Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armoury (Q46945028)

26 December 2017

review article

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title

Carboxypeptidase-G2-based gene-directed enzyme-prodrug therapy: a new weapon in the GDEPT armoury (English)

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26 December 2017

author name string

Douglas Hedley

series ordinal

1

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26 December 2017

Lesley Ogilvie

series ordinal

2

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26 December 2017

Caroline Springer

series ordinal

3

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26 December 2017

language of work or name

English

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publication date

1 November 2007

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26 December 2017

published in

Nature Reviews Cancer

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26 December 2017

volume

7

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26 December 2017

issue

11

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26 December 2017

page(s)

870-879

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26 December 2017

https://scigraph.springernature.com/pub.10.1038/nrc2247

exact match

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cites work

Cytolytic viruses as potential anti-cancer agents

1 reference

Long-term survival after gene therapy for a recurrent glioblastoma

21 January 2018

1 reference

Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis

21 January 2018

1 reference

31 March 2020

Cancer statistics, 2006

1 reference

Retroviral-mediated gene therapy for the treatment of hepatocellular carcinoma: an innovative approach for cancer therapy

31 March 2020

1 reference

Use of bacteria as anticancer agents

31 March 2020

1 reference

Combined suicide gene therapy for pancreatic peritoneal carcinomatosis using BGTC liposomes

31 March 2020

1 reference

Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium

31 March 2020

1 reference

Positron emission tomography (PET) imaging of tumor-localized Salmonella expressing HSV1-TK.

31 March 2020

1 reference

Tumor-targeted Salmonella expressing cytosine deaminase as an anticancer agent.

31 March 2020

1 reference

Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment

31 March 2020

1 reference

Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis

31 March 2020

1 reference

Repeated cycles of Clostridium-directed enzyme prodrug therapy result in sustained antitumour effects in vivo

31 March 2020

1 reference

Bifidobacterium longum as a delivery system for cancer gene therapy: selective localization and growth in hypoxic tumors

31 March 2020

1 reference

Bifidobacterium longum as a delivery system for gene therapy of chemically induced rat mammary tumors

31 March 2020

1 reference

Cloned cytosine deaminase gene expression of Bifidobacterium longum and application to enzyme/pro-drug therapy of hypoxic solid tumors

31 March 2020

1 reference

Genetically engineered Bifidobacterium longum for tumor-targeting enzyme-prodrug therapy of autochthonous mammary tumors in rats

31 March 2020

1 reference

Potential therapeutic applications of recombinant, invasive E. coli

31 March 2020

1 reference

Progress and problems with the use of viral vectors for gene therapy

31 March 2020

1 reference

Oncolytic viral therapies

31 March 2020

1 reference

Replication-selective adenoviruses as oncolytic agents

31 March 2020

1 reference

Conditionally replicating adenoviruses for cancer treatment.

31 March 2020

1 reference

Cancer selective adenoviruses

31 March 2020

1 reference

Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

31 March 2020

1 reference

Adenovirus-mediated thymidine kinase gene therapy for recurrent ovarian cancer: expression of coxsackie-adenovirus receptor and integrins alphavbeta3 and alphavbeta5.

31 March 2020

1 reference

Adenoviral vectors: systemic delivery and tumor targeting

31 March 2020

1 reference

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors

31 March 2020

1 reference

Conditionally replicative adenovirus driven by the human telomerase promoter provides broad-spectrum antitumor activity without liver toxicity

31 March 2020

1 reference

Selective ablation of human cancer cells by telomerase-specific adenoviral suicide gene therapy vectors expressing bacterial nitroreductase

31 March 2020

1 reference

Engineering conditionally replication-competent adenoviral vectors carrying the cytosine deaminase gene increases the infectivity and therapeutic effect for breast cancer gene therapy

31 March 2020

1 reference

Tumor vascular targeting therapy with viral vectors

31 March 2020

1 reference

Improvement of transduction efficiency of recombinant adenovirus vector conjugated with cationic liposome for human oral squamous cell carcinoma cell lines

31 March 2020

1 reference

An oncolytic adenovirus vector combining enhanced cell-to-cell spreading, mediated by the ADP cytolytic protein, with selective replication in cancer cells with deregulated wnt signaling

31 March 2020

1 reference

Second-generation replication-competent oncolytic adenovirus armed with improved suicide genes and ADP gene demonstrates greater efficacy without increased toxicity

31 March 2020

1 reference

Replication-competent adenovirus-mediated suicide gene therapy with radiation in a preclinical model of pancreatic cancer

