Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease (Q46529505)

22 December 2017

title

Statin treatment and a disease-specific pattern of beta-amyloid peptides in Alzheimer's disease (English)

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22 December 2017

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5

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22 December 2017

Kaj Blennow

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object named as

Kaj Blennow

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22 December 2017

1

Kina Höglund

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22 December 2017

Piotr Lewczuk

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object named as

Piotr Lewczuk

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22 December 2017

author name string

Steinar Syversen

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22 December 2017

Anders Wallin

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22 December 2017

publication date

4 June 2005

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22 December 2017

Experimental Brain Research

published in

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22 December 2017

volume

164

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22 December 2017

issue

2

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22 December 2017

page(s)

205-214

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22 December 2017

https://scigraph.springernature.com/pub.10.1007/s00221-005-2243-8

exact match

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cites work

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Effects of statins on human cerebral cholesterol metabolism and secretion of Alzheimer amyloid peptide

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Soluble amyloid beta peptide concentration as a predictor of synaptic change in Alzheimer's disease

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Cationic lipids (lipofectamine) and disturbance of cellular cholesterol and sphingomyelin distribution modulates gamma-secretase activity within amyloid precursor protein in vitro

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Amyloid beta protein (Abeta) starts to deposit as plasma membrane-bound form in diffuse plaques of brains from hereditary cerebral hemorrhage with amyloidosis-Dutch type, Alzheimer disease and nondemented aged subjects

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Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.

21 January 2018

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12 December 2020

Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: differences between early- and late-onset Alzheimer disease and stability during the course of disease.

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12 December 2020

Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity

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Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Pravastatin at 10 mg/day does not decrease plasma levels of either amyloid-β (Aβ) 40 or Aβ 42 in humans

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12 December 2020

The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease

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Improved electrophoretic separation and immunoblotting of beta-amyloid (A beta) peptides 1-40, 1-42, and 1-43.

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Purification and cloning of amyloid precursor protein beta-secretase from human brain

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Soluble pool of Abeta amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease

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12 December 2020

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease

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12 December 2020

Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.

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12 December 2020

Plasma levels of amyloid beta proteins did not differ between subjects taking statins and those not taking statins

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12 December 2020

Statins and the risk of dementia

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12 December 2020

Simultaneous measurement of beta-amyloid(1-42), total tau, and phosphorylated tau (Thr181) in cerebrospinal fluid by the xMAP technology.

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12 December 2020

A novel action of alzheimer's amyloid beta-protein (Abeta): oligomeric Abeta promotes lipid release.

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Treatment with controlled-release lovastatin decreases serum concentrations of human beta-amyloid (A beta) peptide

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12 December 2020

The amyloid-beta (Abeta) peptide pattern in cerebrospinal fluid in Alzheimer's disease: evidence of a novel carboxyterminally elongated Abeta peptide

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12 December 2020

Cholesterol modulates alpha-secretase cleavage of amyloid precursor protein

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12 December 2020

Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha

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12 December 2020

Distribution and fluidizing action of soluble and aggregated amyloid beta-peptide in rat synaptic plasma membranes

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12 December 2020

Low cholesterol stimulates the nonamyloidogenic pathway by its effect on the alpha -secretase ADAM 10.

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12 December 2020

No association between the α2-macroglobulin (A2M) deletion and Alzheimer's disease, and no change in A2M mRNA, protein, or protein expression

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CSF markers for incipient Alzheimer's disease

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12 December 2020

Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial

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12 December 2020

Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains

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12 December 2020

Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor

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12 December 2020

Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

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12 December 2020

Serum lipoprotein levels, statin use, and cognitive function in older women

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12 December 2020

Amyloid beta protein (A beta) deposition: A beta 42(43) precedes A beta 40 in Down syndrome

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12 December 2020

Processing of the beta-amyloid precursor protein and its regulation in Alzheimer's disease

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12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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12 December 2020

Inhibition of intracellular cholesterol transport alters presenilin localization and amyloid precursor protein processing in neuronal cells.

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12 December 2020

Regulation of amyloid precursor protein cleavage

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12 December 2020

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12 December 2020

Beta-secretase cleavage at amino acid residue 34 in the amyloid beta peptide is dependent upon gamma-secretase activity

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12 December 2020

Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE

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12 December 2020

A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells

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12 December 2020

Lovastatin enhances Abeta production and senile plaque deposition in female Tg2576 mice

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12 December 2020

Decreased prevalence of Alzheimer disease associated with 3-hydroxy-3-methyglutaryl coenzyme A reductase inhibitors.

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12 December 2020

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12 December 2020

Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people.

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12 December 2020

A basic amino acid in the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein (APP) is essential for cleavage of APP at the alpha-site.

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12 December 2020

Cholesterol depletion inhibits the generation of beta-amyloid in hippocampal neurons

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12 December 2020

BACE2, a beta -secretase homolog, cleaves at the beta site and within the amyloid-beta region of the amyloid-beta precursor protein

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12 December 2020

Statin effects on cholesterol micro-domains in brain plasma membranes

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12 December 2020

The role of cholesterol in the biosynthesis of beta-amyloid

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12 December 2020

Plasma levels of beta-amyloid(1-40), beta-amyloid(1-42), and total beta-amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins

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12 December 2020

Analysis of heterogeneous A4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive Western blot assay.

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12 December 2020

Beta-amyloid (Abeta) protein in cerebrospinal fluid as a biomarker for Alzheimer's disease

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12 December 2020

Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease

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12 December 2020

Membrane-anchored metalloprotease MDC9 has an alpha-secretase activity responsible for processing the amyloid precursor protein

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12 December 2020

Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation.

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12 December 2020

A new multiphasic buffer system for sodium dodecyl sulfate-polyacrylamide gel electrophoresis of proteins and peptides with molecular masses 100,000-1000, and their detection with picomolar sensitivity

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12 December 2020

Elevation of beta-amyloid peptide 2-42 in sporadic and familial Alzheimer's disease and its generation in PS1 knockout cells.

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12 December 2020

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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12 December 2020

A novel epsilon-cleavage within the transmembrane domain of the Alzheimer amyloid precursor protein demonstrates homology with Notch processing

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12 December 2020

Simvastatin strongly reduces levels of Alzheimer's disease beta -amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo

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12 December 2020

Treatment with simvastatin in patients with Alzheimer's disease lowers both alpha- and beta-cleaved amyloid precursor protein

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12 December 2020

Amyloid beta-peptide1-40 increases neuronal membrane fluidity: role of cholesterol and brain region.

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12 December 2020

10.1007/S00221-005-2243-8

Identifiers

DOI

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22 December 2017

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22 December 2017