Gene disruption in mice: models of development and disease (Q40861559)

24 September 2017

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title

Gene disruption in mice: models of development and disease (English)

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24 September 2017

Shastry BS

1

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24 September 2017

1 April 1998

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Molecular and Cellular Biochemistry

24 September 2017

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24 September 2017

181

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24 September 2017

1-2

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24 September 2017

163-179

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https://scigraph.springernature.com/pub.10.1023/a:1006865210012

24 September 2017

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cites work

Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

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12 December 2020

PDGF-A Signaling Is a Critical Event in Lung Alveolar Myofibroblast Development and Alveogenesis

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12 December 2020

Two genetically separable steps in the differentiation of thymic epithelium.

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12 December 2020

Augmented humoral and anaphylactic responses in Fc gamma RII-deficient mice

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12 December 2020

Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma

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12 December 2020

Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse.

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12 December 2020

Site-directed point mutations in embryonic stem cells: a gene-targeting tag-and-exchange strategy

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12 December 2020

Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice.

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12 December 2020

Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality

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12 December 2020

PCR-based gene targeting of the inducible nitric oxide synthase (NOS2) locus in murine ES cells, a new and more cost-effective approach

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12 December 2020

Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids

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12 December 2020

Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II.

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12 December 2020

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

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12 December 2020

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

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12 December 2020

Failure of B-cell differentiation in mice lacking the transcription factor EBF.

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12 December 2020

Role of transcription factors Brn-3.1 and Brn-3.2 in auditory and visual system development

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12 December 2020

Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors

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12 December 2020

Role of tissue factor in embryonic blood vessel development.

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12 December 2020

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor

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12 December 2020

apo B gene knockout in mice results in embryonic lethality in homozygotes and neural tube defects, male infertility, and reduced HDL cholesterol ester and apo A-I transport rates in heterozygotes

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12 December 2020

Disruption of the adenosine deaminase gene causes hepatocellular impairment and perinatal lethality in mice

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12 December 2020

Hyperresponsive B cells in CD22-deficient mice

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12 December 2020

Targeted disruption of mouse EGF receptor: effect of genetic background on mutant phenotype

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12 December 2020

Elevated blood pressures in mice lacking endothelial nitric oxide synthase.

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12 December 2020

Targeted deletion in astrocyte intermediate filament (Gfap) alters neuronal physiology

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12 December 2020

Shared role of the pRB-related p130 and p107 proteins in limb development

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12 December 2020

Neuronal deficits, not involving motor neurons, in mice lacking BDNF and/or NT4

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12 December 2020

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

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12 December 2020

An animal model for Norrie disease (ND): gene targeting of the mouse ND gene.

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12 December 2020

Semaphorin III is needed for normal patterning and growth of nerves, bones and heart

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12 December 2020

Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicates defects of epithelial-mesenchymal interaction

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12 December 2020

Immunodeficiency in protein kinase cbeta-deficient mice

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12 December 2020

Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.

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12 December 2020

Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration.

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12 December 2020

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

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12 December 2020

Neural tube defects and abnormal brain development in F52-deficient mice

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12 December 2020

E2F-1 functions in mice to promote apoptosis and suppress proliferation

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12 December 2020

Impairment of T-cell-dependent B-cell responses and B-1 cell development in CD19-deficient mice.

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12 December 2020

Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor.

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12 December 2020

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

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12 December 2020

Tumor induction and tissue atrophy in mice lacking E2F-1

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12 December 2020

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice

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12 December 2020

Impaired hippocampal plasticity in mice lacking the Cbeta1 catalytic subunit of cAMP-dependent protein kinase

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12 December 2020

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

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12 December 2020

Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice

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12 December 2020

Epilepsy and brain abnormalities in mice lacking the Otx1 gene

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12 December 2020

Targeted disruption of p107: functional overlap between p107 and Rb

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12 December 2020

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

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12 December 2020

Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice.

