Notch regulation of tumor angiogenesis (Q37861206)

24 August 2017

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title

Notch regulation of tumor angiogenesis (English)

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24 August 2017

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3

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24 August 2017

Chern Ein Oon

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author name string

Esther Bridges

series ordinal

1

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PubMed ID

21463145

24 August 2017

language of work or name

English

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publication date

1 April 2011

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24 August 2017

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24 August 2017

7

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24 August 2017

4

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24 August 2017

569-588

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Tumor angiogenesis: therapeutic implications

24 August 2017

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Notch signaling: cell fate control and signal integration in development

21 January 2018

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Notch signaling in development and cancer.

21 January 2018

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VEGF and endothelial guidance in angiogenic sprouting

21 January 2018

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Endothelial tubes assemble from intracellular vacuoles in vivo

21 January 2018

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Cellular and molecular mechanisms of vascular lumen formation

21 January 2018

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The control of vascular integrity by endothelial cell junctions: molecular basis and pathological implications

21 January 2018

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Pericytes and vascular stability

21 January 2018

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Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

21 January 2018

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Tumorigenesis and the angiogenic switch

21 January 2018

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VEGF receptor signalling - in control of vascular function

21 January 2018

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The VEGF receptor Flt-1 spatially modulates Flk-1 signaling and blood vessel branching.

21 January 2018

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Molecular regulation of angiogenesis and lymphangiogenesis

21 January 2018

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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

21 January 2018

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Endothelial-pericyte interactions in angiogenesis.

21 January 2018

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The role of pericytes in blood-vessel formation and maintenance

21 January 2018

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The canonical Notch signaling pathway: unfolding the activation mechanism

21 January 2018

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The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors

21 January 2018

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A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

21 January 2018

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Signalling downstream of activated mammalian Notch

21 January 2018

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Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

21 January 2018

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Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes

21 January 2018

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Mastermind is a putative activator for Notch.

21 January 2018

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MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors

21 January 2018

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Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors

21 January 2018

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HES and HERP families: multiple effectors of the Notch signaling pathway

21 January 2018

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Crossing paths with Notch in the hyper-network

21 January 2018

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Notch signaling in blood vessels: who is talking to whom about what?

21 January 2018

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Notch signaling in vascular development

21 January 2018

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Delta4, an endothelial specific notch ligand expressed at sites of physiological and tumor angiogenesis

21 January 2018

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Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development.

21 January 2018

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Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants

21 January 2018

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Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

21 January 2018

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Dosage-sensitive requirement for mouse Dll4 in artery development

21 January 2018

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The notch ligands Dll4 and Jagged1 have opposing effects on angiogenesis

21 January 2018

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Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1

21 January 2018

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Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

21 January 2018

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Essential role of endothelial Notch1 in angiogenesis

21 January 2018

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Vascular patterning defects associated with expression of activated Notch4 in embryonic endothelium

21 January 2018

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The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

21 January 2018

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Critical role of endothelial Notch1 signaling in postnatal angiogenesis.

21 January 2018

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VEGF and Notch signaling: the yin and yang of angiogenic sprouting

21 January 2018

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Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting

21 January 2018

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Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

21 January 2018

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Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries

21 January 2018

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The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching.

21 January 2018

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Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos

21 January 2018

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Delta-like ligand 4 plays a critical role in pericyte/vascular smooth muscle cell formation during vasculogenesis and tumor vessel expansion in Ewing's sarcoma.

21 January 2018

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Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation

21 January 2018

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Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.

21 January 2018

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Coexpression of Notch1 and NF-kappaB signaling pathway components in human cervical cancer progression

21 January 2018

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Notch activation induces endothelial cell cycle arrest and participates in contact inhibition: role of p21Cip1 repression

21 January 2018

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The many facets of Notch ligands

21 January 2018

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High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival

21 January 2018

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Association of high levels of Jagged-1 and Notch-1 expression with poor prognosis in head and neck cancer

21 January 2018

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Involvement of notch signaling in wound healing

21 January 2018

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Stem and progenitor cells in skeletal muscle development, maintenance, and therapy

21 January 2018

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Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice

21 January 2018

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Notch expression patterns in the retina: An eye on receptor-ligand distribution during angiogenesis

21 January 2018

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DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

21 January 2018

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Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

21 January 2018

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CADASIL mutations impair Notch3 glycosylation by Fringe

21 January 2018

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CADASIL: a critical look at a Notch disease

21 January 2018

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Mutations in the human Jagged1 gene are responsible for Alagille syndrome

21 January 2018

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Vascular anomalies in Alagille syndrome: a significant cause of morbidity and mortality

21 January 2018

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Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

21 January 2018

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Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells.

