Hypoxia-driven pathways in bone development, regeneration and disease (Q37997304)

26 August 2017

Hypoxia-driven pathways in bone development, regeneration and disease (English)

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26 August 2017

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Christa Maes

1

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26 August 2017

Geert Carmeliet

series ordinal

2

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26 August 2017

Ernestina Schipani

series ordinal

3

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26 August 2017

language of work or name

English

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publication date

27 March 2012

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Nature Reviews Rheumatology

26 August 2017

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26 August 2017

8

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26 August 2017

6

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26 August 2017

358-366

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https://scigraph.springernature.com/pub.10.1038/nrrheum.2012.36

26 August 2017

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cites work

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Regulation of transcription and translation by hypoxia

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Targeting HIF-1 for cancer therapy

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension

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Hypoxia signalling in cancer and approaches to enforce tumour regression

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Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha

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HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

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Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

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Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling

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General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia

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How does PKMζ maintain long-term memory?

21 January 2018

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Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1alpha/ARNT

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Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.

21 January 2018

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Hypoxia, HIFs and bone development

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A central role for hypoxic signaling in cartilage, bone, and hematopoiesis

21 January 2018

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Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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The hypoxic tumor microenvironment and gene expression

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Identification of novel hypoxia dependent and independent target genes of the von Hippel-Lindau (VHL) tumour suppressor by mRNA differential expression profiling

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Up-regulation of gene expression by hypoxia is mediated predominantly by hypoxia-inducible factor 1 (HIF-1).

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Genetic analysis of pathways regulated by the von Hippel-Lindau tumor suppressor in Caenorhabditis elegans

21 January 2018

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The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

21 January 2018

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Multiple roles of vascular endothelial growth factor (VEGF) in skeletal development, growth, and repair

21 January 2018

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The biology of VEGF and its receptors

21 January 2018

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Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

21 January 2018

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Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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Developmental regulation of the growth plate

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Molecular mechanisms of endochondral bone development.

21 January 2018

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Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF

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Role of hypoxia-inducible factor-1alpha in angiogenic-osteogenic coupling

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Angiogenesis inhibitors localized in hypovascular mesenchymal tissues: chondromodulin-I and tenomodulin

21 January 2018

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Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels.

21 January 2018

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VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival.

21 January 2018

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Extracellular matrix genes as hypoxia-inducible targets

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes

21 January 2018

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HIF1alpha regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis.

21 January 2018

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Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development.

21 January 2018

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Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9.

21 January 2018

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Hypoxia promotes the differentiated human articular chondrocyte phenotype through SOX9-dependent and -independent pathways

21 January 2018

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Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

21 January 2018

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Lack of HIF-2α in limb bud mesenchyme causes a modest and transient delay of endochondral bone development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development.

21 January 2018

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VEGFA is necessary for chondrocyte survival during bone development

21 January 2018

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Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1 alpha dependent.

21 January 2018

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VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

21 January 2018

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The forming limb skeleton serves as a signaling center for limb vasculature patterning via regulation of Vegf.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Reaching a genetic and molecular understanding of skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Regulation of the HIF-1alpha level is essential for hematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Genetic control of bone formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxia-inducible factors 1alpha and 2alpha exert both distinct and overlapping functions in long bone development.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Role of the osteoblast lineage in the bone marrow hematopoietic niches

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Uncertainty in the niches that maintain haematopoietic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Detection of functional haematopoietic stem cell niche using real-time imaging.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

The distinct metabolic profile of hematopoietic stem cells reflects their location in a hypoxic niche.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Basic and therapeutic aspects of angiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Bone remodeling during fracture repair: The cellular picture.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Placental growth factor mediates mesenchymal cell development, cartilage turnover, and bone remodeling during fracture repair

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Anti-placental growth factor reduces bone metastasis by blocking tumor cell engraftment and osteoclast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

VEGFs and receptors involved in angiogenesis versus lymphangiogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Activation of the hypoxia-inducible factor-1alpha pathway accelerates bone regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxia and osteoarthritis: how chondrocytes survive hypoxic environments

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble Flt-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Cancer to bone: a fatal attraction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Tumor metastasis: mechanistic insights and clinical challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Bevacizumab inhibits breast cancer-induced osteolysis, surrounding soft tissue metastasis, and angiogenesis in rats as visualized by VCT and MRI.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxia and hypoxia-inducible factor-1 expression enhance osteolytic bone metastases of breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxia and TGF-beta drive breast cancer bone metastases through parallel signaling pathways in tumor cells and the bone microenvironment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Antiangiogenic therapy: impact on invasion, disease progression, and metastasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Whole-exome sequencing detects somatic mutations of IDH1 in metaphyseal chondromatosis with D-2-hydroxyglutaric aciduria (MC-HGA).

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

IDH1 and IDH2 mutations in gliomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Oxygen sensing and molecular adaptation to hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxia induces HIF-1Œ± and VEGF expression in chondrosarcoma cells and chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

IDH1 mutations are not found in cartilaginous tumours other than central and periosteal chondrosarcomas and enchondromas

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRRHEUM.2012.36

How oxygen makes its presence felt

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22450551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22450551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/22450551

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRRHEUM.2012.36

1 reference

26 August 2017

1 reference