Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics (Q46076879)

19 December 2017

title

Cytochrome P450 and Non-Cytochrome P450 Oxidative Metabolism: Contributions to the Pharmacokinetics, Safety, and Efficacy of Xenobiotics (English)

1 reference

19 December 2017

1 reference

Robert S Foti

1

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19 December 2017

Deepak K Dalvie

series ordinal

2

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19 December 2017

language of work or name

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13 June 2016

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19 December 2017

Drug Metabolism and Disposition

published in

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19 December 2017

volume

44

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19 December 2017

issue

8

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19 December 2017

page(s)

1229-1245

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19 December 2017

Simultaneous quantification of the abundance of several cytochrome P450 and uridine 5'-diphospho-glucuronosyltransferase enzymes in human liver microsomes using multiplexed targeted proteomics.

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Absolute quantification of aldehyde oxidase protein in human liver using liquid chromatography-tandem mass spectrometry

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Design of ester prodrugs to enhance oral absorption of poorly permeable compounds: challenges to the discovery scientist

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Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation

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Thienopyridines and other ADP-receptor antagonists

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The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans

21 January 2018

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Carboxylesterase-mediated transesterification of meperidine (Demerol) and methylphenidate (Ritalin) in the presence of [2H6]ethanol: preliminary in vitro findings using a rat liver preparation.

21 January 2018

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Potential bioactivation pathways for the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

21 January 2018

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Prevalence of Non-Cytochrome P450-Mediated Metabolism in Food and Drug Administration-Approved Oral and Intravenous Drugs: 2006-2015.

21 January 2018

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Quantification of Flavin-containing Monooxygenases 1, 3, and 5 in Human Liver Microsomes by UPLC-MRM-Based Targeted Quantitative Proteomics and Its Application to the Study of Ontogeny.

21 January 2018

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Identification of the enzymatic mechanism of nitroglycerin bioactivation

21 January 2018

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Metabolic activation of the N-hydroxy derivative of the carcinogen 4-aminobiphenyl by human tissue sulfotransferases.

21 January 2018

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Metabolic activation of methyl-hydroxylated derivatives of 7,12-dimethylbenz[a]anthracene by human liver dehydroepiandrosterone-steroid sulfotransferase.

21 January 2018

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Interspecies differences in the metabolism of methotrexate: An insight into the active site differences between human and rabbit aldehyde oxidase

21 January 2018

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Structural insights into xenobiotic and inhibitor binding to human aldehyde oxidase

21 January 2018

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The First Mammalian Aldehyde Oxidase Crystal Structure: INSIGHTS INTO SUBSTRATE SPECIFICITY

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Distribution of microsomal epoxide hydrolase in humans: an immunohistochemical study in normal tissues, and benign and malignant tumours

21 January 2018

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The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver

21 January 2018

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Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients

21 January 2018

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Biotransformation reactions of five-membered aromatic heterocyclic rings

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Clinical pharmacokinetics and pharmacodynamics of allopurinol and oxypurinol

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Species-specific metabolism of SGX523 by aldehyde oxidase and the toxicological implications

21 January 2018

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Mechanisms of idiosyncratic drug reactions: the case of felbamate.

21 January 2018

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Human extrahepatic cytochromes P450: function in xenobiotic metabolism and tissue-selective chemical toxicity in the respiratory and gastrointestinal tracts

21 January 2018

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Phase I and pharmacokinetic study of BIBX 1382 BS, an epidermal growth factor receptor (EGFR) inhibitor, given in a continuous daily oral administration

21 January 2018

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Mammalian cytosolic glutathione transferases

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Raising the colors: personal reflections on the glucuronidation revolution 1950-1970.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Characterization of the active site properties of CYP4F12.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

The role of epoxide hydrolases in health and disease

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Lessons learned from marketed and investigational prodrugs

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Liver-based in vitro technologies for drug biotransformation studies - a review.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

"Target-Site" Drug Metabolism and Transport.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Human sulfotransferases and their role in chemical metabolism.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

The role of aldehyde oxidase in drug metabolism

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Subcellular localization of cytochrome P450, and activities of several enzymes responsible for drug metabolism in the human brain

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Membrane transporters in drug development

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Influence of omeprazole on the antiplatelet action of clopidogrel associated with aspirin: the randomized, double-blind OCLA (Omeprazole CLopidogrel Aspirin) study

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Beyond efficacy: pharmacokinetic differences between clopidogrel, prasugrel and ticagrelor.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

An appraisal of the use of monoamine oxidase as an enzyme marker for the outer membrane of rat liver mitochondria

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Bioactivation to an aldehyde metabolite--possible role in the onset of toxicity induced by the anti-HIV drug abacavir

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Soluble epoxide hydrolase: gene structure, expression and deletion

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Hypersensitivity reactions during therapy with the nucleoside reverse transcriptase inhibitor abacavir

