Molecular basis of organ fibrosis: potential therapeutic approaches (Q38121751)

29 August 2017

title

Molecular basis of organ fibrosis: potential therapeutic approaches (English)

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29 August 2017

1

Asish K Ghosh

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29 August 2017

Susan E Quaggin

2

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29 August 2017

Douglas E Vaughan

series ordinal

3

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29 August 2017

publication date

1 May 2013

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Experimental Biology and Medicine

29 August 2017

published in

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29 August 2017

volume

238

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29 August 2017

issue

5

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29 August 2017

page(s)

461-481

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Cellular and molecular mechanisms of fibrosis

29 August 2017

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TGFβ signalling in context

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Role of transforming growth factor beta in human disease

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TGF-beta and fibrosis

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Genetic deficiency of plasminogen activator inhibitor-1 promotes cardiac fibrosis in aged mice: involvement of constitutive transforming growth factor-beta signaling and endothelial-to-mesenchymal transition.

21 January 2018

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TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II.

21 January 2018

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An AP-1 binding sequence is essential for regulation of the human alpha2(I) collagen (COL1A2) promoter activity by transforming growth factor-beta.

21 January 2018

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TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

21 January 2018

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Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for smad3 in TGF-beta-induced transcriptional activation

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor beta transcriptional responses in endothelial cells

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

TGF-beta-stimulated cooperation of smad proteins with the coactivators CBP/p300

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-beta involves functional cooperation with p300/CBP transcriptional coactivators

21 January 2018

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The tumor suppressor p53 abrogates Smad-dependent collagen gene induction in mesenchymal cells

21 January 2018

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Peroxisome proliferator-activated receptor-gamma abrogates Smad-dependent collagen stimulation by targeting the p300 transcriptional coactivator

21 January 2018

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Synergistic cooperation between Sp1 and Smad3/Smad4 mediates transforming growth factor beta1 stimulation of alpha 2(I)-collagen (COL1A2) transcription

21 January 2018

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Non-Smad signaling pathways

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

Smad3 deficiency attenuates bleomycin-induced pulmonary fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Targeted disruption of TGF-beta/Smad3 signaling modulates skin fibrosis in a mouse model of scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Inhibiting scar formation in vitro and in vivo by adenovirus-mediated mutant Smad4: a preliminary report

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Disruption of Smad4 impairs TGF-β/Smad3 and Smad7 transcriptional regulation during renal inflammation and fibrosis in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Targeted disruption of Smad3 confers resistance to the development of dimethylnitrosamine-induced hepatic fibrosis in mice.

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

TGF-beta signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Interleukin-10 therapy--review of a new approach

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

S-adenosylmethionine (AdoMet) modulates endotoxin stimulated interleukin-10 production in monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Immune stimulation of hepatic fibrogenesis by CD8 cells and attenuation by transgenic interleukin-10 from hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Resistance to bleomycin-induced lung fibrosis in MMP-8 deficient mice is mediated by interleukin-10

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Anti-inflammatory and antifibrotic effects of methyl palmitate

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Interleukin-10 treatment attenuates pressure overload-induced hypertrophic remodeling and improves heart function via signal transducers and activators of transcription 3-dependent inhibition of nuclear factor-κB

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

CD11b(+) Gr1(+) bone marrow cells ameliorate liver fibrosis by producing interleukin-10 in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

New concepts of IL-10-induced lung fibrosis: fibrocyte recruitment and M2 activation in a CCL2/CCR2 axis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Signal transducer and activator of transcription (STAT) signalling and T-cell lymphomas.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Tumor necrosis factor-alpha and interferon-gamma suppress the activation of human type I collagen gene expression by transforming growth factor-beta 1. Evidence for two distinct mechanisms of inhibition at the transcriptional and posttranscriptional

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Y-box protein-1 is the crucial mediator of antifibrotic interferon-gamma effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

IL-18 downregulates collagen production in human dermal fibroblasts via the ERK pathway

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

Inhibition of collagen gene expression by interferon-gamma: novel role of the CCAAT/enhancer binding protein beta (C/EBPbeta).

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Molecular mechanisms of antifibrotic effect of interferon gamma in bleomycin-mouse model of lung fibrosis: downregulation of TGF-beta and procollagen I and III gene expression

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

Antifibrotic effect of interferon gamma in silicosis model of rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Clinical Use of Interferon-gamma

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

Shifting players and paradigms in cell-specific transcription

21 January 2018

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https://api.crossref.org/works/10.1177%2F1535370213489441

21 January 2018

Tomio Tada 1934-2010.

