bHLH-PAS proteins in cancer (Q38164994)

30 August 2017

title

bHLH-PAS proteins in cancer (English)

1 reference

30 August 2017

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Adrienne E Sullivan

series ordinal

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

author name string

David C Bersten

series ordinal

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

Murray L Whitelaw

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

language of work or name

English

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publication date

1 December 2013

1 reference

30 August 2017

published in

Nature Reviews Cancer

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

volume

13

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

issue

12

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24263188%20AND%20SRC:MED&resulttype=core&format=json

8 June 2020

page(s)

827-841

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Mammalian Per-Arnt-Sim proteins in environmental adaptation

8 June 2020

cites work

1 reference

Sim1 haploinsufficiency causes hyperphagia, obesity and reduction of the paraventricular nucleus of the hypothalamus

31 March 2020

1 reference

Npas4 regulates a transcriptional program in CA3 required for contextual memory formation

31 March 2020

1 reference

The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors

31 March 2020

1 reference

The mammalian basic helix-loop-helix/PAS family of transcriptional regulators

31 March 2020

1 reference

Role of the PAS domain in regulation of dimerization and DNA binding specificity of the dioxin receptor

31 March 2020

1 reference

Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex

31 March 2020

1 reference

Definition of a dioxin receptor mutant that is a constitutive activator of transcription: delineation of overlapping repression and ligand binding functions within the PAS domain

31 March 2020

1 reference

The phosphorylation status of PAS-B distinguishes HIF-1alpha from HIF-2alpha in NBS1 repression

31 March 2020

1 reference

Regulating the ARNT/TACC3 Axis: Multiple Approaches to Manipulating Protein/Protein Interactions with Small Molecules

31 March 2020

1 reference

Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B

31 March 2020

1 reference

Transcription factor single-minded 2 (SIM2) is ubiquitinated by the RING-IBR-RING-type E3 ubiquitin ligases

31 March 2020

1 reference

Identification of residues in the N-terminal PAS domains important for dimerization of Arnt and AhR.

31 March 2020

1 reference

Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex

31 March 2020

1 reference

Roles of coactivators in hypoxic induction of the erythropoietin gene

31 March 2020

1 reference

Differential activities of murine single minded 1 (SIM1) and SIM2 on a hypoxic response element. Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors

31 March 2020

1 reference

Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis

31 March 2020

1 reference

SUMO modification regulates the transcriptional repressor function of aryl hydrocarbon receptor repressor

31 March 2020

1 reference

Exactly the same but different: promiscuity and diversity in the molecular mechanisms of action of the aryl hydrocarbon (dioxin) receptor

31 March 2020

1 reference

Xenobiotics and loss of cell adhesion drive distinct transcriptional outcomes by aryl hydrocarbon receptor signaling.

31 March 2020

1 reference

The search for endogenous activators of the aryl hydrocarbon receptor

31 March 2020

1 reference

Preferential formation of benzo[a]pyrene adducts at lung cancer mutational hotspots in P53.

31 March 2020

1 reference

31 March 2020

Cancer genome landscapes

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Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor

31 March 2020

1 reference

An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

31 March 2020

1 reference

A constitutively active dioxin/aryl hydrocarbon receptor induces stomach tumors

31 March 2020

1 reference

A constitutively active dioxin/aryl hydrocarbon receptor promotes hepatocarcinogenesis in mice

31 March 2020

1 reference

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

31 March 2020

1 reference

Aryl hydrocarbon receptor suppresses intestinal carcinogenesis in ApcMin/+ mice with natural ligands

31 March 2020

1 reference

ASC-associated inflammation promotes cecal tumorigenesis in aryl hydrocarbon receptor-deficient mice.

31 March 2020

1 reference

Modulation of oestrogen receptor signalling by association with the activated dioxin receptor

31 March 2020

1 reference

Dioxin receptor is a ligand-dependent E3 ubiquitin ligase

31 March 2020

1 reference

The aryl hydrocarbon receptor (AhR) inhibits vanadate-induced vascular endothelial growth factor (VEGF) production in TRAMP prostates

31 March 2020

1 reference

Modulation of natural killer cell antitumor activity by the aryl hydrocarbon receptor.

