Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity (Q39182810)

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scientific article published on 8 March 2013

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English	Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity	scientific article published on 8 March 2013

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scholarly article

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Europe PubMed Central

9 September 2017

Coordinate changes in histone modifications, mRNA levels, and metabolite profiles in clonal INS-1 832/13 β-cells accompany functional adaptations to lipotoxicity (English)

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Europe PubMed Central

9 September 2017

object named as

Siri Malmgren

1

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object named as

Peter Spégel

2

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object named as

Charlotte Ling

9

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object named as

Hindrik Mulder

8

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author name string

Anders P H Danielsson

3

1 reference

Europe PubMed Central

9 September 2017

Cecilia L Nagorny

4

1 reference

Europe PubMed Central

9 September 2017

Lotta E Andersson

5

1 reference

Europe PubMed Central

9 September 2017

Marloes Dekker Nitert

6

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Europe PubMed Central

9 September 2017

Martin Ridderstråle

7

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Europe PubMed Central

9 September 2017

language of work or name

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publication date

8 March 2013

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Europe PubMed Central

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Journal of Biological Chemistry

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Europe PubMed Central

9 September 2017

288

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Europe PubMed Central

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11973-11987

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Europe PubMed Central

9 September 2017

17

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Europe PubMed Central

9 September 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3636884/fullTextXML

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inferred from PubMed Central ID database lookup

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Chromatin modifications associated with diabetes

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Increased DNA methylation and decreased expression of PDX-1 in pancreatic islets from patients with type 2 diabetes

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DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

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Glycemic memory

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Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c

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Tight coupling between glucose and mitochondrial metabolism in clonal beta-cells is required for robust insulin secretion

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Methyltransferase Set7/9 maintains transcription and euchromatin structure at islet-enriched genes

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Glucolipotoxicity: fuel excess and beta-cell dysfunction.

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Chromatin modifications and their function

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Metabolic memory in diabetes--focus on insulin

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The malate-aspartate NADH shuttle member Aralar1 determines glucose metabolic fate, mitochondrial activity, and insulin secretion in beta cells

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Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets

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Biochemical mechanism of lipid-induced impairment of glucose-stimulated insulin secretion and reversal with a malate analogue

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Chronic effects of fatty acids on pancreatic beta-cell function: new insights from functional genomics.

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Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes

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Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function

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Differentiation of glucose toxicity from beta cell exhaustion during the evolution of defective insulin gene expression in the pancreatic islet cell line, HIT-T15

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15 June 2018

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15 June 2018

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21 August 2018

Glucolipotoxicity alters lipid partitioning and causes mitochondrial dysfunction, cholesterol, and ceramide deposition and reactive oxygen species production in INS832/13 ss-cells

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21 August 2018

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21 August 2018

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A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation

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based on heuristic

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https://pubmed.ncbi.nlm.nih.gov/23476019

12 December 2020

based on heuristic

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Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro

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Identifiers

10.1074/JBC.M112.422527

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

1 reference

Europe PubMed Central

9 September 2017

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