The role of immune cells in metabolism-related liver inflammation and development of non-alcoholic steatohepatitis (NASH). (Q38723669)

5 September 2017

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title

The role of immune cells in metabolism-related liver inflammation and development of non-alcoholic steatohepatitis (NASH). (English)

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non-alcoholic steatohepatitis

5 September 2017

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inferred from title

author

Triantafyllos Chavakis

5

object named as

Triantafyllos Chavakis

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5 September 2017

Marina Nati

1

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5 September 2017

David Haddad

2

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5 September 2017

Andreas L Birkenfeld

3

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5 September 2017

Christian A Koch

4

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5 September 2017

Antonios Chatzigeorgiou

6

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5 September 2017

5 February 2016

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Reviews in Endocrine and Metabolic Disorders

5 September 2017

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5 September 2017

17

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5 September 2017

29-39

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5 September 2017

1

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https://scigraph.springernature.com/pub.10.1007/s11154-016-9339-2

5 September 2017

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Increased hepatic myeloperoxidase activity in obese subjects with nonalcoholic steatohepatitis

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Myeloperoxidase-Hepatocyte-Stellate Cell Cross Talk Promotes Hepatocyte Injury and Fibrosis in Experimental Nonalcoholic Steatohepatitis

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Neutrophil-derived myeloperoxidase aggravates non-alcoholic steatohepatitis in low-density lipoprotein receptor-deficient mice

21 January 2018

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Mammalian heme peroxidases: from molecular mechanisms to health implications

21 January 2018

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Protein tyrosine nitration--functional alteration or just a biomarker?

21 January 2018

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Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase

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21 January 2018

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Origin and functional heterogeneity of non-lymphoid tissue dendritic cells in mice

21 January 2018

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Dendritic cells limit fibroinflammatory injury in nonalcoholic steatohepatitis in mice.

21 January 2018

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Impaired dendritic cell functions disrupt antigen-specific adaptive immune responses in mice with nonalcoholic fatty liver disease

21 January 2018

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Dendritic cell populations with different concentrations of lipid regulate tolerance and immunity in mouse and human liver

21 January 2018

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Dendritic cell regulation of carbon tetrachloride-induced murine liver fibrosis regression

21 January 2018

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Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients

21 January 2018

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Progression from Nonalcoholic Fatty Liver to Nonalcoholic Steatohepatitis Is Marked by a Higher Frequency of Th17 Cells in the Liver and an Increased Th17/Resting Regulatory T Cell Ratio in Peripheral Blood and in the Liver.

21 January 2018

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IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice.

21 January 2018

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Tolerogenic role of Kupffer cells in immune-mediated adverse drug reactions

21 January 2018

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Kupffer cells promote hepatic steatosis via interleukin-1beta-dependent suppression of peroxisome proliferator-activated receptor alpha activity

21 January 2018

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Macrophage-mediated inflammation in metabolic disease

21 January 2018

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Factors in the pathophysiology of the liver ischemia-reperfusion injury

21 January 2018

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Kupffer cell activation is a causal factor for hepatic insulin resistance

21 January 2018

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Kupffer cell heterogeneity: functional properties of bone marrow derived and sessile hepatic macrophages

21 January 2018

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C-C chemokine receptor 2 (CCR2) regulates the hepatic recruitment of myeloid cells that promote obesity-induced hepatic steatosis

21 January 2018

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Functional role of intrahepatic monocyte subsets for the progression of liver inflammation and liver fibrosis in vivo

21 January 2018

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Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

21 January 2018

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Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production

21 January 2018

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Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue

21 January 2018

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Activation of CD11b+ Kupffer cells/macrophages as a common cause for exacerbation of TNF/Fas-ligand-dependent hepatitis in hypercholesterolemic mice

21 January 2018

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Depletion of liver Kupffer cells prevents the development of diet-induced hepatic steatosis and insulin resistance

21 January 2018

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IL-1 signaling in obesity-induced hepatic lipogenesis and steatosis

21 January 2018

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Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages

21 January 2018

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Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species

21 January 2018

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Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells

21 January 2018

1 reference

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Non-alcoholic steatohepatitis: the role of oxidized low-density lipoproteins

21 January 2018

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Trapping of oxidized LDL in lysosomes of Kupffer cells is a trigger for hepatic inflammation

21 January 2018

1 reference

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Role of scavenger receptor A and CD36 in diet-induced nonalcoholic steatohepatitis in hyperlipidemic mice.

21 January 2018

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Macrophage specific caspase-1/11 deficiency protects against cholesterol crystallization and hepatic inflammation in hyperlipidemic mice

21 January 2018

1 reference

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Cholesterol-lowering drugs cause dissolution of cholesterol crystals and disperse Kupffer cell crown-like structures during resolution of NASH.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Hepatic regulatory T cells and Kupffer cells are crucial mediators of systemic T cell tolerance to antigens targeting murine liver.

21 January 2018

1 reference

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Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages

21 January 2018

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Regulation of human helper T cell subset differentiation by cytokines

21 January 2018

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21 January 2018

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Altered phenotype and functionality of circulating immune cells characterize adult patients with nonalcoholic steatohepatitis.

21 January 2018

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Reactivity and specificity of CD8+ T cells in mice with defects in the MHC class I antigen-presenting pathway

21 January 2018

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Antigen peptide transporter 1 is involved in the development of fructose-induced hepatic steatosis in mice

21 January 2018

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Th17 T cells: linking innate and adaptive immunity

21 January 2018

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IL-17A plays a critical role in the pathogenesis of liver fibrosis through hepatic stellate cell activation

21 January 2018

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Expression of interleukin-17 associated with disease progression and liver fibrosis with hepatitis B virus infection: IL-17 in HBV infection

21 January 2018

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Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice

21 January 2018

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How regulatory T cells work

21 January 2018

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Regulatory T cells: mechanisms of differentiation and function

21 January 2018

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Circulating regulatory T cells are reduced in obesity and may identify subjects at increased metabolic and cardiovascular risk.

