Histone lysine demethylases as targets for anticancer therapy (Q38162717)

30 August 2017

Histone lysine demethylases as targets for anticancer therapy (English)

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30 August 2017

3

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30 August 2017

Jonas W Højfeldt

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author name string

Karl Agger

series ordinal

2

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30 August 2017

15 November 2013

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Nature Reviews Drug Discovery

30 August 2017

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30 August 2017

12

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30 August 2017

917-930

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30 August 2017

12

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https://scigraph.springernature.com/pub.10.1038/nrd4154

30 August 2017

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Structural studies on human 2-oxoglutarate dependent oxygenases

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The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes

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JmjC-domain-containing proteins and histone demethylation

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Structural basis for human PHF2 Jumonji domain interaction with metal ions

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Crystal Structure and Functional Analysis of JMJD5 Indicate an Alternate Specificity and Function

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Jmjd6 catalyses lysyl-hydroxylation of U2AF65, a protein associated with RNA splicing

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Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity

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EZH2 overexpression in natural killer/T-cell lymphoma confers growth advantage independently of histone methyltransferase activity

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Overexpression of LSD1 contributes to human carcinogenesis through chromatin regulation in various cancers

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Androgen receptor coactivators lysine-specific histone demethylase 1 and four and a half LIM domain protein 2 predict risk of prostate cancer recurrence

21 January 2018

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The histone demethylase KDM1A sustains the oncogenic potential of MLL-AF9 leukemia stem cells

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21 January 2018

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Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis

21 January 2018

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Histone demethylase JMJD2B functions as a co-factor of estrogen receptor in breast cancer proliferation and mammary gland development

21 January 2018

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The histone demethylase JMJD2B is regulated by estrogen receptor alpha and hypoxia, and is a key mediator of estrogen induced growth

21 January 2018

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HIF-1α-induced histone demethylase JMJD2B contributes to the malignant phenotype of colorectal cancer cells via an epigenetic mechanism

21 January 2018

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Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression

21 January 2018

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21 January 2018

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The histone demethylase Jarid1b ensures faithful mouse development by protecting developmental genes from aberrant H3K4me3

21 January 2018

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Jarid1b targets genes regulating development and is involved in neural differentiation

21 January 2018

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A novel gene (PLU-1) containing highly conserved putative DNA/chromatin binding motifs is specifically up-regulated in breast cancer

21 January 2018

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PLU-1 nuclear protein, which is upregulated in breast cancer, shows restricted expression in normal human adult tissues: a new cancer/testis antigen?

21 January 2018

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Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway

21 January 2018

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JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer

21 January 2018

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PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation

21 January 2018

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A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth

21 January 2018

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Fbxl10/Kdm2b recruits polycomb repressive complex 1 to CpG islands and regulates H2A ubiquitylation

21 January 2018

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KDM2b/JHDM1b, an H3K36me2-specific demethylase, is required for initiation and maintenance of acute myeloid leukemia

21 January 2018

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KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

21 January 2018

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Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications

21 January 2018

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trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

21 January 2018

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Structural basis for the inhibition of the LSD1 histone demethylase by the antidepressant trans-2-phenylcyclopropylamine

21 January 2018

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Monoamine oxidase: from genes to behavior

21 January 2018

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Identification of cell-active lysine specific demethylase 1-selective inhibitors

21 January 2018

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Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1

21 January 2018

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Brain-penetrant LSD1 inhibitors can block memory consolidation.

21 January 2018

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Inhibitors of histone demethylases

21 January 2018

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Inhibition of lysine-specific demethylase 1 by polyamine analogues results in reexpression of aberrantly silenced genes

21 January 2018

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Novel oligoamine analogues inhibit lysine-specific demethylase 1 and induce reexpression of epigenetically silenced genes

21 January 2018

1 reference

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

21 January 2018

1 reference

Novel histone demethylase LSD1 inhibitors selectively target cancer cells with pluripotent stem cell properties

21 January 2018

1 reference

Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor

21 January 2018

1 reference

Inhibitor scaffolds for 2-oxoglutarate-dependent histone lysine demethylases

21 January 2018

1 reference

Quantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase Inhibitors

21 January 2018

1 reference

A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response

21 January 2018

1 reference

Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency

21 January 2018

1 reference

Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation

21 January 2018

1 reference

Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer

21 January 2018

1 reference

Expression of Mina53, a novel c-Myc target gene, is a favorable prognostic marker in early stage lung cancer

21 January 2018

1 reference

Mina53, a novel c-Myc target gene, is frequently expressed in lung cancers and exerts oncogenic property in NIH/3T3 cells

21 January 2018

1 reference

21 January 2018

Cancer genome landscapes

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Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1

21 January 2018

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CoREST is an integral component of the CoREST- human histone deacetylase complex

21 January 2018

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A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes

21 January 2018

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Functional interplay between histone demethylase and deacetylase enzymes

21 January 2018

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Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression

21 January 2018

1 reference

Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors

21 January 2018

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New insights into nucleosome and chromatin structure: an ordered state or a disordered affair?

21 January 2018

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The language of covalent histone modifications

21 January 2018

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Crystal structure and mechanism of human lysine-specific demethylase-1.

21 January 2018

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Catalytic mechanism investigation of lysine-specific demethylase 1 (LSD1): a computational study

21 January 2018

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Concerted hydrogen atom and electron transfer mechanism for catalysis by lysine-specific demethylase.