21 January 2018

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Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia

21 January 2018

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Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

21 January 2018

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Targeting DLL4 in tumors shows preclinical activity but potentially significant toxicity

21 January 2018

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Prognostic significance of Notch 3 gene expression in ovarian serous carcinoma.

21 January 2018

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Notch 1 signaling is active in ovarian cancer.

21 January 2018

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Notch1 expression correlates with tumor differentiation status in ovarian carcinoma.

21 January 2018

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Alterations of the Notch pathway in lung cancer.

21 January 2018

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Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor.

21 January 2018

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Regulation of NOTCH signaling by reciprocal inhibition of HES1 and Deltex 1 and its role in osteosarcoma invasiveness

21 January 2018

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Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma

21 January 2018

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Cerebral cavernous malformation protein CCM1 inhibits sprouting angiogenesis by activating DELTA-NOTCH signaling

21 January 2018

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Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

21 January 2018

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Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

21 January 2018

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Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion

21 January 2018

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Blockade of delta-like ligand 4 signaling inhibits both growth and angiogenesis of pancreatic cancer

21 January 2018

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DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency

21 January 2018

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Assessment of tumour hypoxia for prediction of response to therapy and cancer prognosis

21 January 2018

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Up-regulation of delta-like 4 ligand in human tumor vasculature and the role of basal expression in endothelial cell function

21 January 2018

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Inhibition of notch signaling induces neural differentiation in Ewing sarcoma

21 January 2018

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The wnt target jagged-1 mediates the activation of notch signaling by progastrin in human colorectal cancer cells.

21 January 2018

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Jagged1 is the pathological link between Wnt and Notch pathways in colorectal cancer

21 January 2018

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Heterogeneity of Jagged1 expression in human and mouse intestinal tumors: implications for targeting Notch signaling

21 January 2018

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Notch signaling enhances nestin expression in gliomas

21 January 2018

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The role of Notch in tumorigenesis: oncogene or tumour suppressor?

21 January 2018

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A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis

21 January 2018

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MicroRNA-34a suppresses invasion through downregulation of Notch1 and Jagged1 in cervical carcinoma and choriocarcinoma cells.

21 January 2018

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JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer

21 January 2018

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High-level JAG1 mRNA and protein predict poor outcome in breast cancer

21 January 2018

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F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.

21 January 2018

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NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer

21 January 2018

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Aberrant activation of notch signaling in human breast cancer

21 January 2018

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Notch1-induced mammary tumor development is cyclin D1-dependent and correlates with expansion of pre-malignant multipotent duct-limited progenitors

21 January 2018

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Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation

21 January 2018

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Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma

21 January 2018

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Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway.

21 January 2018

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Notch tumor suppressor function

21 January 2018

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Notch1 mediates growth suppression of papillary and follicular thyroid cancer cells by histone deacetylase inhibitors

21 January 2018

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Up-regulation of endothelial delta-like 4 expression correlates with vessel maturation in bladder cancer

21 January 2018

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Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer

21 January 2018

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Dll4 activation of Notch signaling reduces tumor vascularity and inhibits tumor growth

21 January 2018

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Soluble forms of the Notch ligands Delta1 and Jagged1 promote in vivo tumorigenicity in NIH3T3 fibroblasts with distinct phenotypes

21 January 2018

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Rumi is a CAP10 domain glycosyltransferase that modifies Notch and is required for Notch signaling.

21 January 2018

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Fringe is a glycosyltransferase that modifies Notch

21 January 2018

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EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

21 January 2018

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Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs

21 January 2018

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The microRNA miR-8 is a conserved negative regulator of Wnt signaling

21 January 2018

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Regulation of zebrafish fin regeneration by microRNAs

21 January 2018

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Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430.

21 January 2018

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MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads.

21 January 2018

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RAS is regulated by the let-7 microRNA family

21 January 2018

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miR-126 regulates angiogenic signaling and vascular integrity

21 January 2018

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MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 January 2018

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Attribution of vascular phenotypes of the murine Egfl7 locus to the microRNA miR-126.

21 January 2018

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MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer

21 January 2018

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TGF-beta activates Akt kinase through a microRNA-dependent amplifying circuit targeting PTEN

21 January 2018

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miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells

21 January 2018

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MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma

21 January 2018

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Regulation of angiogenesis by oxygen and metabolism.

