications as to the mechanism of nuclease resistance

21 January 2018

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The synthesis and antiviral activity of some 4'-thio-2'-deoxy nucleoside analogs

21 January 2018

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Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidine

21 January 2018

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Practical synthesis of 2'-deoxy-4'-thioribonucleosides: substrates for the synthesis of 4'-thioDNA.

21 January 2018

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Synthesis and characterization of 2'-modified-4'-thioRNA: a comprehensive comparison of nuclease stability

21 January 2018

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Chemical etiology of nucleic acid structure

21 January 2018

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Nucleic acids with a six-membered 'carbohydrate' mimic in the backbone

21 January 2018

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Alpha-homo-DNA and RNA form a parallel oriented non-A, non-B-type double helical structure.

21 January 2018

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Uncharged stereoregular nucleic acid analogs: 2. Morpholino nucleoside oligomers with carbamate internucleoside linkages

21 January 2018

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Morpholino antisense oligomers: design, preparation, and properties

21 January 2018

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NMR solution structure of a peptide nucleic acid complexed with RNA

21 January 2018

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A nucleic acid triple helix formed by a peptide nucleic acid-DNA complex

21 January 2018

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Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide

21 January 2018

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Antisense properties of peptide nucleic acid

21 January 2018

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Conformationally constrained PNA analogues: structural evolution toward DNA/RNA binding selectivity

21 January 2018

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Stereodifferentiation--the effect of P chirality of oligo(nucleoside phosphorothioates) on the activity of bacterial RNase H.

21 January 2018

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Structural effect of complete [Rp]-phosphorothioate and phosphorodithioate substitutions in the DNA strand of a model antisense inhibitor-target RNA complex

21 January 2018

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Conformation of formacetal and 3'-thioformacetal nucleotide linkers and stability of their antisense RNA.DNA hybrid duplexes

21 January 2018

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Promising nucleic acid analogs and mimics: characteristic features and applications of PNA, LNA, and morpholino

21 January 2018

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Evaluation of some properties of a phosphorodithioate oligodeoxyribonucleotide for antisense application

21 January 2018

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Oligonucleotide N3'-->P5' phosphoramidates as antisense agents

21 January 2018

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Synthesis, biophysical properties, and nuclease resistance properties of mixed backbone oligodeoxynucleotides containing cationic internucleoside guanidinium linkages: deoxynucleic guanidine/DNA chimeras

21 January 2018

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Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

21 January 2018

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2'-Modified oligonucleotides for antisense therapeutics

21 January 2018

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Design of antisense oligonucleotides stabilized by locked nucleic acids

21 January 2018

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Expanding the design horizon of antisense oligonucleotides with alpha-L-LNA.

21 January 2018

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Resistance of morpholino phosphorodiamidate oligomers to enzymatic degradation

21 January 2018

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Biodistribution of 68Ga-labelled phosphodiester, phosphorothioate, and 2'-O-methyl phosphodiester oligonucleotides in normal rats

21 January 2018

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Pharmacokinetics and biodistribution of a nucleotide-based thrombin inhibitor in rats

21 January 2018

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In vivo imaging of oligonucleotides with positron emission tomography.

21 January 2018

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Tissue disposition of 2'-O-(2-methoxy) ethyl modified antisense oligonucleotides in monkeys

21 January 2018

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Biodistribution of 68Ga-labeled LNA-DNA mixmer antisense oligonucleotides for rat chromogranin-A.

21 January 2018

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In vivo tumor growth inhibition and biodistribution studies of locked nucleic acid (LNA) antisense oligonucleotides

21 January 2018

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Inhibition of human immunodeficiency virus activity by phosphorodithioate oligodeoxycytidine

21 January 2018

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Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302).

21 January 2018

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Systemic delivery of antisense oligoribonucleotide restores dystrophin expression in body-wide skeletal muscles

21 January 2018

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In vivo comparison of 2'-O-methyl phosphorothioate and morpholino antisense oligonucleotides for Duchenne muscular dystrophy exon skipping

21 January 2018

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Preclinical PK and PD studies on 2'-O-methyl-phosphorothioate RNA antisense oligonucleotides in the mdx mouse model

21 January 2018

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Cross-species pharmacokinetic comparison from mouse to man of a second-generation antisense oligonucleotide, ISIS 301012, targeting human apolipoprotein B-100.

21 January 2018

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An apolipoprotein B antisense oligonucleotide lowers LDL cholesterol in hyperlipidemic mice without causing hepatic steatosis

21 January 2018

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Antisense inhibition of proprotein convertase subtilisin/kexin type 9 reduces serum LDL in hyperlipidemic mice

21 January 2018

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Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.

