Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore. (Q38094017)

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27 February 2020

title

Physiologic functions of cyclophilin D and the mitochondrial permeability transition pore (English)

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1

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27 February 2020

Jeffery D. Molkentin

series ordinal

2

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publication date

29 March 2013

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volume

77

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27 February 2020

page(s)

1111-1122

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issue

5

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Cyclophilin-D binding proteins

27 February 2020

cites work

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12 December 2020

Crystal structure of human p32, a doughnut-shaped acidic mitochondrial matrix protein

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12 December 2020

Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

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12 December 2020

Import and processing of heart mitochondrial cyclophilin D

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12 December 2020

Mitochondrial transport of cations: channels, exchangers, and permeability transition.

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12 December 2020

Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

1 reference

12 December 2020

Calcineurin-mediated hypertrophy protects cardiomyocytes from apoptosis in vitro and in vivo: An apoptosis-independent model of dilated heart failure

1 reference

12 December 2020

Reversal of cardiac hypertrophy in transgenic disease models by calcineurin inhibition.

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12 December 2020

Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo

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12 December 2020

Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells

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12 December 2020

The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ release

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12 December 2020

Control of the mitochondrial permeability transition pore by high-affinity ADP binding at the ADP/ATP translocase in permeabilized mitochondria

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12 December 2020

Single-channel currents of the permeability transition pore from the inner mitochondrial membrane of rat liver and of a human hepatoma cell line

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12 December 2020

Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria

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12 December 2020

VDAC2 inhibits BAK activation and mitochondrial apoptosis

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12 December 2020

Relationship between configuration, function, and permeability in calcium-treated mitochondria

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12 December 2020

Cyclosporin inhibits mitochondrial calcium efflux in isolated adult rat ventricular cardiomyocytes

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12 December 2020

The mitochondrial megachannel is the permeability transition pore

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12 December 2020

THE STEADY STATE MAINTENANCE OF ACCUMULATED CA++ IN RAT LIVER MITOCHONDRIA

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12 December 2020

Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy

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12 December 2020

The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

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12 December 2020

Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32

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12 December 2020

Role of Ca2+/calmodulin-dependent protein kinase II in cardiac hypertrophy and heart failure

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12 December 2020

Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected].

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12 December 2020

Calcium-calcineurin signaling in the regulation of cardiac hypertrophy

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12 December 2020

A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction.

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12 December 2020

Death begets failure in the heart

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12 December 2020

Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D.

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12 December 2020

Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

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12 December 2020

Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

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12 December 2020

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

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12 December 2020

The mitochondrial permeability transition from in vitro artifact to disease target

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12 December 2020

Electrophysiological characterization of the Cyclophilin D-deleted mitochondrial permeability transition pore

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12 December 2020

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

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12 December 2020

Mitochondrial membrane permeabilization in cell death

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12 December 2020

Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

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12 December 2020

Cyclophilin D inactivation protects axons in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis

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12 December 2020

The autophagic inducer smARF interacts with and is stabilized by the mitochondrial p32 protein

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12 December 2020

Preconditioning and postconditioning: the essential role of the mitochondrial permeability transition pore

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12 December 2020

Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure

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12 December 2020

Preconditioning results in S-nitrosylation of proteins involved in regulation of mitochondrial energetics and calcium transport

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12 December 2020

Mitochondrial morphology transition is an early indicator of subsequent cell death in Arabidopsis

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12 December 2020

Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis

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12 December 2020

Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-A resolution

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12 December 2020

Excessive reactive oxygen species induces apoptosis in fibroblasts: role of mitochondrially accumulated hyaluronic acid binding protein 1 (HABP1/p32/gC1qR)

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12 December 2020

The cyclophilin inhibitor Debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus.

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12 December 2020

Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy

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12 December 2020

The giant channel of the inner mitochondrial membrane is inhibited by cyclosporin A.

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12 December 2020

p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity

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12 December 2020

Attenuation of ischemia-reperfusion injury of the liver in dogs by cyclosporine. A comparative study with allopurinol and methylprednisolone

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12 December 2020

Enhancement of anxiety, facilitation of avoidance behavior, and occurrence of adult-onset obesity in mice lacking mitochondrial cyclophilin D

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12 December 2020

Investigation of Debio 025, a cyclophilin inhibitor, in the dystrophic mdx mouse, a model for Duchenne muscular dystrophy

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12 December 2020

The mitochondrial phosphate carrier interacts with cyclophilin D and may play a key role in the permeability transition

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12 December 2020

Effect of cyclosporine on reperfusion injury in acute myocardial infarction

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12 December 2020

Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation

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12 December 2020

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

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12 December 2020

Calcium- and phosphate-dependent release and loading of glutathione by liver mitochondria

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12 December 2020

Beneficial effect of cyclosporine pretreatment in canine liver ischemia. Enzymatic and electronmicroscopic studies

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12 December 2020

Increased expression and intramitochondrial translocation of cyclophilin-D associates with increased vulnerability of the permeability transition pore to stress-induced opening during compensated ventricular hypertrophy

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12 December 2020

Mechanism for resveratrol-induced cardioprotection against reperfusion injury involves glycogen synthase kinase 3beta and mitochondrial permeability transition pore.