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Transcription initiation by human RNA polymerase II visualized at single-molecule resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Modulation of human alpha1(I) procollagen gene activity by interaction with Sp1 and Sp3 transcription factors in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Blocking sp1 transcription factor broadly inhibits extracellular matrix gene expression in vitro and in vivo: implications for the treatment of tissue fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Transcriptional regulation of matrix metalloproteinase-1 and collagen 1A2 explains the anti-fibrotic effect exerted by proteasome inhibition in human dermal fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Characterization of the phenotype of high collagen-producing fibroblast clones in systemic sclerosis, using a new modified limiting-dilution method.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Ring-Sp1 decoy oligonucleotide effectively suppresses extracellular matrix gene expression and fibrosis of rat kidney induced by unilateral ureteral obstruction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Transcription factor Sp1 expression is upregulated in human glomerulonephritis: correlation with pSmad2/3 and p300 expression and renal injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Disruption of Smad7 promotes ANG II-mediated renal inflammation and fibrosis via Sp1-TGF-β/Smad3-NF.κB-dependent mechanisms in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Antifibrotic effect through the regulation of transcription factor using ring type-Sp1 decoy oligodeoxynucleotide in carbon tetrachloride-induced liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Anti-fibrotic effects via regulation of transcription factor Sp1 on hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Sp1 and Sp3 transcription factors mediate leptin-induced collagen α1(I) gene expression in primary culture of male rat hepatic stellate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

CCL18-stimulated upregulation of collagen production in lung fibroblasts requires Sp1 signaling and basal Smad3 activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Antifibrotic effect via the regulation of transcription factor Sp1 in lung fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Pathways of Egr-1-mediated gene transcription in vascular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

p300 is elevated in systemic sclerosis and its expression is positively regulated by TGF-β: epigenetic feed-forward amplification of fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Egr-1, the potential target of calcium channel blockers in cardioprotection with ischemia/reperfusion injury in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Effects of N-n-butyl haloperidol iodide on myocardial ischemia/reperfusion injury and Egr-1 expression in rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Essential roles for early growth response transcription factor Egr-1 in tissue fibrosis and wound healing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Hepatic fibrosis is enhanced and accompanied by robust oval cell activation after chronic carbon tetrachloride administration to Egr-1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Early growth response (EGR)-1 is required for timely cell-cycle entry and progression in hepatocytes after acute carbon tetrachloride exposure in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Early growth response factor-1 limits biliary fibrosis in a model of xenobiotic-induced cholestasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Smad7 suppresses renal fibrosis via altering expression of TGF-β/Smad3-regulated microRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Asiatic acid inhibits liver fibrosis by blocking TGF-beta/Smad signaling in vivo and in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Inhibition by curcumin of multiple sites of the transforming growth factor-beta1 signalling pathway ameliorates the progression of liver fibrosis induced by carbon tetrachloride in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Deficient Smad7 expression: a putative molecular defect in scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

MicroRNA expression abnormalities in limited cutaneous scleroderma and diffuse cutaneous scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

miR-192 mediates TGF-beta/Smad3-driven renal fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Postconditioning promotes the cardiac repair through balancing collagen degradation and synthesis after myocardial infarction in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Curcumin promotes cardiac repair and ameliorates cardiac dysfunction following myocardial infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Transforming growth factor-beta regulates DNA binding activity of transcription factor Fli1 by p300/CREB-binding protein-associated factor-dependent acetylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

The induction of CCN2 by TGFbeta1 involves Ets-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Connective tissue growth factor is induced in bleomycin-induced skin scleroderma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Fli1 and Ets1 have distinct roles in connective tissue growth factor/CCN2 gene regulation and induction of the profibrotic gene program

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Marinobufagenin induces increases in procollagen expression in a process involving protein kinase C and Fli-1: implications for uremic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

In preeclampsia endogenous cardiotonic steroids induce vascular fibrosis and impair relaxation of umbilical arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

PPAR-gamma agonists: therapeutic role in diabetes, inflammation and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

The many faces of PPARgamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

The mechanisms of action of PPARs

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Disruption of transforming growth factor beta signaling and profibrotic responses in normal skin fibroblasts by peroxisome proliferator-activated receptor gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Constitutive Smad signaling and Smad-dependent collagen gene expression in mouse embryonic fibroblasts lacking peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Troglitazone suppresses the secretion of type I collagen by mesangial cells in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Upregulation of type I collagen by TGF-beta in mesangial cells is blocked by PPARgamma activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Troglitazone halts diabetic glomerulosclerosis by blockade of mesangial expansion