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12 December 2020

Requirement for LIM homeobox gene Isl1 in motor neuron generation reveals a motor neuron-dependent step in interneuron differentiation

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12 December 2020

Functional redundancy of the muscle-specific transcription factors Myf5 and myogenin

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12 December 2020

Single-copy transgenic mice with chosen-site integration

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12 December 2020

Keratin 12-deficient mice have fragile corneal epithelia

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12 December 2020

Essential role of Stat6 in IL-4 signalling

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12 December 2020

Requirement of MIP-1 alpha for an inflammatory response to viral infection.

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12 December 2020

Gene modification via "plug and socket" gene targeting

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12 December 2020

Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton

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12 December 2020

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

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12 December 2020

Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxyadenine nephrolithiasis

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12 December 2020

Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4

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12 December 2020

Retinal degeneration in mice lacking the gamma subunit of the rod cGMP phosphodiesterase

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12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

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12 December 2020

Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over

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12 December 2020

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.

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12 December 2020

Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

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12 December 2020

Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function

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12 December 2020

Targeted mutagenesis of the transcription factor GATA-4 gene in mouse embryonic stem cells disrupts visceral endoderm differentiation in vitro

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12 December 2020

Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor

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12 December 2020

A knock-out model of paroxysmal nocturnal hemoglobinuria: Pig-a(-) hematopoiesis is reconstituted following intercellular transfer of GPI-anchored proteins

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12 December 2020

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

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12 December 2020

Relationship between asymmetric nodal expression and the direction of embryonic turning

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12 December 2020

Mice lacking ornithine-delta-aminotransferase have paradoxical neonatal hypoornithinaemia and retinal degeneration

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12 December 2020

Disruption of muscle architecture and myocardial degeneration in mice lacking desmin

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12 December 2020

Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y

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12 December 2020

Rescue of the En-1 mutant phenotype by replacement of En-1 with En-2

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12 December 2020

Syk tyrosine kinase required for mouse viability and B-cell development

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12 December 2020

Fibroblast growth factor receptor 3 is a negative regulator of bone growth

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12 December 2020

Inactivation of Fac in mice produces inducible chromosomal instability and reduced fertility reminiscent of Fanconi anaemia

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12 December 2020

An enhanced immune response in mice lacking the transcription factor NFAT1.

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12 December 2020

Dysgenesis of cephalic neural crest derivatives in Pax7-/- mutant mice

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12 December 2020

Transcription factor AP-2 essential for cranial closure and craniofacial development

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12 December 2020

Fatal embryonic bleeding events in mice lacking tissue factor, the cell-associated initiator of blood coagulation

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12 December 2020

Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile.

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12 December 2020

Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1).

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12 December 2020

Retinal dysplasia and degeneration in RARbeta2/RARgamma2 compound mutant mice

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12 December 2020

Nuk controls pathfinding of commissural axons in the mammalian central nervous system

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12 December 2020

The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory

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12 December 2020

Specification of pituitary cell lineages by the LIM homeobox gene Lhx3

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12 December 2020

Meiotic pachytene arrest in MLH1-deficient mice

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12 December 2020

Altered T cell development in mice with a targeted mutation of the CD3-epsilon gene

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12 December 2020

Synpolydactyly in mice with a targeted deficiency in the HoxD complex

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12 December 2020

Pleiotropic defects in ataxia-telangiectasia protein-deficient mice

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12 December 2020

Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice

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12 December 2020

Targeted disruption of the pituitary glycoprotein hormone alpha-subunit produces hypogonadal and hypothyroid mice.

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12 December 2020

Decreased resistance to bacterial infection and granulocyte defects in IAP-deficient mice.

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12 December 2020

Targeted disruption of mammalian hairy and Enhancer of split homolog-1 (HES-1) leads to up-regulation of neural helix-loop-helix factors, premature neurogenesis, and severe neural tube defects

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12 December 2020

A defect in nurturing in mice lacking the immediate early gene fosB.

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12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

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12 December 2020

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse

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12 December 2020

Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3.

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12 December 2020

Defective activation and survival of T cells lacking the Ets-1 transcription factor

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12 December 2020

Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system

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12 December 2020

Targeted inactivation of the gene encoding the mouse alpha 2c-adrenoceptor homolog.

