APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity (Q40645640)

22 September 2017

APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity (English)

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22 September 2017

Laura Marlow

1

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22 September 2017

Rosa M Canet

2

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22 September 2017

Sharie J Haugabook

3

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22 September 2017

John A Hardy

4

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22 September 2017

Debomoy K Lahiri

5

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22 September 2017

Kumar Sambamurti

6

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22 September 2017

1 June 2003

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Biochemical and Biophysical Research Communications

22 September 2017

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22 September 2017

305

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22 September 2017

3

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22 September 2017

502-509

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Advances in the cellular and molecular biology of the beta-amyloid protein in Alzheimer's disease

22 September 2017

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

New frontiers in Alzheimer's disease genetics

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

A Novel γ-Secretase Assay Based on Detection of the Putative C-terminal Fragment-γ of Amyloid β Protein Precursor

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Nuclear access and action of notch in vivo

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Where Notch and Wnt signaling meet. The presenilin hub

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

In search of gamma-secretase: presenilin at the cutting edge

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Gamma-secretase: never more enigmatic

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Antisense-induced reduction of presenilin 1 expression selectively increases the production of amyloid beta42 in transfected cells.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Regulation of amyloid precursor protein processing by presenilin 1 (PS1) and PS2 in PS1 knockout cells.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

The role of presenilin cofactors in the gamma-secretase complex

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Cell-free assays for gamma-secretase activity

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Production of the Alzheimer amyloid beta protein by normal proteolytic processing

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

The role of the carboxyl-terminal fragments of amyloid precursor protein in Alzheimer's disease.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Glycosylphosphatidylinositol-anchored proteins play an important role in the biogenesis of the Alzheimer's amyloid beta-protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Rank-order of potencies for inhibition of the secretion of abeta40 and abeta42 suggests that both are generated by a single gamma-secretase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Presenilins are required for gamma-secretase cleavage of beta-APP and transmembrane cleavage of Notch-1

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Presenilin and gamma-secretase: structure meets function

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

No endogenous A beta production in presenilin-deficient fibroblasts.

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

spr-2, a suppressor of the egg-laying defect caused by loss of sel-12 presenilin in Caenorhabditis elegans, is a member of the SET protein subfamily

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

The proteolytic fragments of the Alzheimer's disease-associated presenilin-1 form heterodimers and occur as a 100-150-kDa molecular mass complex

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Nicastrin is required for gamma-secretase cleavage of the Drosophila Notch receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Interaction with telencephalin and the amyloid precursor protein predicts a ring structure for presenilins

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

7 January 2021

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https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

Familial Alzheimer's disease-linked presenilin 1 variants elevate Abeta1-42/1-40 ratio in vitro and in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2803%2900797-6

10.1016/S0006-291X(03)00797-6

7 January 2021

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DOI

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22 September 2017

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