Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations. (Q48186706)

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23 February 2020

title

Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations (English)

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23 February 2020

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23 February 2020

Hugo H Marti

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23 February 2020

author name string

Muriel R Kaufmann

1

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23 February 2020

Sandra Barth

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23 February 2020

Uwe Konietzko

3

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23 February 2020

Bei Wu

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23 February 2020

Sascha Egger

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23 February 2020

Meike Hick

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23 February 2020

Ulrike Müller

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23 February 2020

Gieri Camenisch

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23 February 2020

Roland H Wenger

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language of work or name

English

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publication date

1 January 2013

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23 February 2020

published in

Journal of Neuroscience

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23 February 2020

volume

33

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23 February 2020

issue

5

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23 February 2020

page(s)

1915-1926

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity

23 February 2020

cites work

1 reference

12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

1 reference

12 December 2020

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

1 reference

12 December 2020

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1 reference

12 December 2020

Epolones induce erythropoietin expression via hypoxia-inducible factor-1 alpha activation

1 reference

12 December 2020

Mice with combined gene knock-outs reveal essential and partially redundant functions of amyloid precursor protein family members.

1 reference

12 December 2020

Metal chelation as a potential therapy for Alzheimer's disease.

1 reference

12 December 2020

A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60

1 reference

12 December 2020

A conserved family of prolyl-4-hydroxylases that modify HIF

1 reference

12 December 2020

FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity

1 reference

12 December 2020

A galvanic cell suitable for monitoring cortical oxygen in man

1 reference

12 December 2020

Cyclooxygenase-2 and presenilin-1 gene expression induced by interleukin-1beta and amyloid beta 42 peptide is potentiated by hypoxia in primary human neural cells.

1 reference

12 December 2020

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

1 reference

12 December 2020

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

12 December 2020

Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein

1 reference

12 December 2020

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

1 reference

12 December 2020

Altered processing of amyloid precursor protein in the human neuroblastoma SH-SY5Y by chronic hypoxia

1 reference

12 December 2020

Differential display analysis of presenilin 1-deficient mouse brains.

1 reference

12 December 2020

gamma-Secretase activity requires the presenilin-dependent trafficking of nicastrin through the Golgi apparatus but not its complex glycosylation

1 reference

12 December 2020

The antimycotic ciclopirox olamine induces HIF-1alpha stability, VEGF expression, and angiogenesis

1 reference

12 December 2020

C-terminal fragments of amyloid precursor protein exert neurotoxicity by inducing glycogen synthase kinase-3beta expression.

1 reference

12 December 2020

Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration

1 reference

12 December 2020

Oxygen sensing by HIF hydroxylases

1 reference

12 December 2020

Metals in our minds: therapeutic implications for neurodegenerative disorders

1 reference

12 December 2020

Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia

1 reference

12 December 2020

The APP intracellular domain forms nuclear multiprotein complexes and regulates the transcription of its own precursor

1 reference

12 December 2020

Potential roles for presenilin-1 in oxygen sensing and in glial-specific gene expression

1 reference

12 December 2020

Copper-dependent activation of hypoxia-inducible factor (HIF)-1: implications for ceruloplasmin regulation.

1 reference

12 December 2020

Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2.

1 reference

12 December 2020

Reduced synaptic vesicle density and active zone size in mice lacking amyloid precursor protein (APP) and APP-like protein 2.

1 reference

12 December 2020

Bcl-2 regulator FKBP38 is activated by Ca2+/calmodulin

1 reference

12 December 2020

Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition

1 reference

12 December 2020

Integration of oxygen signaling at the consensus HRE.

1 reference

12 December 2020

Hypoxia requires notch signaling to maintain the undifferentiated cell state

1 reference

12 December 2020

Presenilin clinical mutations can affect gamma-secretase activity by different mechanisms

1 reference

12 December 2020

Increased prolyl 4-hydroxylase domain proteins compensate for decreased oxygen levels. Evidence for an autoregulatory oxygen-sensing system

1 reference

12 December 2020

Hypoxia facilitates Alzheimer's disease pathogenesis by up-regulating BACE1 gene expression

1 reference

12 December 2020

The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism

1 reference

12 December 2020

Presenilin diversifies its portfolio.

1 reference

12 December 2020

Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation

1 reference

12 December 2020

The peptidyl prolyl cis/trans isomerase FKBP38 determines hypoxia-inducible transcription factor prolyl-4-hydroxylase PHD2 protein stability

1 reference

12 December 2020

Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain.

1 reference

12 December 2020

Hypoxia-inducible factor 1 (HIF-1) pathway

1 reference

12 December 2020

Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP.

1 reference

12 December 2020

Metals in Alzheimer's and Parkinson's diseases

1 reference

12 December 2020

PHDs overactivation during chronic hypoxia "desensitizes" HIFalpha and protects cells from necrosis

1 reference

12 December 2020

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway

1 reference

12 December 2020

Presenilins: members of the gamma-secretase quartets, but part-time soloists too.

1 reference

12 December 2020

VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion.

1 reference

12 December 2020

Hypoxia-inducible factor prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane anchoring of FKBP38.

1 reference

12 December 2020

Pathological role of hypoxia in Alzheimer's disease

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12 December 2020

Contribution of hypoxia to Alzheimer's disease: is HIF-1alpha a mediator of neurodegeneration?

1 reference

12 December 2020

Nuclear signaling by the APP intracellular domain occurs predominantly through the amyloidogenic processing pathway

1 reference

12 December 2020

Notch signal activates hypoxia pathway through HES1-dependent SRC/signal transducers and activators of transcription 3 pathway

1 reference

12 December 2020

Hypoxia and neurodegeneration

1 reference

12 December 2020

Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors

1 reference

12 December 2020

Up-regulation of hypoxia-inducible factor (HIF)-1α and HIF-target genes in cortical neurons by the novel multifunctional iron chelator anti-Alzheimer drug, M30.

1 reference

12 December 2020

Generation of conditional null alleles for APP and APLP2.

1 reference

12 December 2020

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

1 reference

12 December 2020

Expression of constitutively active erythropoietin receptor in pyramidal neurons of cortex and hippocampus boosts higher cognitive functions in mice

1 reference

12 December 2020

Brain microvasculature and hypoxia-related proteins in Alzheimer's disease

1 reference

12 December 2020

Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α.

1 reference

12 December 2020

Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling

1 reference

12 December 2020

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

1 reference

12 December 2020

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1 reference

12 December 2020

beta-Amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1 reference

12 December 2020

Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

1 reference

12 December 2020

Accumulation of the beta amyloid precursor protein at sites of ischemic injury in rat brain.

1 reference

12 December 2020

The mouse gene for hypoxia-inducible factor-1alpha--genomic organization, expression and characterization of an alternative first exon and 5' flanking sequence

1 reference

12 December 2020

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1 reference

12 December 2020

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1 reference

12 December 2020

Generation of APLP2 KO mice and early postnatal lethality in APLP2/APP double KO mice

1 reference

12 December 2020

Mouse hypoxia-inducible factor-1alpha is encoded by two different mRNA isoforms: expression from a tissue-specific and a housekeeping-type promoter.

1 reference

12 December 2020

10.1523/JNEUROSCI.3402-12.2013

Identifiers

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