TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway (Q39218682)

10 September 2017

TLR4 activation under lipotoxic conditions leads to synergistic macrophage cell death through a TRIF-dependent pathway (English)

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10 September 2017

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Joel D Schilling

1

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10 September 2017

Heather M Machkovech

2

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10 September 2017

Li He

3

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10 September 2017

Abhinav Diwan

4

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10 September 2017

Jean E Schaffer

5

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10 September 2017

language of work or name

English

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publication date

28 December 2012

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10 September 2017

Journal of Immunology

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10 September 2017

190

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10 September 2017

3

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10 September 2017

1285-1296

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TRIF licenses caspase-11-dependent NLRP3 inflammasome activation by gram-negative bacteria

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

PGC-1α rescues Huntington's disease proteotoxicity by preventing oxidative stress and promoting TFEB function.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Eosinophil contamination of thioglycollate-elicited peritoneal macrophage cultures skews the functional readouts of in vitro assays

10 September 2017

1 reference

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Lysosomal pathways to cell death and their therapeutic applications.

10 September 2017

1 reference

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Dietary fatty acids in metabolic syndrome, diabetes and cardiovascular diseases.

10 September 2017

1 reference

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Enhancing lysosome biogenesis attenuates BNIP3-induced cardiomyocyte death

10 September 2017

1 reference

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Increased macrophage migration into adipose tissue in obese mice

10 September 2017

1 reference

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Macrophage-mediated inflammation in metabolic disease

10 September 2017

1 reference

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Lysosomes and lysosomal cathepsins in cell death

10 September 2017

1 reference

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Transcriptional activation of lysosomal exocytosis promotes cellular clearance

10 September 2017

1 reference

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cIAPs block Ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoforms

10 September 2017

1 reference

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Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling

10 September 2017

1 reference

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HMGB1 is a therapeutic target for sterile inflammation and infection

10 September 2017

1 reference

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TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

10 September 2017

1 reference

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Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death

10 September 2017

1 reference

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10 September 2017

1 reference

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Innate immune mechanisms in ischemia/reperfusion.

10 September 2017

1 reference

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Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart

10 September 2017

1 reference

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Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

10 September 2017

1 reference

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Streptozocin-induced diabetic mouse model of urinary tract infection.

10 September 2017

1 reference

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A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

TLR4 links innate immunity and fatty acid-induced insulin resistance

10 September 2017

1 reference

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Multiple roles of Toll-like receptor signaling in atherosclerosis

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Role of HMGB1 in cardiovascular diseases

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Apoptosis induced by the toll-like receptor adaptor TRIF is dependent on its receptor interacting protein homotypic interaction motif

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

10 September 2017

TLR signaling pathways

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Triglyceride accumulation protects against fatty acid-induced lipotoxicity

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Toll receptors and pathogen resistance

10 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3552058

Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling

10 September 2017

1 reference

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Mechanisms of lipoapoptosis: implications for human heart disease

10 September 2017

1 reference

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Lysosomal membrane damage in soluble Abeta-mediated cell death in Alzheimer's disease

10 September 2017

1 reference

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Critical roles of Toll-like receptors in host defense.

10 September 2017

1 reference

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Infections in patients with diabetes mellitus

10 September 2017

1 reference

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Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components

10 September 2017

1 reference

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MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways

10 September 2017

1 reference

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Fatty acid binding to plasma albumin

10 September 2017

1 reference

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Modulation of cellular S1P levels with a novel, potent and specific inhibitor of sphingosine kinase-1.

10 September 2017

1 reference

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Pathogenic lysosomal depletion in Parkinson's disease

10 September 2017

1 reference

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Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

14 September 2017

1 reference

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Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells

14 September 2017

1 reference

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Lysosomal protease pathways to apoptosis. Cleavage of bid, not pro-caspases, is the most likely route

14 September 2017

1 reference

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Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction

25 September 2017

1 reference

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Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart

25 September 2017

1 reference

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Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice

17 June 2018

1 reference

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Decreased cardiolipin synthesis corresponds with cytochrome c release in palmitate-induced cardiomyocyte apoptosis

17 June 2018

1 reference

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Increases in serum unbound free fatty acid levels following coronary angioplasty

17 June 2018

1 reference

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TFEB, a novel mTORC1 effector implicated in lysosome biogenesis, endocytosis and autophagy

17 June 2018

1 reference

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Myocardial infarction and heart failure in the db/db diabetic mouse

21 August 2018

1 reference

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Saturated and polyunsaturated fatty acids reciprocally modulate dendritic cell functions mediated through TLR4.

21 August 2018

1 reference

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Heat shock protein 70 promotes cell survival by inhibiting lysosomal membrane permeabilization

21 August 2018

1 reference

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Saturated fatty acids synergize with elevated glucose to cause pancreatic beta-cell death

21 August 2018

1 reference

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Characterization of fatty acid oxidation in human muscle mitochondria and myoblasts.

21 August 2018

1 reference

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Palmitate-induced apoptosis can occur through a ceramide-independent pathway

21 August 2018

1 reference

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21 August 2018

1 reference

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21 August 2018

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Early glomerular macrophage recruitment in streptozotocin-induced diabetic rats

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Identifiers

DOI

10.4049/JIMMUNOL.1202208

1 reference

10 September 2017

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10 September 2017

PubMed publication ID

23275600

1 reference