Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance (Q37862117)

24 August 2017

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title

Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance (English)

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24 August 2017

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C Lipina

1

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24 August 2017

H S Hundal

series ordinal

2

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24 August 2017

language of work or name

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6 April 2011

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24 August 2017

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24 August 2017

volume

54

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24 August 2017

issue

7

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24 August 2017

page(s)

1596-1607

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An in vitro human muscle preparation suitable for metabolic studies. Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects

24 August 2017

cites work

1 reference

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Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion

21 January 2018

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Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha

21 January 2018

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Intramuscular triacylglycerol and insulin resistance: guilty as charged or wrongly accused?

21 January 2018

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Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Dissociation of Hepatic Steatosis and Insulin Resistance in Mice Overexpressing DGAT in the Liver

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Protein kinase B (PKB/Akt)--a key regulator of glucose transport?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Role of Akt/protein kinase B in metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Mechanism of free fatty acid-induced insulin resistance in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

The PI3K-PDK1 connection: more than just a road to PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide generation is sufficient to account for the inhibition of the insulin-stimulated PKB pathway in C2C12 skeletal muscle cells pretreated with palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide mediates insulin resistance by tumor necrosis factor-alpha in brown adipocytes by maintaining Akt in an inactive dephosphorylated state

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide impairs the insulin-dependent membrane recruitment of protein kinase B leading to a loss in downstream signalling in L6 skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Regulation of insulin action by ceramide: dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide channels and their role in mitochondria-mediated apoptosis

21 January 2018

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https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Regulation of ceramide production and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide-rich platforms in transmembrane signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

The role of neutral sphingomyelinase produced ceramide in lipopolysaccharide-mediated expression of inducible nitric oxide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

De novo sphingolipid biosynthesis: a necessary, but dangerous, pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ataxia telangiectasia-mutated gene product inhibits DNA damage-induced apoptosis via ceramide synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Uncoupling ceramide glycosylation by transfection of glucosylceramide synthase antisense reverses adriamycin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide 1-phosphate inhibits serine palmitoyltransferase and blocks apoptosis in alveolar macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Intramyocellular lipid is associated with resistance to in vivo insulin actions on glucose uptake, antilipolysis, and early insulin signaling pathways in human skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Disassociation of muscle triglyceride content and insulin sensitivity after exercise training in patients with Type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Regulation of insulin-stimulated glucose transporter GLUT4 translocation and Akt kinase activity by ceramide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Intracellular ceramide synthesis and protein kinase Czeta activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide content is increased in skeletal muscle from obese insulin-resistant humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Endurance training in obese humans improves glucose tolerance and mitochondrial fatty acid oxidation and alters muscle lipid content

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide dissociates 3'-phosphoinositide production from pleckstrin homology domain translocation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Long chain ceramides activate protein phosphatase-1 and protein phosphatase-2A. Activation is stereospecific and regulated by phosphatidic acid

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Plasma membrane subdomain compartmentalization contributes to distinct mechanisms of ceramide action on insulin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide-induced inhibition of Akt is mediated through protein kinase Czeta: implications for growth arrest

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Cellular depletion of atypical PKC{lambda} is associated with enhanced insulin sensitivity and glucose uptake in L6 rat skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Targeting of PKCzeta and PKB to caveolin-enriched microdomains represents a crucial step underpinning the disruption in PKB-directed signalling by ceramide

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Functional rafts in cell membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Cellular spelunking: exploring adipocyte caveolae

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Caveolin interaction with protein kinase C. Isoenzyme-dependent regulation of kinase activity by the caveolin scaffolding domain peptide.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ceramide regulation of the tumor suppressor phosphatase PTEN in rafts isolated from neurotumor cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Caveolin-1 maintains activated Akt in prostate cancer cells through scaffolding domain binding site interactions with and inhibition of serine/threonine protein phosphatases PP1 and PP2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Getting rid of caveolins: phenotypes of caveolin-deficient animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Caveolins sequester FA on the cytoplasmic leaflet of the plasma membrane, augment triglyceride formation, and protect cells from lipotoxicity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Protein kinase C Theta inhibits insulin signaling by phosphorylating IRS1 at Ser(1101)

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Lipid-induced insulin resistance is prevented in lean and obese myotubes by AICAR treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Effect of acute exercise on AMPK signaling in skeletal muscle of subjects with type 2 diabetes: a time-course and dose-response study

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Increased mitochondrial fatty acid oxidation is sufficient to protect skeletal muscle cells from palmitate-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Overexpression of carnitine palmitoyltransferase-1 in skeletal muscle is sufficient to enhance fatty acid oxidation and improve high-fat diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Role of sphingolipid mediator ceramide in obesity and renal injury in mice fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Sphingomyelinase stimulates oxidant signaling to weaken skeletal muscle and promote fatigue

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Acid Sphingomyelinase Deficiency Prevents Diet-induced Hepatic Triacylglycerol Accumulation and Hyperglycemia in Mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Toll-like receptors in innate immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Type I Gaucher disease, a glycosphingolipid storage disorder, is associated with insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Ganglioside GM3 participates in the pathological conditions of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Pharmacological inhibition of glucosylceramide synthase enhances insulin sensitivity

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Enhanced insulin sensitivity in mice lacking ganglioside GM3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Human skeletal muscle ceramide content is not a major factor in muscle insulin sensitivity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Sphingomyelinases: their regulation and roles in cardiovascular pathophysiology

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS00125-011-2127-3

Protein kinase Czeta is a negative regulator of protein kinase B activity

21 January 2018

1 reference

12 December 2020

Increased skeletal muscle ceramide level in men at risk of developing type 2 diabetes

1 reference

12 December 2020

Differential regulation of sphingomyelinase and ceramidase activities by growth factors and cytokines. Implications for cellular proliferation and differentiation

1 reference

12 December 2020

Key role for ceramides in mediating insulin resistance in human muscle cells

1 reference

12 December 2020

High fat diet induces ceramide and sphingomyelin formation in rat’s liver nuclei

1 reference

12 December 2020

Analysis of lipids in caveolae

1 reference

12 December 2020

Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes

1 reference

12 December 2020

Effect of endurance training on the sphingomyelin-signalling pathway activity in the skeletal muscles of the rat.

1 reference

12 December 2020

Physiological regulation of Akt activity and stability.

1 reference

12 December 2020

1,2-Diacylglycerol and ceramide levels in rat skeletal muscle and liver in vivo. Studies with insulin, exercise, muscle denervation, and vasopressin.

1 reference

12 December 2020

Stearoyl CoA desaturase 1 is elevated in obesity but protects against fatty acid-induced skeletal muscle insulin resistance in vitro

1 reference

12 December 2020

Protein kinase C modulates insulin action in human skeletal muscle

1 reference

12 December 2020

Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects

1 reference

12 December 2020

Circulating levels of ganglioside GM3 in metabolic syndrome: A pilot study

1 reference

12 December 2020

Rapid impairment of skeletal muscle glucose transport/phosphorylation by free fatty acids in humans

1 reference

12 December 2020

AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle

1 reference

12 December 2020

10.1007/S00125-011-2127-3

Identifiers

DOI

1 reference

24 August 2017

1 reference