Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer (Q38150711)

29 August 2017

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer (English)

1 reference

29 August 2017

Anders M Lindroth

3

0 references

Stefan M. Pfister

object named as

Stefan M Pfister

2

0 references

Peter Lichter

6

object named as

Peter Lichter

1 reference

29 August 2017

Christoph Plass

1

1 reference

29 August 2017

Olga Bogatyrova

4

1 reference

29 August 2017

Rainer Claus

5

1 reference

29 August 2017

language of work or name

1 reference

9 October 2013

1 reference

29 August 2017

Nature Reviews Genetics

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29 August 2017

14

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29 August 2017

11

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29 August 2017

765-780

1 reference

https://scigraph.springernature.com/pub.10.1038/nrg3554

29 August 2017

0 references

1 reference

A decade of exploring the cancer epigenome - biological and translational implications

21 January 2018

1 reference

CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future

21 January 2018

1 reference

Cancer genetics and epigenetics: two sides of the same coin?

21 January 2018

1 reference

Cancer epigenetics: from mechanism to therapy

21 January 2018

1 reference

Interplay between the cancer genome and epigenome

21 January 2018

1 reference

Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma

21 January 2018

1 reference

Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA

21 January 2018

1 reference

Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine

21 January 2018

1 reference

Increased methylation variation in epigenetic domains across cancer types

21 January 2018

1 reference

Induction of Tumors in Mice by Genomic Hypomethylation

21 January 2018

1 reference

EUKARYOTIC CYTOSINE METHYLTRANSFERASES

21 January 2018

1 reference

Aberrant CpG-island methylation has non-random and tumour-type-specific patterns.

21 January 2018

1 reference

Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer

21 January 2018

1 reference

Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.

21 January 2018

1 reference

Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation

21 January 2018

1 reference

CpG island methylator phenotype in colorectal cancer

21 January 2018

1 reference

A DNA hypermethylation module for the stem/progenitor cell signature of cancer.

21 January 2018

1 reference

A stem cell-like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

21 January 2018

1 reference

A bivalent chromatin structure marks key developmental genes in embryonic stem cells

21 January 2018

1 reference

Epigenetic gene silencing in cancer – a mechanism for early oncogenic pathway addiction?

21 January 2018

1 reference

Epigenomic analysis of multilineage differentiation of human embryonic stem cells

21 January 2018

1 reference

Human DNA methylomes at base resolution show widespread epigenomic differences

21 January 2018

1 reference

Large-scale methylation domains mark a functional subset of neuronally expressed genes.

21 January 2018

1 reference

Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer

21 January 2018

1 reference

Regions of focal DNA hypermethylation and long-range hypomethylation in colorectal cancer coincide with nuclear lamina-associated domains

21 January 2018

1 reference

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

21 January 2018

1 reference

Paired-end mapping reveals extensive structural variation in the human genome

21 January 2018

1 reference

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

21 January 2018

1 reference

Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations

21 January 2018

1 reference

DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome

21 January 2018

1 reference

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

21 January 2018

1 reference

Recurring mutations found by sequencing an acute myeloid leukemia genome

21 January 2018

1 reference

DNMT3A Mutations in Acute Myeloid Leukemia

21 January 2018

1 reference

SDH mutations establish a hypermethylator phenotype in paraganglioma.

21 January 2018

1 reference

Succinate dehydrogenase mutation underlies global epigenomic divergence in gastrointestinal stromal tumor

21 January 2018

1 reference

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing

21 January 2018

1 reference

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

21 January 2018

1 reference

Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma

21 January 2018

1 reference

The genetic landscape of the childhood cancer medulloblastoma

21 January 2018

1 reference

Dissecting the genomic complexity underlying medulloblastoma

21 January 2018

1 reference

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

21 January 2018

1 reference

21 January 2018

Cancer genome landscapes

1 reference

Computational approaches to identify functional genetic variants in cancer genomes

21 January 2018

1 reference

DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development

21 January 2018

1 reference

Somatic mutations in the neurofibromatosis 1 gene in human tumors

21 January 2018

1 reference

Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification

21 January 2018

1 reference

Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1

21 January 2018

1 reference

DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45.

21 January 2018

1 reference

Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation.

