Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6. (Q43492573)

24 November 2017

Smad6 inhibits non-canonical TGF-β1 signalling by recruiting the deubiquitinase A20 to TRAF6. (English)

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24 November 2017

11

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24 November 2017

6

Jin Seok Park

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24 November 2017

13

Seok Hee Park

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24 November 2017

7

Youn Sook Lee

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24 November 2017

1

Su Myung Jung

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24 November 2017

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Jun Hwan Kim

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24 November 2017

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Yoe-Sik Bae

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24 November 2017

2

Ji-Hyung Lee

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24 November 2017

Jinyoung Park

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24 November 2017

Young Sun Oh

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24 November 2017

Sung Kyun Lee

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24 November 2017

Jae Young Lee

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24 November 2017

Seong-Jin Kim

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24 November 2017

language of work or name

English

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publication date

1 January 2013

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24 November 2017

Nature Communications

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24 November 2017

4

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24 November 2017

2562

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https://scigraph.springernature.com/pub.10.1038/ncomms3562

24 November 2017

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

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The deubiquitinating enzyme UCH37 interacts with Smads and regulates TGF-beta signalling

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Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3

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The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses

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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

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The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination

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Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells

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The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6

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Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor

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7 January 2021

A20: linking a complex regulator of ubiquitylation to immunity and human disease

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CYLD negatively regulates transforming growth factor-β-signalling via deubiquitinating Akt

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Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene

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The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

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7 January 2021

Identifiers

DOI

10.1038/NCOMMS3562

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24 November 2017

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