Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing (Q38959510)

8 September 2017

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title

Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing (English)

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8 September 2017

Qi Chen

1

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8 September 2017

Lijun Sun

series ordinal

2

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8 September 2017

Zhijian J Chen

series ordinal

3

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8 September 2017

language of work or name

English

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publication date

1 September 2016

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8 September 2017

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8 September 2017

17

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8 September 2017

10

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8 September 2017

1142-1149

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Microbial sensing by Toll-like receptors and intracellular nucleic acid sensors

8 September 2017

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Inflammasomes: mechanism of assembly, regulation and signalling

21 January 2018

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Viral RNA detection by RIG-I-like receptors

21 January 2018

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The cGAS-cGAMP-STING pathway of cytosolic DNA sensing and signaling

21 January 2018

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Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

21 January 2018

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The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop

21 January 2018

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Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization

21 January 2018

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Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

21 January 2018

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Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

21 January 2018

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Structural mechanism of cytosolic DNA sensing by cGAS

21 January 2018

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Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA

21 January 2018

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Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

21 January 2018

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The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING

21 January 2018

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cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING.

21 January 2018

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STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

21 January 2018

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The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation

21 January 2018

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Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response

21 January 2018

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STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity

21 January 2018

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STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease

21 January 2018

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STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway

21 January 2018

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IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway

21 January 2018

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Triggering the interferon antiviral response through an IKK-related pathway

21 January 2018

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Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA

21 January 2018

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Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing

21 January 2018

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Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway

21 January 2018

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Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity

21 January 2018

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A diverse range of gene products are effectors of the type I interferon antiviral response

21 January 2018

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Positive feedback regulation of type I IFN production by the IFN-inducible DNA sensor cGAS

21 January 2018

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RNA polymerase III detects cytosolic DNA and induces type I interferons through the RIG-I pathway

21 January 2018

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Deregulation of STING Signaling in Colorectal Carcinoma Constrains DNA Damage Responses and Correlates With Tumorigenesis

21 January 2018

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Lack of immunological DNA sensing in hepatocytes facilitates hepatitis B virus infection

21 January 2018

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T cells detect intracellular DNA but fail to induce type I IFN responses: implications for restriction of HIV replication

21 January 2018

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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs

21 January 2018

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Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP.

21 January 2018

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Transmission of innate immune signaling by packaging of cGAMP in viral particles

21 January 2018

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Viruses transfer the antiviral second messenger cGAMP between cells

21 January 2018

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Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

21 January 2018

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Cyclic di-GMP sensing via the innate immune signaling protein STING

21 January 2018

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Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system

21 January 2018

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Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

21 January 2018

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Structural Analysis of the STING Adaptor Protein Reveals a Hydrophobic Dimer Interface and Mode of Cyclic di-GMP Binding

21 January 2018

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Ligand-induced Ordering of the C-terminal Tail Primes STING for Phosphorylation by TBK1

21 January 2018

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Molecular basis for the specific recognition of the metazoan cyclic GMP-AMP by the innate immune adaptor protein STING.

21 January 2018

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Anticancer flavonoids are mouse-selective STING agonists.

21 January 2018

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Mouse, but not human STING, binds and signals in response to the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid

21 January 2018

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Species-specific detection of the antiviral small-molecule compound CMA by STING

21 January 2018

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Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation

21 January 2018

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Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling

21 January 2018

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TRIM32 protein modulates type I interferon induction and cellular antiviral response by targeting MITA/STING protein for K63-linked ubiquitination

21 January 2018

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The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA

21 January 2018

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The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING.

21 January 2018

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The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA

21 January 2018

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TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING

21 January 2018

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Activation of STING requires palmitoylation at the Golgi.

21 January 2018

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21 January 2018

Immune sensing of DNA

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TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

21 January 2018

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The AIM2-like Receptors Are Dispensable for the Interferon Response to Intracellular DNA.

21 January 2018

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PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1.

21 January 2018

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Crosstalk between the cGAS DNA sensor and Beclin-1 autophagy protein shapes innate antimicrobial immune responses

21 January 2018

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cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells

21 January 2018

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cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection

21 January 2018

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Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS

21 January 2018

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Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein

21 January 2018

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Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses

21 January 2018

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Pivotal roles of cGAS-cGAMP signaling in antiviral defense and immune adjuvant effects

21 January 2018

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Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity

21 January 2018

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Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING.

21 January 2018

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HIV-1 evades innate immune recognition through specific cofactor recruitment

21 January 2018

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The capsids of HIV-1 and HIV-2 determine immune detection of the viral cDNA by the innate sensor cGAS in dendritic cells.

21 January 2018

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Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses

21 January 2018

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RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

21 January 2018

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The cell biology of Listeria monocytogenes infection: the intersection of bacterial pathogenesis and cell-mediated immunity

21 January 2018

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The Cytosolic Sensor cGAS Detects Mycobacterium tuberculosis DNA to Induce Type I Interferons and Activate Autophagy

21 January 2018

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Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1.

21 January 2018

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Cyclic GMP-AMP Synthase Is an Innate Immune DNA Sensor for Mycobacterium tuberculosis

21 January 2018

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Listeria monocytogenes induces IFNβ expression through an IFI16-, cGAS- and STING-dependent pathway

21 January 2018

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cGAS and Ifi204 cooperate to produce type I IFNs in response to Francisella infection

21 January 2018

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The DNA sensor, cyclic GMP-AMP synthase, is essential for induction of IFN-β during Chlamydia trachomatis infection.

21 January 2018

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Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

21 January 2018

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Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production

21 January 2018

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HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

21 January 2018

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DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway

21 January 2018

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Type I interferonopathies: mendelian type I interferon up-regulation

21 January 2018

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Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome

21 January 2018

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Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

21 January 2018

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Autoimmunity initiates in nonhematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease

21 January 2018

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RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.

21 January 2018

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Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response

21 January 2018

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Biochemical properties of mammalian TREX1 and its association with DNA replication and inherited inflammatory disease

21 January 2018

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Trex1 exonuclease degrades ssDNA to prevent chronic checkpoint activation and autoimmune disease

21 January 2018

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Requirement of DNase II for definitive erythropoiesis in the mouse fetal liver

21 January 2018

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Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

21 January 2018

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Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

21 January 2018

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Activated STING in a vascular and pulmonary syndrome

21 January 2018

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Interferons, immunity and cancer immunoediting

21 January 2018

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Type I interferon response and innate immune sensing of cancer

21 January 2018

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Endogenous and pharmacologic targeting of the STING pathway in cancer immunotherapy

21 January 2018

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STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.

21 January 2018

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STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors.

21 January 2018

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c-kit(+) cells adopt vascular endothelial but not epithelial cell fates during lung maintenance and repair.

21 January 2018

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STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity

21 January 2018

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Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

21 January 2018

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Cutting edge: DNA sensing via the STING adaptor in myeloid dendritic cells induces potent tolerogenic responses

21 January 2018

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STING Promotes the Growth of Tumors Characterized by Low Antigenicity via IDO Activation

21 January 2018

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Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer

21 January 2018

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CD47 blockade triggers T cell-mediated destruction of immunogenic tumors

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27648547

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1038/NI.3558

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8 September 2017

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