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Cynomolgus monkey as a surrogate for human aldehyde oxidase metabolism of the EGFR inhibitor BIBX1382.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Characterization of aldehyde oxidase enzyme activity in cryopreserved human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Unexpected renal toxicity associated with SGX523, a small molecule inhibitor of MET.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Oxidative metabolic pathway of lenvatinib mediated by aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Species differences in metabolism of ripasudil (K-115) are attributed to aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Pharmacokinetics and pharmacodynamics of the triptan antimigraine agents: a comparative review

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Covalent modification of microsomal lipids by thiobenzamide metabolites in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Clinical drug interaction profile of idelalisib in healthy subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Some observations upon a new inhibitor of monoamine oxidase in brain tissue.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Temporary forced laughter after unilateral strokes

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Reactivity of atropaldehyde, a felbamate metabolite in human liver tissue in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Mechanism of differential inhibition of hepatic and pancreatic fatty acid ethyl ester synthase by inhibitors of serine-esterases: in vitro and cell culture studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Simultaneous absolute quantification of 11 cytochrome P450 isoforms in human liver microsomes by liquid chromatography tandem mass spectrometry with in silico target peptide selection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Oxidative metabolism of carbazeran in vitro by liver cytosol of baboon and man.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Membrane transporters in drug development

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Phylogenetic and functional analyses of the cytochrome P450 family 4.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Pathway-Targeted Pharmacogenomics of CYP1A2 in Human Liver.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Developmental expression of human hepatic CYP2C9 and CYP2C19.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

6-Deoxyacyclovir: a xanthine oxidase-activated prodrug of acyclovir

21 January 2018

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Characterization of sulfoxygenation and structural implications of human flavin-containing monooxygenase isoform 2 (FMO2.1) variants S195L and N413K.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Hepatic CYP2B6 expression: gender and ethnic differences and relationship to CYP2B6 genotype and CAR (constitutive androstane receptor) expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Comparison of in vitro methods for carboxylesterase activity determination in immortalized cells representative of the intestine, liver and kidney.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Mass spectrometry-based absolute quantification of microsomal cytochrome P450 2D6 in human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor

21 January 2018

1 reference

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The c-Met Tyrosine Kinase Inhibitor JNJ-38877605 Causes Renal Toxicity through Species-Specific Insoluble Metabolite Formation

21 January 2018

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Meperidine carboxylesterase in mouse and human livers

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Carbonyl reduction pathways in drug metabolism.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Non-P450 aldehyde oxidizing enzymes: the aldehyde dehydrogenase superfamily

21 January 2018

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The MPTP story: MAO activates tetrahydropyridine derivatives to toxins causing parkinsonism

21 January 2018

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Biochemistry and molecular biology of drug-metabolizing sulfotransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Localization of microsomal epoxide hydrolase in normal and neoplastic human kidney.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

The revised human liver cytochrome P450 "Pie": absolute protein quantification of CYP4F and CYP3A enzymes using targeted quantitative proteomics

21 January 2018

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Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches.

21 January 2018

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Mechanism of neurotoxic action of beta,beta'-iminodipropionitrile (IDPN): N-hydroxylation enhances neurotoxic potency

21 January 2018

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Effect of methimazole, an FMO substrate and competitive inhibitor, on the neurotoxicity of 3,3'-iminodipropionitrile in male rats.

21 January 2018

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Expression of UGT1A and UGT2B mRNA in human normal tissues and various cell lines.

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Human liver expression of CYP2C8: gender, age, and genotype effects

21 January 2018

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The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Enzymologic and pharmacologic profile of loxoprofen sodium and its metabolites

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Potent inhibition of human liver aldehyde oxidase by raloxifene

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Human liver aldehyde oxidase: inhibition by 239 drugs

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Simultaneous absolute protein quantification of transporters, cytochromes P450, and UDP-glucuronosyltransferases as a novel approach for the characterization of individual human liver: comparison with mRNA levels and activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Carbonyl reductases: the complex relationships of mammalian carbonyl- and quinone-reducing enzymes and their role in physiology

21 January 2018

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https://api.crossref.org/works/10.1124%2FDMD.116.071753

Oxidizing species in the mechanism of cytochrome P450.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Quantitation and kinetic properties of hepatic microsomal and recombinant flavin-containing monooxygenases 3 and 5 from humans

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Felbamate: consensus of current clinical experience

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Oxidative activation of thiacetazone by the Mycobacterium tuberculosis flavin monooxygenase EtaA and human FMO1 and FMO3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Structure of UDP-glucuronosyltransferases in membranes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Prodrugs: design and clinical applications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

An in vitro mechanistic study to elucidate the desipramine/bupropion clinical drug-drug interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Inhibition of zaleplon metabolism by cimetidine in the human liver: in vitro studies with subcellular fractions and precision-cut liver slices