31 March 2020

1 reference

Selective oestrogen receptor modulators in prevention of breast cancer: an updated meta-analysis of individual participant data

31 March 2020

1 reference

Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt

31 March 2020

1 reference

Reciprocal regulation of the basic helix-loop-helix/Per-Arnt-Sim partner proteins, Arnt and Arnt2, during neuronal differentiation

31 March 2020

1 reference

Hypoxia-inducible factors in physiology and medicine

31 March 2020

1 reference

A conserved family of prolyl-4-hydroxylases that modify HIF

31 March 2020

1 reference

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

31 March 2020

1 reference

HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing

31 March 2020

1 reference

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation

31 March 2020

1 reference

Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family

31 March 2020

1 reference

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

31 March 2020

1 reference

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch

31 March 2020

1 reference

Roles of the human hypoxia-inducible factor (HIF)-3α variants in the hypoxia response

31 March 2020

1 reference

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

31 March 2020

1 reference

Cancer and altered metabolism: potential importance of hypoxia-inducible factor and 2-oxoglutarate-dependent dioxygenases

31 March 2020

1 reference

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

31 March 2020

1 reference

Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics

31 March 2020

1 reference

An oxygen-regulated switch in the protein synthesis machinery

31 March 2020

1 reference

Influence of metabolism on epigenetics and disease

31 March 2020

1 reference

Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer.

31 March 2020

1 reference

The TCA cycle and tumorigenesis: the examples of fumarate hydratase and succinate dehydrogenase.

31 March 2020

1 reference

HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: novel role of fumarate in regulation of HIF stability

31 March 2020

1 reference

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.

31 March 2020

1 reference

What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer

31 March 2020

1 reference

Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-alpha prolyl hydroxylase

31 March 2020

1 reference

Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha

31 March 2020

1 reference

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function

31 March 2020

1 reference

IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics

31 March 2020

1 reference

Targeting the hypoxia-inducible factor (HIF) pathway in cancer.

31 March 2020

1 reference

Cancer therapeutic agents targeting hypoxia-inducible factor-1.

31 March 2020

1 reference

Structural basis for PAS domain heterodimerization in the basic helix-loop-helix-PAS transcription factor hypoxia-inducible factor

31 March 2020

1 reference

Artificial ligand binding within the HIF2 PAS-B domain of the HIF2 transcription factor

31 March 2020

1 reference

New aryl hydrocarbon receptor homology model targeted to improve docking reliability

31 March 2020

1 reference

Allosteric inhibition of hypoxia inducible factor-2 with small molecules

31 March 2020

1 reference

N- and C-terminal flanking regions modulate light-induced signal transduction in the LOV2 domain of the blue light sensor phototropin 1 from Avena sativa

31 March 2020

1 reference

Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization

31 March 2020

1 reference

A cyclic peptide inhibitor of HIF-1 heterodimerization that inhibits hypoxia signaling in cancer cells.

31 March 2020

1 reference

Genetics of circadian rhythms in Mammalian model organisms

31 March 2020

1 reference

Unwinding the differences of the mammalian PERIOD clock proteins from crystal structure to cellular function

31 March 2020

1 reference

Metabolism and cancer: the circadian clock connection

31 March 2020

1 reference

The circadian clock: pacemaker and tumour suppressor

31 March 2020

1 reference

Disrupting circadian homeostasis of sympathetic signaling promotes tumor development in mice

31 March 2020

1 reference

The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo

31 March 2020

1 reference

The circadian gene per1 plays an important role in cell growth and DNA damage control in human cancer cells

31 March 2020

1 reference

Deregulated expression of the PER1, PER2 and PER3 genes in breast cancers.

31 March 2020

1 reference

Loss of corepressor PER2 under hypoxia up-regulates OCT1-mediated EMT gene expression and enhances tumor malignancy

31 March 2020

1 reference

Loss of cryptochrome reduces cancer risk in p53 mutant mice

31 March 2020

1 reference

The circadian molecular clock creates epidermal stem cell heterogeneity.

