Translational control of immune responses: from transcripts to translatomes (Q38212816)

31 August 2017

Translational control of immune responses: from transcripts to translatomes (English)

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31 August 2017

4

Nahum Sonenberg

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31 August 2017

Ola Larsson

5

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Ivan Topisirovic

object named as

Ivan Topisirovic

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3

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author name string

Ciriaco A Piccirillo

series ordinal

1

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31 August 2017

Eva Bjur

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2

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31 August 2017

language of work or name

English

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publication date

1 June 2014

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31 August 2017

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31 August 2017

15

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31 August 2017

503-511

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31 August 2017

6

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https://scigraph.springernature.com/pub.10.1038/ni.2891

31 August 2017

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cites work

Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

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Parallel human genome analysis: microarray-based expression monitoring of 1000 genes

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Quantitative monitoring of gene expression patterns with a complementary DNA microarray

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Expression monitoring by hybridization to high-density oligonucleotide arrays

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Toward a genome-wide landscape of translational control

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Global quantification of mammalian gene expression control

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P53 mRNA controls p53 activity by managing Mdm2 functions

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Principles of translational control: an overview

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Widespread regulation of translation by elongation pausing in heat shock

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Cotranslational response to proteotoxic stress by elongation pausing of ribosomes

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Genome-wide ribosome profiling reveals complex translational regulation in response to oxidative stress

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The eEF2 kinase confers resistance to nutrient deprivation by blocking translation elongation

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Regulation of translation initiation in eukaryotes: mechanisms and biological targets

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The mechanism of eukaryotic translation initiation and principles of its regulation

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The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts

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Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

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RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

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A mammalian protein targeted by G1-arresting rapamycin-receptor complex

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AMPK phosphorylation of raptor mediates a metabolic checkpoint

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TSC2 mediates cellular energy response to control cell growth and survival

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Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

21 January 2018

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The LKB1 tumor suppressor negatively regulates mTOR signaling

21 January 2018

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Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism

21 January 2018

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Amino acid availability regulates p70 S6 kinase and multiple translation factors

21 January 2018

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Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling

21 January 2018

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Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

21 January 2018

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mTOR signaling in growth control and disease

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mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery

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Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action

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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

21 January 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

21 January 2018

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Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB

21 January 2018

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Targets for Cell Cycle Arrest by the Immunosuppressant Rapamycin in Yeast

21 January 2018

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Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism

21 January 2018

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

21 January 2018

1 reference

Regulation of eIF-4E BP1 phosphorylation by mTOR.

21 January 2018

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TOR signaling in growth and metabolism

21 January 2018

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S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth

21 January 2018

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Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases

21 January 2018

1 reference

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

21 January 2018

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Regulation of mRNA translation by signaling pathways

21 January 2018

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Regulation of translation initiation by FRAP/mTOR

21 January 2018

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Apoptosis resistance downstream of eIF4E: posttranscriptional activation of an anti-apoptotic transcript carrying a consensus hairpin structure.

21 January 2018

1 reference

The translational landscape of mTOR signalling steers cancer initiation and metastasis

21 January 2018

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A unifying model for mTORC1-mediated regulation of mRNA translation.

21 January 2018

1 reference

Tuberous sclerosis complex proteins 1 and 2 control serum-dependent translation in a TOP-dependent and -independent manner

21 January 2018

1 reference

The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner

21 January 2018

1 reference

Vertebrate mRNAs with a 5'-terminal pyrimidine tract are candidates for translational repression in quiescent cells: characterization of the translational cis-regulatory element.

21 January 2018

1 reference

Translational coregulation of 5'TOP mRNAs by TIA-1 and TIAR.

21 January 2018

1 reference

Proteomic analysis of cap-dependent translation identifies LARP1 as a key regulator of 5'TOP mRNA translation

21 January 2018

1 reference

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

21 January 2018

1 reference

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

21 January 2018

1 reference

eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression

21 January 2018

1 reference

Genomic targets of the human c-Myc protein

21 January 2018

1 reference

Stability of eukaryotic translation initiation factor 4E mRNA is regulated by HuR, and this activity is dysregulated in cancer.

21 January 2018

1 reference

TCR-dependent translational control of GATA-3 enhances Th2 differentiation

21 January 2018

1 reference

Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation.

21 January 2018

1 reference

OASL1 inhibits translation of the type I interferon-regulating transcription factor IRF7.

21 January 2018

1 reference

Distinct translational control in CD4+ T cell subsets

21 January 2018

1 reference

The good, the bad and the ugly - TFH cells in human health and disease

21 January 2018

1 reference

21 January 2018

TOR in the immune system

1 reference

Notch-RBP-J signaling regulates the transcription factor IRF8 to promote inflammatory macrophage polarization

21 January 2018

1 reference

Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E.

21 January 2018

1 reference

IRF5 promotes inflammatory macrophage polarization and TH1-TH17 responses

21 January 2018

1 reference

Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein

21 January 2018

1 reference

Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1

21 January 2018

1 reference

Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells

21 January 2018

1 reference

Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells

21 January 2018

1 reference

Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells

21 January 2018

1 reference

Inflammation meets cancer, with NF-κB as the matchmaker

21 January 2018

1 reference

Multi-copper oxidases and human iron metabolism

21 January 2018

1 reference

Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3' untranslated region

21 January 2018

1 reference

Transcript-selective translational silencing by gamma interferon is directed by a novel structural element in the ceruloplasmin mRNA 3' untranslated region

21 January 2018

1 reference

Genome-wide polysome profiling reveals an inflammation-responsive posttranscriptional operon in gamma interferon-activated monocytes

21 January 2018

1 reference

DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression

21 January 2018

1 reference

Activation of the integrated stress response during T helper cell differentiation

21 January 2018

1 reference

Coping with stress: eIF2 kinases and translational control

21 January 2018

1 reference

Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells

21 January 2018

1 reference

TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha

21 January 2018

1 reference

HuR as a negative posttranscriptional modulator in inflammation

21 January 2018

1 reference

An essential function of the SRC-3 coactivator in suppression of cytokine mRNA translation and inflammatory response

21 January 2018

1 reference

Regulation of cyclooxygenase-2 expression by the translational silencer TIA-1.