21 January 2018

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Antisense oligonucleotide directed to human apolipoprotein B-100 reduces lipoprotein(a) levels and oxidized phospholipids on human apolipoprotein B-100 particles in lipoprotein(a) transgenic mice

21 January 2018

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Effect of mipomersen, an apolipoprotein B synthesis inhibitor, on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia

21 January 2018

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Efficacy and safety of mipomersen, an antisense inhibitor of apolipoprotein B, in hypercholesterolemic subjects receiving stable statin therapy

21 January 2018

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Apolipoprotein B synthesis inhibition: results from clinical trials

21 January 2018

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Short locked nucleic acid antisense oligonucleotides potently reduce apolipoprotein B mRNA and serum cholesterol in mice and non-human primates

21 January 2018

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LNA-mediated microRNA silencing in non-human primates

21 January 2018

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A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo

21 January 2018

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Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection

21 January 2018

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Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

21 January 2018

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Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

21 January 2018

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Peptide-mediated cellular delivery of antisense oligonucleotides and their analogues

21 January 2018

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Modulation of the pharmacokinetic properties of PNA: preparation of galactosyl, mannosyl, fucosyl, N-acetylgalactosaminyl, and N-acetylglucosaminyl derivatives of aminoethylglycine peptide nucleic acid monomers and their incorporation into PNA oligo

21 January 2018

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Improved cell-penetrating peptide-PNA conjugates for splicing redirection in HeLa cells and exon skipping in mdx mouse muscle.

21 January 2018

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Optimization of peptide nucleic acid antisense oligonucleotides for local and systemic dystrophin splice correction in the mdx mouse.

21 January 2018

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Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

21 January 2018

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Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers.

21 January 2018

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miR-122 targeting with LNA/2'-O-methyl oligonucleotide mixmers, peptide nucleic acids (PNA), and PNA-peptide conjugates

21 January 2018

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Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro.

21 January 2018

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Overview of the transradial approach in percutaneous coronary intervention

21 January 2018

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Efficacy of systemic morpholino exon-skipping in Duchenne dystrophy dogs

21 January 2018

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Dystrophin expression in the mdx mouse after localised and systemic administration of a morpholino antisense oligonucleotide

21 January 2018

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Comparative analysis of antisense oligonucleotide analogs for targeted DMD exon 46 skipping in muscle cells

21 January 2018

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Prevention of dystrophic pathology in severely affected dystrophin/utrophin-deficient mice by morpholino-oligomer-mediated exon-skipping

21 January 2018

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Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse

21 January 2018

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Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

21 January 2018

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Systemic delivery of morpholino oligonucleotide restores dystrophin expression bodywide and improves dystrophic pathology

21 January 2018

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Functional amounts of dystrophin produced by skipping the mutated exon in the mdx dystrophic mouse

21 January 2018

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Gene knockdowns in adult animals: PPMOs and vivo-morpholinos

21 January 2018

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Randomized phase III trial of fludarabine plus cyclophosphamide with or without oblimersen sodium (Bcl-2 antisense) in patients with relapsed or refractory chronic lymphocytic leukemia

21 January 2018

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5-year survival in patients with relapsed or refractory chronic lymphocytic leukemia in a randomized, phase III trial of fludarabine plus cyclophosphamide with or without oblimersen

21 January 2018

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Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer

21 January 2018

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Phase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemia

21 January 2018

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Antisense-mediated exon skipping: a versatile tool with therapeutic and research applications

21 January 2018

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Molecular treatments in Duchenne muscular dystrophy

21 January 2018

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Synthesis and characterization of dinucleoside phosphorodithioates

21 January 2018

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1′, 5′ -Anhydrohexitol Oligonucleotides: Synthesis, Base Pairing and Recognition by Regular Oligodeoxyribonucleotides and Oligoribonucleotides

21 January 2018

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Cyclohexene Nucleic Acids (CeNA): Serum Stable Oligonucleotides that Activate RNase H and Increase Duplex Stability with Complementary RNA

21 January 2018

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1′,5′-Anhydrohexitol Oligonucleotides: Hybridisation and Strand Displacement with Oligoribonucleotides, Interaction with RNase H and HIV Reverse Transcriptase

21 January 2018

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Synthesis of 3‘-C- and 4‘-C-Branched Oligodeoxynucleotides and the Development of Locked Nucleic Acid (LNA)

21 January 2018

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21 January 2018

Identifiers

DOI

10.4155/FMC.11.2

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24 August 2017

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