31 March 2020

1 reference

Gene therapy death prompts review of adenovirus vector

31 March 2020

1 reference

Developing VDEPT for DT-diaphorase (NQO1) using an AAV vector plasmid

31 March 2020

1 reference

MIA (melanoma inhibitory activity) promoter mediated tissue-specific suicide gene therapy of malignant melanoma

31 March 2020

1 reference

Transduction of ovarian cancer cells: a recombinant adeno-associated viral vector compared to an adenoviral vector

31 March 2020

1 reference

Suicide gene therapy of sarcoma cell lines using recombinant adeno-associated virus 2 vectors

31 March 2020

1 reference

Suicide gene therapy using AAV-HSVtk/ganciclovir in combination with irradiation results in regression of human head and neck cancer xenografts in nude mice

31 March 2020

1 reference

Replicative retroviral vectors for cancer gene therapy

31 March 2020

1 reference

Genetically engineered vesicular stomatitis virus in gene therapy: application for treatment of malignant disease

31 March 2020

1 reference

Oncolytic viral therapies - the clinical experience

31 March 2020

1 reference

Local inflammation and devascularization--in vivo mechanisms of the "bystander effect" in VPC-mediated HSV-Tk/GCV gene therapy for human malignant glioma

31 March 2020

1 reference

A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme.

31 March 2020

1 reference

The potential for efficacy of the modified (ICP 34.5(-)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study

31 March 2020

1 reference

Brain tumor oncolysis with replication-conditional herpes simplex virus type 1 expressing the prodrug-activating genes, CYP2B1 and secreted human intestinal carboxylesterase, in combination with cyclophosphamide and irinotecan

31 March 2020

1 reference

Cancer gene therapy using a replication-competent herpes simplex virus type 1 vector

31 March 2020

1 reference

Engineered herpes simplex virus expressing bacterial cytosine deaminase for experimental therapy of brain tumors

31 March 2020

1 reference

Proliferative activity and in vitro replication of HSV1716 in human metastatic brain tumours

31 March 2020

1 reference

Efficient gene transfer into human hepatocytes by baculovirus vectors

31 March 2020

1 reference

Vaccinia virus preferentially infects and controls human and murine ovarian tumors in mice

31 March 2020

1 reference

Development of a replication-selective, oncolytic poxvirus for the treatment of human cancers

31 March 2020

1 reference

A new recombinant vaccinia with targeted deletion of three viral genes: its safety and efficacy as an oncolytic virus

31 March 2020

1 reference

Suicide genes for cancer therapy

31 March 2020

1 reference

Mustard prodrugs for activation by Escherichia coli nitroreductase in gene-directed enzyme prodrug therapy

31 March 2020

1 reference

Appropriate subcellular localisation of prodrug-activating enzymes has important consequences for suicide gene therapy

31 March 2020

1 reference

Prodrugs in Cancer Chemotherapy

31 March 2020

1 reference

Kinetic and structural characterisation of Escherichia coli nitroreductase mutants showing improved efficacy for the prodrug substrate CB1954.

31 March 2020

1 reference

Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates

31 March 2020

1 reference

A cell surface tethered enzyme improves efficiency in gene-directed enzyme prodrug therapy

31 March 2020

1 reference

Regressions of established breast carcinoma xenografts by carboxypeptidase G2 suicide gene therapy and the prodrug CMDA are due to a bystander effect

31 March 2020

1 reference

Adenovirus vector-mediated delivery of the prodrug-converting enzyme carboxypeptidase G2 in a secreted or GPI-anchored form: High-level expression of this active conditional cytotoxic enzyme at the plasma membrane

31 March 2020

1 reference

Self-immolative anthracycline prodrugs for suicide gene therapy

31 March 2020

1 reference

Self-immolative nitrogen mustards prodrugs cleavable by carboxypeptidase G2 (CPG2) showing large cytotoxicity differentials in GDEPT.

31 March 2020

1 reference

Significant differences in biological parameters between prodrugs cleavable by carboxypeptidase G2 that generate 3,5-difluoro-phenol and -aniline nitrogen mustards in gene-directed enzyme prodrug therapy systems

31 March 2020

1 reference

Novel fluorinated prodrugs for activation by carboxypeptidase G2 showing good in vivo antitumor activity in gene-directed enzyme prodrug therapy

31 March 2020

1 reference

Self-immolative nitrogen mustard prodrugs for suicide gene therapy.