21 January 2018

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Oxygen sensors and angiogenesis

21 January 2018

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Hypoxia-induced transcriptional activation and increased mRNA stability of vascular endothelial growth factor in C6 glioma cells.

21 January 2018

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Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion

21 January 2018

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Angiogenesis: a team effort coordinated by notch.

21 January 2018

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Periodic Delta-like 4 expression in developing retinal arteries.

21 January 2018

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Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

21 January 2018

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The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development

21 January 2018

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Regulation of Notch1 and Dll4 by vascular endothelial growth factor in arterial endothelial cells: implications for modulating arteriogenesis and angiogenesis

21 January 2018

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Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function

21 January 2018

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Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells

21 January 2018

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Notch activation during endothelial cell network formation in vitro targets the basic HLH transcription factor HESR-1 and downregulates VEGFR-2/KDR expression

21 January 2018

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Notch4 inhibits endothelial apoptosis via RBP-Jkappa-dependent and -independent pathways

21 January 2018

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Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression

21 January 2018

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Notch3 activation modulates cell growth behaviour and cross-talk to Wnt/TCF signalling pathway

21 January 2018

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Convergence of Notch and beta-catenin signaling induces arterial fate in vascular progenitors

21 January 2018

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NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon

21 January 2018

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The Wnt/beta-catenin pathway modulates vascular remodeling and specification by upregulating Dll4/Notch signaling

21 January 2018

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TNF primes endothelial cells for angiogenic sprouting by inducing a tip cell phenotype

21 January 2018

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Delta-4 expression on a stromal cell line is augmented by interleukin-6 via STAT3 activation

21 January 2018

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Molecular mechanisms underlying tumor dormancy

21 January 2018

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The angiogenic switch: implications in the regulation of tumor dormancy.

21 January 2018

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Models, mechanisms and clinical evidence for cancer dormancy

21 January 2018

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Cross-talk between tumor and endothelial cells involving the Notch3-Dll4 interaction marks escape from tumor dormancy

21 January 2018

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Mouse Notch 3 expression in the pre- and postnatal brain: relationship to the stroke and dementia syndrome CADASIL.

21 January 2018

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An overview of Notch3 function in vascular smooth muscle cells

21 January 2018

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Angiogenic co-operation of VEGF and stromal cell TP in endometrial carcinomas

21 January 2018

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The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies

21 January 2018

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A cytokine-mediated link between innate immunity, inflammation, and cancer

21 January 2018

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Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues.

21 January 2018

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Necrosis correlates with high vascular density and focal macrophage infiltration in invasive carcinoma of the breast

21 January 2018

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Distinct role of macrophages in different tumor microenvironments

21 January 2018

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Delta-like 4 induces notch signaling in macrophages: implications for inflammation

21 January 2018

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Exosomes--vesicular carriers for intercellular communication

21 January 2018

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Paracrine induction of endothelium by tumor exosomes.

21 January 2018

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New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes

21 January 2018

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Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis

21 January 2018

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Biological function of mutant forms of JAGGED1 proteins in Alagille syndrome: inhibitory effect on Notch signaling

21 January 2018

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Autocrine pathways of the vascular endothelial growth factor (VEGF) in glioblastoma multiforme: clinical relevance of radiation-induced increase of VEGF levels.

21 January 2018

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Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.

21 January 2018

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Glioblastoma stem-like cells give rise to tumour endothelium.

21 January 2018

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The perivascular niche microenvironment in brain tumor progression

21 January 2018

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Endothelial signalling by the Notch ligand Delta-like 4 restricts angiogenesis.

21 January 2018

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Anti-Dll4 therapy: can we block tumour growth by increasing angiogenesis?

21 January 2018

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Lessons from phase III clinical trials on anti-VEGF therapy for cancer

21 January 2018

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Angiogenesis as a therapeutic target

21 January 2018

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Notch signaling, gamma-secretase inhibitors, and cancer therapy

21 January 2018

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Evaluation of selective gamma-secretase inhibitor PF-03084014 for its antitumor efficacy and gastrointestinal safety to guide optimal clinical trial design

21 January 2018

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The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas

21 January 2018

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Nonspecificity of binding of gamma-secretase modulators to the amyloid precursor protein

21 January 2018

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Therapeutic antibody targeting of individual Notch receptors

21 January 2018

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Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model.

21 January 2018

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Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors

21 January 2018

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Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1alpha/CXCR4 axis

21 January 2018

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Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling

21 January 2018

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MicroRNA control of Nodal signalling

21 January 2018

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Chronic DLL4 blockade induces vascular neoplasms

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.11.20

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24 August 2017

1 reference

PubMed ID

21463145