Adipose tissue browning and metabolic health (Q38154504)

29 August 2017

Adipose tissue browning and metabolic health (English)

1 reference

29 August 2017

Alexander Bartelt

1

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PubMed ID

24146030

29 August 2017

Joerg Heeren

series ordinal

2

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29 August 2017

22 October 2013

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Nature Reviews Endocrinology

29 August 2017

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29 August 2017

10

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29 August 2017

24-36

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29 August 2017

1

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https://scigraph.springernature.com/pub.10.1038/nrendo.2013.204

29 August 2017

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The presence of UCP1 demonstrates that metabolically active adipose tissue in the neck of adult humans truly represents brown adipose tissue.

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The vascular endothelium of the adipose tissue gives rise to both white and brown fat cells

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In vivo identification of bipotential adipocyte progenitors recruited by β3-adrenoceptor activation and high-fat feeding

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Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells

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Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic [...]

31 March 2020

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Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat.

31 March 2020

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Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human

31 March 2020

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Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes

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The emergence of cold-induced brown adipocytes in mouse white fat depots is determined predominantly by white to brown adipocyte transdifferentiation.

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Human BAT possesses molecular signatures that resemble beige/brite cells

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Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat.

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Evidence for two types of brown adipose tissue in humans.

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Transcriptional control of adipocyte formation

31 March 2020

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Adipocyte differentiation from the inside out

31 March 2020

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C/EBPalpha is required for differentiation of white, but not brown, adipose tissue

31 March 2020

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Shox2 is a molecular determinant of depot-specific adipocyte function

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Retinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.

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Rb regulates fate choice and lineage commitment in vivo

31 March 2020

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Rb and p107 regulate preadipocyte differentiation into white versus brown fat through repression of PGC-1alpha.

31 March 2020

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Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1.

31 March 2020

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Nuclear receptor corepressor RIP140 regulates fat accumulation

31 March 2020

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SRC-1 and TIF2 control energy balance between white and brown adipose tissues

31 March 2020

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Pharmacological and nutritional agents promoting browning of white adipose tissue.

31 March 2020

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p38 mitogen-activated protein kinase is the central regulator of cyclic AMP-dependent transcription of the brown fat uncoupling protein 1 gene

31 March 2020

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Insulin increases the adrenergic stimulation of 5' deiodinase activity and mRNA expression in rat brown adipocytes; role of MAPK and PI3K.

31 March 2020

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p62 links β-adrenergic input to mitochondrial function and thermogenesis

31 March 2020

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Fat cells directly sense temperature to activate thermogenesis

31 March 2020

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UCP1 mRNA does not produce heat.

31 March 2020

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A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis

31 March 2020

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Thiazolidinediones and Rexinoids Induce Peroxisome Proliferator-Activated Receptor-Coactivator (PGC)-1α Gene Transcription: An Autoregulatory Loop Controls PGC-1α Expression in Adipocytes via Peroxisome Proliferator-Activated Receptor-γ Coactivati

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Peroxisome proliferator-activated receptor α (PPARα) induces PPARγ coactivator 1α (PGC-1α) gene expression and contributes to thermogenic activation of brown fat: involvement of PRDM16.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

A Novel Regulatory Pathway of Brown Fat Thermogenesis

31 March 2020

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Remodeling of white adipose tissue after retinoic acid administration in mice

31 March 2020

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Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue

31 March 2020

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Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolism

31 March 2020

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Transcriptional control of brown fat determination by PRDM16

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Transcriptional control of brown fat development

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

PPARγ agonists induce a white-to-brown fat conversion through stabilization of PRDM16 protein.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

MyomiR-133 regulates brown fat differentiation through Prdm16.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

miR-133a regulates adipocyte browning in vivo

31 March 2020

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Mir193b-365 is essential for brown fat differentiation

31 March 2020

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miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit.

31 March 2020

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Essential role for miR-196a in brown adipogenesis of white fat progenitor cells

31 March 2020

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Inhibition of class I histone deacetylases unveils a mitochondrial signature and enhances oxidative metabolism in skeletal muscle and adipose tissue

31 March 2020

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Adipose subtype-selective recruitment of TLE3 or Prdm16 by PPARγ specifies lipid storage versus thermogenic gene programs

31 March 2020

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Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Pparγ

31 March 2020

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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

31 March 2020

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AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

31 March 2020

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AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha

31 March 2020

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Use of cells expressing gamma subunit variants to identify diverse mechanisms of AMPK activation

31 March 2020

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Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases

31 March 2020

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Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

31 March 2020

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Chronic AMP-kinase activation with AICAR reduces adiposity by remodeling adipocyte metabolism and increasing leptin sensitivity

31 March 2020

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Adenosine 5'-monophosphate-activated protein kinase-mammalian target of rapamycin cross talk regulates brown adipocyte differentiation

31 March 2020

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The ancient drug salicylate directly activates AMP-activated protein kinase

31 March 2020

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ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

31 March 2020

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Defective lipolysis and altered energy metabolism in mice lacking adipose triglyceride lipase

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

31 March 2020

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Lipolytic products activate peroxisome proliferator-activated receptor (PPAR) α and δ in brown adipocytes to match fatty acid oxidation with supply