21 January 2018

1 reference

Epigenetic reprogramming in mammalian development

21 January 2018

1 reference

Exome sequencing identifies somatic mutations of DNA methyltransferase gene DNMT3A in acute monocytic leukemia

21 January 2018

1 reference

Mutant DNMT3A: a marker of poor prognosis in acute myeloid leukemia

21 January 2018

1 reference

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

21 January 2018

1 reference

TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group

21 January 2018

1 reference

IDH mutation impairs histone demethylation and results in a block to cell differentiation

21 January 2018

1 reference

Detection of 2-hydroxyglutarate in IDH-mutated glioma patients by in vivo spectral-editing and 2D correlation magnetic resonance spectroscopy

21 January 2018

1 reference

Magnetic resonance of 2-hydroxyglutarate in IDH1-mutated low-grade gliomas

21 January 2018

1 reference

IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype

21 January 2018

1 reference

New functions for an old variant: no substitute for histone H3.3.

21 January 2018

1 reference

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias

21 January 2018

1 reference

The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosome

21 January 2018

1 reference

Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

21 January 2018

1 reference

MLL translocations, histone modifications and leukaemia stem-cell development

21 January 2018

1 reference

H3K79 methylation profiles define murine and human MLL-AF4 leukemias

21 January 2018

1 reference

hDOT1L links histone methylation to leukemogenesis

21 January 2018

1 reference

Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes

21 January 2018

1 reference

The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma

21 January 2018

1 reference

EZH2 is a marker of aggressive breast cancer and promotes neoplastic transformation of breast epithelial cells

21 January 2018

1 reference

Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer

21 January 2018

1 reference

Characterization of the EZH2-MMSET histone methyltransferase regulatory axis in cancer

21 January 2018

1 reference

Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas

21 January 2018

1 reference

Medulloblastomics: the end of the beginning

21 January 2018

1 reference

Collections of simultaneously altered genes as biomarkers of cancer cell drug response

21 January 2018

1 reference

ATP-dependent chromatin remodeling: genetics, genomics and mechanisms

21 January 2018

1 reference

The biology of chromatin remodeling complexes

21 January 2018

1 reference

The spectrum of SWI/SNF mutations, ubiquitous in human cancers

21 January 2018

1 reference

SWI/SNF nucleosome remodellers and cancer.

21 January 2018

1 reference

Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes

21 January 2018

1 reference

Mutations and deletions of ARID1A in breast tumors.

21 January 2018

1 reference

The genetic landscape of mutations in Burkitt lymphoma

21 January 2018

1 reference

Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma

21 January 2018

1 reference

ARID1A mutations in cancer: another epigenetic tumor suppressor?

21 January 2018

1 reference

Rhabdoid tumors: an initial clue to the role of chromatin remodeling in cancer

21 January 2018

1 reference

Truncating mutations of hSNF5/INI1 in aggressive paediatric cancer

21 January 2018

1 reference

Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas

21 January 2018

1 reference

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas

21 January 2018

1 reference

Evaluation of histone 3 lysine 27 trimethylation (H3K27me3) and enhancer of Zest 2 (EZH2) in pediatric glial and glioneuronal tumors shows decreased H3K27me3 in H3F3A K27M mutant glioblastomas

21 January 2018

1 reference

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma

21 January 2018

1 reference

The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression

21 January 2018

1 reference

DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors

21 January 2018

1 reference

Association of age at diagnosis and genetic mutations in patients with neuroblastoma.

21 January 2018

1 reference

ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cells

21 January 2018

1 reference

Distinct factors control histone variant H3.3 localization at specific genomic regions

21 January 2018

1 reference

The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9

21 January 2018

1 reference

Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin

21 January 2018

1 reference

ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome

21 January 2018

1 reference

Altered telomeres in tumors with ATRX and DAXX mutations

21 January 2018

1 reference

Methyltransferase recruitment and DNA hypermethylation of target promoters by an oncogenic transcription factor

21 January 2018

1 reference

Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia.

21 January 2018

1 reference

Epigenome scans and cancer genome sequencing converge on WNK2, a kinase-independent suppressor of cell growth

21 January 2018

1 reference

Integrated genomic and epigenomic analyses pinpoint biallelic gene inactivation in tumors

21 January 2018

1 reference

Epigenetic regulation of the tumor suppressor gene TCF21 on 6q23-q24 in lung and head and neck cancer.

