Why lipids are important for Alzheimer disease? (Q46179010)

20 December 2017

title

Why lipids are important for Alzheimer disease? (English)

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20 December 2017

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Veronica Hirsch-Reinshagen

series ordinal

1

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20 December 2017

Braydon L Burgess

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2

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20 December 2017

Cheryl L Wellington

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3

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20 December 2017

publication date

31 December 2008

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20 December 2017

Molecular and Cellular Biochemistry

published in

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20 December 2017

volume

326

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20 December 2017

issue

1-2

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20 December 2017

page(s)

121-129

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20 December 2017

https://scigraph.springernature.com/pub.10.1007/s11010-008-0012-2

exact match

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cites work

Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease

1 reference

https://api.crossref.org/works/10.1007%2FS11010-008-0012-2

Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11010-008-0012-2

Impact of APOE genotype on neuropathologic and neurochemical markers of Alzheimer disease

21 January 2018

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https://api.crossref.org/works/10.1007%2FS11010-008-0012-2

ABCA1 mRNA and protein distribution patterns predict multiple different roles and levels of regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-008-0012-2

Lipid efflux by the ATP-binding cassette transporters ABCA1 and ABCG1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11010-008-0012-2

The liver X receptor ligand T0901317 decreases amyloid beta production in vitro and in a mouse model of Alzheimer's disease

21 January 2018

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12 December 2020

ATP-binding cassette transporter A1 (ABCA1) functions as a cholesterol efflux regulatory protein

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12 December 2020

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides

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12 December 2020

Lipoproteins in the central nervous system

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12 December 2020

Human E apoprotein heterogeneity. Cysteine-arginine interchanges in the amino acid sequence of the apo-E isoforms

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12 December 2020

The LXR agonist TO901317 selectively lowers hippocampal Abeta42 and improves memory in the Tg2576 mouse model of Alzheimer's disease.

1 reference

12 December 2020

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice.

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12 December 2020

ABCA1 is required for normal central nervous system ApoE levels and for lipidation of astrocyte-secreted apoE.

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12 December 2020

Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model

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12 December 2020

Apolipoprotein E and Alzheimer disease

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12 December 2020

Glycoprotein 330/megalin: probable role in receptor-mediated transport of apolipoprotein J alone and in a complex with Alzheimer disease amyloid beta at the blood-brain and blood-cerebrospinal fluid barriers

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12 December 2020

Apolipoprotein specificity for lipid efflux by the human ABCAI transporter

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12 December 2020

Influence of lipoproteins on microglial degradation of Alzheimer's amyloid beta-protein

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12 December 2020

Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease

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12 December 2020

The human ATP-binding cassette (ABC) transporter superfamily.

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12 December 2020

Purification of apolipoprotein E attenuates isoform-specific binding to beta-amyloid

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12 December 2020

Reduction of atherosclerosis in apolipoprotein E knockout mice by activation of the retinoid X receptor.

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12 December 2020

High-density lipoprotein protects macrophages from oxidized low-density lipoprotein-induced apoptosis by promoting efflux of 7-ketocholesterol via ABCG1

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12 December 2020

Lack of apolipoprotein E dramatically reduces amyloid beta-peptide deposition.

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12 December 2020

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts

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12 December 2020

Regulation of ATP-binding cassette sterol transporters ABCG5 and ABCG8 by the liver X receptors alpha and beta.

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12 December 2020

Efflux of sphingomyelin, cholesterol, and phosphatidylcholine by ABCG1

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12 December 2020

Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier

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12 December 2020

Interaction of nascent ApoE2, ApoE3, and ApoE4 isoforms expressed in mammalian cells with amyloid peptide beta (1-40). Relevance to Alzheimer's disease.

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12 December 2020

ATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteins

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12 December 2020

ABCA1 and ABCG1 synergize to mediate cholesterol export to apoA-I.

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12 December 2020

Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice

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12 December 2020

Apolipoprotein E is essential for amyloid deposition in the APP(V717F) transgenic mouse model of Alzheimer's disease

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12 December 2020

Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease.

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12 December 2020

Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo.

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease.

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12 December 2020

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

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12 December 2020

Alzheimer's disease: the cholesterol connection

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12 December 2020

Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

Cholesterol metabolism in the brain

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12 December 2020

Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1

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12 December 2020

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

1 reference

12 December 2020

Expression of Liver X Receptor Target Genes Decreases Cellular Amyloid β Peptide Secretion

1 reference

12 December 2020

Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease

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12 December 2020

LXR, a nuclear receptor that defines a distinct retinoid response pathway

1 reference

12 December 2020

Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype.

