Regulation of metabolism by the innate immune system (Q38629225)

4 September 2017

Regulation of metabolism by the innate immune system (English)

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4 September 2017

2

Jerrold M Olefsky

1 reference

4 September 2017

Denise E Lackey

1

1 reference

PubMed ID

26553134

4 September 2017

language of work or name

1 reference

10 November 2015

1 reference

Nature Reviews Endocrinology

4 September 2017

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4 September 2017

12

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4 September 2017

15-28

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4 September 2017

1

1 reference

https://scigraph.springernature.com/pub.10.1038/nrendo.2015.189

4 September 2017

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cites work

Mechanisms linking obesity to insulin resistance and type 2 diabetes

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Abdominal obesity and metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipose tissue macrophages, low grade inflammation and insulin resistance in human obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inflammatory links between obesity and metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The cellular and signaling networks linking the immune system and metabolism in disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Obesity is associated with macrophage accumulation in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Immune regulation of metabolic homeostasis in health and disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Macrophages, immunity, and metabolic disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adaptive immunity in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Immunological goings-on in visceral adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

NF-κB, inflammation, and metabolic disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inflammation and the IKK beta/I kappa B/NF-kappa B axis in obesity- and diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A central role for JNK in obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A stress signaling pathway in adipose tissue regulates hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Toll-like receptors and NLRP3 as central regulators of pancreatic islet inflammation in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

NLRP3 at the interface of metabolism and inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inflammasome is a central player in the induction of obesity and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Monounsaturated fatty acid-enriched high-fat diets impede adipose NLRP3 inflammasome-mediated IL-1β secretion and insulin resistance despite obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The antiinflammatory cytokine interleukin-1 receptor antagonist protects from high-fat diet-induced hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Interleukin-1-receptor antagonist in type 2 diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

TLR4 links innate immunity and fatty acid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Insulin signaling, resistance, and the metabolic syndrome: insights from mouse models into disease mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Insulin resistance due to phosphorylation of insulin receptor substrate-1 at serine 302.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

High-fat feeding increases insulin receptor and IRS-1 coimmunoprecipitation with SOCS-3, IKKalpha/beta phosphorylation and decreases PI-3 kinase activity in muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Insulin receptor and IRS-1 co-immunoprecipitation with SOCS-3, and IKKα/β phosphorylation are increased in obese Zucker rat skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Oleic and linoleic fatty acids downregulate Slc2a4/GLUT4 expression via NFKB and SREBP1 in skeletal muscle cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Tumor necrosis factor-alpha suppresses adipocyte-specific genes and activates expression of preadipocyte genes in 3T3-L1 adipocytes: nuclear factor-kappaB activation by TNF-alpha is obligatory

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

MicroRNA regulatory networks in human adipose tissue and obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

TNFα-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

microRNAs as a new mechanism regulating adipose tissue inflammation in obesity and as a novel therapeutic strategy in the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Hepatocyte-specific IKK-β activation enhances VLDL-triglyceride production in APOE*3-Leiden mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Macrophages block insulin action in adipocytes by altering expression of signaling and glucose transport proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

IKK-beta links inflammation to obesity-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Blocking IL-6 trans-signaling prevents high-fat diet-induced adipose tissue macrophage recruitment but does not improve insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The protein kinase IKKepsilon regulates energy balance in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Prolonged interleukin-6 administration enhances glucose tolerance and increases skeletal muscle PPARalpha and UCP2 expression in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

PKC-theta knockout mice are protected from fat-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A high-fat meal is accompanied by increased plasma interleukin-6 concentrations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Lipid-overloaded enlarged adipocytes provoke insulin resistance independent of inflammation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Inflammation is necessary for long-term but not short-term high-fat diet-induced insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Alternative activation of macrophages: mechanism and functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Macrophage plasticity and polarization: in vivo veritas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Macrophage activation and polarization: nomenclature and experimental guidelines

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Obesity activates a program of lysosomal-dependent lipid metabolism in adipose tissue macrophages independently of classic activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Metabolic dysfunction drives a mechanistically distinct proinflammatory phenotype in adipose tissue macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Functional heterogeneity of CD11c-positive adipose tissue macrophages in diet-induced obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Glucocorticoids and thiazolidinediones interfere with adipocyte-mediated macrophage chemotaxis and recruitment

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Obesity induces a phenotypic switch in adipose tissue macrophage polarization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Increased macrophage migration into adipose tissue in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Absence of CC chemokine ligand 2 does not limit obesity-associated infiltration of macrophages into adipose tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Monocyte chemoattractant protein deficiency fails to restrain macrophage infiltration into adipose tissue [corrected].

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Microparticles release by adipocytes act as "find-me" signals to promote macrophage migration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Depot-specific differences in inflammatory mediators and a role for NK cells and IFN-gamma in inflammation in human adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Perforin is a novel immune regulator of obesity-related insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Systemic NK cell ablation attenuates intra-abdominal adipose tissue macrophage infiltration in murine obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

NK cells link obesity-induced adipose stress to inflammation and insulin resistance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Hematopoietic Kit Deficiency, rather than Lack of Mast Cells, Protects Mice from Obesity and Insulin Resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Chronic helminth infection and helminth-derived egg antigens promote adipose tissue M2 macrophages and improve insulin sensitivity in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

21 January 2018

IL-5 and eosinophilia.

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Type 2 innate lymphoid cells control eosinophil homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Cutting edge: IL-25 elicits innate lymphoid type 2 and type II NKT cells that regulate obesity in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Brown and beige fat: development, function and therapeutic potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adaptive thermogenesis in adipocytes: is beige the new brown?