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12 December 2020

Notch1 is required for the coordinate segmentation of somites

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12 December 2020

Negative regulation of T-cell adhesion and activation by CD43

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12 December 2020

Mice develop normally without the H1(0) linker histone

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12 December 2020

Gene targeting in human somatic cells. Complete inactivation of an interferon-inducible gene

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12 December 2020

Regulation of an early developmental checkpoint in the B cell pathway by Ig beta.

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12 December 2020

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

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12 December 2020

Altering the genome by homologous recombination

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12 December 2020

Targeted disruption of the arylsulfatase B gene results in mice resembling the phenotype of mucopolysaccharidosis VI

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12 December 2020

Thyroid hormone receptor beta is essential for development of auditory function

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12 December 2020

Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue

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12 December 2020

Targeted gene replacement.

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12 December 2020

Renal and neuronal abnormalities in mice lacking GDNF

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12 December 2020

Independent modes of natural killing distinguished in mice lacking Lag3

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12 December 2020

Sensory but not motor neuron deficits in mice lacking NT4 and BDNF

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12 December 2020

Normal development of mice lacking metablastin (P19), a phosphoprotein implicated in cell cycle regulation

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12 December 2020

Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene

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12 December 2020

Radiation-induced cell cycle arrest compromised by p21 deficiency

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12 December 2020

Impairment of axonal development and of synaptogenesis in hippocampal neurons of synapsin I-deficient mice

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12 December 2020

Genetic knockouts in mice: an update

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12 December 2020

Impaired energy homeostasis in C/EBP alpha knockout mice

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12 December 2020

Lymphoproliferative disorder and imbalanced T-helper response in C/EBP beta-deficient mice

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12 December 2020

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase.

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12 December 2020

Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter

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12 December 2020

Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension

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12 December 2020

Benzodiazepine-insensitive mice generated by targeted disruption of the gamma 2 subunit gene of gamma-aminobutyric acid type A receptors

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12 December 2020

Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice.

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12 December 2020

T-cell alpha beta + and gamma delta + deficient mice display abnormal but distinct phenotypes toward a natural, widespread infection of the intestinal epithelium

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12 December 2020

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

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12 December 2020

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B

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12 December 2020

Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation

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12 December 2020

Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism

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12 December 2020

Early death due to defective neonatal lung liquid clearance in alpha-ENaC-deficient mice.

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12 December 2020

MSH2 deficient mice are viable and susceptible to lymphoid tumours

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12 December 2020

Targeted disruption of the tyrosine hydroxylase locus results in severe catecholamine depletion and perinatal lethality in mice

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12 December 2020

Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression

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12 December 2020

High levels of c-rel expression are associated with programmed cell death in the developing avian embryo and in bone marrow cells in vitro

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12 December 2020

Knockouts of Src-family kinases: stiff bones, wimpy T cells, and bad memories.

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12 December 2020

Acid sphingomyelinase deficient mice: a model of types A and B Niemann-Pick disease

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12 December 2020

Salt-resistant hypertension in mice lacking the guanylyl cyclase-A receptor for atrial natriuretic peptide

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12 December 2020

Targeted transgenesis

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12 December 2020

Mouse model of human beta zero thalassemia: targeted deletion of the mouse beta maj- and beta min-globin genes in embryonic stem cells

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12 December 2020

Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

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12 December 2020

Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism

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12 December 2020

Altering mice by homologous recombination using embryonic stem cells

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12 December 2020

Essential role for ZAP-70 in both positive and negative selection of thymocytes

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12 December 2020

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice

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12 December 2020

Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein

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12 December 2020

Intestinal Secretory Defects and Dwarfism in Mice Lacking cGMP-Dependent Protein Kinase II

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12 December 2020

Requirement for neuregulin receptor erbB2 in neural and cardiac development

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12 December 2020

Mice with targeted disruption of Hoxb-1 fail to form the motor nucleus of the VIIth nerve

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12 December 2020

Pain responses, anxiety and aggression in mice deficient in pre-proenkephalin

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12 December 2020

Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes

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12 December 2020

Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.

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12 December 2020

Delayed early embryonic lethality following disruption of the murine cyclin A2 gene.

