Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2. (Q44849807)

6 December 2017

title

Nuclear accumulation of p53 following inhibition of transcription is not due to diminished levels of MDM2. (English)

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6 December 2017

Heather M O'Hagan

1

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6 December 2017

Mats Ljungman

series ordinal

2

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6 December 2017

language of work or name

English

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publication date

1 July 2004

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6 December 2017

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6 December 2017

volume

23

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6 December 2017

issue

32

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6 December 2017

page(s)

5505-5512

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Regulation of p53 function and stability by phosphorylation

6 December 2017

cites work

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Stress signals utilize multiple pathways to stabilize p53

21 January 2018

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Enhanced phosphorylation of p53 by ATM in response to DNA damage

21 January 2018

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Phosphorylation of serines 15 and 37 is necessary for efficient accumulation of p53 following irradiation with UV.

21 January 2018

1 reference

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Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53

21 January 2018

1 reference

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DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

21 January 2018

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An intact HDM2 RING-finger domain is required for nuclear exclusion of p53.

21 January 2018

1 reference

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

21 January 2018

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Common and reversible regulation of wild-type p53 function and of ribosomal biogenesis by protein kinases in human cells

21 January 2018

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p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

21 January 2018

1 reference

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

The MDM2 RING-finger domain is required to promote p53 nuclear export

21 January 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Downregulation of MDM2 stabilizes p53 by inhibiting p53 ubiquitination in response to specific alkylating agents

21 January 2018

1 reference

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Nuclear and cytoplasmic degradation of endogenous p53 and HDM2 occurs during down-regulation of the p53 response after multiple types of DNA damage

21 January 2018

1 reference

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Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation

21 January 2018

1 reference

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ATM associates with and phosphorylates p53: mapping the region of interaction

21 January 2018

1 reference

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Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Regulation of p53 stability by Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

p53 and MDM2 are regulated by PI-3-kinases on multiple levels under stress induced by UV radiation and proteasome dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stress

21 January 2018

1 reference

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Induction of ser15 and lys382 modifications of p53 by blockage of transcription elongation.

21 January 2018

1 reference

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

1 reference

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Ubiquitination of p53 and p21 is differentially affected by ionizing and UV radiation

21 January 2018

1 reference

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UV Irradiation Stimulates Levels of p53 Cellular Tumor Antigen in Nontransformed Mouse Cells

21 January 2018

1 reference

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ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Multiple lysine mutations in the C-terminal domain of p53 interfere with MDM2-dependent protein degradation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Phosphorylation and nuclear accumulation are distinct events contributing to the activation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Functional and dynamic aspects of the mammalian nucleolus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Drug-induced dispersal of transcribed rRNA genes and transcriptional products: immunolocalization and silver staining of different nucleolar components in rat cells treated with 5,6-dichloro-beta-D-ribofuranosylbenzimidazole

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Nitric oxide induces phosphorylation of p53 and impairs nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Nuclear accumulation of p53 protein is mediated by several nuclear localization signals and plays a role in tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Functional role of Mdm2 phosphorylation by ATR in attenuation of p53 nuclear export

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Stabilization of p53 by CP-31398 inhibits ubiquitination without altering phosphorylation at serine 15 or 20 or MDM2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

p53 Activation by nitric oxide involves down-regulation of Mdm2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

The p53-mdm-2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Cocompartmentalization of p53 and Mdm2 is a major determinant for Mdm2-mediated degradation of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

A p53 amino-terminal nuclear export signal inhibited by DNA damage-induced phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

Ubiquitous induction of p53 in tumor cells by antisense inhibition of MDM2 expression.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

Inhibition of RNA polymerase II as a trigger for the p53 response

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

p53-dependent induction of apoptosis by proteasome inhibitors

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

P53 transformation-related protein accumulates in the nucleus of transformed fibroblasts in association with the chromatin and is found in the cytoplasm of non-transformed fibroblasts

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

p53-dependent apoptosis suppresses tumor growth and progression in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

Differential regulation of the p21/WAF-1 and mdm2 genes after high-dose UV irradiation: p53-dependent and p53-independent regulation of the mdm2 gene.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

MDM2-dependent ubiquitination of nuclear and cytoplasmic P53

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207709

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207709

1 reference

Dimensions Publication ID

6 December 2017

1041161775

0 references

1 reference