DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication (Q38097227)

28 August 2017

DExD/H-box RNA helicases as mediators of anti-viral innate immunity and essential host factors for viral replication (English)

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28 August 2017

Anthony Fullam

1

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PubMed ID

23567047

28 August 2017

Martina Schröder

series ordinal

2

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PubMed ID

23567047

28 August 2017

language of work or name

English

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publication date

6 April 2013

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Biochimica et Biophysica Acta

28 August 2017

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28 August 2017

1829

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28 August 2017

8

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28 August 2017

854-865

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Recruitment of the RNA helicase RHAU to stress granules via a unique RNA-binding domain

28 August 2017

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12 December 2020

Molecular mechanisms of viral inhibitors of RIG-I-like receptors

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12 December 2020

Human DEAD-box protein 3 has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation

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12 December 2020

An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K

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12 December 2020

Interferon-stimulated genes and their antiviral effector functions

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12 December 2020

LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.

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12 December 2020

A diverse range of gene products are effectors of the type I interferon antiviral response

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12 December 2020

Promotion of hepatocellular carcinoma by hepatitis C virus

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12 December 2020

P-body components LSM1, GW182, DDX3, DDX6 and XRN1 are recruited to WNV replication sites and positively regulate viral replication

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12 December 2020

The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response

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12 December 2020

Human DEAD box helicase 3 couples IκB kinase ε to interferon regulatory factor 3 activation.

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12 December 2020

The DEAD-box RNA helicase DDX1 interacts with RelA and enhances nuclear factor kappaB-mediated transcription

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12 December 2020

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

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12 December 2020

Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3'-end processing of pre-MRNA.

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12 December 2020

TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity

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12 December 2020

Sensing of viral nucleic acids by RIG-I: from translocation to translation

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12 December 2020

A DEAD box protein facilitates HIV-1 replication as a cellular co-factor of Rev.

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12 December 2020

DDX1 promotes proliferation of the JC virus through transactivation of its promoter

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12 December 2020

Delineation of a CpG phosphorothioate oligodeoxynucleotide for activating primate immune responses in vitro and in vivo

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12 December 2020

Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses

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12 December 2020

Principles of intracellular viral recognition.

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12 December 2020

A role for RNA helicase A in post-transcriptional regulation of HIV type 1

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12 December 2020

IFI16 is an innate immune sensor for intracellular DNA

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12 December 2020

RNA helicase A modulates translation of HIV-1 and infectivity of progeny virions

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12 December 2020

The thermodynamic basis for viral RNA detection by the RIG-I innate immune sensor

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12 December 2020

Hepatitis C virus core protein interacts with cellular putative RNA helicase

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12 December 2020

c-Jun supports ribosomal RNA processing and nucleolar localization of RNA helicase DDX21.

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12 December 2020

VISA is an adapter protein required for virus-triggered IFN-beta signaling

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12 December 2020

The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication

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12 December 2020

DDX3 DEAD-Box RNA helicase inhibits hepatitis B virus reverse transcription by incorporation into nucleocapsids.

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12 December 2020

A novel, retromer-independent role for sorting nexins 1 and 2 in RhoG-dependent membrane remodeling

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12 December 2020

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

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12 December 2020

Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation

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12 December 2020

Recognition of 5' triphosphate by RIG-I helicase requires short blunt double-stranded RNA as contained in panhandle of negative-strand virus

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12 December 2020

Genetic evidence for a mammalian retromer complex containing sorting nexins 1 and 2.

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12 December 2020

Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells

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12 December 2020

The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control

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12 December 2020

DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential

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12 December 2020

Facilitation of mRNA deadenylation and decay by the exosome-bound, DExH protein RHAU

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12 December 2020

Single-molecule studies reveal that DEAD box protein DDX1 promotes oligomerization of HIV-1 Rev on the Rev response element

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12 December 2020

Viruses and interferon: a fight for supremacy

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12 December 2020

Nuclear factors are involved in hepatitis C virus RNA replication

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12 December 2020

Critical role of TRAF3 in the Toll-like receptor-dependent and -independent antiviral response

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12 December 2020

The RIG-I-like receptor LGP2 recognizes the termini of double-stranded RNA

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12 December 2020

Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2

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12 December 2020

Coordinate roles of Gag and RNA helicase A in promoting the annealing of formula to HIV-1 RNA

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12 December 2020

Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

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12 December 2020

Association of RNA helicase a with human immunodeficiency virus type 1 particles

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12 December 2020

Ubiquitin-induced oligomerization of the RNA sensors RIG-I and MDA5 activates antiviral innate immune response

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12 December 2020

Innate immunity: cytoplasmic DNA sensing by the AIM2 inflammasome.