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12 December 2020

Generation and characterization of mutant mice lacking ryanodine receptor type 3.

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12 December 2020

High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene

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12 December 2020

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

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12 December 2020

Targeted disruption in the mouse Hoxc-4 locus results in axial skeleton homeosis and malformation of the xiphoid process

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12 December 2020

Defective forebrain development in mice lacking gp330/megalin

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12 December 2020

Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

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12 December 2020

Transgenic knockouts reveal a critical requirement for pancreatic beta cell glucokinase in maintaining glucose homeostasis

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12 December 2020

Altered surfactant function and structure in SP-A gene targeted mice

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12 December 2020

Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities

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12 December 2020

Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities

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12 December 2020

Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver

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12 December 2020

Targeted disruption of an essential vertebrate gene: ASF/SF2 is required for cell viability

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12 December 2020

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

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12 December 2020

B-cell-specif ic coactivator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation

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12 December 2020

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

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12 December 2020

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

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12 December 2020

Redundancies, development and the flow of information

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12 December 2020

Generation and characterization of urokinase receptor-deficient mice

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12 December 2020

Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene.

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12 December 2020

Defective lymphoid development in mice lacking Jak3

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12 December 2020

Modulation of disease severity in cystic fibrosis transmembrane conductance regulator deficient mice by a secondary genetic factor

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12 December 2020

Pax-2 controls multiple steps of urogenital development

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12 December 2020

Sustained somatic gene inactivation by viral transfer of Cre recombinase.

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12 December 2020

Knockout mouse fault lines.

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12 December 2020

Recent advances in gene mutagenesis by site-directed recombination

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12 December 2020

Conditional gene targeting

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12 December 2020

Impaired locomotor activity and exploratory behavior in mice lacking histamine H1 receptors

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12 December 2020

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

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12 December 2020

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death

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12 December 2020

Targeted disruption of the surfactant protein B gene disrupts surfactant homeostasis, causing respiratory failure in newborn mice

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12 December 2020

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

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12 December 2020

Acid sphingomyelinase-deficient mice mimic the neurovisceral form of human lysosomal storage disease (Niemann-Pick disease).

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12 December 2020

Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors

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12 December 2020

Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia

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12 December 2020

Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis

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12 December 2020

Failure of embryonic hematopoiesis and lethal hemorrhages in mouse embryos heterozygous for a knocked-in leukemia gene CBFB-MYH11.

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12 December 2020

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

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12 December 2020

Recessive resistance to thyroid hormone in mice lacking thyroid hormone receptor beta: evidence for tissue-specific modulation of receptor function

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12 December 2020

Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

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12 December 2020

A mouse model of familial hypertrophic cardiomyopathy

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12 December 2020

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

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12 December 2020

Role of the thrombin receptor in development and evidence for a second receptor.

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12 December 2020

Spermiogenesis deficiency and germ-cell apoptosis in CREM-mutant mice

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12 December 2020

Targeted gene disruption of Hsp70-2 results in failed meiosis, germ cell apoptosis, and male infertility

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12 December 2020

Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice

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12 December 2020

Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins

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12 December 2020

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

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12 December 2020

Targeted disruption of hoxc-4 causes esophageal defects and vertebral transformations

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12 December 2020

Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77)

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12 December 2020

Lethal alpha-thalassaemia created by gene targeting in mice and its genetic rescue

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12 December 2020

Keratinocyte growth factor is required for hair development but not for wound healing

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12 December 2020

Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48

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12 December 2020

Mouse knockouts rule OK

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12 December 2020

Targeted disruption of the housekeeping gene encoding glucose 6-phosphate dehydrogenase (G6PD): G6PD is dispensable for pentose synthesis but essential for defense against oxidative stress

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12 December 2020

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells

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12 December 2020

Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele

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12 December 2020

Disruption of the mouse MRF4 gene identifies multiple waves of myogenesis in the myotome

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12 December 2020

Neurogenic amplification of immune complex inflammation

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12 December 2020

Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene

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12 December 2020

Absence of integrin alpha 6 leads to epidermolysis bullosa and neonatal death in mice.

