SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells (Q39523760)

12 September 2017

SIRT1 RNAi knockdown induces apoptosis and senescence, inhibits invasion and enhances chemosensitivity in pancreatic cancer cells (English)

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12 September 2017

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G Zhao

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J Cui

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J-G Zhang

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Q Qin

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Q Chen

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T Yin

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S-C Deng

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Y Liu

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L Liu

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B Wang

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K Tian

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G-B Wang

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C-Y Wang

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language of work or name

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16 June 2011

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https://scigraph.springernature.com/pub.10.1038/gt.2011.81

12 September 2017

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Sirtuins as potential targets for metabolic syndrome

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Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction

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hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

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Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

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Mammalian SIRT1 represses forkhead transcription factors

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Sirtuins in mammals: insights into their biological function

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Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

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The fundamental role of epigenetic events in cancer

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SIRT1 is significantly elevated in mouse and human prostate cancer.

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Histone deacetylases in acute myeloid leukaemia show a distinctive pattern of expression that changes selectively in response to deacetylase inhibitors.

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Function of the SIRT1 protein deacetylase in cancer

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Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells

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The significances of lymph node micrometastasis and its correlation with E-cadherin expression in pT1-T3N0 gastric adenocarcinoma

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Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.

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SIRT1: tumor promoter or tumor suppressor?

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SirT1 is an inhibitor of proliferation and tumor formation in colon cancer

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Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer.

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Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cells

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Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

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Overexpression of neuropilin-1 promotes constitutive MAPK signalling and chemoresistance in pancreatic cancer cells

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High histone deacetylase 7 (HDAC7) expression is significantly associated with adenocarcinomas of the pancreas.

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SIRT1 expression is associated with poor prognosis of diffuse large B-cell lymphoma

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Expression of DBC1 and SIRT1 is associated with poor prognosis for breast carcinoma

21 January 2018

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Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma

21 January 2018

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SIRT1 histone deacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer.

21 January 2018

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Expression and prognostic significance of SIRT1 in ovarian epithelial tumours

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Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes

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Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition?

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Phosphorylation of forkhead transcription factors by erythropoietin and stem cell factor prevents acetylation and their interaction with coactivator p300 in erythroid progenitor cells

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p53, the cellular gatekeeper for growth and division

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Double identity for proteins of the Bcl-2 family

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Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation

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The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation

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Caspase-3 activation downstream from reactive oxygen species in heat-induced apoptosis of pancreatic carcinoma cells carrying a mutant p53 gene

21 January 2018

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 January 2018

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Autocrine motility factor signaling enhances pancreatic cancer metastasis

21 January 2018

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Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

21 January 2018

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Involvement of mitochondria and caspase pathways in N-demethyl-clarithromycin-induced apoptosis in human cervical cancer HeLa cell

21 January 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Sirt1 inhibitor, Sirtinol, induces senescence-like growth arrest with attenuated Ras-MAPK signaling in human cancer cells

1 reference

https://api.crossref.org/works/10.1038%2FGT.2011.81

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/GT.2011.81

1 reference

Dimensions Publication ID

12 September 2017

1004192321

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Fatcat ID

release_ut3cggeanrhapkbkkyayf7ai7a

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1 reference