Inflammasomes in the CNS. (Q38176535)

30 August 2017

Inflammasomes in the CNS. (English)

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30 August 2017

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3

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30 August 2017

John G Walsh

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30 August 2017

Daniel A Muruve

series ordinal

2

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30 August 2017

language of work or name

English

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publication date

8 January 2014

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Nature Reviews Neuroscience

30 August 2017

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30 August 2017

15

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30 August 2017

84-97

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30 August 2017

2

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https://scigraph.springernature.com/pub.10.1038/nrn3638

30 August 2017

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cites work

Innate immunity in the central nervous system

1 reference

Mechanisms underlying inflammation in neurodegeneration

31 March 2020

1 reference

Cytokines and acute neurodegeneration

31 March 2020

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The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta

31 March 2020

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Regulation of inflammasome signaling

31 March 2020

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NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

31 March 2020

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Human astrocytes express a novel NLRP2 inflammasome.

31 March 2020

1 reference

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

31 March 2020

1 reference

Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation

31 March 2020

1 reference

Asc modulates the function of NLRC4 in response to infection of macrophages by Legionella pneumophila.

31 March 2020

1 reference

Sensing and reacting to microbes through the inflammasomes

31 March 2020

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Interleukin-1 and neuronal injury

31 March 2020

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Interleukin 18 in the CNS.

31 March 2020

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IL-1-regulated responses in astrocytes: relevance to injury and recovery

31 March 2020

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Pyroptosis: host cell death and inflammation

31 March 2020

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Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death

31 March 2020

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A molecular platform in neurons regulates inflammation after spinal cord injury

31 March 2020

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Therapeutic neutralization of the NLRP1 inflammasome reduces the innate immune response and improves histopathology after traumatic brain injury

31 March 2020

1 reference

The pannexin 1 channel activates the inflammasome in neurons and astrocytes

31 March 2020

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Involvement of the AIM2, NLRC4, and NLRP3 inflammasomes in caspase-1 activation by Listeria monocytogenes

31 March 2020

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Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection.

31 March 2020

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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf

31 March 2020

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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

31 March 2020

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Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

31 March 2020

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The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus.

31 March 2020

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NAIP and Ipaf control Legionella pneumophila replication in human cells.

31 March 2020

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The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7

31 March 2020

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Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

31 March 2020

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Anthrax and the inflammasome

31 March 2020

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Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity

31 March 2020

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Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis

31 March 2020

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Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

31 March 2020

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Anthrax lethal factor cleavage of Nlrp1 is required for activation of the inflammasome

31 March 2020

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CARD8 and NLRP1 undergo autoproteolytic processing through a ZU5-like domain

31 March 2020

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Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis

31 March 2020

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Bcl-2 and Bcl-XL regulate proinflammatory caspase-1 activation by interaction with NALP1

31 March 2020

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Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

31 March 2020

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Cellular inhibitors of apoptosis proteins cIAP1 and cIAP2 are required for efficient caspase-1 activation by the inflammasome

31 March 2020

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Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

31 March 2020

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Pannexin-1 mediates large pore formation and interleukin-1beta release by the ATP-gated P2X7 receptor

31 March 2020

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Spreading depression triggers headache by activating neuronal Panx1 channels

31 March 2020

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Pannexin-1 is required for ATP release during apoptosis but not for inflammasome activation

31 March 2020

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Functional outcome of pannexin-deficient mice after cerebral ischemia

31 March 2020

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Promises and pitfalls of a Pannexin1 transgenic mouse line

31 March 2020

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Non-junction functions of pannexin-1 channels

31 March 2020

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NALP1/NLRP1 genetic variants are associated with Alzheimer disease.

31 March 2020

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Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome

31 March 2020

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Inflammasome recognition of influenza virus is essential for adaptive immune responses

31 March 2020

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Cryopyrin activates the inflammasome in response to toxins and ATP

31 March 2020

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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta

31 March 2020

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Gout-associated uric acid crystals activate the NALP3 inflammasome

31 March 2020

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Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

31 March 2020

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Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression

31 March 2020

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ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way

31 March 2020

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Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

31 March 2020

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K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter

31 March 2020

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Sodium overload and water influx activate the NALP3 inflammasome

31 March 2020

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Cell volume regulation modulates NLRP3 inflammasome activation

31 March 2020

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Cholesterol-dependent cytolysins induce rapid release of mature IL-1beta from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

31 March 2020

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Antiviral antibodies target adenovirus to phagolysosomes and amplify the innate immune response.

31 March 2020

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The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release

31 March 2020

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Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

31 March 2020

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Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

31 March 2020

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ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages

31 March 2020

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Thioredoxin-interacting protein links oxidative stress to inflammasome activation

31 March 2020

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NLRP3 inflammasome: key mediator of neuroinflammation in murine Japanese encephalitis

31 March 2020

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Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

31 March 2020

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Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

31 March 2020

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A role for mitochondria in NLRP3 inflammasome activation

31 March 2020

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Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

31 March 2020

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The adaptor MAVS promotes NLRP3 mitochondrial localization and inflammasome activation

31 March 2020

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IL-1β signaling promotes CNS-intrinsic immune control of West Nile virus infection

31 March 2020

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Caspase signalling controls microglia activation and neurotoxicity.

