Metformin as a Tool to Target Aging (Q38865781)

15 June 2018

review article

1 reference

title

Metformin as a Tool to Target Aging (English)

1 reference

15 June 2018

1 reference

4

Mark A Espeland

1 reference

PMC publication ID

5943638

15 June 2018

Stephen B Kritchevsky

series ordinal

3

object named as

Stephen B Kritchevsky

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15 June 2018

1

Nir Barzilai

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15 June 2018

author name string

Jill P Crandall

series ordinal

2

1 reference

15 June 2018

publication date

1 June 2016

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15 June 2018

published in

Cell Metabolism

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15 June 2018

volume

23

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15 June 2018

issue

6

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15 June 2018

page(s)

1060-1065

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15 June 2018

Long-term Metformin Use and Vitamin B12 Deficiency in the Diabetes Prevention Program Outcomes Study

cites work

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Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice

17 June 2018

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17 June 2018

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17 June 2018

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Metformin and Inflammation: Its Potential Beyond Glucose-lowering Effect

17 June 2018

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Antihyperglycemic mechanism of metformin occurs via the AMPK/LXRα/POMC pathway

17 June 2018

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Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway

17 June 2018

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17 June 2018

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HbA1c as a predictor of diabetes and as an outcome in the diabetes prevention program: a randomized clinical trial

17 June 2018

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Mechanism of metformin-dependent inhibition of mammalian target of rapamycin (mTOR) and Ras activity in pancreatic cancer: role of specificity protein (Sp) transcription factors

17 June 2018

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Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

17 June 2018

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17 June 2018

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The search for antiaging interventions: from elixirs to fasting regimens

17 June 2018

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Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2

17 June 2018

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Metformin lowers Ser-129 phosphorylated α-synuclein levels via mTOR-dependent protein phosphatase 2A activation.

17 June 2018

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Effect of metformin on left ventricular function after acute myocardial infarction in patients without diabetes: the GIPS-III randomized clinical trial

17 June 2018

1 reference

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Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk.

17 June 2018

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Antidiabetic drugs and their potential role in treating mild cognitive impairment and Alzheimer's disease

17 June 2018

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Metformin limits ceramide-induced senescence in C2C12 myoblasts

17 June 2018

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Acarbose, 17-α-estradiol, and nordihydroguaiaretic acid extend mouse lifespan preferentially in males

17 June 2018

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Increased risk of cognitive impairment in patients with diabetes is associated with metformin

17 June 2018

1 reference

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Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program

17 June 2018

1 reference

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Metformin improves healthspan and lifespan in mice

17 June 2018

1 reference

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Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling

17 June 2018

1 reference

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Metformin-mediated growth inhibition involves suppression of the IGF-I receptor signalling pathway in human pancreatic cancer cells

17 June 2018

1 reference

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Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

17 June 2018

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Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-κB activation

17 June 2018

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17 June 2018

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mTOR is a key modulator of ageing and age-related disease

17 June 2018

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Chronic metformin associated cardioprotection against infarction: not just a glucose lowering phenomenon.

17 June 2018

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Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

17 June 2018

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17 June 2018

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The critical role of metabolic pathways in aging

17 June 2018

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Rapamycin slows aging in mice

17 June 2018

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Long-term safety, tolerability, and weight loss associated with metformin in the Diabetes Prevention Program Outcomes Study

17 June 2018

1 reference

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Metformin reduces endogenous reactive oxygen species and associated DNA damage

17 June 2018

1 reference

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Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin

17 June 2018

1 reference

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Caveolin-1 is essential for metformin inhibitory effect on IGF1 action in non-small-cell lung cancer cells

17 June 2018

1 reference

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Potent anti-proliferative effects of metformin on trastuzumab-resistant breast cancer cells via inhibition of erbB2/IGF-1 receptor interactions.

17 June 2018

1 reference

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Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

If started early in life, metformin treatment increases life span and postpones tumors in female SHR mice.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Type 2 diabetes increases and metformin reduces total, colorectal, liver and pancreatic cancer incidences in Taiwanese: a representative population prospective cohort study of 800,000 individuals

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Metformin and cancer occurrence in insulin-treated type 2 diabetic patients

17 June 2018

1 reference

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Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

17 June 2018

1 reference

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Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

17 June 2018

1 reference

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17 June 2018

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Metformin supplementation and life span in Fischer-344 rats

17 June 2018

1 reference

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Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1

17 June 2018

1 reference

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Metformin associated with lower cancer mortality in type 2 diabetes: ZODIAC-16

17 June 2018

1 reference

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

17 June 2018

1 reference

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New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

17 June 2018

1 reference

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17 June 2018

1 reference

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Long-term effects of metformin on metabolism and microvascular and macrovascular disease in patients with type 2 diabetes mellitus

17 June 2018

1 reference

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Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice

17 June 2018

1 reference

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An Aging Interventions Testing Program: study design and interim report

17 June 2018

1 reference

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Intensive lifestyle intervention or metformin on inflammation and coagulation in participants with impaired glucose tolerance

17 June 2018

1 reference

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Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin

17 June 2018

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17 June 2018

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Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group

17 June 2018

1 reference

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Type 2 diabetes in the elderly: an assessment of metformin (metformin in the elderly).

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Effect of Metformin on Breast Ductal Carcinoma In Situ Proliferation in a Randomized Presurgical Trial.

17 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Metformin activates a duodenal Ampk-dependent pathway to lower hepatic glucose production in rats.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Activation of AMPK by metformin inhibits TGF-β-induced collagen production in mouse renal fibroblasts

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Type 2 diabetes and antidiabetic medications in relation to dementia diagnosis

22 August 2018

1 reference

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Metformin may produce antidepressant effects through improvement of cognitive function among depressed patients with diabetes mellitus

22 August 2018

1 reference

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22 August 2018

1 reference

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Long-term metformin usage and cognitive function among older adults with diabetes

22 August 2018

1 reference

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Diabetes, metformin use, and colon cancer: a population-based cohort study in Taiwan.

22 August 2018

1 reference

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Metformin extends life span of HER-2/neu transgenic mice and in combination with melatonin inhibits growth of transplantable tumors in vivo.

22 August 2018

1 reference

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Metformin decreases IGF1-induced cell proliferation and protein synthesis through AMP-activated protein kinase in cultured bovine granulosa cells

22 August 2018

1 reference

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The cardiovascular effects of metformin: further reasons to consider an old drug as a cornerstone in the therapy of type 2 diabetes mellitus.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Metformin slows down aging and extends life span of female SHR mice.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Metformin therapy in a transgenic mouse model of Huntington's disease.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

The ROS production induced by a reverse-electron flux at respiratory-chain complex 1 is hampered by metformin.

22 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5943638

Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls

22 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/27304507

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CMET.2016.05.011

1 reference

15 June 2018

PMC publication ID

5943638

1 reference

15 June 2018

PubMed publication ID

27304507

1 reference

15 June 2018