Sirtuins' modulation of autophagy (Q38108575)

29 August 2017

Sirtuins' modulation of autophagy (English)

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29 August 2017

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Fanny Ng

1

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PubMed ID

23696314

29 August 2017

Bor Luen Tang

series ordinal

2

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29 August 2017

1 December 2013

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Journal of Cellular Physiology

29 August 2017

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29 August 2017

228

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29 August 2017

2262-2270

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29 August 2017

12

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The SIRT1 activator resveratrol protects SK-N-BE cells from oxidative stress and against toxicity caused by alpha-synuclein or amyloid-beta (1-42) peptide.

29 August 2017

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Sirtuins as novel targets for Alzheimer's disease and other neurodegenerative disorders: experimental and genetic evidence

21 January 2018

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Sirt1 regulates aging and resistance to oxidative stress in the heart

21 January 2018

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Inhibition of mammalian S6 kinase by resveratrol suppresses autophagy

21 January 2018

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Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

21 January 2018

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Autophagy in neurodegenerative disorders: pathogenic roles and therapeutic implications

21 January 2018

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The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs).

21 January 2018

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Are sirtuins viable targets for improving healthspan and lifespan?

21 January 2018

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Autophagosomes and human diseases

21 January 2018

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A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

21 January 2018

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NAD(+), sirtuins, and cardiovascular disease

21 January 2018

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

21 January 2018

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Caloric restriction, SIRT1 and longevity

21 January 2018

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PGC-1alpha, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

21 January 2018

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The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae

21 January 2018

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Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

21 January 2018

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

21 January 2018

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IKK-dependent, NF-κB-independent control of autophagic gene expression.

21 January 2018

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IKK connects autophagy to major stress pathways

21 January 2018

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The IKK complex contributes to the induction of autophagy

21 January 2018

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Augmentation of oridonin-induced apoptosis observed with reduced autophagy

21 January 2018

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Regulation of FoxO transcription factors by acetylation and protein-protein interactions

21 January 2018

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Resveratrol attenuates renal hypertrophy in early-stage diabetes by activating AMPK.

21 January 2018

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Gemcitabine/cannabinoid combination triggers autophagy in pancreatic cancer cells through a ROS-mediated mechanism

21 January 2018

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SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

21 January 2018

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Aging and disease: connections to sirtuins

21 January 2018

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

21 January 2018

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Autophagy and multivesicular bodies: two closely related partners

21 January 2018

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JNK2-dependent regulation of SIRT1 protein stability

21 January 2018

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The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy

21 January 2018

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Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity

21 January 2018

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SIRT1 negatively regulates the mammalian target of rapamycin

21 January 2018

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SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging.

21 January 2018

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Autophagy during cardiac stress: joys and frustrations of autophagy

21 January 2018

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Sirtuins in aging and disease

21 January 2018

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Mammalian sirtuins: biological insights and disease relevance

21 January 2018

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Autophagosomes form at ER-mitochondria contact sites

21 January 2018

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Where do they come from? Insights into autophagosome formation

21 January 2018

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SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

21 January 2018

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Sirtuins and their relevance to the kidney.

21 January 2018

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Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

21 January 2018

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

21 January 2018

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Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes.

21 January 2018

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Sirt1 protects the heart from aging and stress.

21 January 2018

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Nicotinamide phosphoribosyltransferase regulates cell survival through NAD+ synthesis in cardiac myocytes.

21 January 2018

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The controversial links among calorie restriction, SIRT1, and resveratrol

21 January 2018

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Dynamic FoxO transcription factors

21 January 2018

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Autophagy protects neuron from Abeta-induced cytotoxicity

21 January 2018

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Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: implication in pathogenesis of COPD.

21 January 2018

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The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation

21 January 2018

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Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins

21 January 2018

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Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation

21 January 2018

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Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

21 January 2018

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Autophagy induced by the class III histone deacetylase Sirt1 prevents prion peptide neurotoxicity

21 January 2018

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Emerging roles of SIRT6 on telomere maintenance, DNA repair, metabolism and mammalian aging

21 January 2018

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Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

21 January 2018

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Autophagy and polyglutamine diseases

21 January 2018

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p53, Autophagy and tumor suppression

21 January 2018

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Sir2 and calorie restriction in yeast: a skeptical perspective.

21 January 2018

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The sirtuin SIRT6 regulates lifespan in male mice

21 January 2018

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Neuronal Sirt3 protects against excitotoxic injury in mouse cortical neuron culture

21 January 2018

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Dietary restriction ameliorates diabetic nephropathy through anti-inflammatory effects and regulation of the autophagy via restoration of Sirt1 in diabetic Wistar fatty (fa/fa) rats: a model of type 2 diabetes

21 January 2018

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Autophagy as a regulated pathway of cellular degradation

21 January 2018

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Autophagy and the integrated stress response

21 January 2018

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

21 January 2018

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SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation

21 January 2018

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A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

21 January 2018

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Reactive oxygen species regulation of autophagy in cancer: implications for cancer treatment

21 January 2018

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Sirtuin 2, a mammalian homolog of yeast silent information regulator-2 longevity regulator, is an oligodendroglial protein that decelerates cell differentiation through deacetylating alpha-tubulin

21 January 2018

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IRE1 signaling affects cell fate during the unfolded protein response

21 January 2018

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21 January 2018

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Autophagy plays a critical role in kidney tubule maintenance, aging and ischemia-reperfusion injury.