31 March 2020

1 reference

Systemic gene-directed enzyme prodrug therapy of hepatocellular carcinoma using a targeted adenovirus armed with carboxypeptidase G2.

31 March 2020

1 reference

Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2.

31 March 2020

1 reference

Complex interactions between the replicating oncolytic effect and the enzyme/prodrug effect of vaccinia-mediated tumor regression

31 March 2020

1 reference

Essential roles of zinc ligation and enzyme dimerization for catalysis in the aminoacylase-1/M20 family

31 March 2020

1 reference

Enzymatic cleavage of methotrexate provides a method for prevention of drug toxicity

31 March 2020

1 reference

hTERT promoter induces tumor-specific Bax gene expression and cell killing in syngenic mouse tumor model and prevents systemic toxicity

31 March 2020

1 reference

Combined transcriptional and transductional targeting improves the specificity and efficacy of adenoviral gene delivery to ovarian carcinoma

31 March 2020

1 reference

Adenovirus 5 vector genetically re-targeted by an Affibody molecule with specificity for tumor antigen HER2/neu.

31 March 2020

1 reference

Tumor-selective gene expression in a hepatic metastasis model after locoregional delivery of a replication-competent retrovirus vector

31 March 2020

1 reference

Targeting vaccinia to solid tumors with local hyperthermia

31 March 2020

1 reference

Gene therapy: designer promoters for tumour targeting

31 March 2020

1 reference

Transcriptional Targeting in Cancer Gene Therapy

31 March 2020

1 reference

Transcriptional control: an essential component of cancer gene therapy strategies?

31 March 2020

1 reference

Tumor cell-specific transgene expression prevents liver toxicity of the adeno-HSVtk/GCV approach

31 March 2020

1 reference

Cancer-specific targeting of an adenovirus-delivered herpes simplex virus thymidine kinase suicide gene using translational control.

31 March 2020

1 reference

Targeting and killing of prostate cancer cells using lentiviral constructs containing a sequence recognized by translation factor eIF4E and a prostate-specific promoter.

31 March 2020

1 reference

Current developments in adenovirus-based cancer gene therapy

31 March 2020

1 reference

AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study

31 March 2020

1 reference

Adenoviral-mediated suicide gene therapy for ovarian cancer

31 March 2020

1 reference

Phase I dose escalation clinical trial of adenovirus vector carrying osteocalcin promoter-driven herpes simplex virus thymidine kinase in localized and metastatic hormone-refractory prostate cancer

31 March 2020

1 reference

Suicide gene therapy with adenoviral delivery of HSV-tK gene for patients with local recurrence of prostate cancer after hormonal therapy

31 March 2020

1 reference

Virus specific immune responses after human neoadjuvant adenovirus-mediated suicide gene therapy for prostate cancer.

31 March 2020

1 reference

Phase I trial of replication-competent adenovirus-mediated suicide gene therapy combined with IMRT for prostate cancer

31 March 2020

1 reference

Intratumoral adenovirus-mediated suicide gene transfer for hepatic metastases from colorectal adenocarcinoma: results of a phase I clinical trial

31 March 2020

1 reference

Five-year follow-up of trial of replication-competent adenovirus-mediated suicide gene therapy for treatment of prostate cancer

31 March 2020

1 reference

Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer

31 March 2020

1 reference

Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma.

31 March 2020

1 reference

A pilot study of combined suicide/cytokine gene therapy in two patients with end-stage anaplastic thyroid carcinoma

31 March 2020

1 reference

Toxicity assessment of intratumoral injection of the herpes simplex type I thymidine kinase gene delivered by retrovirus in patients with refractory cancer

31 March 2020

1 reference

Antitumor efficacy and tumor-selective replication with a single intravenous injection of OAS403, an oncolytic adenovirus dependent on two prevalent alterations in human cancer

31 March 2020

1 reference

Metabolism and metabolic actions of 6-methylpurine and 2-fluoroadenine in human cells

31 March 2020

1 reference

The current status of camptothecin analogues as antitumor agents

31 March 2020

1 reference

Novel prodrugs which are activated to cytotoxic alkylating agents by carboxypeptidase G2

31 March 2020

1 reference

Fluorouracil: biochemistry and pharmacology

31 March 2020

1 reference

Positron emission tomography imaging of adenoviral-mediated transgene expression in liver cancer patients

31 March 2020

1 reference

31 March 2020

Identifiers

DOI

10.1038/NRC2247

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26 December 2017

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26 December 2017