Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment (Q38120310)

29 August 2017

title

Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment (English)

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29 August 2017

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Antonis E Koromilas

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29 August 2017

Zineb Mounir

series ordinal

2

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29 August 2017

language of work or name

English

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publication date

1 July 2013

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29 August 2017

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29 August 2017

volume

9

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29 August 2017

issue

7

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29 August 2017

page(s)

1005-1015

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Translational control in cancer.

29 August 2017

cites work

1 reference

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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Regulation of cap-dependent translation by eIF4E inhibitory proteins

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Coping with stress: eIF2 kinases and translational control

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The dsRNA protein kinase PKR: virus and cell control

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Novel role of PKR in inflammasome activation and HMGB1 release

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Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

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Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

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Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

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Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response

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Internal ribosome entry sites in cellular mRNAs: mystery of their existence.

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The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.

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Targeting the eukaryotic translation initiation factor 4E for cancer therapy

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Translation initiation and its deregulation during tumorigenesis

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

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Tumor-suppressor genes: news about the interferon connection

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PKR; a sentinel kinase for cellular stress

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Uncovering the PKR pathway's potential for treatment of tumors.

21 January 2018

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Double-stranded-RNA-activated protein kinase PKR enhances transcriptional activation by tumor suppressor p53

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Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death

21 January 2018

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eIF2{alpha} Kinase PKR modulates the hypoxic response by Stat3-dependent transcriptional suppression of HIF-1{alpha}.

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HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.

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The mammalian unfolded protein response

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The role of the unfolded protein response in tumour development: friend or foe?

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The glucose-regulated proteins: stress induction and clinical applications

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ER stress-regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

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ER stress-mediated autophagy promotes Myc-dependent transformation and tumor growth

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ATF4, an ER stress and hypoxia-inducible transcription factor and its potential role in hypoxia tolerance and tumorigenesis.

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An integrated stress response regulates amino acid metabolism and resistance to oxidative stress

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The PERK-eIF2α phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells

21 January 2018

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Endoplasmic reticulum stress induces p53 cytoplasmic localization and prevents p53-dependent apoptosis by a pathway involving glycogen synthase kinase-3beta

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Endoplasmic reticulum stress accelerates p53 degradation by the cooperative actions of Hdm2 and glycogen synthase kinase 3beta

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The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation.

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The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6/eIF3e in responses to endogenous oxidative stress during histidine starvation.

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Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses

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Phosphorylation of eIF2α at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

21 January 2018

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The double-stranded RNA activated protein kinase PKR physically associates with the tumor suppressor p53 protein and phosphorylates human p53 on serine 392 in vitro

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Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense

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Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

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PERK utilizes intrinsic lipid kinase activity to generate phosphatidic acid, mediate Akt activation, and promote adipocyte differentiation

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Tyrosine phosphorylation acts as a molecular switch to full-scale activation of the eIF2alpha RNA-dependent protein kinase

21 January 2018

1 reference

Modulation of the eukaryotic initiation factor 2 alpha-subunit kinase PERK by tyrosine phosphorylation

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Protein tyrosine phosphatase 1B deficiency potentiates PERK/eIF2α signaling in brown adipocytes

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H2S-Induced sulfhydration of the phosphatase PTP1B and its role in the endoplasmic reticulum stress response

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Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway

21 January 2018

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Double-stranded RNA-dependent protein kinase phosphorylation of the alpha-subunit of eukaryotic translation initiation factor 2 mediates apoptosis

21 January 2018

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Targeting the phosphoinositide 3-kinase pathway in cancer

21 January 2018

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Regulation of the Akt kinase by interacting proteins

21 January 2018

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PKB/AKT: functional insights from genetic models

21 January 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

21 January 2018

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AKT/PKB signaling: navigating downstream

21 January 2018

1 reference

Molecular mechanisms of mTOR-mediated translational control

21 January 2018

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PI3K pathway alterations in cancer: variations on a theme

21 January 2018

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Recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors

21 January 2018

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A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway

21 January 2018

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PTEN: a new guardian of the genome.

21 January 2018

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Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway

21 January 2018

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ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

21 January 2018

1 reference

Tuberous sclerosis complex: a review

21 January 2018

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Tuberous sclerosis complex: linking cancer to metabolism

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Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2

21 January 2018

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Loss of the tuberous sclerosis complex tumor suppressors triggers the unfolded protein response to regulate insulin signaling and apoptosis

21 January 2018

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The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins

21 January 2018

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The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis

21 January 2018

1 reference

Glucocorticoids regulate glutamate and GABA synapse-specific retrograde transmission via divergent nongenomic signaling pathways

21 January 2018

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Uncoupling proteostasis and development in vitro with a small molecule inhibitor of the pancreatic endoplasmic reticulum kinase, PERK.

21 January 2018

1 reference

Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity

21 January 2018

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Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.

21 January 2018

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Diabetes mellitus and exocrine pancreatic dysfunction in perk-/- mice reveals a role for translational control in secretory cell survival

21 January 2018

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PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis.

21 January 2018

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Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency

21 January 2018

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Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells

21 January 2018

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Translational control is required for the unfolded protein response and in vivo glucose homeostasis

21 January 2018

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Development of transgenic mice expressing a conditionally active form of the eIF2α kinase PKR.

21 January 2018

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Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1.

21 January 2018

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Ppp1r15 gene knockout reveals an essential role for translation initiation factor 2 alpha (eIF2alpha) dephosphorylation in mammalian development

21 January 2018

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Inhibition of a constitutive translation initiation factor 2alpha phosphatase, CReP, promotes survival of stressed cells

21 January 2018

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Ribosomal protein S6 phosphorylation: from protein synthesis to cell size.

21 January 2018

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Higher-Order Substrate Recognition of eIF2α by the RNA-Dependent Protein Kinase PKR

21 January 2018

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21 January 2018

Identifiers

DOI

10.2217/FON.13.49

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29 August 2017

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