31 March 2020

1 reference

Circadian topology of metabolism

31 March 2020

1 reference

Crosstalk between components of circadian and metabolic cycles in mammals

31 March 2020

1 reference

Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock

31 March 2020

1 reference

Identification of NUP98 abnormalities in acute leukemia: JARID1A (12p13) as a new partner gene

31 March 2020

1 reference

Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger

31 March 2020

1 reference

Hypoxia induces trimethylated H3 lysine 4 by inhibition of JARID1A demethylase

31 March 2020

1 reference

The NAD metabolome--a key determinant of cancer cell biology

31 March 2020

1 reference

Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis

31 March 2020

1 reference

Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1

31 March 2020

1 reference

Regulation of clock and NPAS2 DNA binding by the redox state of NAD cofactors

31 March 2020

1 reference

The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control

31 March 2020

1 reference

SIRT1 regulates circadian clock gene expression through PER2 deacetylation

31 March 2020

1 reference

Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1

31 March 2020

1 reference

Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

31 March 2020

1 reference

CLOCK-mediated acetylation of BMAL1 controls circadian function

31 March 2020

1 reference

Circadian regulator CLOCK is a histone acetyltransferase

31 March 2020

1 reference

Poly(ADP-ribose) polymerase 1 participates in the phase entrainment of circadian clocks to feeding

31 March 2020

1 reference

Brain and muscle Arnt-like protein-1 (BMAL1) controls circadian cell proliferation and susceptibility to UVB-induced DNA damage in the epidermis

31 March 2020

1 reference

Circadian control of XPA and excision repair of cisplatin-DNA damage by cryptochrome and HERC2 ubiquitin ligase

31 March 2020

1 reference

Circadian oscillation of nucleotide excision repair in mammalian brain

31 March 2020

1 reference

Circadian clock disruption improves the efficacy of chemotherapy through p73-mediated apoptosis

31 March 2020

1 reference

Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

31 March 2020

1 reference

Small molecule modifiers of circadian clocks.

31 March 2020

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Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

31 March 2020

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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

31 March 2020

1 reference

Identification of small molecule activators of cryptochrome

31 March 2020

1 reference

High-throughput chemical screen identifies a novel potent modulator of cellular circadian rhythms and reveals CKIα as a clock regulatory kinase

31 March 2020

1 reference

Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family

31 March 2020

1 reference

Steroid receptor coactivator-1 is a histone acetyltransferase

31 March 2020

1 reference

Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300

31 March 2020

1 reference

Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain

31 March 2020

1 reference

P160/SRC/NCoA coactivators form complexes via specific interaction of their PAS-B domain with the CID/AD1 domain

31 March 2020

1 reference

Steroid receptor coactivator-1 and its family members differentially regulate transactivation by the tumor suppressor protein p53

31 March 2020

1 reference

CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators

31 March 2020

1 reference

AIB1/SRC-3 deficiency affects insulin-like growth factor I signaling pathway and suppresses v-Ha-ras-induced breast cancer initiation and progression in mice

31 March 2020

1 reference

Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes

31 March 2020

1 reference

Steroid receptor coactivators 1, 2, and 3: critical regulators of nuclear receptor activity and steroid receptor modulator (SRM)-based cancer therapy

31 March 2020

1 reference

Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha

31 March 2020

1 reference

Expression of SRC-1, AIB1, and PEA3 in HER2 mediated endocrine resistant breast cancer; a predictive role for SRC-1.

31 March 2020

1 reference

A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors

31 March 2020

1 reference

An isoform of the coactivator AIB1 that increases hormone and growth factor sensitivity is overexpressed in breast cancer.

31 March 2020

1 reference

Impact of the nuclear receptor coactivator AIB1 isoform AIB1-Delta3 on estrogenic ligands with different intrinsic activity.

31 March 2020

1 reference

AIB1, a steroid receptor coactivator amplified in breast and ovarian cancer

31 March 2020

1 reference

High tumor incidence and activation of the PI3K/AKT pathway in transgenic mice define AIB1 as an oncogene

31 March 2020

1 reference

Mice lacking the amplified in breast cancer 1/steroid receptor coactivator-3 are resistant to chemical carcinogen-induced mammary tumorigenesis

31 March 2020

1 reference

The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice.

31 March 2020

1 reference

Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation

31 March 2020

1 reference

Steroid receptor coactivator-3/AIB1 promotes cell migration and invasiveness through focal adhesion turnover and matrix metalloproteinase expression

31 March 2020

1 reference

The genomic complexity of primary human prostate cancer

31 March 2020

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Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer

31 March 2020

1 reference

Diverse somatic mutation patterns and pathway alterations in human cancers

31 March 2020

1 reference

Prostate cancer-associated mutations in speckle-type POZ protein (SPOP) regulate steroid receptor coactivator 3 protein turnover

31 March 2020

1 reference

Integrative genomic profiling of human prostate cancer

31 March 2020

1 reference

A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer.