21 January 2018

1 reference

Interleukin-17 (IL-17) and IL-1 activate translation of overlapping sets of mRNAs, including that of the negative regulator of inflammation, MCPIP1

21 January 2018

1 reference

Regulation of Toll/IL-1-receptor-mediated gene expression by the inducible nuclear protein IkappaBzeta

21 January 2018

1 reference

Posttranscriptional control of T cell effector function by aerobic glycolysis

21 January 2018

1 reference

A multiple ribosomal structure in protein synthesis

21 January 2018

1 reference

Identification of eukaryotic mRNAs that are translated at reduced cap binding complex eIF4F concentrations using a cDNA microarray

21 January 2018

1 reference

Remodeling of Ago2-mRNA interactions upon cellular stress reflects miRNA complementarity and correlates with altered translation rates

21 January 2018

1 reference

Genome-wide analysis in vivo of translation with nucleotide resolution using ribosome profiling

21 January 2018

1 reference

The ribosome profiling strategy for monitoring translation in vivo by deep sequencing of ribosome-protected mRNA fragments

21 January 2018

1 reference

A rapid ribosome profiling method elucidates chloroplast ribosome behavior in vivo.

21 January 2018

1 reference

Identification of differential translation in genome wide studies

21 January 2018

1 reference

Assessing gene-level translational control from ribosome profiling

21 January 2018

1 reference

Re-analysis of genome wide data on mammalian microRNA-mediated suppression of gene expression

21 January 2018

1 reference

In silico motif analysis suggests an interplay of transcriptional and translational control in mTOR response

21 January 2018

1 reference

anota: Analysis of differential translation in genome-wide studies

21 January 2018

1 reference

Genome-wide analysis of host mRNA translation during hepatitis C virus infection

21 January 2018

1 reference

Distinct perturbation of the translatome by the antidiabetic drug metformin

21 January 2018

1 reference

Fibrotic extracellular matrix activates a profibrotic positive feedback loop

21 January 2018

1 reference

The translational landscape of the mammalian cell cycle

21 January 2018

1 reference

tRanslatome: an R/Bioconductor package to portray translational control

21 January 2018

1 reference

GWIPS-viz: development of a ribo-seq genome browser

21 January 2018

1 reference

Inhibition of eukaryotic translation elongation by cycloheximide and lactimidomycin

21 January 2018

1 reference

Global mapping of translation initiation sites in mammalian cells at single-nucleotide resolution

21 January 2018

1 reference

Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes

21 January 2018

1 reference

Ribosome profiling provides evidence that large noncoding RNAs do not encode proteins

21 January 2018

1 reference

Inhibition of Translation in Eukaryotic Systems by Harringtonine

21 January 2018

1 reference

Eukaryotic translation initiation factor 4E induced progression of primary human mammary epithelial cells along the cancer pathway is associated with targeted translational deregulation of oncogenic drivers and inhibitors

21 January 2018

1 reference

Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation

21 January 2018

1 reference

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

21 January 2018

1 reference

Translational deregulation in PDK-1-/- embryonic stem cells

21 January 2018

1 reference

Isolation of translationally controlled mRNAs by differential screening.

21 January 2018

1 reference

Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics

21 January 2018

1 reference

Ribosomal protein mRNAs are translationally-regulated during human dendritic cells activation by LPS.

21 January 2018

1 reference

Genome-wide identification and characterization of transcripts translationally regulated by bacterial lipopolysaccharide in macrophage-like J774.1 cells

21 January 2018

1 reference

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

21 January 2018

1 reference

Translational control of the innate immune response through IRF-7

21 January 2018

1 reference

The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection

21 January 2018

1 reference

CPEB1 coordinates alternative 3′-UTR formation with translational regulation

21 January 2018

1 reference

Phosphorylation state of the cap-binding protein eIF4E during viral infection

21 January 2018

1 reference

12 December 2020

Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells

1 reference

12 December 2020

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

1 reference

12 December 2020

Eukaryotic mRNPs may represent posttranscriptional operons

1 reference

12 December 2020

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1 reference

12 December 2020

Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells

1 reference

12 December 2020

Bactericidal effect of Fe2+, ceruloplasmin, and phosphate

1 reference

12 December 2020

Protein synthesis rate is the predominant regulator of protein expression during differentiation

1 reference

12 December 2020

A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes

1 reference

12 December 2020

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses

1 reference

12 December 2020

The second Sir Hans Krebs Lecture. Informosomes

1 reference

12 December 2020

Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway

1 reference

12 December 2020

Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner.

1 reference

12 December 2020

Translational control of malignancy: the mRNA cap-binding protein, eIF-4E, as a central regulator of tumor formation, growth, invasion and metastasis

1 reference

12 December 2020

Identifiers

DOI

10.1038/NI.2891

1 reference

Dimensions Publication ID

31 August 2017

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