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12 December 2020

A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP recombination.

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12 December 2020

Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor

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12 December 2020

Targeted disruption of the beta 3-adrenergic receptor gene.

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12 December 2020

Defects in enteric innervation and kidney development in mice lacking GDNF

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12 December 2020

Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase A

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12 December 2020

Mice lacking the myotonic dystrophy protein kinase develop a late onset progressive myopathy

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12 December 2020

Vascular system defects and neuronal apoptosis in mice lacking ras GTPase-activating protein

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12 December 2020

Thinking about genetic redundancy

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12 December 2020

The C5a chemoattractant receptor mediates mucosal defence to infection

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12 December 2020

Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis

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12 December 2020

H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

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12 December 2020

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

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12 December 2020

Alpha 3 beta 1 integrin has a crucial role in kidney and lung organogenesis

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12 December 2020

Targeted disruption of the mouse sphingolipid activator protein gene: a complex phenotype, including severe leukodystrophy and wide-spread storage of multiple sphingolipids.

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12 December 2020

Impaired Negative Selection of T Cells in Hodgkin's Disease Antigen CD30–Deficient Mice

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12 December 2020

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

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12 December 2020

Critical role for β7 integrins in formation of the gut-associated lymphoid tissue

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12 December 2020

High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.

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12 December 2020

Gene knockout by viral delivery.

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12 December 2020

Lack of beta-catenin affects mouse development at gastrulation

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12 December 2020

Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis

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12 December 2020

Disruption of the mouse RBP-J kappa gene results in early embryonic death

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12 December 2020

Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta

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12 December 2020

General anosmia caused by a targeted disruption of the mouse olfactory cyclic nucleotide-gated cation channel

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12 December 2020

Growth differentiation factor-9 is required during early ovarian folliculogenesis

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12 December 2020

A syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27(Kip1)-deficient mice

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12 December 2020

Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion

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12 December 2020

A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain

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12 December 2020

Gsh-1, an orphan Hox gene, is required for normal pituitary development

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12 December 2020

Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)

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12 December 2020

Porphobilinogen deaminase deficiency in mice causes a neuropathy resembling that of human hepatic porphyria

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12 December 2020

Granzyme A-deficient mice retain potent cell-mediated cytotoxicity.

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12 December 2020

Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null mice

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12 December 2020

Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluR delta 2 mutant mice

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12 December 2020

Targeted DNA recombination in vivo using an adenovirus carrying the cre recombinase gene

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12 December 2020

Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death

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12 December 2020

Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease

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12 December 2020

Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase

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12 December 2020

Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

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12 December 2020

Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes

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12 December 2020

The new mouse genetics: altering the genome by gene targeting

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12 December 2020

Metaxin, a gene contiguous to both thrombospondin 3 and glucocerebrosidase, is required for embryonic development in the mouse: implications for Gaucher disease

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12 December 2020

Defective neuromuscular synaptogenesis in agrin-deficient mutant mice

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12 December 2020

Transforming growth factor-beta 3 is required for secondary palate fusion

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12 December 2020

Targeted disruption of the mouse beta1-adrenergic receptor gene: developmental and cardiovascular effects

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12 December 2020

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

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12 December 2020

Renal agenesis and the absence of enteric neurons in mice lacking GDNF

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12 December 2020

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development

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12 December 2020

Compound mutants for the paralogous hoxa-4, hoxb-4, and hoxd-4 genes show more complete homeotic transformations and a dose-dependent increase in the number of vertebrae transformed

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12 December 2020

Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice

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12 December 2020

Gene disruption in mammals

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12 December 2020

Strain-dependent epithelial defects in mice lacking the EGF receptor

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12 December 2020

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.

1 reference

12 December 2020

Severe impairment of spermatogenesis in mice lacking the CREM gene

1 reference

12 December 2020

Targeted disruption of the mouse topoisomerase I gene by camptothecin selection

1 reference

12 December 2020

A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice

1 reference

12 December 2020

Mutation of the Emx-1 homeobox gene disrupts the corpus callosum

1 reference

12 December 2020

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

1 reference

12 December 2020

RXR gamma null mice are apparently normal and compound RXR alpha +/-/RXR beta -/-/RXR gamma -/- mutant mice are viable.