31 March 2020

1 reference

MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.

31 March 2020

1 reference

MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors.

31 March 2020

1 reference

Sim2 contributes to neuroendocrine hormone gene expression in the anterior hypothalamus

31 March 2020

1 reference

Sim2 prevents entry into the myogenic program by repressing MyoD transcription during limb embryonic myogenesis.

31 March 2020

1 reference

Mice trisomic for a bacterial artificial chromosome with the single-minded 2 gene (Sim2) show phenotypes similar to some of those present in the partial trisomy 16 mouse models of Down syndrome

31 March 2020

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Identification of Down's syndrome critical locus gene SIM2-s as a drug therapy target for solid tumors

31 March 2020

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Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells

31 March 2020

1 reference

Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2.

31 March 2020

1 reference

Down's syndrome-associated Single Minded 2 gene as a pancreatic cancer drug therapy target

31 March 2020

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Increased expression of SIM2-s protein is a novel marker of aggressive prostate cancer

31 March 2020

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Identification of the transcription factor single-minded homologue 2 as a potential biomarker and immunotherapy target in prostate cancer

31 March 2020

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Protein-coding and microRNA biomarkers of recurrence of prostate cancer following radical prostatectomy

31 March 2020

1 reference

Singleminded-2s (Sim2s) promotes delayed involution of the mouse mammary gland through suppression of Stat3 and NFκB

31 March 2020

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Regulation of DCIS to invasive breast cancer progression by Singleminded-2s (SIM2s).

31 March 2020

1 reference

The bHLH/PAS transcription factor singleminded 2s promotes mammary gland lactogenic differentiation

31 March 2020

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AHR signaling in prostate growth, morphogenesis, and disease

31 March 2020

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Differential transcriptional regulation by mouse single-minded 2s.

31 March 2020

1 reference

The HIF1alpha-inducible pro-cell death gene BNIP3 is a novel target of SIM2s repression through cross-talk on the hypoxia response element

31 March 2020

1 reference

Interacting molecular loops in the mammalian circadian clock

31 March 2020

1 reference

Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression

31 March 2020

1 reference

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm

31 March 2020

1 reference

SCFbeta-TRCP controls clock-dependent transcription via casein kinase 1-dependent degradation of the mammalian period-1 (Per1) protein

31 March 2020

1 reference

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins

31 March 2020

1 reference

AMPK regulates the circadian clock by cryptochrome phosphorylation and degradation

31 March 2020

1 reference

Posttranslational mechanisms regulate the mammalian circadian clock

31 March 2020

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Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β

31 March 2020

1 reference

The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator

31 March 2020

1 reference

A functional genomics strategy reveals Rora as a component of the mammalian circadian clock

31 March 2020

1 reference

Rev-erbalpha, a heme sensor that coordinates metabolic and circadian pathways

31 March 2020

1 reference

Why does ARNT2 behave differently from ARNT?

31 March 2020

1 reference

Structure of an Enclosed Dimer Formed by the Drosophila Period Protein

31 March 2020

1 reference

Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha

31 March 2020

1 reference

Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1.

31 March 2020

1 reference

The aryl hydrocarbon receptor functions as a tumor suppressor of liver carcinogenesis

31 March 2020

1 reference

Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

31 March 2020

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HIF-2alpha deletion promotes Kras-driven lung tumor development.

31 March 2020

1 reference

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

31 March 2020

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Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation

31 March 2020

1 reference

Period 2 mutation accelerates ApcMin/+ tumorigenesis

31 March 2020

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SIRT1 mediates central circadian control in the SCN by a mechanism that decays with aging

31 March 2020

1 reference

Nuclear receptor coactivator SRC-1 interacts with the Q-rich subdomain of the AhR and modulates its transactivation potential.

31 March 2020

1 reference

12 December 2020

Acute mixed lineage leukemia with an inv(8)(p11q13) resulting in fusion of the genes for MOZ and TIF2.

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12 December 2020

In breast cancer, amplification of the steroid receptor coactivator gene AIB1 is correlated with estrogen and progesterone receptor positivity

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12 December 2020

Overexpression of the steroid receptor coactivator AIB1 in breast cancer correlates with the absence of estrogen and progesterone receptors and positivity for p53 and HER2/neu.

1 reference

12 December 2020

PAS domains: internal sensors of oxygen, redox potential, and light

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12 December 2020

A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia

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12 December 2020