The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity. (Q40227600)

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19 December 2019

title

The kinase-inhibitory domain of p21-activated kinase 1 (PAK1) inhibits cell cycle progression independent of PAK1 kinase activity (English)

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19 December 2019

2

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19 December 2019

Jonathan Chernoff

4

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19 December 2019

Staffan Strömblad

5

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19 December 2019

author name string

M Thullberg

1

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19 December 2019

A Beeser

3

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19 December 2019

language of work or name

English

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publication date

25 September 2006

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19 December 2019

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19 December 2019

volume

26

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19 December 2019

issue

12

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19 December 2019

page(s)

1820-1828

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Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1

19 December 2019

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p21-activated Kinase-1 Signaling Mediates Cyclin D1 Expression in Mammary Epithelial and Cancer Cells

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Detailed map of a region commonly amplified at 11q13-->q14 in human breast carcinoma

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Interaction of the Nck adapter protein with p21-activated kinase (PAK1)

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Human Ste20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway

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Pak regulates calpain-dependent degradation of E3b1.

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The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity

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Ste20-like protein kinases are required for normal localization of cell growth and for cytokinesis in budding yeast.

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Phosphorylation of RhoGDI by Pak1 mediates dissociation of Rac GTPase

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The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1

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PAK-family kinases regulate cell and actin polarization throughout the cell cycle of Saccharomyces cerevisiae

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p21-activated kinases: three more join the Pak.

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BetaPix-enhanced p38 activation by Cdc42/Rac/PAK/MKK3/6-mediated pathway. Implication in the regulation of membrane ruffling

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Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch

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Essential role of CIB1 in regulating PAK1 activation and cell migration

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p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells

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Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.

21 January 2018

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Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

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A brain serine/threonine protein kinase activated by Cdc42 and Rac1

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PAK kinases are directly coupled to the PIX family of nucleotide exchange factors

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Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1

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Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system

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Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma

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p21-activated kinase 1 (Pak1) regulates cell motility in mammalian fibroblasts

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Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells

21 January 2018

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A modified tetracycline-regulated system provides autoregulatory, inducible gene expression in cultured cells and transgenic mice

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Adhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylation

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Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts

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Cell cycle-regulated phosphorylation of p21-activated kinase 1.

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Timing of cyclin D1 expression within G1 phase is controlled by Rho.

21 January 2018

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Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity

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The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

21 January 2018

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A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1.

21 January 2018

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Regulatable Expression of p21-activated Kinase-1 Promotes Anchorage-independent Growth and Abnormal Organization of Mitotic Spindles in Human Epithelial Breast Cancer Cells

21 January 2018

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Function of the Rho family GTPases in Ras-stimulated Raf activation

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inferred from DOI database lookup

7 January 2021

based on heuristic

Ubiquitin/proteasome-mediated degradation of p19INK4d determines its periodic expression during the cell cycle

1 reference

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1209983

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17001318%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

19 December 2019

1018490809

0 references

1 reference