31 March 2020

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The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

31 March 2020

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Inflammasome activation and IL-1β/IL-18 processing are influenced by distinct pathways in microglia

31 March 2020

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Activation of neuronal P2X7 receptor-pannexin-1 mediates death of enteric neurons during colitis

31 March 2020

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Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes: what did we learn?

31 March 2020

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The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

31 March 2020

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Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

31 March 2020

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Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response

31 March 2020

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Inflammasomes are differentially expressed in cardiovascular and other tissues

31 March 2020

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Differential expression of NLRP3 among hematopoietic cells.

31 March 2020

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DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

31 March 2020

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NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

31 March 2020

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Inflammatory stimuli regulate caspase substrate profiles

31 March 2020

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Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease

31 March 2020

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Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis.

31 March 2020

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Interleukin-18 in acute ischaemic stroke patients

31 March 2020

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Apoptosis: controlled demolition at the cellular level

31 March 2020

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Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

31 March 2020

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Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.

31 March 2020

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Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes

31 March 2020

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Evidence for multiple cell death pathways during development of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression: apoptosis, necroptosis, and pyroptosis

31 March 2020

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The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation

31 March 2020

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Instrumental activation of bid by caspase-1 in a transgenic mouse model of ALS

31 March 2020

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Expression of a dominant negative mutant of interleukin-1 beta converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury

31 March 2020

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Excitotoxicity: bridge to various triggers in neurodegenerative disorders

31 March 2020

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Pneumolysin activates the NLRP3 inflammasome and promotes proinflammatory cytokines independently of TLR4.

31 March 2020

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Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.

31 March 2020

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Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis.

31 March 2020

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Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria

31 March 2020

1 reference

Inflammasome adaptor protein Apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in west Nile virus encephalitis

31 March 2020

1 reference

Impaired microglial activation in the brain of IL-18-gene-disrupted mice after neurovirulent influenza A virus infection

31 March 2020

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Tumor necrosis factor-alpha and interleukin-1 beta play a critical role in the resistance against lethal herpes simplex virus encephalitis

31 March 2020

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Reduced ischemic brain injury in interleukin-1 beta converting enzyme-deficient mice.

31 March 2020

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No role for interleukin-18 in acute murine stroke-induced brain injury.

31 March 2020

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Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats

31 March 2020

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Role of IL-1alpha and IL-1beta in ischemic brain damage.

31 March 2020

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Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1α.

31 March 2020

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Intracellular interleukin-1 receptor 2 binding prevents cleavage and activity of interleukin-1α, controlling necrosis-induced sterile inflammation

31 March 2020

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Active caspase-1 is a regulator of unconventional protein secretion

31 March 2020

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Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice.

31 March 2020

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Induced expression of death domain genes NALP1 and NALP5 following neuronal injury

31 March 2020

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Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome: clinical article

31 March 2020

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NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses

31 March 2020

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NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

31 March 2020

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Caspase-1-processed cytokines IL-1beta and IL-18 promote IL-17 production by gammadelta and CD4 T cells that mediate autoimmunity.

31 March 2020

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The inflammasome sensor, NLRP3, regulates CNS inflammation and demyelination via caspase-1 and interleukin-18.

31 March 2020

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Interleukin-1beta promotes repair of the CNS.

31 March 2020

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Mutant superoxide dismutase 1-induced IL-1beta accelerates ALS pathogenesis.

31 March 2020

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Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human beta-amyloid

31 March 2020

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Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

31 March 2020

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NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice

31 March 2020

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NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis

31 March 2020

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The NLRP12 inflammasome recognizes Yersinia pestis

31 March 2020

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Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization

31 March 2020

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Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

31 March 2020

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria

31 March 2020

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Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

31 March 2020

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Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

31 March 2020

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Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles.

31 March 2020

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HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

31 March 2020

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Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis

31 March 2020

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Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

31 March 2020

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The cytokine release inhibitory drug CRID3 targets ASC oligomerisation in the NLRP3 and AIM2 inflammasomes

31 March 2020

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MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

31 March 2020

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Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.

31 March 2020

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Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

31 March 2020

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The immunology of neurodegeneration

31 March 2020

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Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

31 March 2020

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Necroptosis: the release of damage-associated molecular patterns and its physiological relevance

31 March 2020

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Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia-ischemia

31 March 2020

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Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

31 March 2020

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Caspase-6 and neurodegeneration.

31 March 2020

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Malarial hemozoin is a Nalp3 inflammasome activating danger signal

31 March 2020

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Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

31 March 2020

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NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

31 March 2020

1 reference

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages

31 March 2020

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24399084

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NRN3638

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Dimensions Publication ID

30 August 2017

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