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Pioglitazone prevents early-phase hepatic fibrogenesis caused by carbon tetrachloride.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Proteasomal inhibition after injury prevents fibrosis by modulating TGF-β(1) signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Proteasome inhibition reduces proliferation, collagen expression, and inflammatory cytokine production in nasal mucosa and polyp fibroblasts.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-γ

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Tumor suppressor p53: regulation and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Changes in p53 expression in mouse fibroblasts can modify motility and extracellular matrix organization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Macrophages produce TGF-beta-induced (beta-ig-h3) following ingestion of apoptotic cells and regulate MMP14 levels and collagen turnover in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

The p53 inhibitor pifithrin-α can stimulate fibrosis in a rat model of ischemic acute kidney injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

p53 is renoprotective after ischemic kidney injury by reducing inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Nicotinamide induces apoptosis and reduces collagen I and pro-inflammatory cytokines expression in rat hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Therapeutic value of small molecule inhibitor to plasminogen activator inhibitor-1 for lung fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Klotho in health and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Klotho protects against mouse renal fibrosis by inhibiting Wnt signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Plasma klotho and cardiovascular disease in adults

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Wnt/β-catenin signaling is hyperactivated in systemic sclerosis and induces Smad-dependent fibrotic responses in mesenchymal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Canonical Wnt/β-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Nuclear β-catenin is increased in systemic sclerosis pulmonary fibrosis and promotes lung fibroblast migration and proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Augmented Wnt signaling in a mammalian model of accelerated aging

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

HATs and HDACs in neurodegeneration: a tale of disconcerted acetylation homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

MicroRNAs as a therapeutic target for cardiovascular diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

MeCP2 controls an epigenetic pathway that promotes myofibroblast transdifferentiation and fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

MicroRNAs, transforming growth factor beta-1, and tissue fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Chemical phylogenetics of histone deacetylases

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

A histone deacetylase inhibitor, trichostatin A, suppresses myofibroblastic differentiation of rat hepatic stellate cells in primary culture

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Trichostatin A, a histone deacetylase inhibitor, suppresses collagen synthesis and prevents TGF-beta(1)-induced fibrogenesis in skin fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Trichostatin A blocks TGF-beta-induced collagen gene expression in skin fibroblasts: involvement of Sp1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Trichostatin A prevents the accumulation of extracellular matrix in a mouse model of bleomycin-induced skin fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Histone deacetylase modulates the proinflammatory and -fibrotic changes in tubulointerstitial injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Inhibition of histone deacetylase activity attenuates renal fibroblast activation and interstitial fibrosis in obstructive nephropathy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Histone-deacetylase inhibition reverses atrial arrhythmia inducibility and fibrosis in cardiac hypertrophy independent of angiotensin

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Suppression of class I and II histone deacetylases blunts pressure-overload cardiac hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Sodium valproate, a histone deacetylase inhibitor, but not captopril, prevents right ventricular hypertrophy in rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Suppression of histone deacetylases worsens right ventricular dysfunction after pulmonary artery banding in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Histone lysine methylation dynamics: establishment, regulation, and biological impact

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Histone methyltransferase ASH1 orchestrates fibrogenic gene transcription during myofibroblast transdifferentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Repression of IP-10 by interactions between histone deacetylation and hypermethylation in idiopathic pulmonary fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Identification of a microRNA signature in renal fibrosis: role of miR-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Perspectives on endothelial-to-mesenchymal transition: potential contribution to vascular remodeling in chronic pulmonary hypertension.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Endothelial-to-mesenchymal transition contributes to cardiac fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Molecular basis of cardiac endothelial-to-mesenchymal transition (EndMT): differential expression of microRNAs during EndMT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Experimental myocardial infarction triggers canonical Wnt signaling and endothelial-to-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Transforming growth factor-β-induced endothelial-to-mesenchymal transition is partly mediated by microRNA-21.

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Hepatocyte growth factor reduces cardiac fibrosis by inhibiting endothelial-mesenchymal transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Effects of angiotensin II receptor blocker on myocardial endothelial-to-mesenchymal transition in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

Interleukin-22 induces hepatic stellate cell senescence and restricts liver fibrosis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1177%2F1535370213489441

21 January 2018

Identifiers

DOI

10.1177/1535370213489441

1 reference

29 August 2017

1 reference