1 reference

12 December 2020

The CBFbeta subunit is essential for CBFalpha2 (AML1) function in vivo

1 reference

12 December 2020

Male–female differences in fertility and blood pressure in ACE-deficient mice

1 reference

12 December 2020

Multiple essential functions of neuregulin in development

1 reference

12 December 2020

Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling

1 reference

12 December 2020

Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1

1 reference

12 December 2020

Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome

1 reference

12 December 2020

Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

1 reference

12 December 2020

Atm-deficient mice: a paradigm of ataxia telangiectasia

1 reference

12 December 2020

Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice

1 reference

12 December 2020

Altered Hox expression and segmental identity in Mll-mutant mice

1 reference

12 December 2020

Epithelial immaturity and multiorgan failure in mice lacking epidermal growth factor receptor

1 reference

12 December 2020

Inducible gene targeting in mice

1 reference

12 December 2020

Gene targeting of BPAG1: abnormalities in mechanical strength and cell migration in stratified epithelia and neurologic degeneration

1 reference

12 December 2020

The receptor tyrosine kinase TIE is required for integrity and survival of vascular endothelial cells.

1 reference

12 December 2020

Targeted inactivation of the mouse alpha 2-macroglobulin gene

1 reference

12 December 2020

Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene

1 reference

12 December 2020

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities

1 reference

12 December 2020

Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway

1 reference

12 December 2020

Cyclin D1 is a nuclear protein required for cell cycle progression in G1

1 reference

12 December 2020

Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally

1 reference

12 December 2020

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene

1 reference

12 December 2020

The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes

1 reference

12 December 2020

Defective propagation of signals generated by sympathetic nerve stimulation in the liver of connexin32-deficient mice

1 reference

12 December 2020

Central hypotensive effects of the alpha2a-adrenergic receptor subtype.

1 reference

12 December 2020

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1 reference

12 December 2020

Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V

1 reference

12 December 2020

The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse.

1 reference

12 December 2020

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1 reference

12 December 2020

Neural tube, skeletal and body wall defects in mice lacking transcription factor AP-2

1 reference

12 December 2020

Antigen presentation and T cell development in H2-M-deficient mice

1 reference

12 December 2020

More to learn from gene knockouts

1 reference

12 December 2020

Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2

1 reference

12 December 2020

Double replacement gene targeting for the production of a series of mouse strains with different prion protein gene alterations

1 reference

12 December 2020

Gene targeting and gene transfer studies of the plasminogen/plasmin system: implications in thrombosis, hemostasis, neointima formation, and atherosclerosis.

1 reference

12 December 2020

Specific and redundant functions of the paralogous Hoxa-9 and Hoxd-9 genes in forelimb and axial skeleton patterning

1 reference

12 December 2020

Increased bone formation in osteocalcin-deficient mice.

1 reference

12 December 2020

Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury

1 reference

12 December 2020

Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism

1 reference

12 December 2020

Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death

1 reference

12 December 2020

Crucial role of the pre-T-cell receptor α gene in development of ap but not γδ T cells

1 reference

12 December 2020

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene

1 reference

12 December 2020

Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11

1 reference

12 December 2020

Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice

1 reference

12 December 2020

Neuronal abnormalities in microtubule-associated protein 1B mutant mice

1 reference

12 December 2020

Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation

1 reference

12 December 2020

Targeted disruption of the Wnt2 gene results in placentation defects

1 reference

12 December 2020

The redox/DNA repair protein, Ref-1, is essential for early embryonic development in mice.

1 reference

12 December 2020

Interleukin 7 receptor-deficient mice lack gammadelta T cells

1 reference

12 December 2020

Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1.

1 reference

12 December 2020

Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic

1 reference

12 December 2020

Identifiers

DOI

10.1023/A:1006865210012

1 reference

PubMed ID

9562253

Dimensions Publication ID

24 September 2017

0 references

1 reference

PubMed ID

9562253