A Human-Based Integrated Framework for Alzheimer's Disease Research (Q40507217)

21 September 2017

A Human-Based Integrated Framework for Alzheimer's Disease Research (English)

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21 September 2017

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Francesca Pistollato

1

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PubMed ID

26401764

21 September 2017

Sarah E Cavanaugh

series ordinal

2

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PubMed ID

26401764

21 September 2017

P Charukeshi Chandrasekera

series ordinal

3

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21 September 2017

1 August 2015

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Journal of Alzheimer's Disease

21 September 2017

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21 September 2017

47

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21 September 2017

4

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21 September 2017

857-868

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Creative Commons Attribution-NonCommercial 4.0 International

21 September 2017

start time

11 August 2015

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Alzheimer disease in the United States (2010-2050) estimated using the 2010 census

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Is Alzheimer's disease related to metabolic syndrome? A Wnt signaling conundrum

21 January 2018

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Considering a new paradigm for Alzheimer's disease research

21 January 2018

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Thirty years of Alzheimer's disease genetics: the implications of systematic meta-analyses

21 January 2018

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APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150281

Alzheimer's disease genetics: current knowledge and future challenges

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150281

Tau-mediated neurodegeneration in Alzheimer's disease and related disorders

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150281

A three-dimensional human neural cell culture model of Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

The genetics of Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction

21 January 2018

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Alzheimer disease models and human neuropathology: similarities and differences

21 January 2018

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Animal models of Alzheimer disease: historical pitfalls and a path forward

21 January 2018

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Stem cell models of Alzheimer's disease and related neurological disorders

21 January 2018

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https://api.crossref.org/works/10.3233%2FJAD-150281

Look back in anger - what clinical studies tell us about preclinical work

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Role of Genes and Environments for Explaining Alzheimer Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Clinical features of sporadic and familial Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Cardiovascular Risk Factors for Alzheimer's Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Socioeconomic status as a risk factor for dementia death: individual participant meta-analysis of 86 508 men and women from the UK.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Cognitive activity, education and socioeconomic status as preventive factors for mild cognitive impairment and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Systematic review of the effect of education on survival in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Physical activity attenuates age-related biomarker alterations in preclinical AD

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

The sleep-wake cycle and Alzheimer's disease: what do we know?

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

'The clocks that time us'--circadian rhythms in neurodegenerative disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Sleep and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Amyloid-β diurnal pattern: possible role of sleep in Alzheimer's disease pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Sleep and Alzheimer disease pathology--a bidirectional relationship

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Air pollution, oxidative stress, and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Cigarette smoking is a risk factor for Alzheimer's Disease: an analysis controlling for tobacco industry affiliation

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Copper excess, zinc deficiency, and cognition loss in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Proinflammatory cytokines, aging, and age-related diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Association of Biomarkers for Inflammation, Endothelial Dysfunction and Oxidative Stress with Cognitive Impairment. The Epidemiology of Hearing Loss Study (EHLS).

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Thrombin, a mediator of cerebrovascular inflammation in AD and hypoxia

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Elevated levels of homocysteine compromise blood-brain barrier integrity in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Why is homocysteine toxic for the nervous and immune systems?

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Serum uric acid levels in patients with Alzheimer's disease: a meta-analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Serum metabolomic biomarkers of dementia

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Insulin resistance predicts brain amyloid deposition in late middle-aged adults.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Impaired glycemia increases disease progression in mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

The mitochondrial O-linked N-acetylglucosamine transferase (mOGT) in the diabetic patient could be the initial trigger to develop Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

HDL and cholesterol handling in the brain

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

The influence of vascular risk factors on cognitive decline in patients with dementia: a systematic review

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Associations between serum cholesterol levels and cerebral amyloidosis

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Possible role of orexin in the pathogenesis of Alzheimer disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Sleep disorders, obesity, and aging: the role of orexin

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Hypocretin (orexin) loss in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

YKL-40: a novel prognostic fluid biomarker for preclinical Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Clinical indications for analysis of Alzheimer's disease CSF biomarkers

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Supportive CSF biomarker evidence to enhance the National Institute on Aging-Alzheimer's Association criteria for diagnosis of Alzheimer's type dementia--a study from Southern India.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Discovering environmental causes of disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Role of environmental contaminants in the etiology of Alzheimer's disease: a review

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Environment, epigenetics and neurodegeneration: Focus on nutrition in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Food, nutrigenomics, and neurodegeneration--neuroprotection by what you eat!

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Omega-3 fatty acids: potential role in the management of early Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Potential benefits of adherence to the Mediterranean diet on cognitive health.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Effects of polyphenols on brain ageing and Alzheimer's disease: focus on mitochondria

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Nutrition, brain aging, and neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Conversion from mild cognitive impairment to dementia: influence of folic acid and vitamin B12 use in the VITA cohort.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Mediterranean diet habits in older individuals: associations with cognitive functioning and brain volumes.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Tractography: where do we go from here?

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

The Alzheimer structural connectome: changes in cortical network topology with increased amyloid plaque burden

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Improving dementia assessment by reducing sample heterogeneity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Induced pluripotent stem cells in the study of neurological diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Instant neurons: directed somatic cell reprogramming models of central nervous system disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Induced pluripotent stem cells as tools for disease modelling and drug discovery in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Induced pluripotent stem cells: a new tool to confront the challenge of neuropsychiatric disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Remodeling neurodegeneration: somatic cell reprogramming-based models of adult neurological disorders

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Microglial activation in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Investigations with cultured human microglia on pathogenic mechanisms of Alzheimer's disease and other neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Microengineered physiological biomimicry: organs-on-chips.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

The National Institutes of Health Microphysiological Systems Program focuses on a critical challenge in the drug discovery pipeline

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Learning in human neural networks on microelectrode arrays.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Short-term memory in networks of dissociated cortical neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Integrative genomics identifies APOE ε4 effectors in Alzheimer's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Phosphoproteome profiling of substantia nigra and cortex regions of Alzheimer's disease patients.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Chlorpyrifos PBPK/PD model for multiple routes of exposure.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Amyloid β peptide levels increase in brain of AβPP Swedish mice after exposure to chlorpyrifos.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Population PKPD modeling of BACE1 inhibitor-induced reduction in Aβ levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Computational design of apolipoprotein E4 inhibitors for Alzheimer's disease therapy from traditional Chinese medicine.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

CREB regulates the expression of neuronal glucose transporter 3: a possible mechanism related to impaired brain glucose uptake in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

S100B induces tau protein hyperphosphorylation via Dickopff-1 up-regulation and disrupts the Wnt pathway in human neural stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Toxicity testing in the 21st century: a vision and a strategy.

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Can animal models of disease reliably inform human studies?

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Drug development: Raise standards for preclinical cancer research

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Of mice and men: bridging the translational disconnect in CNS drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

A map of Alzheimer's disease-signaling pathways: a hope for drug target discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

National Institutes of Health funding for behavioral interventions to prevent chronic diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Structural networks in Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Genetics of Alzheimer’s Disease

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3233%2FJAD-150281

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

21 January 2018

1 reference

24 May 2022

https://opencitations.net/index/coci/api/v1/citations/10.1038/NATURE10821

Identifiers

DOI

10.3233/JAD-150281

1 reference

21 September 2017

1 reference

PubMed ID

26401764