Regulation of innate and adaptive immunity by Notch (Q38105858)

28 August 2017

Regulation of innate and adaptive immunity by Notch (English)

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Fabienne Tacchini-Cottier

28 August 2017

object named as

Fabienne Tacchini-Cottier

series ordinal

3

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Freddy Radtke

object named as

Freddy Radtke

series ordinal

1

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author name string

H Robson MacDonald

series ordinal

2

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28 August 2017

13 May 2013

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Nature Reviews Immunology

28 August 2017

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28 August 2017

13

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28 August 2017

6

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28 August 2017

427-437

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28 August 2017

The Theory of the Gene

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Notch signalling: a simple pathway becomes complex

31 March 2020

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The canonical Notch signaling pathway: unfolding the activation mechanism

31 March 2020

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Modulating Notch signaling by pathway-intrinsic and pathway-extrinsic mechanisms.

31 March 2020

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Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells

31 March 2020

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Biodiversity and noncanonical Notch signaling

31 March 2020

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NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growth

31 March 2020

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c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma

31 March 2020

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HES and HERP families: multiple effectors of the Notch signaling pathway

31 March 2020

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

31 March 2020

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Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision

31 March 2020

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Notch1 expression in early lymphopoiesis influences B versus T lineage determination.

31 March 2020

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Subversion of the T/B lineage decision in the thymus by lunatic fringe-mediated inhibition of Notch-1.

31 March 2020

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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.

31 March 2020

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Notch-regulated ankyrin-repeat protein inhibits Notch1 signaling: multiple Notch1 signaling pathways involved in T cell development

31 March 2020

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Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

31 March 2020

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Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus.

31 March 2020

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The earliest thymic progenitors for T cells possess myeloid lineage potential.

31 March 2020

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Adult T-cell progenitors retain myeloid potential

31 March 2020

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Deletion of Notch1 converts pro-T cells to dendritic cells and promotes thymic B cells by cell-extrinsic and cell-intrinsic mechanisms.

31 March 2020

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Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation.

31 March 2020

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Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation

31 March 2020

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Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro.

31 March 2020

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Delta-like 4 is indispensable in thymic environment specific for T cell development

31 March 2020

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Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T cell lineage commitment.

31 March 2020

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Direct comparison of Dll1- and Dll4-mediated Notch activation levels shows differential lymphomyeloid lineage commitment outcomes.

31 March 2020

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Developmental and molecular characterization of emerging beta- and gammadelta-selected pre-T cells in the adult mouse thymus

31 March 2020

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An early decrease in Notch activation is required for human TCR-alphabeta lineage differentiation at the expense of TCR-gammadelta T cells.

31 March 2020

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Notch signaling is required for proliferation but not for differentiation at a well-defined beta-selection checkpoint during human T-cell development.

31 March 2020

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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.

31 March 2020

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The follicular versus marginal zone B lymphocyte cell fate decision

31 March 2020

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Blood dendritic cells interact with splenic marginal zone B cells to initiate T-independent immune responses.

31 March 2020

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Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo

31 March 2020

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Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

31 March 2020

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Notch-RBP-J signaling is involved in cell fate determination of marginal zone B cells

31 March 2020

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Mastermind-1 is required for Notch signal-dependent steps in lymphocyte development in vivo

31 March 2020

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The transcriptional coactivator Maml1 is required for Notch2-mediated marginal zone B-cell development

31 March 2020

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Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development

31 March 2020

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ADAM10 is essential for Notch2-dependent marginal zone B cell development and CD23 cleavage in vivo

31 March 2020

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Regulation of marginal zone B cell development by MINT, a suppressor of Notch/RBP-J signaling pathway

31 March 2020

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Lunatic and manic fringe cooperatively enhance marginal zone B cell precursor competition for delta-like 1 in splenic endothelial niches

31 March 2020

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Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen.

31 March 2020

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Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine.

31 March 2020

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Notch1 deficiency dissociates the intrathymic development of dendritic cells and T cells.

31 March 2020

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Mouse CD11c(+) B220(+) Gr1(+) plasmacytoid dendritic cells develop independently of the T-cell lineage.

31 March 2020

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Innate lymphoid cells: emerging insights in development, lineage relationships, and function

31 March 2020

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Innate lymphoid cells--a proposal for uniform nomenclature

31 March 2020

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The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling.

31 March 2020

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Notch, Id2, and RORγt sequentially orchestrate the fetal development of lymphoid tissue inducer cells

31 March 2020

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Microbial flora drives interleukin 22 production in intestinal NKp46+ cells that provide innate mucosal immune defense

31 March 2020

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Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

31 March 2020

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Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles

31 March 2020

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Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation

31 March 2020

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AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

31 March 2020

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Innate lymphoid cells drive interleukin-23-dependent innate intestinal pathology.

31 March 2020

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Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity

31 March 2020

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Systemically dispersed innate IL-13-expressing cells in type 2 immunity

31 March 2020

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Transcription factor RORα is critical for nuocyte development

31 March 2020

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

31 March 2020

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TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells

31 March 2020

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Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

31 March 2020

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Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.