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12 December 2020

Role of cyclophilin D-dependent mitochondrial permeability transition in glutamate-induced calcium deregulation and excitotoxic neuronal death

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12 December 2020

Developmental shift of cyclophilin D contribution to hypoxic-ischemic brain injury

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12 December 2020

The mitochondrial permeability transition pore in motor neurons: involvement in the pathobiology of ALS mice

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12 December 2020

Genetic ablation of cyclophilin D rescues mitochondrial defects and prevents muscle apoptosis in collagen VI myopathic mice

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12 December 2020

Anti-hypertrophic effect of NHE-1 inhibition involves GSK-3beta-dependent attenuation of mitochondrial dysfunction

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12 December 2020

The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naïve hepatitis C patients.

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12 December 2020

Cyclophilin D deficiency improves mitochondrial function and learning/memory in aging Alzheimer disease mouse model

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12 December 2020

The role of cyclophilin D in learning and memory

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12 December 2020

The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-/- myopathic mice.

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12 December 2020

Cyclophilin D gene ablation protects mice from ischemic renal injury.

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12 December 2020

Mitochondria and cell death pathways in plants: Actions speak louder than words

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12 December 2020

Cyclophilin D modulates mitochondrial F0F1-ATP synthase by interacting with the lateral stalk of the complex

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12 December 2020

The NCBI BioSystems database

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12 December 2020

Calcium/calmodulin-dependent protein kinase II contributes to cardiac arrhythmogenesis in heart failure

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12 December 2020

Activation of mitochondrial ERK protects cancer cells from death through inhibition of the permeability transition

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12 December 2020

Protein S-nitrosylation and cardioprotection

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12 December 2020

Signal transduction to the permeability transition pore.

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12 December 2020

Sirtuin-3 deacetylation of cyclophilin D induces dissociation of hexokinase II from the mitochondria

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12 December 2020

The mitochondrial permeability transition from yeast to mammals

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12 December 2020

Mitochondrial cyclophilin-D as a critical mediator of ischaemic preconditioning

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12 December 2020

Targeting cyclophilin D and the mitochondrial permeability transition enhances beta-cell survival and prevents diabetes in Pdx1 deficiency

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12 December 2020

Emerging therapies for hepatitis C virus

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12 December 2020

Mitochondrial Ca2+ transport and permeability transition in zebrafish (Danio rerio).

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12 December 2020

The molecular identity of the mitochondrial Ca2+ sequestration system

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12 December 2020

Structural and biochemical characterization of the human cyclophilin family of peptidyl-prolyl isomerases

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12 December 2020

Mitochondria and cell death: outer membrane permeabilization and beyond

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12 December 2020

Cyclophilin D controls mitochondrial pore-dependent Ca(2+) exchange, metabolic flexibility, and propensity for heart failure in mice

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12 December 2020

Cyclophilin D deficiency protects against acetaminophen-induced oxidant stress and liver injury

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12 December 2020

Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death

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12 December 2020

Mitochondrial cyclophilin-D as a potential therapeutic target for post-myocardial infarction heart failure

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12 December 2020

Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

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12 December 2020

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

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12 December 2020

Characterization of potential S-nitrosylation sites in the myocardium

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12 December 2020

Modulation of F0F1-ATP synthase activity by cyclophilin D regulates matrix adenine nucleotide levels

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12 December 2020

Cyclophilin D and the mitochondrial permeability transition in kidney proximal tubules after hypoxic and ischemic injury

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12 December 2020

Mitochondrial permeability transition pore component cyclophilin D distinguishes nigrostriatal dopaminergic death paradigms in the MPTP mouse model of Parkinson's disease

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12 December 2020

Modulation of the mitochondrial permeability transition by cyclophilin D: moving closer to F(0)-F(1) ATP synthase?

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12 December 2020

The roles of phosphate and the phosphate carrier in the mitochondrial permeability transition pore

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12 December 2020

Mitochondrial permeability transition in Ca(2+)-dependent apoptosis and necrosis

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12 December 2020

Inhibition of Ca2(+)-induced large-amplitude swelling of liver and heart mitochondria by cyclosporin is probably caused by the inhibitor binding to mitochondrial-matrix peptidyl-prolyl cis-trans isomerase and preventing it interacting with the adeni

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12 December 2020

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

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12 December 2020

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

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12 December 2020

Protective role of transient pore openings in calcium handling by cardiac mitochondria

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12 December 2020

Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore

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12 December 2020

Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent.

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12 December 2020

Database resources of the National Center for Biotechnology Information

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12 December 2020

Phosphate is not an absolute requirement for the inhibitory effects of cyclosporin A or cyclophilin D deletion on mitochondrial permeability transition

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12 December 2020

Bax regulates primary necrosis through mitochondrial dynamics

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12 December 2020

The permeability transition pore as a Ca(2+) release channel: new answers to an old question

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12 December 2020

Mechanisms of cell death in heart disease

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12 December 2020

p53 opens the mitochondrial permeability transition pore to trigger necrosis

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12 December 2020

Mitochondrial control of cellular life, stress, and death

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12 December 2020

Is p53 the Long-Sought Molecular Trigger for Cyclophilin D–Regulated Mitochondrial Permeability Transition Pore Formation and Necrosis?