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12 December 2020

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

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12 December 2020

Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels

1 reference

12 December 2020

Multiple, diverse senile plaque-associated proteins are ligands of an apolipoprotein E receptor, the alpha 2-macroglobulin receptor/low-density-lipoprotein receptor-related protein.

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12 December 2020

Alzheimer's disease: genetic studies and transgenic models

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12 December 2020

Physiologically regulated transgenic ABCA1 does not reduce amyloid burden or amyloid-beta peptide levels in vivo.

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12 December 2020

Apolipoprotein E in sporadic Alzheimer's disease: allelic variation and receptor interactions

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12 December 2020

Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia

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12 December 2020

Defective removal of cellular cholesterol and phospholipids by apolipoprotein A-I in Tangier Disease

1 reference

12 December 2020

Human apolipoprotein E4 accelerates beta-amyloid deposition in APPsw transgenic mouse brain.

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12 December 2020

LXRS and FXR: the yin and yang of cholesterol and fat metabolism

1 reference

12 December 2020

The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein

1 reference

12 December 2020

Diet-induced hypercholesterolemia enhances brain A beta accumulation in transgenic mice

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12 December 2020

LXR-induced redistribution of ABCG1 to plasma membrane in macrophages enhances cholesterol mass efflux to HDL

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12 December 2020

ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL.

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12 December 2020

Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1

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12 December 2020

Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model.

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12 December 2020

Transport pathways for clearance of human Alzheimer's amyloid beta-peptide and apolipoproteins E and J in the mouse central nervous system

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12 December 2020

Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation

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12 December 2020

ABCG1 has a critical role in mediating cholesterol efflux to HDL and preventing cellular lipid accumulation

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12 December 2020

Expression of ABCG1, but not ABCA1, correlates with cholesterol release by cerebellar astroglia

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12 December 2020

Expression and function of the low density lipoprotein receptor-related protein (LRP) in mammalian central neurons.

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12 December 2020

Deletion of the transmembrane transporter ABCG1 results in progressive pulmonary lipidosis

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12 December 2020

Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

ATP-binding cassette transporters G1 and G4 mediate cholesterol and desmosterol efflux to HDL and regulate sterol accumulation in the brain

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12 December 2020

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

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12 December 2020

The absence of ABCA1 decreases soluble ApoE levels but does not diminish amyloid deposition in two murine models of Alzheimer disease.

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12 December 2020

Lipidation of apolipoprotein E influences its isoform-specific interaction with Alzheimer's amyloid beta peptides

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12 December 2020

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

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12 December 2020

22R-hydroxycholesterol and 9-cis-retinoic acid induce ATP-binding cassette transporter A1 expression and cholesterol efflux in brain cells and decrease amyloid beta secretion

1 reference

12 December 2020

ATP-binding cassette transporter A1: a cell cholesterol exporter that protects against cardiovascular disease

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12 December 2020

ABCG1 and ABCG4 are coexpressed in neurons and astrocytes of the CNS and regulate cholesterol homeostasis through SREBP-2

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12 December 2020

The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo.

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12 December 2020

Human very low density lipoprotein apolipoprotein E isoprotein polymorphism is explained by genetic variation and posttranslational modification

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12 December 2020

Deficiency of ABCA1 impairs apolipoprotein E metabolism in brain

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12 December 2020

ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins

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12 December 2020

Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease

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12 December 2020

Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families

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12 December 2020

Attenuation of neuroinflammation and Alzheimer's disease pathology by liver x receptors

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12 December 2020

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo.

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12 December 2020

Cholesterol efflux regulatory protein, Tangier disease and familial high-density lipoprotein deficiency

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12 December 2020

Complete characterization of the human ABC gene family.

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12 December 2020

Liver X receptors as integrators of metabolic and inflammatory signaling

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12 December 2020

Expression of human apolipoprotein E reduces amyloid-beta deposition in a mouse model of Alzheimer's disease

1 reference

12 December 2020

Modulation of A beta deposition in APP transgenic mice by an apolipoprotein E null background.

1 reference

12 December 2020

Cholesterol depletion with physiological concentrations of a statin decreases the formation of the Alzheimer amyloid Abeta peptide.

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12 December 2020

Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation.

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12 December 2020

Clinical assessment of Alzheimer's disease

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12 December 2020

Total body ABCG1 expression protects against early atherosclerotic lesion development in mice

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Isoform-specific binding of apolipoprotein E to beta-amyloid

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12 December 2020

ABC transporters in cellular lipid trafficking

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12 December 2020

Role of ABCG1 and other ABCG family members in lipid metabolism

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12 December 2020

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease

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12 December 2020

10.1007/S11010-008-0012-2

Identifiers

DOI

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20 December 2017

PubMed ID

19116777

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20 December 2017