A tale of two domains - a structural perspective of the pseudokinase, MLKL. (Q38580336)

4 September 2017

title

A tale of two domains - a structural perspective of the pseudokinase, MLKL. (English)

1 reference

4 September 2017

James M Murphy

2

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author name string

Peter E Czabotar

series ordinal

1

1 reference

4 September 2017

language of work or name

English

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publication date

3 September 2015

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4 September 2017

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4 September 2017

volume

282

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4 September 2017

issue

22

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4 September 2017

page(s)

4268-4278

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Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4.

4 September 2017

cites work

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The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism

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Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

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RIPK1 can function as an inhibitor rather than an initiator of RIPK3-dependent necroptosis

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The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis

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Necroptosis signalling is tuned by phosphorylation of MLKL residues outside the pseudokinase domain activation loop

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

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Activity of protein kinase RIPK3 determines whether cells die by necroptosis or apoptosis

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Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo

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Structural basis of RIP1 inhibition by necrostatins

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RIPK1 blocks early postnatal lethality mediated by caspase-8 and RIPK3

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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1.

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RIPK1- and RIPK3-induced cell death mode is determined by target availability

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RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.

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Distinct roles of RIP1-RIP3 hetero- and RIP3-RIP3 homo-interaction in mediating necroptosis

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DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB

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Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death

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Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis

21 January 2018

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Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3.

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Necroptosis induced by RIPK3 requires MLKL but not Drp1.

21 January 2018

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Widespread mitochondrial depletion via mitophagy does not compromise necroptosis

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Necroptosis: is there a role for mitochondria?

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TNFR1-dependent cell death drives inflammation in Sharpin-deficient mice.

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Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury

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RIP3, a kinase promoting necroptotic cell death, mediates adverse remodelling after myocardial infarction

21 January 2018

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RIP3 induces apoptosis independent of pronecrotic kinase activity

21 January 2018

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Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome.

21 January 2018

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Inhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activation.

21 January 2018

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Going for broke: targeting the human cancer pseudokinome

21 January 2018

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An ATP-Competitive Inhibitor Modulates the Allosteric Function of the HER3 Pseudokinase

21 January 2018

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Pharmacological targeting of the pseudokinase Her3

21 January 2018

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Electrostatics of nanosystems: application to microtubules and the ribosome

21 January 2018

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PDB2PQR: expanding and upgrading automated preparation of biomolecular structures for molecular simulations

21 January 2018

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https://api.fatcat.wiki/v0/release/x7wclzijujhwxlx445663rmzc4

21 January 2018

Identifiers

1 reference

mapped directly with Wikidata item

30 July 2022

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Fatcat ID

release_x7wclzijujhwxlx445663rmzc4

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/x7wclzijujhwxlx445663rmzc4

mapped directly with Wikidata item

30 July 2022

based on heuristic

https://api.fatcat.wiki/v0/release/x7wclzijujhwxlx445663rmzc4

1 reference