Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response. (Q42680947)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19617345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Susceptibility of p53 unstructured N terminus to 20 S proteasomal degradation programs the stress response (English)

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2 February 2020

1

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2 February 2020

3

Carol Prives

1 reference

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2 February 2020

author name string

Nina Reuven

series ordinal

2

1 reference

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2 February 2020

Yosef Shaul

series ordinal

4

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2 February 2020

language of work or name

English

0 references

publication date

17 July 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19617345%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

2 February 2020

published in

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2 February 2020

volume

284

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2 February 2020

issue

39

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2 February 2020

page(s)

26234-26242

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Biological and chemical approaches to diseases of proteostasis deficiency

2 February 2020

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27 May 2018

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Ubiquitin-independent degradation of p53 mediated by high-risk human papillomavirus protein E6.

27 May 2018

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MDMX regulation of p53 response to ribosomal stress

27 May 2018

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27 May 2018

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MDMX overexpression prevents p53 activation by the MDM2 inhibitor Nutlin.

27 May 2018

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Oscillations and variability in the p53 system

27 May 2018

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Some p53-binding proteins that can function as arbiters of life and death.

27 May 2018

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The triage of damaged proteins: degradation by the ubiquitin-proteasome pathway or repair by molecular chaperones.

27 May 2018

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Flexible nets. The roles of intrinsic disorder in protein interaction networks.

27 May 2018

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Mechanism of direct degradation of IkappaBalpha by 20S proteasome

27 May 2018

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NMR chemical shift and relaxation measurements provide evidence for the coupled folding and binding of the p53 transactivation domain

27 May 2018

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Inhibition of NAD(P)H:quinone oxidoreductase 1 activity and induction of p53 degradation by the natural phenolic compound curcumin.

27 May 2018

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Intrinsically unstructured proteins and their functions

27 May 2018

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A mechanism of ubiquitin-independent proteasomal degradation of the tumor suppressors p53 and p73

27 May 2018

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p53 Stabilization and accumulation induced by human vaccinia-related kinase 1

27 May 2018

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The ubiquitin ligase COP1 is a critical negative regulator of p53

27 May 2018

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Dynamics of the p53-Mdm2 feedback loop in individual cells

27 May 2018

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Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation

27 May 2018

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27 May 2018

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Endoproteolytic activity of the proteasome

27 May 2018

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p53 contains large unstructured regions in its native state

27 May 2018

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Mdm-2 and ubiquitin-independent p53 proteasomal degradation regulated by NQO1.

27 May 2018

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Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms

27 May 2018

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A degradation signal located in the C-terminus of p21WAF1/CIP1 is a binding site for the C8 alpha-subunit of the 20S proteasome

27 May 2018

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27 May 2018

Surfing the p53 network

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The N terminus of p53 regulates its dissociation from DNA.

27 May 2018

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Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination

27 May 2018

1 reference

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Rapid degradation of a large fraction of newly synthesized proteins by proteasomes.

27 May 2018

1 reference

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Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein

27 May 2018

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27 May 2018

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The regulatory particle of the Saccharomyces cerevisiae proteasome.

27 May 2018

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The carboxy-terminus of I kappaB alpha determines susceptibility to degradation by the catalytic core of the proteasome

27 May 2018

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Functional dissection of p53 tumor suppressor protein

27 May 2018

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Regulation of p53 stability by Mdm2

27 May 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

27 May 2018

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Different mechanisms control signal-induced degradation and basal turnover of the NF-kappaB inhibitor IkappaB alpha in vivo

27 May 2018

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MDMX: a novel p53-binding protein with some functional properties of MDM2

27 May 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

27 May 2018

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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

27 May 2018

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Accumulation of p53 in a mutant cell line defective in the ubiquitin pathway

27 May 2018

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Activation of p53 sequence-specific DNA bindingby short single strands of DNA requires the p53 C-terminus

27 May 2018

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Operational definition of intrinsically unstructured protein sequences based on susceptibility to the 20S proteasome.

27 May 2018

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Characterization of rapidly degraded polypeptides in mammalian cells reveals a novel layer of nascent protein quality control.

16 August 2018

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An unstructured initiation site is required for efficient proteasome-mediated degradation

16 August 2018

1 reference

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Proteasomes begin ornithine decarboxylase digestion at the C terminus

16 August 2018

1 reference

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alpha-synuclein metabolism and aggregation is linked to ubiquitin-independent degradation by the proteasome

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785311

Kinetics of degradation of "short-" and "long-lived" proteins in cultured mammalian cells.

16 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2785311

Hdmx stabilizes Mdm2 and p53

16 August 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19617345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Intrinsic protein disorder in complete genomes

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19617345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

mdmx is a negative regulator of p53 activity in vivo

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19617345

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1074/JBC.M109.040493

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19617345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19617345%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

19617345

1 reference