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Clinical and toxicological relevance of CYP2C9: drug-drug interactions and pharmacogenetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Prochiral sulfides as in vitro probes for multiple forms of the flavin-containing monooxygenase.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Targeted antipeptide antibodies to cytochrome P450 2C18 based on epitope mapping of an inhibitory monoclonal antibody to P450 2C51

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Heterogeneity of NADPH-dependent aldehyde reductase from human and rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

N-deacetyl ketoconazole-induced hepatotoxicity in a primary culture system of rat hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent binding

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Interaction between human serum albumin and the felbamate metabolites 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Contribution of Major Metabolites toward Complex Drug-Drug Interactions of Deleobuvir: In Vitro Predictions and In Vivo Outcomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Structure, function and regulation of carboxylesterases

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Absolute quantification and differential expression of drug transporters, cytochrome P450 enzymes, and UDP-glucuronosyltransferases in cultured primary human hepatocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Interactions between cytochrome P450 and cytochrome b5.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Sumatriptan clinical pharmacokinetics

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Flavin containing monooxygenase 3 exerts broad effects on glucose and lipid metabolism and atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Potent inhibition of CYP2D6 by haloperidol metabolites: stereoselective inhibition by reduced haloperidol

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

A novel reaction mediated by human aldehyde oxidase: amide hydrolysis of GDC-0834

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Targeted label-free approach for quantification of epoxide hydrolase and glutathione transferases in microsomes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Aldehyde dehydrogenase 1B1: molecular cloning and characterization of a novel mitochondrial acetaldehyde-metabolizing enzyme

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Clinical pharmacokinetics and pharmacodynamics of the oral direct thrombin inhibitor dabigatran etexilate

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

FAD-dependent enzymes involved in the metabolic oxidation of xenobiotics

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Biochemical characterization of some pyrazolopyrimidine-based inhibitors of xanthine oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

P-glycoprotein, CYP3A, and Plasma Carboxylesterase Determine Brain Disposition and Oral Availability of the Novel Taxane Cabazitaxel (Jevtana) in Mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

In vitro drug metabolism by human carboxylesterase 1: focus on angiotensin-converting enzyme inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Immunocytochemical localization of monoamine oxidases A and B in human peripheral tissues and brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Stereochemistry of cytochrome P-450 reactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Human UDP-glucuronosyltransferases: metabolism, expression, and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Immunochemical quantification of cynomolgus CYP2J2, CYP4A and CYP4F enzymes in liver and small intestine.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Microsomal epoxide hydrolase 1 (EPHX1): Gene, structure, function, and role in human disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

The antituberculosis drug ethionamide is activated by a flavoprotein monooxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Comparative hepatic and extrahepatic enantioselective sulfoxidation of albendazole and fenbendazole in sheep and cattle

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

The metabolic activation of abacavir by human liver cytosol and expressed human alcohol dehydrogenase isozymes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Gemfibrozil inhibits CYP2C8-mediated cerivastatin metabolism in human liver microsomes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Site-directed mutagenesis of aldehyde dehydrogenase-2 suggests three distinct pathways of nitroglycerin biotransformation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Comparative analysis of CYP3A expression in human liver suggests only a minor role for CYP3A5 in drug metabolism

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Predicting in vivo drug interactions from in vitro drug discovery data

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Immunohistochemical localization of carbonyl reductase in human tissues

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Cytochrome P450 2J2: distribution, function, regulation, genetic polymorphisms and clinical significance

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Lisofylline: a potential lead for the treatment of diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Are circulating metabolites important in drug-drug interactions?: Quantitative analysis of risk prediction and inhibitory potency

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

The therapeutic potential of monoamine oxidase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Comprehensive analysis of the genetic factors determining expression and function of hepatic CYP2D6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

In silico and in vitro pharmacogenetics: aldehyde oxidase rapidly metabolizes a p38 kinase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Effects of major transporter and metabolizing enzyme gene polymorphisms on carbamazepine metabolism in Chinese patients with epilepsy

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Flavin-containing monooxygenases: enzymes adapted for multisubstrate specificity

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

In vitro-in vivo correlation for intrinsic clearance for drugs metabolized by human aldehyde oxidase

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Characterization of the effects of N-hydroxy-IDPN on the auditory, vestibular, and olfactory systems in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Glucuronidation Converts Clopidogrel to a Strong Time-Dependent Inhibitor of CYP2C8: A Phase II Metabolite as a Perpetrator of Drug–Drug Interactions

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Monitoring abacavir bioactivation in humans: screening for an aldehyde metabolite

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

Potential for drug interactions mediated by polymorphic flavin-containing monooxygenase 3 in human livers

21 January 2018

1 reference

https://api.crossref.org/works/10.1124%2FDMD.116.071753

The fate of foreign compounds in man and animals

21 January 2018

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/citations/10.1351/PAC196918010129

Identifiers

DOI

10.1124/DMD.116.071753

1 reference

19 December 2017

1 reference

19 December 2017