Toward a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system (Q39420866)

11 September 2017

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title

Toward a structural understanding of nucleic acid-sensing Toll-like receptors in the innate immune system (English)

1 reference

11 September 2017

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Zhikuan Zhang

1

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11 September 2017

Umeharu Ohto

series ordinal

2

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11 September 2017

Toshiyuki Shimizu

series ordinal

3

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11 September 2017

language of work or name

English

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publication date

7 July 2017

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11 September 2017

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Pattern recognition receptors and inflammation

11 September 2017

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

A human homologue of the Drosophila Toll protein signals activation of adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Toll-like receptors in autoimmunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Therapeutic targeting of microRNAs: current status and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structure-Based Design of Human TLR8-Specific Agonists with Augmented Potency and Adjuvanticity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

A Toll-like receptor recognizes bacterial DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Determinants of activity at human Toll-like receptors 7 and 8: quantitative structure-activity relationship (QSAR) of diverse heterocyclic scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

TLR13 recognizes bacterial 23S rRNA devoid of erythromycin resistance-forming modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Toll like receptors and autoimmunity: a critical appraisal

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Emerging roles of TLR7 and TLR9 in murine SLE.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Vaccine adjuvants: putting innate immunity to work

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Ad26/MVA therapeutic vaccination with TLR7 stimulation in SIV-infected rhesus monkeys

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

TLR3-specific double-stranded RNA oligonucleotide adjuvants induce dendritic cell cross-presentation, CTL responses, and antiviral protection

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Sustained efficacy and seroconversion with the Toll-like receptor 7 agonist GS-9620 in the Woodchuck model of chronic hepatitis B

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Leucine-rich repeats and pathogen recognition in Toll-like receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Comparative sequence analysis of leucine-rich repeats (LRRs) within vertebrate toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The structural biology of Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structural aspects of nucleic acid-sensing Toll-like receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structural Analysis Reveals that Toll-like Receptor 7 Is a Dual Receptor for Guanosine and Single-Stranded RNA.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structural reorganization of the Toll-like receptor 8 dimer induced by agonistic ligands

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Nucleic acid-sensing TLRs: trafficking and regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Characterization of bovine Toll-like receptor 8: ligand specificity, signaling essential sites and dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Ligand-induced conformational changes allosterically activate Toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Toll-like receptor 8 senses degradation products of single-stranded RNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Dimerization of Toll-like receptor 3 (TLR3) is required for ligand binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The TLR3 signaling complex forms by cooperative receptor dimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Small interfering RNAs mediate sequence-independent gene suppression and induce immune activation by signaling through toll-like receptor 3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Classification, mechanisms of action, and therapeutic applications of inhibitory oligonucleotides for Toll-like receptors (TLR) 7 and 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Of mice and man: TLR11 (finally) finds profilin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

A novel Toll-like receptor that recognizes vesicular stomatitis virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: Activation of Toll-like receptor 7

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Guanosine and its modified derivatives are endogenous ligands for TLR7.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Physiological concentrations of purines and pyrimidines

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The concentrative nucleoside transporter family, SLC28

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The equilibrative nucleoside transporter family, SLC29

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Nucleoside transporters: from scavengers to novel therapeutic targets

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Urinary 8-OHdG: a marker of oxidative stress to DNA and a risk factor for cancer, atherosclerosis and diabetics.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

UNC93B1 mediates differential trafficking of endosomal TLRs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

LRRC59 Regulates Trafficking of Nucleic Acid-Sensing TLRs from the Endoplasmic Reticulum via Association with UNC93B1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Primary blood neutrophils express a functional cell surface Toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Nucleic acid-sensing TLRs and autoimmunity: novel insights from structural and cell biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Processing of human toll-like receptor 7 by furin-like proprotein convertases is required for its accumulation and activity in endosomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Essential role for Toll-like receptor 7 (TLR7)-unique cysteines in an intramolecular disulfide bond, proteolytic cleavage and RNA sensing

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Endosomal localization of TLR8 confers distinctive proteolytic processing on human myeloid cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Identification of an N-terminal recognition site in TLR9 that contributes to CpG-DNA-mediated receptor activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Cleavage of Toll-like receptor 3 by cathepsins B and H is essential for signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Proteolytic processing regulates Toll-like receptor 3 stability and endosomal localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Cleaved/associated TLR3 represents the primary form of the signaling receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Autoinhibition and relief mechanism by the proteolytic processing of Toll-like receptor 8.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The phagocytes: neutrophils and monocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Mechanisms of pathogen entry through the endosomal compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Autophagy-dependent viral recognition by plasmacytoid dendritic cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Unveiling the roles of autophagy in innate and adaptive immunity

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Virus entry by endocytosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Toll-like receptor-independent gene induction program activated by mammalian DNA escaped from apoptotic DNA degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Features of systemic lupus erythematosus in Dnase1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Mutation of DNASE1 in people with systemic lupus erythematosus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Mutations in SLC29A3, encoding an equilibrative nucleoside transporter ENT3, cause a familial histiocytosis syndrome (Faisalabad histiocytosis) and familial Rosai-Dorfman disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. turtle nija occasionally

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Lysosomal acidification mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Negative regulation of signaling by a soluble form of toll-like receptor 9.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Soluble TLR2 reduces inflammation without compromising bacterial clearance by disrupting TLR2 triggering

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Phagocytosis of apoptotic cells in homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

The TIM and TAM families of phosphatidylserine receptors mediate dengue virus entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

TAM receptors are pleiotropic inhibitors of the innate immune response

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

TAM receptor signaling and autoimmune disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Enveloped viruses disable innate immune responses in dendritic cells by direct activation of TAM receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

Association analysis identifies TLR7 and TLR8 as novel risk genes in asthma and related disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2F1873-3468.12749

21 January 2018

Identifiers

DOI

10.1002/1873-3468.12749

1 reference

11 September 2017

1 reference