21 January 2018

1 reference

Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia

21 January 2018

1 reference

An integrated encyclopedia of DNA elements in the human genome

21 January 2018

1 reference

Integrative genomic analyses reveal an androgen-driven somatic alteration landscape in early-onset prostate cancer

21 January 2018

1 reference

In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma

21 January 2018

1 reference

Low-dose decitabine versus best supportive care in elderly patients with intermediate- or high-risk myelodysplastic syndrome (MDS) ineligible for intensive chemotherapy: final results of the randomized phase III study of the European Organisation fo

21 January 2018

1 reference

Inhibitors of DNA methylation: beyond myelodysplastic syndromes

21 January 2018

1 reference

Multicenter, randomized, open-label, phase III trial of decitabine versus patient choice, with physician advice, of either supportive care or low-dose cytarabine for the treatment of older patients with newly diagnosed acute myeloid leukemia

21 January 2018

1 reference

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

21 January 2018

1 reference

Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma

21 January 2018

1 reference

Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.

21 January 2018

1 reference

A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer.

21 January 2018

1 reference

Histone acetyl transferases as emerging drug targets.

21 January 2018

1 reference

The MYST family of histone acetyltransferases and their intimate links to cancer.

21 January 2018

1 reference

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates

21 January 2018

1 reference

The structural basis of protein acetylation by the p300/CBP transcriptional coactivator

21 January 2018

1 reference

EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations

21 January 2018

1 reference

Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

21 January 2018

1 reference

Progress in the discovery of small-molecule inhibitors of bromodomain--histone interactions

21 January 2018

1 reference

Selective inhibition of BET bromodomains

21 January 2018

1 reference

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

21 January 2018

1 reference

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

21 January 2018

1 reference

Targeting MYC dependence in cancer by inhibiting BET bromodomains

21 January 2018

1 reference

Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming

21 January 2018

1 reference

FLASH assembly of TALENs for high-throughput genome editing

21 January 2018

1 reference

SnapShot: glioblastoma multiforme.

21 January 2018

1 reference

Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN.

21 January 2018

1 reference

Histone methylation by PRC2 is inhibited by active chromatin marks

21 January 2018

1 reference

H3K36 methylation antagonizes PRC2-mediated H3K27 methylation

21 January 2018

1 reference

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

21 January 2018

1 reference

Validation of a DNA methylation microarray for 450,000 CpG sites in the human genome

21 January 2018

1 reference

Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia

21 January 2018

1 reference

Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

21 January 2018

1 reference

Reduced representation bisulfite sequencing for comparative high-resolution DNA methylation analysis

21 January 2018

1 reference

High-throughput DNA methylation profiling using universal bead arrays

21 January 2018

1 reference

Ultra-low-input, tagmentation-based whole-genome bisulfite sequencing

21 January 2018

1 reference

The GLIB technique for genome-wide mapping of 5-hydroxymethylcytosine

21 January 2018

1 reference

Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome.

21 January 2018

1 reference

Mapping accessible chromatin regions using Sono-Seq

21 January 2018

1 reference

Methods for identifying higher-order chromatin structure

21 January 2018

1 reference

High-resolution genome-wide mapping of histone modifications

21 January 2018

1 reference

High-resolution profiling of histone methylations in the human genome

21 January 2018

1 reference

A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis

21 January 2018

1 reference

Principles and challenges of genomewide DNA methylation analysis

21 January 2018

1 reference

Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells

21 January 2018

1 reference

Whole-genome chromatin profiling from limited numbers of cells using nano-ChIP-seq

21 January 2018

1 reference

Restriction landmark genome scanning for aberrant methylation in primary refractory and relapsed acute myeloid leukemia; involvement of the WIT-1 gene

21 January 2018

1 reference

Excessive CpG island hypermethylation in cancer cell lines versus primary human malignancies

31 March 2020

1 reference

IntOGen-mutations identifies cancer drivers across tumor types.

31 March 2020

1 reference

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

31 March 2020

1 reference

Role of TET2 mutations in myeloproliferative neoplasms

31 March 2020

1 reference

Molecular biology. Genetic events that shape the cancer epigenome

31 March 2020

1 reference

Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance

31 March 2020

1 reference

Decitabine induces very early in vivo DNA methylation changes in blasts from patients with acute myeloid leukemia

31 March 2020

1 reference

Methylation profiling of CpG islands in human breast cancer cells

31 March 2020

1 reference

DNA methylation patterns of the calcitonin gene in human lung cancers and lymphomas.

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24105274

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

New approach for detection of amplification in cancer DNA using restriction landmark genomic scanning

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24105274

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRG3554

1 reference

Dimensions Publication ID

29 August 2017

0 references

1 reference