21 January 2018

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Lysine-specific demethylase 1 is strongly expressed in poorly differentiated neuroblastoma: implications for therapy

21 January 2018

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Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

21 January 2018

1 reference

KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints

21 January 2018

1 reference

Tiling resolution array CGH and high density expression profiling of urothelial carcinomas delineate genomic amplicons and candidate target genes specific for advanced tumors

21 January 2018

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Histone demethylase JHDM2A is critical for Tnp1 and Prm1 transcription and spermatogenesis

21 January 2018

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Obesity and metabolic syndrome in histone demethylase JHDM2a-deficient mice.

21 January 2018

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Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

21 January 2018

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Jmjd1a demethylase-regulated histone modification is essential for cAMP-response element modulator-regulated gene expression and spermatogenesis

21 January 2018

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Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: in vivo identification from hypoxic tumor cells

21 January 2018

1 reference

Siah2-dependent concerted activity of HIF and FoxA2 regulates formation of neuroendocrine phenotype and neuroendocrine prostate tumors

21 January 2018

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The expression of histone demethylase JMJD1A in renal cell carcinoma

21 January 2018

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The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice

21 January 2018

1 reference

Microarray comparative genomic hybridization detection of copy number changes in desmoplastic melanoma and malignant peripheral nerve sheath tumor.

21 January 2018

1 reference

Mucosa-associated lymphoid tissue lymphoma: novel translocations including rearrangements of ODZ2, JMJD2C, and CNN3.

21 January 2018

1 reference

The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility

21 January 2018

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The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

21 January 2018

1 reference

Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis

21 January 2018

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The H3K27me3 demethylase, KDM6B, is induced by Epstein-Barr virus and over-expressed in Hodgkin's Lymphoma

21 January 2018

1 reference

Phenotypic annotation of the mouse X chromosome

21 January 2018

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UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program

21 January 2018

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Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulation: UTX, EZH2, and DNMT3A.

21 January 2018

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Deletion of KDM6A, a histone demethylase interacting with MLL2, in three patients with Kabuki syndrome

21 January 2018

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Fbxl10/Kdm2b deficiency accelerates neural progenitor cell death and leads to exencephaly

21 January 2018

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FGF-2 regulates cell proliferation, migration, and angiogenesis through an NDY1/KDM2B-miR-101-EZH2 pathway

21 January 2018

1 reference

Alterations in candidate genes PHF2, FANCC, PTCH1 and XPA at chromosomal 9q22.3 region: pathological significance in early- and late-onset breast carcinoma

21 January 2018

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Association of FANCC and PTCH1 with the development of early dysplastic lesions of the head and neck

21 January 2018

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Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate

21 January 2018

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A novel mutation in the PHF8 gene is associated with X-linked mental retardation with cleft lip/cleft palate

21 January 2018

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Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate

21 January 2018

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The retinoblastoma binding protein RBP2 is an H3K4 demethylase

21 January 2018

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Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia

21 January 2018

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Mutations in the JARID1C gene, which is involved in transcriptional regulation and chromatin remodeling, cause X-linked mental retardation

21 January 2018

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A novel mutation in JARID1C gene associated with mental retardation

21 January 2018

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Novel JARID1C/SMCX mutations in patients with X-linked mental retardation

21 January 2018

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A distinctive gene expression fingerprint in mentally retarded male patients reflects disease-causing defects in the histone demethylase KDM5C.

21 January 2018

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A novel nonsense mutation in KDM5C/JARID1C gene causing intellectual disability, short stature and speech delay.

21 January 2018

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jumonji gene is essential for the neurulation and cardiac development of mouse embryos with a C3H/He background

21 January 2018

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MMSET Is Highly Expressed and Associated with Aggressiveness in Neuroblastoma

21 January 2018

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Molecular mechanisms and potential functions of histone demethylases

21 January 2018

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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

31 March 2020

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An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation

31 March 2020

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High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases

31 March 2020

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A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth

31 March 2020

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Jmjd5, an H3K36me2 histone demethylase, modulates embryonic cell proliferation through the regulation of Cdkn1a expression

31 March 2020

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The histone demethylase JARID1A is associated with susceptibility to ankylosing spondylitis

31 March 2020

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A novel mutation in JARID1C/SMCX in a patient with autism spectrum disorder (ASD)

31 March 2020

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Deletion of Y-chromosome specific genes in human prostate cancer

31 March 2020

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12 December 2020

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

1 reference

12 December 2020

Deficiency of a novel retinoblastoma binding protein 2-homolog is a consistent feature of sporadic human melanoma skin cancer

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12 December 2020

Histone demethylase JMJD3 contributes to epigenetic control of INK4a/ARF by oncogenic RAS

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12 December 2020

Role of the hypoxia-related gene, JMJD1A, in hepatocellular carcinoma: clinical impact on recurrence after hepatic resection

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12 December 2020

Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines

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12 December 2020

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

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12 December 2020

Histone-modifier gene expression profiles are associated with pathological and clinical outcomes in human breast cancer

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12 December 2020

KDM2B promotes pancreatic cancer via Polycomb-dependent and -independent transcriptional programs

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12 December 2020

The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence

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12 December 2020

PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells

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12 December 2020

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

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12 December 2020

Identifiers

DOI

10.1038/NRD4154

1 reference

30 August 2017

1 reference

PubMed ID

24232376