21 January 2018

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The critical role of the class III histone deacetylase SIRT1 in cancer

21 January 2018

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Vesicular trafficking and autophagosome formation

21 January 2018

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Linking sirtuins, IGF-I signaling, and starvation

21 January 2018

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Sirtuins in aging and age-related disease.

21 January 2018

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Negative control of p53 by Sir2alpha promotes cell survival under stress

21 January 2018

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Autophagy for tissue homeostasis and neuroprotection

21 January 2018

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Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night

21 January 2018

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The role of ESCRT proteins in fusion events involving lysosomes, endosomes and autophagosomes

21 January 2018

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Sirtuins in mammals: insights into their biological function

21 January 2018

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Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

21 January 2018

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The life span-prolonging effect of sirtuin-1 is mediated by autophagy

21 January 2018

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Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

21 January 2018

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Effects of Longevinex (modified resveratrol) on cardioprotection and its mechanisms of action

21 January 2018

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SIRT1-mediated acute cardioprotection

21 January 2018

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JNK1 phosphorylates SIRT1 and promotes its enzymatic activity

21 January 2018

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The role of Sirt1 in renal rejuvenation and resistance to stress

21 January 2018

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Nutrient availability regulates SIRT1 through a forkhead-dependent pathway.

21 January 2018

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SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}

21 January 2018

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p62 at the interface of autophagy, oxidative stress signaling, and cancer

21 January 2018

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Discovery of Atg5/Atg7-independent alternative macroautophagy

21 January 2018

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The late stages of autophagy: how does the end begin?

21 January 2018

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The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase

21 January 2018

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Membrane trafficking events that partake in autophagy

21 January 2018

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Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease

21 January 2018

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Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection

21 January 2018

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The regulation of SIRT2 function by cyclin-dependent kinases affects cell motility

21 January 2018

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Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma

21 January 2018

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Disruption of a Sirt1-dependent autophagy checkpoint in the prostate results in prostatic intraepithelial neoplasia lesion formation

21 January 2018

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Acute induction of autophagy as a novel strategy for cardioprotection: getting to the heart of the matter

21 January 2018

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

21 January 2018

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Autophagy in the eukaryotic cell

21 January 2018

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The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure

21 January 2018

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

21 January 2018

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

21 January 2018

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The multiple roles of autophagy in cancer

21 January 2018

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SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy.

21 January 2018

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Atg17 recruits Atg9 to organize the pre-autophagosomal structure

21 January 2018

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FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress

21 January 2018

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FoxO transcription factors promote autophagy in cardiomyocytes

21 January 2018

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Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy

21 January 2018

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Protective roles of SIRT1 in atherosclerosis.

21 January 2018

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PPAR control: it's SIRTainly as easy as PGC.

21 January 2018

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Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy

21 January 2018

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SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

21 January 2018

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Mammalian Sir2-related protein (SIRT) 2-mediated modulation of resistance to axonal degeneration in slow Wallerian degeneration mice: a crucial role of tubulin deacetylation

21 January 2018

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Bif-1/endophilin B1: a candidate for crescent driving force in autophagy

21 January 2018

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Sirt1's complex roles in neuroprotection.

21 January 2018

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Sirt1's systemic protective roles and its promise as a target in antiaging medicine

21 January 2018

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SIRT1 and neuronal diseases

21 January 2018

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A dual role of p53 in the control of autophagy

21 January 2018

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Regulation of autophagy by cytoplasmic p53

21 January 2018

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p53 represses autophagy in a cell cycle-dependent fashion

21 January 2018

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The journey of resveratrol from yeast to human

21 January 2018

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The origin of the autophagosomal membrane

21 January 2018

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Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings

21 January 2018

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Interplay between histone deacetylases and autophagy--from cancer therapy to neurodegeneration

21 January 2018

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21 January 2018

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

21 January 2018

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mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart.

21 January 2018

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Triple layer control: phosphorylation, acetylation and ubiquitination of FOXO proteins.

21 January 2018

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SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

21 January 2018

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Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia

21 January 2018

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Sirtuin activators mimic caloric restriction and delay ageing in metazoans

21 January 2018

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Resveratrol-activated AMPK/SIRT1/autophagy in cellular models of Parkinson's disease

21 January 2018

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Autophagy in the central nervous system: implications for neurodegenerative disorders

21 January 2018

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JNK regulates FoxO-dependent autophagy in neurons

21 January 2018

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Eaten alive: a history of macroautophagy

21 January 2018

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Mammalian autophagy: core molecular machinery and signaling regulation

21 January 2018

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

21 January 2018

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SIRT1 and p53, effect on cancer, senescence and beyond

21 January 2018

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Starvation and ULK1-dependent cycling of mammalian Atg9 between the TGN and endosomes

21 January 2018

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Autophagy counteracts apoptosis in human multiple myeloma cells exposed to oridonin in vitro via regulating intracellular ROS and SIRT1

21 January 2018

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The time-dependent autophagy protects against apoptosis with possible involvement of Sirt1 protein in multiple myeloma under nutrient depletion

21 January 2018

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Protective effects and mechanisms of sirtuins in the nervous system

21 January 2018

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Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

21 January 2018

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Cytosolic FoxO1: alive and killing

21 January 2018

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SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/JCP.24399

1 reference

29 August 2017

1 reference

PubMed ID

23696314