31 March 2020

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IL-4 inhibits TGF-beta-induced Foxp3+ T cells and, together with TGF-beta, generates IL-9+ IL-10+ Foxp3(-) effector T cells

31 March 2020

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Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation

31 March 2020

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Bcl6 mediates the development of T follicular helper cells

31 March 2020

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Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cells

31 March 2020

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Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors

31 March 2020

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How are T(H)1 and T(H)2 effector cells made?

31 March 2020

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Notch signaling in the immune system

31 March 2020

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Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells.

31 March 2020

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The different faces of Notch in T-helper-cell differentiation

31 March 2020

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Notch3 inhibition in myelin-reactive T cells down-regulates protein kinase C theta and attenuates experimental autoimmune encephalomyelitis

31 March 2020

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Notch directly regulates Gata3 expression during T helper 2 cell differentiation

31 March 2020

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Notch signaling is an important regulator of type 2 immunity.

31 March 2020

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Redundant Notch1 and Notch2 signaling is necessary for IFNγ secretion by T helper 1 cells during infection with Leishmania major

31 March 2020

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TCR-mediated Notch signaling regulates proliferation and IFN-gamma production in peripheral T cells

31 March 2020

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Notch1 augments NF-kappaB activity by facilitating its nuclear retention

31 March 2020

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Direct regulation of Gata3 expression determines the T helper differentiation potential of Notch

31 March 2020

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The interleukin-4 enhancer CNS-2 is regulated by Notch signals and controls initial expression in NKT cells and memory-type CD4 T cells.

31 March 2020

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The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells

31 March 2020

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Notch receptors and Smad3 signaling cooperate in the induction of interleukin-9-producing T cells

31 March 2020

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T(H)17 cytokines in autoimmune neuro-inflammation.

31 March 2020

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Phenotypical and functional specialization of FOXP3+ regulatory T cells

31 March 2020

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Expression of activated Notch3 in transgenic mice enhances generation of T regulatory cells and protects against experimental autoimmune diabetes

31 March 2020

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Notch3 and pTalpha/pre-TCR sustain the in vivo function of naturally occurring regulatory T cells.

31 March 2020

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Notch3 and canonical NF-kappaB signaling pathways cooperatively regulate Foxp3 transcription.

31 March 2020

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Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling

31 March 2020

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Notch ligand delta-like 4 blockade alleviates experimental autoimmune encephalomyelitis by promoting regulatory T cell development

31 March 2020

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JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis

31 March 2020

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Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice

31 March 2020

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Differentiation and expansion of T cells with regulatory function from human peripheral lymphocytes by stimulation in the presence of TGF-{beta}.

31 March 2020

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Serrate1-induced notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells

31 March 2020

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Induction of antigen-specific regulatory T cells following overexpression of a Notch ligand by human B lymphocytes

31 March 2020

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Notch1 signaling and regulatory T cell function

31 March 2020

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Notch1 modulates mesenchymal stem cells mediated regulatory T-cell induction

31 March 2020

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Programming of regulatory T cells from pluripotent stem cells and prevention of autoimmunity

31 March 2020

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Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism.

31 March 2020

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Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity.

31 March 2020

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Blockade of Notch ligand δ1 promotes allograft survival by inhibiting alloreactive Th1 cells and cytotoxic T cell generation

31 March 2020

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Notch2 signaling is required for potent antitumor immunity in vivo.

31 March 2020

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Notch regulates cytolytic effector function in CD8+ T cells.

31 March 2020

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Notch controls generation and function of human effector CD8+ T cells

31 March 2020

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Immunobiology of allogeneic hematopoietic stem cell transplantation

31 March 2020

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Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease.

31 March 2020

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Blockade of individual Notch ligands and receptors controls graft-versus-host disease

31 March 2020

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Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease

31 March 2020

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Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient mice

31 March 2020

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Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis.

31 March 2020

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gamma-Secretase inhibitors as molecular probes of presenilin function

31 March 2020

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Modulation of receptor signaling by glycosylation: fringe is an O-fucose-beta1,3-N-acetylglucosaminyltransferase

31 March 2020

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Glycosyltransferase activity of Fringe modulates Notch-Delta interactions.

31 March 2020

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Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

31 March 2020

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Hierarchy of Notch-Delta interactions promoting T cell lineage commitment and maturation

31 March 2020

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The origin and application of experimental autoimmune encephalomyelitis

31 March 2020

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Ameliorating effects of anti-Dll4 mAb on Theiler's murine encephalomyelitis virus-induced demyelinating disease

31 March 2020

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Delta-like ligand 4 regulates central nervous system T cell accumulation during experimental autoimmune encephalomyelitis

31 March 2020

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Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23665520

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23665520

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The role of Notch in the differentiation of CD4⁺ T helper cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/23665520

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRI3445

1 reference

28 August 2017

1 reference

PubMed ID

23665520