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12 December 2020

Oncogenic role of DDX3 in breast cancer biogenesis.

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12 December 2020

Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3

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12 December 2020

Hepatitis B virus polymerase blocks pattern recognition receptor signaling via interaction with DDX3: implications for immune evasion

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12 December 2020

Translational regulation of HIV-1 replication by HIV-1 Rev cellular cofactors Sam68, eIF5A, hRIP, and DDX3.

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12 December 2020

Comparative analysis of IRF and IFN-alpha expression in human plasmacytoid and monocyte-derived dendritic cells

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12 December 2020

Abstrakt interacts with and regulates the expression of sorting nexin-2

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12 December 2020

DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response

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12 December 2020

The DEAD-box RNA helicase DDX6 is required for efficient encapsidation of a retroviral genome

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12 December 2020

Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity

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12 December 2020

An antiviral response directed by PKR phosphorylation of the RNA helicase A

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12 December 2020

Hepatitis C virus core-derived peptides inhibit genotype 1b viral genome replication via interaction with DDX3X

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12 December 2020

Viral targeting of DEAD box protein 3 reveals its role in TBK1/IKKepsilon-mediated IRF activation

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12 December 2020

Nuclear DNA helicase II unwinds both DNA and RNA.

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12 December 2020

Hepatitis B virus polymerase inhibits RIG-I- and Toll-like receptor 3-mediated beta interferon induction in human hepatocytes through interference with interferon regulatory factor 3 activation and dampening of the interaction between TBK1/IKKepsilo

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12 December 2020

Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core protein

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12 December 2020

Human cytomegalovirus induces the interferon response via the DNA sensor ZBP1.

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12 December 2020

Innate immune sensing of modified vaccinia virus Ankara (MVA) is mediated by TLR2-TLR6, MDA-5 and the NALP3 inflammasome

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12 December 2020

Modulation of the type I interferon pathways by culture-adaptive hepatitis C virus core mutants

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12 December 2020

Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity

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12 December 2020

RIG-I detects viral genomic RNA during negative-strand RNA virus infection

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12 December 2020

The DEXD/H-box RNA helicase RHII/Gu is a co-factor for c-Jun-activated transcription

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12 December 2020

IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9

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12 December 2020

Impaired cellular responses to cytosolic DNA or infection with Listeria monocytogenes and vaccinia virus in the absence of the murine LGP2 protein

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12 December 2020

ATP hydrolysis enhances RNA recognition and antiviral signal transduction by the innate immune sensor, laboratory of genetics and physiology 2 (LGP2)

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12 December 2020

DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs

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12 December 2020

Discovery of an RNA virus 3'->5' exoribonuclease that is critically involved in coronavirus RNA synthesis

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12 December 2020

Yin Yang 1 contains G-quadruplex structures in its promoter and 5'-UTR and its expression is modulated by G4 resolvase 1

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12 December 2020

Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction

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12 December 2020

DDX3, a DEAD box RNA helicase with tumor growth-suppressive property and transcriptional regulation activity of the p21waf1/cip1 promoter, is a candidate tumor suppressor

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12 December 2020

DDX60, a DEXD/H box helicase, is a novel antiviral factor promoting RIG-I-like receptor-mediated signaling

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12 December 2020

Discovery of the first small molecule inhibitor of human DDX3 specifically designed to target the RNA binding site: towards the next generation HIV-1 inhibitors.

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12 December 2020

Mitochondrial dynamics regulate the RIG-I-like receptor antiviral pathway

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12 December 2020

Innate immune recognition: mechanisms and pathways

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12 December 2020

Toward the discovery of novel anti-HIV drugs. Second-generation inhibitors of the cellular ATPase DDX3 with improved anti-HIV activity: synthesis, structure-activity relationship analysis, cytotoxicity studies, and target validation.

