β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage. (Q43846570)

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title

β-amyloid inhibits protein prenylation and induces cholesterol sequestration by impairing SREBP-2 cleavage (English)

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author name string

Amany Mohamed

1

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1 February 2020

Lucila Saavedra

2

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Simonetta Sipione

4

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Elena Posse de Chaves

5

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language of work or name

English

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publication date

1 May 2012

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1 February 2020

published in

Journal of Neuroscience

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volume

32

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issue

19

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page(s)

6490-6500

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Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol

1 February 2020

cites work

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Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Time sequence of maturation of dystrophic neurites associated with Abeta deposits in APP/PS1 transgenic mice

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Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities

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HMG-CoA reductase inhibition causes neurite loss by interfering with geranylgeranylpyrophosphate synthesis

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Alzheimer disease: mechanistic understanding predicts novel therapies

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Elevated endosomal cholesterol levels in Niemann-Pick cells inhibit rab4 and perturb membrane recycling

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Axon-dominant localization of cell-surface cholesterol in cultured hippocampal neurons and its disappearance in Niemann-Pick type C model cells

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Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model

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Subcellular topography of neuronal Abeta peptide in APPxPS1 transgenic mice

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Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

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Statins cause intracellular accumulation of amyloid precursor protein, beta-secretase-cleaved fragments, and amyloid beta-peptide via an isoprenoid-dependent mechanism.

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Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice

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Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production

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Protein transduction of Rab9 in Niemann-Pick C cells reduces cholesterol storage.

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Phosphonocarboxylate inhibitors of Rab geranylgeranyl transferase disrupt the prenylation and membrane localization of Rab proteins in osteoclasts in vitro and in vivo

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Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Abeta in distal axons

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Brain cholesterol turnover required for geranylgeraniol production and learning in mice

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Cholesterol accumulation sequesters Rab9 and disrupts late endosome function in NPC1-deficient cells

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Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease

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SREBP-2 positively regulates transcription of the cholesterol efflux gene, ABCA1, by generating oxysterol ligands for LXR.

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12 December 2020

Survival of adult neurons lacking cholesterol synthesis in vivo

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12 December 2020

Ultrastructural localization of intraneuronal Abeta-peptide in Alzheimer disease brains

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12 December 2020

Isolation and culture of adult neurons and neurospheres

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12 December 2020

Impact of HMG-CoA reductase inhibition on brain pathology

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12 December 2020

Statins reduce amyloid-beta production through inhibition of protein isoprenylation

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12 December 2020

Internalization of beta-amyloid peptide by primary neurons in the absence of apolipoprotein E.

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12 December 2020

Endosomal accumulation of GM1 ganglioside-bound amyloid beta-protein in neurons of aged monkey brains.

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Cholesterol retention in Alzheimer's brain is responsible for high beta- and gamma-secretase activities and Abeta production

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Biphasic requirement for geranylgeraniol in hippocampal long-term potentiation

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Intracellular Aß triggers neuron loss in the cholinergic system of the APP/PS1KI mouse model of Alzheimer's disease.

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The selective Alzheimer's disease indicator-1 gene (Seladin-1/DHCR24) is a liver X receptor target gene

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Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice.

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Why lipids are important for Alzheimer disease?

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12 December 2020

SREBPs: SREBP function in glia-neuron interactions

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12 December 2020

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats.

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Amyloid beta-protein stimulates trafficking of cholesterol and caveolin-1 from the plasma membrane to the Golgi complex in mouse primary astrocytes

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Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes

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Mitochondrial cholesterol loading exacerbates amyloid beta peptide-induced inflammation and neurotoxicity

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12 December 2020

Regulation of the brain isoprenoids farnesyl- and geranylgeranylpyrophosphate is altered in male Alzheimer patients.

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12 December 2020

Cholesterol involvement in the pathogenesis of neurodegenerative diseases.

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12 December 2020

Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers

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A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo.

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Inhibition by compactin demonstrates a requirement of isoprenoid metabolism for long-term potentiation in rat hippocampal slices

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Amyloid beta peptide alters intracellular vesicle trafficking and cholesterol homeostasis

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10.1523/JNEUROSCI.0630-12.2012

Identifiers

DOI

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1 February 2020

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1 February 2020

PubMed publication ID

22573671

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