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipose tissue browning and metabolic health

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Invariant NKT cells and CD1d(+) cells amass in human omentum and are depleted in patients with cancer and obesity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A novel function of adipocytes in lipid antigen presentation to iNKT cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of T(reg) cells and macrophages in adipose tissue

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Impact of CD1d deficiency on metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Lack of invariant natural killer T cells affects lipid metabolism in adipose tissue of diet-induced obese mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Adipose invariant natural killer T cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Activated Kupffer cells inhibit insulin sensitivity in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Opposite cross-talk by oleate and palmitate on insulin signaling in hepatocytes through macrophage activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Characterization of distinct subpopulations of hepatic macrophages in HFD/obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Infiltrating monocyte-derived macrophages and resident kupffer cells display different ontogeny and functions in acute liver injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Kupffer cell activation is a causal factor for hepatic insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Ceramides as modulators of cellular and whole-body metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Ceramide inhibits protein kinase B/Akt by promoting dephosphorylation of serine 473.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Expression of anti-inflammatory macrophage genes within skeletal muscle correlates with insulin sensitivity in human obesity and type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Muscle inflammatory response and insulin resistance: synergistic interaction between macrophages and fatty acids leads to impaired insulin action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Insulin resistance is associated with MCP1-mediated macrophage accumulation in skeletal muscle in mice and humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Short-term high-fat diet increases macrophage markers in skeletal muscle accompanied by impaired insulin signalling in healthy male subjects.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Muscle cells challenged with saturated fatty acids mount an autonomous inflammatory response that activates macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Islet-associated macrophages in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Increased number of islet-associated macrophages in type 2 diabetes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Minireview: Emerging Concepts in Islet Macrophage Biology in Type 2 Diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Type 2 diabetes as an inflammatory disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Free fatty acids induce a proinflammatory response in islets via the abundantly expressed interleukin-1 receptor I.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Functional interactions between the gut microbiota and host metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Microbial ecology: human gut microbes associated with obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

An obesity-associated gut microbiome with increased capacity for energy harvest

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Intestinal permeability parameters in obese patients are correlated with metabolic syndrome risk factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

High fat diet causes depletion of intestinal eosinophils associated with intestinal permeability

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A randomised trial of salsalate for insulin resistance and cardiovascular risk factors in persons with abnormal glucose tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The impact of salsalate treatment on serum levels of advanced glycation end products in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Aspirin in type 2 diabetes, a randomised controlled study: effect of different doses on inflammation, oxidative stress, insulin resistance and endothelial function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The effect of high-dose sodium salicylate on chronically elevated plasma nonesterified fatty acid-induced insulin resistance and β-cell dysfunction in overweight and obese nondiabetic men.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Salicylates increase insulin secretion in healthy obese subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Chronic TNF-α neutralization does not improve insulin resistance or endothelial function in "healthy" men with metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

TNF-alpha antagonism with etanercept decreases glucose and increases the proportion of high molecular weight adiponectin in obese subjects with features of the metabolic syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Association between disease-modifying antirheumatic drugs and diabetes risk in patients with rheumatoid arthritis and psoriasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Impact of interleukin-1β antibody (canakinumab) on glycaemic indicators in patients with type 2 diabetes mellitus: results of secondary endpoints from a randomized, placebo-controlled trial

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Effects of gevokizumab on glycemia and inflammatory markers in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Double-blind, randomized study evaluating the glycemic and anti-inflammatory effects of subcutaneous LY2189102, a neutralizing IL-1β antibody, in patients with type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Insulin sensitizing and anti-inflammatory effects of thiazolidinediones are heightened in obese patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Reduced adipose tissue macrophage content is associated with improved insulin sensitivity in thiazolidinedione-treated diabetic humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

PPARγ signaling and metabolism: the good, the bad and the future

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Omega-3 fatty acids reduce adipose tissue macrophages in human subjects with insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

A Gpr120-selective agonist improves insulin resistance and chronic inflammation in obese mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

CCR2 antagonism in patients with type 2 diabetes mellitus: a randomized, placebo-controlled study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Activation of leukocytes by postprandial lipemia in healthy volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Increased Inflammatory Properties of Adipose Tissue Macrophages Recruited During Diet-Induced Obesity

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Palmitate induces endoplasmic reticulum stress and autophagy in mature adipocytes: implications for apoptosis and inflammation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Decoding insulin resistance and metabolic syndrome for promising therapeutic intervention

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

LTB4 promotes insulin resistance in obese mice by acting on macrophages, hepatocytes and myocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Increase in intranuclear nuclear factor kappaB and decrease in inhibitor kappaB in mononuclear cells after a mixed meal: evidence for a proinflammatory effect.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Semaphorin3E-induced inflammation contributes to insulin resistance in dietary obesity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Pro-inflammatory macrophages increase in skeletal muscle of high fat-fed mice and correlate with metabolic risk markers in humans

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

31 March 2020

12 December 2020

Angiotensin II induces interleukin-1β-mediated islet inflammation and β-cell dysfunction independently of vasoconstrictive effects

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRENDO.2015.189

Transcriptional repression of the GLUT4 and C/EBP genes in 3T3-L1 adipocytes by tumor necrosis factor-alpha.

31 March 2020

1 reference

PubMed

12 December 2020

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

1 reference

PubMed

12 December 2020

Ontogeny and polarization of macrophages in inflammation: blood monocytes versus tissue macrophages

1 reference

PubMed

12 December 2020

Identifiers

DOI

10.1038/NRENDO.2015.189

1 reference

4 September 2017

1 reference

PubMed ID

26553134