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12 December 2020

The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells

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12 December 2020

Identification of DDX1 as a JC virus transcriptional control region-binding protein

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12 December 2020

Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I

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12 December 2020

Knockdown of cellular RNA helicase DDX3 by short hairpin RNAs suppresses HIV-1 viral replication without inducing apoptosis

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12 December 2020

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

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12 December 2020

Solution structures of cytosolic RNA sensor MDA5 and LGP2 C-terminal domains: identification of the RNA recognition loop in RIG-I-like receptors

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12 December 2020

MDA-5 recognition of a murine norovirus

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12 December 2020

Sam68, RNA helicase A and Tap cooperate in the post-transcriptional regulation of human immunodeficiency virus and type D retroviral mRNA

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12 December 2020

DDX3 DEAD-box RNA helicase is required for hepatitis C virus RNA replication

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12 December 2020

The mitochondrial targeting chaperone 14-3-3ε regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity.

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12 December 2020

Role of the amino terminal RHAU-specific motif in the recognition and resolution of guanine quadruplex-RNA by the DEAH-box RNA helicase RHAU

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12 December 2020

Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells

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12 December 2020

Hepatitis C virus core protein interacts with a human DEAD box protein DDX3

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12 December 2020

A Role of RNA Helicase A in cis-Acting Transactivation Response Element-mediated Transcriptional Regulation of Human Immunodeficiency Virus Type 1.

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12 December 2020

Structural basis of RNA recognition and activation by innate immune receptor RIG-I

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12 December 2020

From promoting to inhibiting: diverse roles of helicases in HIV-1 Replication

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12 December 2020

Subproteomic analysis of the cellular proteins associated with the 3' untranslated region of the hepatitis C virus genome in human liver cells

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12 December 2020

DDX1 is an RNA-dependent ATPase involved in HIV-1 Rev function and virus replication

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12 December 2020

Nuclear DNA helicase II is recruited to IFN-alpha-activated transcription sites at PML nuclear bodies.

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12 December 2020

Identification of RNA helicase A as a cellular factor that interacts with influenza A virus NS1 protein and its role in the virus life cycle

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12 December 2020

A synthetic HIV-1 Rev inhibitor interfering with the CRM1-mediated nuclear export

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12 December 2020

Mitochondrial-associated endoplasmic reticulum membranes (MAM) form innate immune synapses and are targeted by hepatitis C virus

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12 December 2020

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I

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12 December 2020

Nonself RNA-sensing mechanism of RIG-I helicase and activation of antiviral immune responses

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12 December 2020

Human DHX9 helicase unwinds triple-helical DNA structures

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12 December 2020

Proteomic profiling of the TRAF3 interactome network reveals a new role for the ER-to-Golgi transport compartments in innate immunity

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12 December 2020

IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction

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12 December 2020

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

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12 December 2020

A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA.

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12 December 2020

Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction

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12 December 2020

HIV-1 Gag co-opts a cellular complex containing DDX6, a helicase that facilitates capsid assembly

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12 December 2020

Molecular mechanism of signal perception and integration by the innate immune sensor retinoic acid-inducible gene-I (RIG-I).

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12 December 2020

Pharmacophore modeling and molecular docking led to the discovery of inhibitors of human immunodeficiency virus-1 replication targeting the human cellular aspartic acid-glutamic acid-alanine-aspartic acid box polypeptide 3.

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12 December 2020

Cooperative assembly and dynamic disassembly of MDA5 filaments for viral dsRNA recognition

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12 December 2020

Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

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12 December 2020

The DEXH protein product of the DHX36 gene is the major source of tetramolecular quadruplex G4-DNA resolving activity in HeLa cell lysates

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12 December 2020

Cytosolic DNA sensors regulating type I interferon induction.

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12 December 2020

MDA5 assembles into a polar helical filament on dsRNA.

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12 December 2020

Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

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12 December 2020

The RNA helicase Lgp2 inhibits TLR-independent sensing of viral replication by retinoic acid-inducible gene-I.

