Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols (Q38164635)

30 August 2017

Molecular mechanisms underlying the potential antiobesity-related diseases effect of cocoa polyphenols (English)

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30 August 2017

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Sander Kersten

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Amin Ismail

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Amin Ismail

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author name string

Faisal Ali

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30 August 2017

21 November 2013

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Molecular Nutrition and Food Research

30 August 2017

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30 August 2017

58

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30 August 2017

33-48

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30 August 2017

1

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Flavanol and flavonol contents of cocoa powder products: influence of the manufacturing process.

30 August 2017

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Plant phenolics: extraction, analysis and their antioxidant and anticancer properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

High-performance liquid chromatography separation and purification of cacao (Theobroma cacao L.) procyanidins according to degree of polymerization using a diol stationary phase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Identification of procyanidins in cocoa (Theobroma cacao) and chocolate using high-performance liquid chromatography/mass spectrometry

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Plasma antioxidants: health benefits of eating chocolate?

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

A new process to develop a cocoa powder with higher flavonoid monomer content and enhanced bioavailability in healthy humans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dietary proanthocyanidins: occurrence, dietary intake, bioavailability, and protection against cardiovascular disease

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

In vitro biological properties of flavonoid conjugates found in vivo.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Milk does not affect the bioavailability of cocoa powder flavonoid in healthy human.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Uptake of quercetin and quercetin 3-glucoside from whole onion and apple peel extracts by Caco-2 cell monolayers

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Absorption of anthocyanins through intestinal epithelial cells - Putative involvement of GLUT2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Flavanols and anthocyanins in cardiovascular health: a review of current evidence

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dietary flavonoids: bioavailability, metabolic effects, and safety

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Absorption of black currant anthocyanins by monolayers of human intestinal epithelial Caco-2 cells mounted in ussing type chambers.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Polyphenols from cocoa and vascular health-a critical review

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Diet-derived phenols in plasma and tissues and their implications for health

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Effect of cocoa flavanols and exercise on cardiometabolic risk factors in overweight and obese subjects.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Polyphenolic phytochemicals--just antioxidants or much more?

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Chocolate, lifestyle, and health.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cocoa, chocolate, and cardiovascular disease

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

PPARs, Obesity, and Inflammation

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Regulation of apo A-I gene expression by fibrates.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Transcriptional regulation of human and rat hepatic lipid metabolism by the grapefruit flavonoid naringenin: role of PPARalpha, PPARgamma and LXRalpha

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Antioxidants in chocolate

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Polyphenols in chocolate, which have antioxidant activity, modulate immune functions in humans in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Influence of flavan-3-ols and procyanidins on UVC-mediated formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in isolated DNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Flavanol-rich cocoa drink lowers plasma F(2)-isoprostane concentrations in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Effect of circulating forms of soy isoflavones on the oxidation of low density lipoprotein

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Comparison of the antioxidant activity of commonly consumed polyphenolic beverages (coffee, cocoa, and tea) prepared per cup serving

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Chronic consumption of a flavanol- and procyanindin-rich diet is associated with reduced levels of 8-hydroxy-2'-deoxyguanosine in rat testes

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Chocolate is a powerful ex vivo and in vivo antioxidant, an antiatherosclerotic agent in an animal model, and a significant contributor to antioxidants in the European and American Diets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cacao procyanidins reduce plasma cholesterol and increase fecal steroid excretion in rats fed a high-cholesterol diet

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Effects of cocoa extract on glucometabolism, oxidative stress, and antioxidant enzymes in obese-diabetic (Ob-db) rats.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dark chocolate consumption increases HDL cholesterol concentration and chocolate fatty acids may inhibit lipid peroxidation in healthy humans

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Chocolate and blood pressure in elderly individuals with isolated systolic hypertension

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Genistein enhances expression of genes involved in fatty acid catabolism through activation of PPARalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Adipokines: molecular links between obesity and atheroslcerosis

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E-knockout mice by alleviating inflammation and endothelial dysfunction.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cocoa flavanols lower vascular arginase activity in human endothelial cells in vitro and in erythrocytes in vivo

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cocoa procyanidins inhibit expression and activation of MMP-2 in vascular smooth muscle cells by direct inhibition of MEK and MT1-MMP activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Inhibition of angiotensin converting enzyme (ACE) activity by flavan-3-ols and procyanidins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Nitric oxide formation in macrophages detected by spin trapping with iron-dithiocarbamate complex: effect of purified flavonoids and plant extracts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Assessing bioflavonoids as regulators of NF-kappa B activity and inflammatory gene expression in mammalian cells

