Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo. (Q45971854)

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21 February 2020

title

Specific inhibition of p25/Cdk5 activity by the Cdk5 inhibitory peptide reduces neurodegeneration in vivo (English)

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21 February 2020

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Gavin S. Dawe

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Kai-Hsiang Chuang

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Markus R Wenk

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21 February 2020

author name string

Jeyapriya Raja Sundaram

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Charlene Priscilla Poore

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21 February 2020

Noor Hazim Bin Sulaimee

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21 February 2020

A B M A Asad

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21 February 2020

Ramamoorthy Rajkumar

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21 February 2020

Wei Fun Cheong

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Harish C Pant

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21 February 2020

Sashi Kesavapany

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language of work or name

English

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publication date

1 January 2013

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21 February 2020

published in

Journal of Neuroscience

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volume

33

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issue

1

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page(s)

334-343

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Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration

21 February 2020

cites work

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12 December 2020

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

1 reference

12 December 2020

Neurotoxicity induces cleavage of p35 to p25 by calpain

1 reference

12 December 2020

Processing of cdk5 Activator p35 to Its Truncated Form (p25) by Calpain in Acutely Injured Neuronal Cells

1 reference

12 December 2020

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

1 reference

12 December 2020

Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25.

1 reference

12 December 2020

Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase inhibitors?

1 reference

12 December 2020

The levels of cdk5 and p35 proteins and tau phosphorylation are reduced during neuronal apoptosis

1 reference

12 December 2020

New temperature modification makes the Bielschowsky silver stain reproducible.

1 reference

12 December 2020

Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain

1 reference

12 December 2020

Neurobiology: p25 protein in neurodegeneration

1 reference

12 December 2020

1 reference

12 December 2020

Cyclin-dependent kinase 5 (cdk5) activation requires interaction with three domains of p35.

1 reference

12 December 2020

Comparative analysis of an improved thioflavin-s stain, Gallyas silver stain, and immunohistochemistry for neurofibrillary tangle demonstration on the same sections.

1 reference

12 December 2020

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25-transgenic mice

1 reference

12 December 2020

p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro

1 reference

12 December 2020

A peptide derived from cyclin-dependent kinase activator (p35) specifically inhibits Cdk5 activity and phosphorylation of tau protein in transfected cells

1 reference

12 December 2020

Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration

1 reference

12 December 2020

AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.

1 reference

12 December 2020

Cdk5 as a drug target for the treatment of Alzheimer's disease

1 reference

12 December 2020

A within-subjects, within-task demonstration of intact spatial reference memory and impaired spatial working memory in glutamate receptor-A-deficient mice.

1 reference

12 December 2020

Cdk5 is a key factor in tau aggregation and tangle formation in vivo

1 reference

12 December 2020

Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles

1 reference

12 December 2020

Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease

1 reference

12 December 2020

Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles

1 reference

12 December 2020

Cyclin-dependent kinase 5 in amyotrophic lateral sclerosis

1 reference

12 December 2020

Neuronal cyclin-dependent kinase 5: role in nervous system function and its specific inhibition by the Cdk5 inhibitory peptide

1 reference

12 December 2020

The glamour and gloom of glycogen synthase kinase-3

1 reference

12 December 2020

A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons

1 reference

12 December 2020

In vivo detection of neuroarchitecture in the rodent brain using manganese-enhanced MRI.

1 reference

12 December 2020

Cdk5 deregulation in the pathogenesis of Alzheimer's disease

1 reference

12 December 2020

A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

1 reference

12 December 2020

Improved neuronal tract tracing using manganese enhanced magnetic resonance imaging with fast T(1) mapping.

1 reference

12 December 2020

The roles of cyclin-dependent kinase 5 and glycogen synthase kinase 3 in tau hyperphosphorylation

1 reference

12 December 2020

Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation.

1 reference

12 December 2020

p25/cyclin-dependent kinase 5 induces production and intraneuronal accumulation of amyloid beta in vivo.

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12 December 2020

p25/cyclin-dependent kinase 5 promotes the progression of cell death in nucleus of endoplasmic reticulum-stressed neurons

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12 December 2020

Peptides derived from Cdk5 activator p35, specifically inhibit deregulated activity of Cdk5.

1 reference

12 December 2020

Neurodegeneration and neuroinflammation in cdk5/p25-inducible mice: a model for hippocampal sclerosis and neocortical degeneration

1 reference

12 December 2020

Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing.

1 reference

12 December 2020

Cdk5-mediated phosphorylation of delta-catenin regulates its localization and GluR2-mediated synaptic activity

1 reference

12 December 2020

A 24-residue peptide (p5), derived from p35, the Cdk5 neuronal activator, specifically inhibits Cdk5-p25 hyperactivity and tau hyperphosphorylation

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12 December 2020

Cyclin-dependent kinase 5 promotes pancreatic β-cell survival via Fak-Akt signaling pathways.

1 reference

12 December 2020

Cdk5/p25-induced cytosolic PLA2-mediated lysophosphatidylcholine production regulates neuroinflammation and triggers neurodegeneration.

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12 December 2020

Early cerebrovascular inflammation in a transgenic mouse model of Alzheimer's disease

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12 December 2020

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

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12 December 2020

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

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12 December 2020

Nitric oxide synthase inhibitors impair reference memory formation in a radial arm maze task in rats.

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12 December 2020

10.1523/JNEUROSCI.3593-12.2013

Identifiers

DOI

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21 February 2020

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21 February 2020

PubMed publication ID

23283346

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