Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma. (Q42206056)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611241%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

title

Pten loss in CD4 T cells enhances their helper function but does not lead to autoimmunity or lymphoma (English)

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1 February 2020

8

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1 February 2020

Martin Turner

5

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1 February 2020

Cheryl Scudamore

6

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1 February 2020

author name string

Dalya R Soond

1

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1 February 2020

Fabien Garçon

2

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1 February 2020

Daniel T Patton

3

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1 February 2020

Julia Rolf

4

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1 February 2020

Oliver A Garden

7

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1 February 2020

language of work or name

English

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publication date

18 May 2012

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1 February 2020

published in

Journal of Immunology

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1 February 2020

volume

188

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1 February 2020

issue

12

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1 February 2020

page(s)

5935-5943

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Origins of CD4(+) effector and central memory T cells

1 February 2020

cites work

1 reference

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The PI3K p110δ regulates expression of CD38 on regulatory T cells

26 October 2017

1 reference

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Follicular helper CD4 T cells (TFH)

26 October 2017

1 reference

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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism

26 October 2017

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Suppression of leukemia development caused by PTEN loss

26 October 2017

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Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction

26 October 2017

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26 October 2017

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26 October 2017

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Control of immunity by the TNFR-related molecule OX40 (CD134)

26 October 2017

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26 October 2017

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26 October 2017

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Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells

26 October 2017

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Thymic OX40 expression discriminates cells undergoing strong responses to selection ligands.

26 October 2017

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26 October 2017

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26 October 2017

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Regulation of T-cell responses by PTEN

26 October 2017

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Tailoring T-cell receptor signals by proximal negative feedback mechanisms

26 October 2017

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The p110gamma isoform of phosphatidylinositol 3-kinase regulates migration of effector CD4 T lymphocytes into peripheral inflammatory sites.

26 October 2017

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Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking

26 October 2017

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Lymphoproliferative disease and autoimmunity in mice with increased miR-17-92 expression in lymphocytes

26 October 2017

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Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice

26 October 2017

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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia

26 October 2017

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Single-cell dynamics of T-cell priming

26 October 2017

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The PI3K p110delta controls T-cell development, differentiation and regulation

26 October 2017

1 reference

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A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress

26 October 2017

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Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.

26 October 2017

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Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies.

26 October 2017

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Effector and memory CTL differentiation

26 October 2017

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PTEN inhibits IL-2 receptor-mediated expansion of CD4+ CD25+ Tregs

26 October 2017

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FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal

26 October 2017

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Cooperation between CD4+ and CD8+ T cells: when, where, and how.

26 October 2017

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CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells.

26 October 2017

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The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling

26 October 2017

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Jurkat T cells and development of the T-cell receptor signalling paradigm

26 October 2017

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The costimulation-regulated duration of PKB activation controls T cell longevity

26 October 2017

1 reference

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Pten dose dictates cancer progression in the prostate

26 October 2017

1 reference

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Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

26 October 2017

1 reference

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PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

26 October 2017

1 reference

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Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus

26 October 2017

1 reference

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CD4+ Th1 and CD8+ type 1 cytotoxic T cells both play a crucial role in the full development of contact hypersensitivity

26 October 2017

1 reference

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Pten is essential for embryonic development and tumour suppression

26 October 2017

1 reference

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RAG-1-deficient mice have no mature B and T lymphocytes

26 October 2017

1 reference

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

26 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378038

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

26 October 2017

1 reference

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PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.

29 May 2018

1 reference

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Distinct roles for PTEN in prevention of T cell lymphoma and autoimmunity in mice

17 August 2018

1 reference

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MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells

17 August 2018

1 reference

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Resistance of mature T cells to oncogene transformation

17 August 2018

1 reference

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Selective regulation of CD8 effector T cell migration by the p110 gamma isoform of phosphatidylinositol 3-kinase

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378038

T-cell lymphomas in T-cell-specific Pten-deficient mice originate in the thymus

17 August 2018

1 reference

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CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer.

17 August 2018

1 reference

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PI3Kgamma is the dominant isoform involved in migratory responses of human T lymphocytes: effects of ex vivo maintenance and limitations of non-viral delivery of siRNA.

17 August 2018

1 reference

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Generation of CD8 T cell memory is regulated by IL-12.

17 August 2018

1 reference

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Class IB-phosphatidylinositol 3-kinase (PI3K) deficiency ameliorates IA-PI3K-induced systemic lupus but not T cell invasion

17 August 2018

1 reference

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PI3Kgamma inhibition blocks glomerulonephritis and extends lifespan in a mouse model of systemic lupus

17 August 2018

1 reference

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Differential requirements for DOCK2 and phosphoinositide-3-kinase gamma during T and B lymphocyte homing

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378038

Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378038

High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice

1 December 2018

1 reference

12 December 2020

Cutting edge: T cell requirement for CD28 costimulation is due to negative regulation of TCR signals by PTEN

1 reference

12 December 2020

The p110delta isoform of phosphoinositide 3-kinase controls clonal expansion and differentiation of Th cells

1 reference

12 December 2020

T Cell-Specific Loss of Pten Leads to Defects in Central and Peripheral Tolerance

1 reference

12 December 2020

Identifiers

DOI

10.4049/JIMMUNOL.1102116

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611241%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611241%20AND%20SRC:MED&resulttype=core&format=json

1 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22611241%20AND%20SRC:MED&resulttype=core&format=json