ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets (Q39070125)

8 September 2017

title

ARF triggers senescence in Brca2-deficient cells by altering the spectrum of p53 transcriptional targets (English)

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8 September 2017

1

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3 June 2020

Panagiotis Kotsantis

3

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3 June 2020

Peter Bouwman

5

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3 June 2020

Gonzalo Gómez-López

9

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3 June 2020

David G. Pisano

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3 June 2020

author name string

Jose Miguel Escandell

2

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3 June 2020

Natsuko Suwaki

4

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3 June 2020

Sophie Badie

6

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3 June 2020

Cecilia Folio

7

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3 June 2020

Jos Jonkers

11

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3 June 2020

Madalena Tarsounas

12

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3 June 2020

Javier Benitez

8

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3 June 2020

language of work or name

English

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publication date

1 January 2013

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8 September 2017

published in

Nature Communications

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3 June 2020

volume

4

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3 June 2020

page(s)

2697

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Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all.

3 June 2020

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Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2

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The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53

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p53-Dependent and -independent functions of the Arf tumor suppressor

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Self-excising retroviral vectors encoding the Cre recombinase overcome Cre-mediated cellular toxicity

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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The alternative product from the human CDKN2A locus, p14(ARF), participates in a regulatory feedback loop with p53 and MDM2.

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Differential requirement for p19ARF in the p53-dependent arrest induced by DNA damage, microtubule disruption, and ribonucleotide depletion

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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DNA end resection--unraveling the tail

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BRCA1 functions independently of homologous recombination in DNA interstrand crosslink repair

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A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

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Molecular views of recombination proteins and their control

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BRCA2 acts as a RAD51 loader to facilitate telomere replication and capping

21 January 2018

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Discovery of potent and selective inhibitors of ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase as potential anticancer agents.

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Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

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Combining ATR suppression with oncogenic Ras synergistically increases genomic instability, causing synthetic lethality or tumorigenesis in a dosage-dependent manner

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Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses

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Blinded by the Light: The Growing Complexity of p53

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Profiling of residual breast cancers after neoadjuvant chemotherapy identifies DUSP4 deficiency as a mechanism of drug resistance

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Clonogenic assay of cells in vitro.

21 January 2018

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Telomeres, stem cells, senescence, and cancer

21 January 2018

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Promoter hypermethylation and homozygous deletion of the p14ARF and p16INK4a genes in oligodendrogliomas.

21 January 2018

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7 January 2021

Telomeres, stem cells, senescence, and cancer

1 reference

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7 January 2021

p53 mutations in BRCA1-associated familial breast cancer

1 reference

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7 January 2021

A third-generation lentivirus vector with a conditional packaging system

1 reference

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7 January 2021

Model-based variance-stabilizing transformation for Illumina microarray data.

1 reference

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7 January 2021

Identifiers

DOI

10.1038/NCOMMS3697

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24162189%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

3 June 2020

ADS bibcode

2013NatCo...4.2697C

0 references

1047103985

0 references

1 reference

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