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12 December 2020

G4-forming sequences in the non-transcribed DNA strand pose blocks to T7 RNA polymerase and mammalian RNA polymerase II.

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12 December 2020

MDA5 cooperatively forms dimers and ATP-sensitive filaments upon binding double-stranded RNA

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12 December 2020

Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

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12 December 2020

Functional coherence of the human Y chromosome

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12 December 2020

DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells

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12 December 2020

From unwinding to clamping - the DEAD box RNA helicase family

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12 December 2020

LGP2 is a positive regulator of RIG-I- and MDA5-mediated antiviral responses

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12 December 2020

Cytoplasmic DNA innate immune pathways

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12 December 2020

Crystal structure of human RNA helicase A (DHX9): structural basis for unselective nucleotide base binding in a DEAD-box variant protein

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12 December 2020

Sensing adenovirus infection: activation of interferon regulatory factor 3 in RAW 264.7 cells

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12 December 2020

Helicase structure and mechanism

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12 December 2020

DHX9 pairs with IPS-1 to sense double-stranded RNA in myeloid dendritic cells

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12 December 2020

DDX3 regulates cell growth through translational control of cyclin E1

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12 December 2020

Identification of RNA helicase A as a new host factor in the replication cycle of foot-and-mouth disease virus

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12 December 2020

RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1

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12 December 2020

Activation of MDA5 requires higher-order RNA structures generated during virus infection

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12 December 2020

Ring Expanded Nucleoside Analogues Inhibit RNA Helicase and Intracellular Human Immunodeficiency Virus Type 1 Replication

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12 December 2020

Requirement of DDX3 DEAD box RNA helicase for HIV-1 Rev-RRE export function

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12 December 2020

Pattern recognition receptors and the innate immune response to viral infection

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12 December 2020

Structural insights into RNA recognition and activation of RIG-I-like receptors

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12 December 2020

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

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12 December 2020

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

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12 December 2020

RNA helicases: emerging roles in viral replication and the host innate response

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12 December 2020

The DEAD-box protein family of RNA helicases

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12 December 2020

Hepatitis C virus core protein binds to a DEAD box RNA helicase

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12 December 2020

Structural and functional insights into 5′-ppp RNA pattern recognition by the innate immune receptor RIG-I

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12 December 2020

Structural basis for the activation of innate immune pattern-recognition receptor RIG-I by viral RNA

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12 December 2020

Structural insights into regulation and action of SWI2/SNF2 ATPases

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12 December 2020

STING is a direct innate immune sensor of cyclic di-GMP

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12 December 2020

Preference of RIG-I for short viral RNA molecules in infected cells revealed by next-generation sequencing

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12 December 2020

Small self-RNA generated by RNase L amplifies antiviral innate immunity

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12 December 2020

DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation

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12 December 2020

Silencing of RNA Helicase II/Guα Inhibits Mammalian Ribosomal RNA Production

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12 December 2020

Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production

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12 December 2020

Direct evidence for translational regulation by leader RNA and Tat protein of human immunodeficiency virus type 1.

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12 December 2020

Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1

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12 December 2020

The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response

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12 December 2020

Cellular cofactors affecting hepatitis C virus infection and replication

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12 December 2020

Virus-infection or 5'ppp-RNA activates antiviral signal through redistribution of IPS-1 mediated by MFN1

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12 December 2020

DDX6 (Rck/p54) is required for efficient hepatitis C virus replication but not for internal ribosome entry site-directed translation

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12 December 2020

Structural basis of double-stranded RNA recognition by the RIG-I like receptor MDA5

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12 December 2020

DDX3, a DEAD box RNA helicase, is deregulated in hepatitis virus-associated hepatocellular carcinoma and is involved in cell growth control

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12 December 2020

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

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12 December 2020

Inverse interference: how viruses fight the interferon system

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12 December 2020

IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

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12 December 2020

Identification of RNA-protein interaction networks involved in the norovirus life cycle

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12 December 2020

Viral evasion and subversion of pattern-recognition receptor signalling

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12 December 2020

10.1016/J.BBAGRM.2013.03.012

Identifiers

DOI

1 reference

28 August 2017

1 reference

PubMed ID

23567047