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12 December 2020

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

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12 December 2020

CDD: conserved domains and protein three-dimensional structure

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12 December 2020

Cyclophilin inhibitors: an emerging class of therapeutics for the treatment of chronic hepatitis C infection

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12 December 2020

CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism

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12 December 2020

The mitochondrial transporter family SLC25: identification, properties and physiopathology

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12 December 2020

Role of the c subunit of the FO ATP synthase in mitochondrial permeability transition

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12 December 2020

Cyclosporin A is a potent inhibitor of the inner membrane permeability transition in liver mitochondria

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12 December 2020

A receptor for the immunosuppressant FK506 is a cis-trans peptidyl-prolyl isomerase

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12 December 2020

Mitochondrial channel activity studied by patch-clamping mitoplasts

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12 December 2020

The inner mitochondrial membrane contains ion-conducting channels similar to those found in bacteria.

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12 December 2020

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

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12 December 2020

Evidence that cyclosporine pretreatment protects lysosomal membrane in liver ischemia in dogs

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12 December 2020

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

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12 December 2020

The beneficial effect of cyclosporine on liver ischemia in rats

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12 December 2020

Involvement of the ADP/ATP carrier in calcium-induced perturbations of the mitochondrial inner membrane permeability: importance of the orientation of the nucleotide binding site

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12 December 2020

Kinetic evidence for a heart mitochondrial pore activated by Ca2+, inorganic phosphate and oxidative stress. A potential mechanism for mitochondrial dysfunction during cellular Ca2+ overload

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12 December 2020

Influence of cyclosporin A on the respiration of isolated rat kidney mitochondria

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12 December 2020

Action of cyclosporine on mitochondrial calcium fluxes

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12 December 2020

Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress

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12 December 2020

Beneficial effect of cyclosporine pretreatment in preventing ischemic damage to the liver in dogs

1 reference

12 December 2020

Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium

1 reference

12 December 2020

The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms

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12 December 2020

The Ca2+-induced membrane transition in mitochondria. II. Nature of the Ca2+ trigger site

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12 December 2020

Crucial role of sulfhydryl groups in the mitochondrial inner membrane structure

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12 December 2020

Giant mitochondria in renal tubular cells and cyclosporin A

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12 December 2020

On the State of Calcium Ions in Isolated Rat Liver Mitochondria. II. Effects of Phosphate and pH on Ca2⊕-Induced Ca2⊕Release

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12 December 2020

Allosteric inhibition of the Ca2+-activated hydrophilic channel of the mitochondrial inner membrane by nucleotides

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12 December 2020

Evidence for identity between the hexokinase-binding protein and the mitochondrial porin in the outer membrane of rat liver mitochondria

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12 December 2020

Mitochondrial VDAC can be phosphorylated by cyclic AMP-dependent protein kinase

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12 December 2020

The mitochondrial permeability transition pore may comprise VDAC molecules. I. Binary structure and voltage dependence of the pore

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12 December 2020

The mitochondrial permeability transition pore may comprise VDAC molecules

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12 December 2020

Release of mitochondrial glutathione and calcium by a cyclosporin A-sensitive mechanism occurs without large amplitude swelling

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12 December 2020

Interactions of cyclophilin with the mitochondrial inner membrane and regulation of the permeability transition pore, and cyclosporin A-sensitive channel.

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12 December 2020

Involvement of Cyclophilin D in the Activation of A mitochondrial Pore by Ca2+ and Oxidant Stress

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12 December 2020

Complexes between kinases, mitochondrial porin and adenylate translocator in rat brain resemble the permeability transition pore.

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12 December 2020

Perspectives on the mitochondrial multiple conductance channel

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12 December 2020

Mitochondria are excitable organelles capable of generating and conveying electrical and calcium signals.

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12 December 2020

Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases

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12 December 2020

The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins

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12 December 2020

Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore

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12 December 2020

Reversible S-nitrosation of creatine kinase by nitric oxide in adult rat ventricular myocytes

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12 December 2020

A model of mitochondrial Ca(2+)-induced Ca2+ release simulating the Ca2+ oscillations and spikes generated by mitochondria.

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12 December 2020

From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state

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12 December 2020

Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis

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12 December 2020

Direct demonstration of a specific interaction between cyclophilin-D and the adenine nucleotide translocase confirms their role in the mitochondrial permeability transition

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12 December 2020

Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria

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12 December 2020

Cyclophilin-D binds strongly to complexes of the voltage-dependent anion channel and the adenine nucleotide translocase to form the permeability transition pore

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12 December 2020

The molecular structure of mitochondrial contact sites. Their role in regulation of energy metabolism and permeability transition

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12 December 2020

Identifiers

DOI

10.1253/CIRCJ.CJ-13-0321

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27 February 2020

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