31 March 2020

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Up-regulation of mitochondrial activity and acquirement of brown adipose tissue-like property in the white adipose tissue of fsp27 deficient mice

31 March 2020

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Perilipin overexpression in white adipose tissue induces a brown fat-like phenotype

31 March 2020

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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease

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Autophagy regulates lipid metabolism

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Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

31 March 2020

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TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop

31 March 2020

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Novel aspects of brown adipose tissue biology

31 March 2020

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Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

31 March 2020

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Obesity induces a phenotypic switch in adipose tissue macrophage polarization

31 March 2020

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UCP1 induction during recruitment of brown adipocytes in white adipose tissue is dependent on cyclooxygenase activity

31 March 2020

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Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes

31 March 2020

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BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis

31 March 2020

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FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis

31 March 2020

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Inhibiting adipose tissue lipogenesis reprograms thermogenesis and PPARγ activation to decrease diet-induced obesity

31 March 2020

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Effects of adipocyte lipoprotein lipase on de novo lipogenesis and white adipose tissue browning.

31 March 2020

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Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

31 March 2020

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Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat.

31 March 2020

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Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

31 March 2020

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New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

31 March 2020

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BMP8B increases brown adipose tissue thermogenesis through both central and peripheral actions

31 March 2020

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Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineage

31 March 2020

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A role for bone morphogenetic protein-4 in adipocyte development

31 March 2020

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Central control of brown adipose tissue thermogenesis

31 March 2020

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Endocannabinoid control of food intake and energy balance

31 March 2020

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Synaptic plasticity in neuronal circuits regulating energy balance

31 March 2020

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Brain-gut-adipose-tissue communication pathways at a glance

31 March 2020

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White to brown fat phenotypic switch induced by genetic and environmental activation of a hypothalamic-adipocyte axis

31 March 2020

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Muscles, exercise and obesity: skeletal muscle as a secretory organ

31 March 2020

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Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes

31 March 2020

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Increased cGMP promotes healthy expansion and browning of white adipose tissue

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Cardiovascular responses to cold exposure

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

The role of exercise and PGC1alpha in inflammation and chronic disease

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Inhibition of myostatin protects against diet-induced obesity by enhancing fatty acid oxidation and promoting a brown adipose phenotype in mice

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Myostatin knockout drives browning of white adipose tissue through activating the AMPK-PGC1α-Fndc5 pathway in muscle

31 March 2020

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A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy

31 March 2020

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FNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise

31 March 2020

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Expression of the irisin precursor FNDC5 in skeletal muscle correlates with aerobic exercise performance in patients with heart failure.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Irisin is expressed and produced by human muscle and adipose tissue in association with obesity and insulin resistance

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Evidence against a beneficial effect of irisin in humans

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Common genetic variation in the human FNDC5 locus, encoding the novel muscle-derived 'browning' factor irisin, determines insulin sensitivity

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

A new, powerful player in lipoprotein metabolism: brown adipose tissue

31 March 2020

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Brown adipose tissue activity controls triglyceride clearance.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity.

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Brown adipose tissue transplantation improves whole-body energy metabolism

31 March 2020

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Interleukin-6 and insulin resistance

31 March 2020

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Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity

31 March 2020

1 reference

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Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice

31 March 2020

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Beneficial effects of subcutaneous fat transplantation on metabolism

31 March 2020

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Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat.

31 March 2020

1 reference

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Sarcolipin is a newly identified regulator of muscle-based thermogenesis in mammals.

31 March 2020

1 reference

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Brown fat like gene expression in the epicardial fat depot correlates with circulating HDL-cholesterol and triglycerides in patients with coronary artery disease.

31 March 2020

1 reference

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Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

31 March 2020

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Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Blunted metabolic responses to cold and insulin stimulation in brown adipose tissue of obese humans.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Tumor necrosis factor alpha mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Beneficial effects of PTP1B deficiency on brown adipocyte differentiation and protection against apoptosis induced by pro- and anti-inflammatory stimuli.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Vascular endothelial growth factor is important for brown adipose tissue development and maintenance.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Exercise ameliorates high-fat diet-induced metabolic and vascular dysfunction, and increases adipocyte progenitor cell population in brown adipose tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Brown adipocyte progenitor population is modified in obese and diabetic skeletal muscle.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Identification of brown adipose tissue in mice with fat-water IDEAL-MRI.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Anatomical and functional assessment of brown adipose tissue by magnetic resonance imaging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Measurement of human brown adipose tissue volume and activity using anatomic MR imaging and functional MR imaging

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Dual-energy CT of the heart

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Real-time magnetic resonance imaging and quantification of lipoprotein metabolism in vivo using nanocrystals.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Nanocrystals, a new tool to study lipoprotein metabolism and atherosclerosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2013.204

Autophagy regulates adipose mass and differentiation in mice

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24146030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

FSP27 contributes to efficient energy storage in murine white adipocytes by promoting the formation of unilocular lipid droplets

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24146030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Functional assessment of white and brown adipocyte development and energy metabolism in cell culture. Dissociation of terminal differentiation and thermogenesis in brown adipocytes.

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24146030

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRENDO.2013.204

1 reference

29 August 2017

1 reference

PubMed ID

24146030