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dark chocolate improves endothelial and platelet function

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Flavanol-rich cocoa induces nitric-oxide-dependent vasodilation in healthy humans

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Effect of dark chocolate on arterial function in healthy individuals

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Sustained benefits in vascular function through flavanol-containing cocoa in medicated diabetic patients a double-masked, randomized, controlled trial

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Acute and chronic effects of flavanol-rich cocoa on vascular function in subjects with coronary artery disease: a randomized double-blind placebo-controlled study.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dark chocolate improves coronary vasomotion and reduces platelet reactivity

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Mulberry water extracts possess an anti-obesity effect and ability to inhibit hepatic lipogenesis and promote lipolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Antidiabetes and Anti-obesity Activity of Lagerstroemia speciosa

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Development of insulin resistance and its relation to diet in the obese child

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Type 2 diabetes: principles of pathogenesis and therapy

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

The effect of Malaysian cocoa extract on glucose levels and lipid profiles in diabetic rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Resveratrol improves health and survival of mice on a high-calorie diet

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Potential mechanisms by which polyphenol-rich grapes prevent obesity-mediated inflammation and metabolic diseases

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Metabolic benefits from Sirt1 and Sirt1 activators

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Reactive oxygen species in vascular wall

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Inflammation and oxidative stress in obesity-related glomerulopathy

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Novel isoforms of NADPH oxidase in vascular physiology and pathophysiology

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Redox-dependent signalling by angiotensin II and vascular remodelling in hypertension

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Hydrogen peroxide regulation of endothelial function: origins, mechanisms, and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Regulation of inflammation and redox signaling by dietary polyphenols

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cocoa: antioxidant and immunomodulator.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-alpha-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Blockade of oxidized LDL-triggered endothelial apoptosis by quercetin and rutin through differential signaling pathways involving JAK2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Roles of PPARs in health and disease.

21 January 2018

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https://api.crossref.org/works/10.1002%2FMNFR.201300277

PPAR control: it's SIRTainly as easy as PGC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Nuclear receptors and lipid physiology: opening the X-files

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Peroxisome proliferator-activated receptor gamma as a drug target in the pathogenesis of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Effects of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Modulation of TNF-alpha secretion in peripheral blood mononuclear cells by cocoa flavanols and procyanidins

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Inflammation and metabolic disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Grape powder extract attenuates tumor necrosis factor α-mediated inflammation and insulin resistance in primary cultures of human adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Quercetin is equally or more effective than resveratrol in attenuating tumor necrosis factor-{alpha}-mediated inflammation and insulin resistance in primary human adipocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

The effect of cocoa procyanidins on the transcription and secretion of interleukin 1 beta in peripheral blood mononuclear cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Polyphenols of cocoa: inhibition of mammalian 15-lipoxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Effect of cocoa powder on the modulation of inflammatory biomarkers in patients at high risk of cardiovascular disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Bilberry juice modulates plasma concentration of NF-kappaB related inflammatory markers in subjects at increased risk of CVD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Grape-seed procyanidins prevent low-grade inflammation by modulating cytokine expression in rats fed a high-fat diet

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Raf and MEK protein kinases are direct molecular targets for the chemopreventive effect of quercetin, a major flavonol in red wine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Macrophage alpha1 AMP-activated protein kinase (alpha1AMPK) antagonizes fatty acid-induced inflammation through SIRT1

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Anti-inflammatory effect of resveratrol on TNF-alpha-induced MCP-1 expression in adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

DUSP meet immunology: dual specificity MAPK phosphatases in control of the inflammatory response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cocoa flavonoids improve insulin signalling and modulate glucose production via AKT and AMPK in HepG2 cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Hypoglycemic effect of resveratrol in type 2 diabetic model db/db mice and its actions in cultured L6 myotubes and RIN-5F pancreatic β-cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Prevention mechanisms of glucose intolerance and obesity by cacao liquor procyanidin extract in high-fat diet-fed C57BL/6 mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

Cocoa and cardiovascular health

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FMNFR.201300277

21 January 2018

Identifiers

DOI

10.1002/MNFR.201300277

1 reference

30 August 2017

1 reference

PubMed ID

24259381