MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated. (Q42354586)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27922010%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

title

MEK inhibitors block growth of lung tumours with mutations in ataxia-telangiectasia mutated (English)

1 reference

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29 March 2020

15

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29 March 2020

Michal Smida

1

1 reference

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29 March 2020

Ferran Fece de la Cruz

2

1 reference

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Iris Z Uras

4

1 reference

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Barbara Mair

5

1 reference

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29 March 2020

Tomasz Konopka

8

1 reference

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29 March 2020

author name string

Claudia Kerzendorfer

3

1 reference

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29 March 2020

Abdelghani Mazouzi

6

1 reference

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Tereza Suchankova

7

1 reference

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Amanda M Katz

9

1 reference

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29 March 2020

Keren Paz

10

1 reference

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29 March 2020

Katalin Nagy-Bojarszky

11

1 reference

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29 March 2020

Markus K Muellner

12

1 reference

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29 March 2020

Zsuzsanna Bago-Horvath

13

1 reference

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29 March 2020

Eric B Haura

14

1 reference

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29 March 2020

Sebastian M B Nijman

16

1 reference

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29 March 2020

language of work or name

English

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publication date

6 December 2016

1 reference

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29 March 2020

published in

Nature Communications

1 reference

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29 March 2020

volume

7

1 reference

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29 March 2020

page(s)

13701

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Creative Commons Attribution 4.0 International

29 March 2020

copyright license

start time

1 December 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC5150652/fullTextXML

inferred from PubMed Central ID database lookup

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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29 May 2018

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Somatic mutations affect key pathways in lung adenocarcinoma

29 May 2018

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Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

29 May 2018

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ATM and breast cancer susceptibility

29 May 2018

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Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150652

A family with severe insulin resistance and diabetes due to a mutation in AKT2.

29 May 2018

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

29 May 2018

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Functional consequences of ATM sequence variants for chromosomal radiosensitivity

29 May 2018

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

29 May 2018

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Immortalization and transformation of primary human airway epithelial cells by gene transfer.

29 May 2018

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Dominant Negative ATM Mutations in Breast Cancer Families

29 May 2018

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Missense mutations but not allelic variants alter the function of ATM by dominant interference in patients with breast cancer

29 May 2018

1 reference

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Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

29 May 2018

1 reference

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Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1.

29 May 2018

1 reference

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ATM mutations and phenotypes in ataxia-telangiectasia families in the British Isles: expression of mutant ATM and the risk of leukemia, lymphoma, and breast cancer

29 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150652

Extreme insulin resistance in ataxia telangiectasia: defect in affinity of insulin receptors

29 May 2018

1 reference

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Cancer. Potential of the synthetic lethality principle

29 May 2018

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The clinical effect of the dual-targeting strategy involving PI3K/AKT/mTOR and RAS/MEK/ERK pathways in patients with advanced cancer.

17 August 2018

1 reference

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AZD7762, a novel checkpoint kinase inhibitor, drives checkpoint abrogation and potentiates DNA-targeted therapies

17 August 2018

1 reference

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Atm heterozygosity does not increase tumor susceptibility to ionizing radiation alone or in a p53 heterozygous background.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150652

Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer.

17 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5150652

Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia

17 August 2018

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https://api.crossref.org/works/10.1038%2FNCOMMS13701

Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition

21 January 2018

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PubMed

https://pubmed.ncbi.nlm.nih.gov/27922010

12 December 2020

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Cancer research and the $90 billion metaphor

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PubMed

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12 December 2020

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Deficiency in the Repair of DNA Damage by Homologous Recombination and Sensitivity to Poly(ADP-Ribose) Polymerase Inhibition

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7 January 2021

inferred from DOI database lookup

Identifiers

DOI

10.1038/NCOMMS13701

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27922010%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:27922010%20AND%20SRC:MED&resulttype=core&format=json

29 March 2020

PubMed publication ID

27922010

1 reference