21 January 2018

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Adipose tissue-resident regulatory T cells: phenotypic specialization, functions and therapeutic potential

21 January 2018

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Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

21 January 2018

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B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes

21 January 2018

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CD28 deletion improves obesity-induced liver steatosis but increases adiposity in mice.

21 January 2018

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T-cell costimulation protects obesity-induced adipose inflammation and insulin resistance

21 January 2018

1 reference

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Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance

21 January 2018

1 reference

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CD40 deficiency in mice exacerbates obesity-induced adipose tissue inflammation, hepatic steatosis, and insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Coinhibitory suppression of T cell activation by CD40 protects against obesity and adipose tissue inflammation in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.

21 January 2018

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21 January 2018

The biology of NKT cells

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Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis

21 January 2018

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Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.

21 January 2018

1 reference

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Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

21 January 2018

1 reference

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Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks

21 January 2018

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Hepatic stellate cell lipid droplets: a specialized lipid droplet for retinoid storage

21 January 2018

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Antidiabetic thiazolidinediones inhibit collagen synthesis and hepatic stellate cell activation in vivo and in vitro.

21 January 2018

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Immunohistochemical identification of Ito cells and their myofibroblastic transformation in adult human liver.

21 January 2018

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Molecular mechanism of hepatic stellate cell activation and antifibrotic therapeutic strategies.

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Involvement of reactive oxygen species and nitric oxide radicals in activation and proliferation of rat hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

The role of Kupffer cell oxidant production in early ethanol-induced liver disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Hepatic macrophages but not dendritic cells contribute to liver fibrosis by promoting the survival of activated hepatic stellate cells in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Inhibition of inhibitor of kappaB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Sterile inflammation in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Influence of leptin in the development of hepatic fibrosis produced in mice by Schistosoma mansoni infection and by chronic carbon tetrachloride administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity?

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Expression of leptin and leptin receptor during the development of liver fibrosis and cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Leptin receptor-mediated signaling regulates hepatic fibrogenesis and remodeling of extracellular matrix in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Kupffer cells mediate leptin-induced liver fibrosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Peroxisome proliferator-activated receptors and hepatic stellate cell activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Epigenetic cell fate regulation of hepatic stellate cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Role of metabolic lipases and lipolytic metabolites in the pathogenesis of NAFLD.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Causes and metabolic consequences of Fatty liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Pharmacological inhibition of the chemokine CXCL16 diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

CXC chemokine receptor 3 promotes steatohepatitis in mice through mediating inflammatory cytokines, macrophages and autophagy.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Pharmacological IKK2 inhibition blocks liver steatosis and initiation of non-alcoholic steatohepatitis

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11154-016-9339-2

Treatment of experimental non-alcoholic steatohepatitis by targeting α7 nicotinic acetylcholine receptor-mediated inflammatory responses in mice

21 January 2018

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Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity

21 January 2018

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12 December 2020

Kupffer cell engulfment of apoptotic bodies stimulates death ligand and cytokine expression

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12 December 2020

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

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12 December 2020

Molecular pathways in non-alcoholic fatty liver disease.

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12 December 2020

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

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12 December 2020

Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells

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12 December 2020

The inflammasome in liver injury and non-alcoholic fatty liver disease

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12 December 2020

Kupffer cell depletion prevents but has no therapeutic effect on metabolic and inflammatory changes induced by a high-fat diet

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12 December 2020

CCR2 and CD44 promote inflammatory cell recruitment during fatty liver formation in a lithogenic diet fed mouse model

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12 December 2020

Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet

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12 December 2020

Decreased nucleotide excision repair in steatotic livers associates with myeloperoxidase-immunoreactivity

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12 December 2020

CXCL10 plays a key role as an inflammatory mediator and a non-invasive biomarker of non-alcoholic steatohepatitis

1 reference

12 December 2020

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A high-fat diet and regulatory T cells influence susceptibility to endotoxin-induced liver injury

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Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology

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Hepatocyte apoptosis and fas expression are prominent features of human nonalcoholic steatohepatitis

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Metabolic phenotype and adipose and liver features in a high-fat Western diet-induced mouse model of obesity-linked NAFLD.

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Depletion of fat-resident Treg cells prevents age-associated insulin resistance

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Pro-inflammatory activated Kupffer cells by lipids induce hepatic NKT cells deficiency through activation-induced cell death

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Lack of interleukin-1α in Kupffer cells attenuates liver inflammation and expression of inflammatory cytokines in hypercholesterolaemic mice

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Ligands of peroxisome proliferator-activated receptor γ modulate profibrogenic and proinflammatory actions in hepatic stellate cells

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Transforming growth factor-beta gene expression in normal and fibrotic rat liver

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Disease progression of non-alcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years

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Formation of nitric oxide-derived oxidants by myeloperoxidase in monocytes: pathways for monocyte-mediated protein nitration and lipid peroxidation In vivo

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CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

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Interleukin-17 exacerbates hepatic steatosis and inflammation in non-alcoholic fatty liver disease

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Dual role of B7 costimulation in obesity-related nonalcoholic steatohepatitis and metabolic dysregulation

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Adipogenic phenotype of hepatic stellate cells

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10.1007/S11154-016-9339-2

Identifiers

DOI

1 reference

Dimensions Publication ID

5 September 2017

0 references

1 reference