Towards systematic functional characterization of cancer genomes (Q37890867)

24 August 2017

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title

Towards systematic functional characterization of cancer genomes (English)

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24 August 2017

2

William C Hahn

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24 August 2017

1

Jesse S Boehm

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24 August 2017

publication date

17 June 2011

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24 August 2017

published in

Nature Reviews Genetics

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24 August 2017

volume

12

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24 August 2017

issue

7

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24 August 2017

page(s)

487-498

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https://scigraph.springernature.com/pub.10.1038/nrg3013

24 August 2017

exact match

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Direct inhibition of the NOTCH transcription factor complex

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An RNAi screen identifies TRRAP as a regulator of brain tumor-initiating cell differentiation.

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Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells

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Cell microarrays and RNA interference chip away at gene function

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A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer

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A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability

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In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression

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Toolkit for evaluating genes required for proliferation and survival using tetracycline-regulated RNAi

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Genome-scale RNAi profiling of cell division in human tissue culture cells

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SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis

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CellProfiler: image analysis software for identifying and quantifying cell phenotypes

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A large-scale RNAi screen in human cells identifies new components of the p53 pathway

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A genetic screen for candidate tumor suppressors identifies REST

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A genetic screen identifies PITX1 as a suppressor of RAS activity and tumorigenicity

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CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity

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A functional screen identifies hDRIL1 as an oncogene that rescues RAS-induced senescence

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A small interfering RNA screen for modulators of tumor cell motility identifies MAP4K4 as a promigratory kinase

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A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors

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A genome-wide camptothecin sensitivity screen identifies a mammalian MMS22L-NFKBIL2 complex required for genomic stability

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Genome-wide loss-of-function screen reveals an important role for the proteasome in HDAC inhibitor-induced apoptosis

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Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomib

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Phosphatidylinositol 3-kinase hyperactivation results in lapatinib resistance that is reversed by the mTOR/phosphatidylinositol 3-kinase inhibitor NVP-BEZ235.

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Candidate biomarkers of response to an experimental cancer drug identified through a large-scale RNA interference genetic screen

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Proteomic and genetic approaches identify Syk as an AML target

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Chemical genetic strategy identifies histone deacetylase 1 (HDAC1) and HDAC2 as therapeutic targets in sickle cell disease

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Bead-based profiling of tyrosine kinase phosphorylation identifies SRC as a potential target for glioblastoma therapy

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Network modeling links breast cancer susceptibility and centrosome dysfunction

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Monitoring proteins and protein networks using reverse phase protein arrays

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Kinome siRNA screen identifies regulators of ciliogenesis and hedgehog signal transduction

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Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen

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An activated ErbB3/NRG1 autocrine loop supports in vivo proliferation in ovarian cancer cells

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Kinase requirements in human cells: II. Genetic interaction screens identify kinase requirements following HPV16 E7 expression in cancer cells

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB

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The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

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Integrative genomic approaches identify IKBKE as a breast cancer oncogene

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High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy.

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Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

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A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

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Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models.

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Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells

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Kinase requirements in human cells: V. Synthetic lethal interactions between p53 and the protein kinases SGK2 and PAK3

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Kinase requirements in human cells: III. Altered kinase requirements in VHL-/- cancer cells detected in a pilot synthetic lethal screen

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A synthetic lethal siRNA screen identifying genes mediating sensitivity to a PARP inhibitor

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IRF4 addiction in multiple myeloma

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Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization

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Subtype-specific genomic alterations define new targets for soft-tissue sarcoma therapy

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Identification of a therapeutic strategy targeting amplified FGF19 in liver cancer by Oncogenomic screening

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Identification of RPS14 as a 5q- syndrome gene by RNA interference screen

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Cyfip1 is a putative invasion suppressor in epithelial cancers

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Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

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Oncogenically active MYD88 mutations in human lymphoma

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers

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Identification of selective inhibitors of cancer stem cells by high-throughput screening

21 January 2018

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Minimizing the risk of reporting false positives in large-scale RNAi screens

21 January 2018

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Comparative Oncogenomics Identifies NEDD9 as a Melanoma Metastasis Gene

21 January 2018

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Second-generation shRNA libraries covering the mouse and human genomes

21 January 2018

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Genome-wide resources of endoribonuclease-prepared short interfering RNAs for specific loss-of-function studies

31 March 2020

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Gene expression-based high-throughput screening(GE-HTS) and application to leukemia differentiation

31 March 2020

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31 March 2020

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PubMed

https://pubmed.ncbi.nlm.nih.gov/21681210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

A public genome-scale lentiviral expression library of human ORFs

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21681210

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3013

1 reference

Dimensions Publication ID

24 August 2017

1020190062

0 references

1 reference